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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNTB2 Gene

protein-coding   GIFtS: 54
GCID: GC16P069221

syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa,...

(Previous names: syntrophin, beta 2 (dystrophin-associated protein A1, 59kD,...)
(Previous symbols: SNT2B2, SNTL, D16S2531E)
 Explore 10 diseases affiliated with
SNTB2 via
MalaCards
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 Human Malady Compendium 
Biological research products
for SNTB2    

Aliases
for SNTB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Syntrophin, Beta 2 (Dystrophin-Associated Protein A1, 59kDa, Basic Component
2)1 2
     Syntrophin, Beta 2 (Dystrophin-Associated Protein A1, 59kD, Basic Component 2)1
SNT2B21 2 3 5     Beta-2-Syntrophin1
SNTL1 2 3 5     Dystrophin-Associated Protein A1, 59kD, Basic Component 22
D16S2531E1 2 3     Syntrophin-33
SNT31 2 3     Syntrophin-33
EST252631 2     Syntrophin-Like1
59 KDa Dystrophin-Associated Protein A1 Basic Component 22 3     

External Ids:    HGNC: 111691   Entrez Gene: 66452   Ensembl: ENSG000001688077   OMIM: 6000275   UniProtKB: Q134253   

Export aliases for SNTB2 gene to outside databases

Previous GC identifers: GC16P059906 GC16P069598 GC16P068956 GC16P068997 GC16P067778 GC16P055093


Summaries
for SNTB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SNTB2:
Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing
in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The
protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related
proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related
genes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SNTB2_HUMAN, Q13425
Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane
proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a
role in the regulation of secretory granules via its interaction with PTPRN

Gene Wiki entry for SNTB2


Genomic Views
for SNTB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNTB2 gene promoter:
         p53   SREBP-1c   POU6F1 (c2)   CUTL1   POU3F2   SREBP-1b   FOXL1   POU2F1   SREBP-1a   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNTB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNTB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNTB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

SNTB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNTB2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P069221:  view genomic region     (about GC identifiers)

Start:
 69,221,032 bp from pter      End:
 69,342,955 bp from pter
Size:
 121,924 bases      Orientation:
 plus strand

Proteins
for SNTB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SNTB2_HUMAN, Q13425 (See protein sequence)
Recommended Name: Beta-2-syntrophin  
Size: 540 amino acids; 57950 Da
Subunit: Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family: SNTA1 and SNTB1;
and with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and
microtubule-associated proteins (By similarity). Interacts with the dystrophin protein DMD and related proteins DTNA
and UTRN, and with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from
protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results
in the cleavage of PTPRN
Subcellular location: Membrane. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cell
junction (By similarity). Cytoplasm, cytoskeleton. Note=Membrane-associated. In muscle, it is exclusively localized at
the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules
1 PDB 3D structure from and Proteopedia for SNTB2:
2VRF (3D)    
Secondary accessions: Q9BY09
Alternative splicing: 2 isoforms:  Q13425-1   Q13425-2   (Lacks domains required for interaction with dystrophin related proteins. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SNTB2: NX_Q13425

Post-translational modifications:

  • Phosphorylated. Partially dephosphorylated upon insulin stimulation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13425

    • SNTB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006741.1  
    ENSEMBL proteins: 
     ENSP00000338191   ENSP00000436443   ENSP00000462765   ENSP00000432201   ENSP00000353686  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm IDA19786618
    GO:0005874microtubule IEA--
    GO:0016010dystrophin-associated glycoprotein complex TAS8576247
    GO:0016020membrane TAS8576247


    SNTB2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SNTB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNTB2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001478 PDZ
     IPR001849 Pleckstrin_homology
     IPR015482 Syntrophin

    Graphical View of Domain Structure for InterPro Entry Q13425

    ProtoNet protein and cluster: Q13425

    2 Blocks protein families:
    IPB001478 PDZ/DHR/GLGF domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: SNTB2_HUMAN, Q13425
    Domain: The PH 1 domain mediates the oligomerization in a calcium dependent manner (By similarity)
    Domain: The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The
    association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the
    membrane (By similarity)
    Domain: The SU domain binds calmodulin in a calcium-dependent manner (By similarity)
    Similarity: Belongs to the syntrophin family
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 2 PH domains
    Similarity: Contains 1 SU (syntrophin unique) domain


