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Aliases for SNTB2 Gene

Aliases for SNTB2 Gene

  • Syntrophin, Beta 2 (Dystrophin-Associated Protein A1, 59kDa, Basic Component 2) 2 3
  • SNT2B2 3 4 6
  • SNTL 3 4 6
  • 59 KDa Dystrophin-Associated Protein A1 Basic Component 2 3 4
  • Syntrophin-3 3 4
  • D16S2531E 3 4
  • SNT3 3 4
  • Syntrophin, Beta 2 (Dystrophin-Associated Protein A1, 59kD, Basic Component 2) 2
  • Dystrophin-Associated Protein A1, 59kD, Basic Component 2 3
  • Beta-2-Syntrophin 3
  • Syntrophin-Like 4
  • EST25263 3

External Ids for SNTB2 Gene

Previous HGNC Symbols for SNTB2 Gene

  • SNT2B2
  • SNTL
  • D16S2531E

Previous GeneCards Identifiers for SNTB2 Gene

  • GC16P059906
  • GC16P069598
  • GC16P068956
  • GC16P068997
  • GC16P067778
  • GC16P055093

Summaries for SNTB2 Gene

Entrez Gene Summary for SNTB2 Gene

  • Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNTB2 Gene

SNTB2 (Syntrophin, Beta 2 (Dystrophin-Associated Protein A1, 59kDa, Basic Component 2)) is a Protein Coding gene. Diseases associated with SNTB2 include duchenne muscular dystrophy. GO annotations related to this gene include phospholipid binding and calmodulin binding. An important paralog of this gene is SNTG1.

UniProtKB/Swiss-Prot for SNTB2 Gene

  • Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN

Gene Wiki entry for SNTB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNTB2 Gene

Genomics for SNTB2 Gene

Regulatory Elements for SNTB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNTB2 Gene

69,187,129 bp from pter
69,309,052 bp from pter
121,924 bases
Plus strand

Genomic View for SNTB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNTB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNTB2 Gene

Proteins for SNTB2 Gene

  • Protein details for SNTB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q9BY09

    Protein attributes for SNTB2 Gene

    540 amino acids
    Molecular mass:
    57950 Da
    Quaternary structure:
    • Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family: SNTA1 and SNTB1; and with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins (By similarity). Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN, and with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN.

    Three dimensional structures from OCA and Proteopedia for SNTB2 Gene

    Alternative splice isoforms for SNTB2 Gene


neXtProt entry for SNTB2 Gene

Proteomics data for SNTB2 Gene at MOPED

Post-translational modifications for SNTB2 Gene

  • Phosphorylated. Partially dephosphorylated upon insulin stimulation
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNTB2 Gene

No data available for DME Specific Peptides for SNTB2 Gene

Domains for SNTB2 Gene

Protein Domains for SNTB2 Gene

Suggested Antigen Peptide Sequences for SNTB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q13425
  • The PH 1 domain mediates the oligomerization in a calcium dependent manner.
  • The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).
  • The SU domain binds calmodulin in a calcium-dependent manner.
  • Contains 1 PDZ (DHR) domain.
  • Contains 2 PH domains.
  • Contains 1 SU (syntrophin unique) domain.
  • Belongs to the syntrophin family.
genes like me logo Genes that share domains with SNTB2: view

No data available for Gene Families for SNTB2 Gene

Function for SNTB2 Gene

Molecular function for SNTB2 Gene

UniProtKB/Swiss-Prot Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN

Gene Ontology (GO) - Molecular Function for SNTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 12763866
GO:0005516 calmodulin binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SNTB2: view

Phenotypes for SNTB2 Gene

genes like me logo Genes that share phenotypes with SNTB2: view

Animal Models for SNTB2 Gene

MGI Knock Outs for SNTB2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNTB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SNTB2 Gene

Localization for SNTB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNTB2 Gene

Membrane. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cell junction. Cytoplasm, cytoskeleton. Note=Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SNTB2 Gene COMPARTMENTS Subcellular localization image for SNTB2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
mitochondrion 2
nucleus 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SNTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19786618
GO:0005874 microtubule IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0016010 dystrophin-associated glycoprotein complex TAS 8576247
GO:0016020 membrane TAS 8576247
genes like me logo Genes that share ontologies with SNTB2: view

Pathways for SNTB2 Gene

SuperPathways for SNTB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNTB2 Gene


No data available for Pathways by source for SNTB2 Gene

Compounds for SNTB2 Gene

(2) HMDB Compounds for SNTB2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • Sodium
genes like me logo Genes that share compounds with SNTB2: view

