SNTA1 Gene
protein-coding GIFtS: 62
GCID: GC20M031995
|
|
syntrophin, alpha 1(Previous names: syntrophin, alpha 1 (dystrophin-associated protein A1,...)
(Previous symbol: SNT1)
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Aliases
for SNTA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Syntrophin, Alpha 11 2 | | Acidic Alpha 1 Syntrophin2 | | SNT11 2 3 5 | | Alpha-1-Syntrophin1 | | TACIP11 2 3 | | DJ1187J4.51 | | LQT121 2 5 | | Dystrophin-Associated Protein A1, 59kDa, Acidic Component2 | | Pro-TGF-Alpha Cytoplasmic Domain-Interacting Protein 12 3 | | Syntrophin, Alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component)2 | | 59 KDa Dystrophin-Associated Protein A1 Acidic Component 12 3 | | Syntrophin-13 | | Syntrophin, Alpha 1 (Dystrophin-Associated Protein A1, 59kD, Acidic Component)1 | | Syntrophin-13 |
Export aliases for SNTA1 gene to outside databasesPrevious GC identifers: GC20M031754 GC20M032664 GC20M032711 GC20M031459 GC20M028783 |
Summaries
for SNTA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SNTA1:
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associatedprotein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoformfound in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of thepore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodiumchannels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. Thisgene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac deathfrom arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin anddystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscletissue. (provided by RefSeq, Jan 2013)
UniProtKB/Swiss-Prot: SNTA1_HUMAN, Q13424Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membraneproteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophinglycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholinereceptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity)
Gene Wiki entry for SNTA1 (Syntrophin, alpha 1)
|
Genomic Views
for SNTA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNTA1 gene promoter:
NF-1 NRSF form 1 NF-E2 p45 NRSF form 2 Max N-Myc ZID NF-E2 Pax-4a c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNTA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNTA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.2 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.2SNTA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M031995: view genomic region
(about GC identifiers)
Start:
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31,995,761 bp from pter |
End:
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32,031,698 bp from pter |
Size:
|
35,938 bases |
Orientation:
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minus strand |
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Proteins
for SNTA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNTA1_HUMAN, Q13424 (See
protein sequence)Recommended Name: Alpha-1-syntrophin Size: 505 amino acids; 53895 Da
Subunit: Monomer and homodimer. Interacts with the other members of the syntrophin family SNTB1 and SNTB2; SGCG andSGCA of the dystrophin glycoprotein complex; NOS1; GRB2; the sodium channel proteins SCN4A and SCN5A; F-actin andcalmodulin (By similarity). Interacts with dystrophin protein DMD and related proteins DTNA and UTRN and with MAPK12,TGFA and GA
Subcellular location: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side (By similarity). Celljunction (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=In skeletal muscle, it localizes at thecytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions (By similarity)
Secondary accessions: A8K7H9 E1P5N1 Q16438Explore the universe of human proteins at neXtProt for SNTA1: NX_Q13424
Post-translational modifications:
Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13424
SNTA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003089.1
ENSEMBL proteins: ENSP00000217381
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
SNTA1 for ontologies About GeneDecksing
SNTA1 Antibody Products:
Assay Products for SNTA1: |
Protein
Domains /
Families
for SNTA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNTA1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13424ProtoNet protein and cluster: Q13424 2 Blocks protein families: IPB001478 PDZ/DHR/GLGF domain IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: SNTA1_HUMAN, Q13424Domain: The PH 1 domain mediates the oligomerization in a calcium dependent manner, and the association with thephosphatidylinositol 4,5-bisphosphate (By similarity)Domain: The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. Theassociation with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to themembrane (By similarity)Domain: The SU domain binds calmodulin in a calcium-dependent manner (By similarity)Similarity: Belongs to the syntrophin familySimilarity: Contains 1 PDZ (DHR) domainSimilarity: Contains 2 PH domainsSimilarity: Contains 1 SU (syntrophin unique) domain |
Function
for SNTA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNTA1_HUMAN, Q13424Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membraneproteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophinglycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholinereceptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNTA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNTA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNTA1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
SNTA1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SNTA1:
Animal Models:
Mouse knock-outs for SNTA1: Snta1tm1Stk Snta1tm1Scf
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Snta1):
SNTA1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SNTA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRKA Signaling | | | 2 | SIDS Susceptibility Pathways | | | 3 | Signaling mediated by p38-gamma and p38-delta | | | 4 | Muscular Dystrophies and Dystrophin-Glycoprotein Complex | | | 5 | DREAM Repression and Dynorphin Expression | |