    Function
    for SNTB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SNTB2_HUMAN, Q13425
    Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane
    proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a
    role in the regulation of secretory granules via its interaction with PTPRN

    miRNA
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    hsa-miR-140-5p hsa-miR-520f hsa-miR-361-5p hsa-miR-106a hsa-miR-605 hsa-miR-519a hsa-miR-3622b-3p hsa-miR-149
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI19786618
    GO:0005516calmodulin binding IEA--
    GO:0005543phospholipid binding IEA--


    SNTB2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SNTB2:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Sntb2tm1Maad for SNTB2
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sntb2):
     behavior/neurological  nervous system  normal 

    SNTB2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SNTB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNTB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for SNTB2 (Q134252, 3 ENSP000003381914) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCA1O954772, 3, ENSP000003638684MINT-59502 MINT-59503 MINT-59501 I2D: score=4 STRING: ENSP00000363868
    PTPRNQ168493, ENSP000002957184I2D: score=4 STRING: ENSP00000295718
    MAST1Q9Y2H93, ENSP000002514724I2D: score=3 STRING: ENSP00000251472
    UTRNP469393, ENSP000003565154I2D: score=3 STRING: ENSP00000356515
    DGKZQ135743, ENSP000003203404I2D: score=2 STRING: ENSP00000320340
    About this table

    Drugs & Compounds
    for SNTB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNTB2

    2 HMDB Compounds for SNTB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    SodiumSodium (see all 2)7440-23-5--
    Search CenterWatch for drugs/clinical trials and news about SNTB2 

    Transcripts
    for SNTB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNTB2 gene (2 alternative transcripts): 
    NM_006750.3  NM_130845.1  

    Unigene Cluster for SNTB2:

    Syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
    Hs.461117  [show with all ESTs]
    Unigene Representative Sequence: NM_006750
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336278(uc002ewu.3 uc021tkg.1) ENST00000467311 ENST00000524887
    ENST00000525632 ENST00000360496 ENST00000528525

    miRNA
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    8/142 QIAGEN miScript miRNA Assays for microRNAs that regulate SNTB2 (see all 142):
    hsa-miR-140-5p hsa-miR-520f hsa-miR-361-5p hsa-miR-106a hsa-miR-605 hsa-miR-519a hsa-miR-3622b-3p hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: SNTB2
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC031058.1 BC035134.1 BC036429.1 BC048215.1 U40572.1 

    9 DOTS entries:

    DT.317014  DT.97801389  DT.92423026  DT.443412  DT.100033800  DT.95159768  DT.120681056  DT.204175 
    DT.92063784 

    24/648 AceView cDNA sequences (see all 648):

    BF438374 AI588965 BF062645 AI383671 AI694536 AA463989 BU507064 BU581525 
    AI083530 BM704904 AF159063 NM_013245 BQ705926 BM554319 BE464460 BU849977 
    BQ009595 AI217642 BF528086 AA176853 BU742039 U40572 CD671251 BF222948 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SNTB2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9
    SP1:                    -                                                     -                     
    SP2:                    -           -     -     -     -                       -                     
    SP3:                                                                                                
    SP4:                    -                       -     -                                             
    SP5:              -     -                                                                           


    ECgene alternative splicing isoforms for SNTB2

    Expression
    for SNTB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNTB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACCTGCACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SNTB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNTB2

    SOURCE GeneReport for Unigene cluster: Hs.461117

    UniProtKB/Swiss-Prot: SNTB2_HUMAN, Q13425
    Tissue specificity: Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested
    tissues, except in liver and heart where it is highly expressed