Transcripts for SNTB2 Gene

Unigene Clusters for SNTB2 Gene

Syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNTB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNTB2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - - - - -
SP4: - - -
SP5: - -
SP6: - -
SP7: - - - -

Relevant External Links for SNTB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNTB2 Gene

mRNA expression in normal human tissues for SNTB2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNTB2 Gene

SOURCE GeneReport for Unigene cluster for SNTB2 Gene Hs.461117

mRNA Expression by UniProt/SwissProt for SNTB2 Gene

Tissue specificity: Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed
genes like me logo Genes that share expressions with SNTB2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SNTB2 Gene

Orthologs for SNTB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNTB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNTB2 35
  • 99.63 (n)
  • 99.44 (a)
SNTB2 36
  • 99 (a)
(Bos Taurus)
Mammalia SNTB2 35
  • 92.65 (n)
  • 98.33 (a)
SNTB2 36
  • 98 (a)
(Canis familiaris)
Mammalia SNTB2 35
  • 94.32 (n)
  • 97.96 (a)
SNTB2 36
  • 93 (a)
(Mus musculus)
Mammalia Sntb2 35
  • 91.18 (n)
  • 96.53 (a)
Sntb2 16
Sntb2 36
  • 97 (a)
(Monodelphis domestica)
Mammalia SNTB2 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia SNTB2 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Sntb2 35
  • 90.82 (n)
  • 96.15 (a)
(Gallus gallus)
Aves SNTB2 35
  • 76.41 (n)
  • 83.64 (a)
SNTB2 36
  • 83 (a)
(Anolis carolinensis)
Reptilia SNTB2 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sntb2 35
  • 64.33 (n)
  • 62.32 (a)
(Danio rerio)
Actinopterygii LOC100331323 35
  • 62.54 (n)
  • 62.28 (a)
SNTB2 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syn1 36
  • 34 (a)
Syn1 37
  • 38 (a)
(Caenorhabditis elegans)
Secernentea stn-1 36
  • 41 (a)
stn-1 37
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
Species with no ortholog for SNTB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNTB2 Gene

Gene Tree for SNTB2 (if available)
Gene Tree for SNTB2 (if available)

Paralogs for SNTB2 Gene

Paralogs for SNTB2 Gene

Selected SIMAP similar genes for SNTB2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SNTB2: view

Variants for SNTB2 Gene

Sequence variations from dbSNP and Humsavar for SNTB2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs10650 -- 69,187,607(-) TTCCC(C/G)GGGCT reference, synonymous-codon
rs153046 -- 69,275,236(+) ccagg(C/T)taatt intron-variant
rs153047 -- 69,276,233(-) CCACA(C/T)TCTAA intron-variant
rs153048 -- 69,283,020(-) ctgcc(A/G)tgagc intron-variant
rs153049 -- 69,283,087(+) cacag(A/G)tgcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNTB2 Gene

Variant ID Type Subtype PubMed ID
nsv1851 CNV Insertion 18451855
nsv509628 CNV Insertion 20534489
esv1482035 CNV Insertion 17803354
esv993295 CNV Insertion 20482838
esv2714661 CNV Deletion 23290073
nsv103191 CNV Loss 16902084
esv2714663 CNV Deletion 23290073
esv2180832 CNV Deletion 18987734
nsv819598 CNV Loss 19587683
nsv906820 CNV Loss 21882294

Relevant External Links for SNTB2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNTB2 Gene

Disorders for SNTB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SNTB2 Gene including...

Search for SNTB2 Gene in MalaCards »

Relevant External Links for SNTB2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with SNTB2: view

No data available for UniProtKB/Swiss-Prot for SNTB2 Gene

Publications for SNTB2 Gene

  1. The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. (PMID: 8576247) Ahn A.H. … Kunkel L.M. (J. Biol. Chem. 1996) 2 3 4 23
  2. Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24. (PMID: 8183929) Ahn A.H. … Kunkel L.M. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells. (PMID: 11043403) Ort T. … Solimena M. (Eur. J. Cell Biol. 2000) 3 4
  5. Deficiency of the syntrophins and alpha-dystrobrevin in patients with inherited myopathy. (PMID: 12899872) Jones K.J. … North K.N. (Neuromuscul. Disord. 2003) 3 48

Products for SNTB2 Gene

  • Addgene plasmids for SNTB2

Sources for SNTB2 Gene

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