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    In Situ
    Assay Products:     
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    Orthologs
    for SNTB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SNTB2 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SNTB21 syntrophin, beta 2 (dystrophin-associated protein A1, more 76.78(n)
    84.11(a)    		   769654  XM_001232941.2  XP_001232942.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SNTB26
    SNTA16
    (see all 3)    		 --
    		 73(a)
    48(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 GL343643.1(2143-15732)
    4(136242444-136252823)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003313231 beta-2-syntrophin-like 63.43(n)
    65.08(a)    		   100331323  XM_002666912.2  XP_002666958.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Syn13 cytoskeletal protein binding 38(a)   78F1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea stn-13 beta1-syntrophin 39(a)   I(9509379-9512877)   --


    ENSEMBL Gene Tree for SNTB2 (if available)
    TreeFam Gene Tree for SNTB2 (if available) 

    Paralogs
    for SNTB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNTB2 gene
    SNTG12  SNTA12  SNTB12  SNTG22  
    3 SIMAP similar genes for SNTB2 using alignment to 8 protein entries:     SNTB2_HUMAN (see all proteins):
    DLG4    SNTA1    SNTB1

    SNTB2 for paralogs           About GeneDecksing



    Genomic Variants
    for SNTB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1829 NCBI SNPs in SNTB2 are shown (see all 1829)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1865639071,2
    		--69219285(+) AGCTGC/GAATTA 1 -- us2k10--------
    rs1897207001,2
    		--69219691(+) ACCCCA/GGGTGA 1 -- us2k10--------
    rs104009271,2
    		C--69219786(+) tctttC/Tttttt 1 -- us2k1 trp31Minor allele frequency- T:0.00NA 2
    rs713847391,2
    		C--69219790(+) TCTTTC/TTTTTT 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1120051811,2
    		C,--69219893(+) AAGCAG/ATTCTC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1830896591,2
    		--69220045(+) TCAGCA/CTCTCA 1 -- us2k10--------
    rs1119648921,2
    		C,--69220080(+) CCACCG/ACGCCC 1 -- us2k13Minor allele frequency- A:0.05NA EA 242
    rs1141223441,2
    		F,--69220237(+) CCAGTC/TCCTTG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1413139721,2
    		--69220241(+) TCCCTG/TGTAAT 1 -- us2k10--------
    rs285697941,2
    		C,F,--69220451(+) TTTGCT/CTGAGC 1 -- us2k110Minor allele frequency- C:0.16NA EA WA 520

    HapMap Linkage Disequilibrium report for SNTB2 (69221032 - 69342955 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for SNTB2
         7 CNVs: 23513 35399 5832 35398 35397 35400 58771

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    Disorders / Diseases
    for SNTB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNTB2 for disorders           About GeneDecksing

    OMIM gene information: 600027    OMIM disorders: --

    10 diseases for SNTB2:    About MalaCards
    duchenne muscular dystrophy    muscular dystrophy    north american indian childhood cirrhosis    becker muscular dystrophy
    insulinoma    t-cell leukemia    myopathy    leukemia
    pancreatitis    neuronitis

    Genetic Association Database (GAD): SNTB2

    Export disorders for SNTB2 gene to outside databases

    Publications
    for SNTB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNTB2 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with SNTB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. (PubMed id 8576247)1, 2, 3, 9 Ahn A.H.... Kunkel L.M. (1996)
    2. Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24. (PubMed id 8183929)1, 3, 9 Ahn A.H.... Kunkel L.M. (1994)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Deficiency of the syntrophins and alpha-dystrobrevin in patients with inherited myopathy. (PubMed id 12899872)1, 4 Jones K.J....North K.N. (2003)
    7. Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion. (PubMed id 11483505)1, 2 Ort T....Solimena M. (2001)
    8. The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. (PubMed id 10725395)1, 2 Garcia R.A.... Buonanno A. (2000)
    9. The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells. (PubMed id 11043403)1, 2 Ort T.... Solimena M. (2000)
    10. Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases. (PubMed id 10404183)1, 9 Lumeng C....Chamberlain J.S. (1999)

    External Searches for SNTB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SNTB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6645 HGNC: 11169 AceView: SNTB2andVPS4A Ensembl:ENSG00000168807 euGenes: HUgn6645
    ECgene: SNTB2 H-InvDB: SNTB2

    Other Databases showing SNTB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SNTB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNTB2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SNTB2 gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SNTB2 gene:
    Search GeneIP for patents involving SNTB2

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