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SNTA1
2  BioSystems Pathways for SNTA1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNTA1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/79 Interacting proteins for SNTA1 (Q134241, 2, 3 ENSP000002173814) via UniProtKB, MINT, STRING, and/or I2D (see all 79)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003117 | regulation of vasoconstriction by circulating norepinephrine |
IEA | -- | | GO:0006936 | muscle contraction |
TAS | 8576247 | | GO:0007528 | neuromuscular junction development |
IEA | -- |
SNTA1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNTA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SNTA1 for compounds About GeneDecksing
 Browse Tocris compounds for SNTA1
2 HMDB Compounds for SNTA1 About this table
1 Novoseek chemical compound relationship for SNTA1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nitric oxide |
31.5 |
1 |
9536265 (1) |
Search CenterWatch for drugs/clinical trials and news about SNTA1
|
Transcripts
for SNTA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNTA1 gene: NM_003098.2 Unigene Cluster for SNTA1: Syntrophin, alpha 1 Hs.31121 [show with all ESTs]Unigene Representative Sequence: NM_0030981 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000217381(uc002wzd.1 uc010zuf.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNTA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNTA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SNTA1 (NM_003098) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNTA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNTA1 |
Additional cDNA sequence: AK095942.1 AK291994.1 AK301800.1 BC026215.2 BC113813.1 S81737.1 U40571.1 10 DOTS entries: DT.447299 DT.100670261 DT.100023111 DT.100779916 DT.98131732 DT.120807643 DT.95094050 DT.100844603 DT.92439224 DT.95094024 24/219 AceView cDNA sequences (see all 219): CD514526 AK095942 BG683199 BQ772114 BC026215 AJ709275 BE562959 BU687261 BU634073 CA311255 CF455383 AI972490 BU509051 BM702291 BM017871 AJ573021 BM708591 CR593272 CF456427 U40571 BU726905 BM910778 CA392810 BM547446
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SNTA1 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | - | | | | | | |
| SP2: | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SNTA1
|
Expression
for SNTA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNTA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTGAGCTG
About this image
See SNTA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNTA1
SOURCE GeneReport for Unigene cluster: Hs.31121
UniProtKB/Swiss-Prot: SNTA1_HUMAN, Q13424Tissue specificity: High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney andlung. Not detected in placenta
SABiosciences Custom PCR Arrays for SNTA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNTA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNTA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNTA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNTA1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNTA1 |
Orthologs
for SNTA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SNTA1 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
SNTA16SNTB26(see all 3) |
-- |
61(a)47(a)(see all 3) |
possible orthologpossible ortholog(see all 3) |
4(136242444-136252823) GL343643.1(2143-15732) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.238702 |
Xenopus laevis transcribed sequence with weak similarity more |
74.74(n) |
|
CD328098.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01087330.16 |
-- |
50(a) |
1 ↔ 1 |
6(57638387-57683630) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Syn16 |
Syntrophin-like 1 |
31(a) |
1 → many |
3L(21738459-21763634) |
worm
(Caenorhabditis elegans) |
Secernentea |
stn-13 |
beta1-syntrophin |
37(a) |
|
I(9509379-9512877) -- |
ENSEMBL Gene Tree for SNTA1 (if available)
TreeFam Gene Tree for SNTA1 (if available) |
Paralogs
for SNTA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SNTA1 gene
- SNTG12 SNTB12 SNTB22 SNTG22
2 SIMAP similar genes for SNTA1 using alignment to 3 protein entries: SNTA1_HUMAN (see all proteins):SNTB1 SNTB2
SNTA1 for paralogs About GeneDecksing
|
Genomic Variants
for SNTA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNTA1 (31995761 - 32031698 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SNTA1
1 Indel: 40447
Human Gene Mutation Database (HGMD): SNTA1
Locus Specific Mutation Databases (LSDB): SNTA1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNTA1 |
|
Disorders
/ Diseases
for SNTA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNTA1 for disorders About GeneDecksing
OMIM gene information: 601017
OMIM disorders: 612955
UniProtKB/Swiss-Prot: SNTA1_HUMAN, Q13424
Defects in SNTA1 are the cause of long QT syndrome type 12 (LQT12) [MIM:612955]. A heart disordercharacterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope andsudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiacdeath in infancy
10  diseases for SNTA1: About MalaCardslong qt syndrome sudden infant death syndrome long qt syndrome 12 left ventricular noncompaction
becker muscular dystrophy duchenne muscular dystrophy muscular dystrophy myopathy
cholesterol neuronitis
2 diseases from the University of Copenhagen DISEASES database for SNTA1:Long QT syndrome Duchenne muscular dystrophy Genetic Association Database (GAD): SNTA1
Human Genome Epidemiology (HuGE) Navigator: SNTA1 (2 documents)
Export disorders for SNTA1 gene to outside databases
|
Publications
for SNTA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNTA1 gene, integrated from 9 sources (see all 54):
(articles sorted by number of sources associating them with SNTA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. (PubMed id 8576247)1, 2, 3, 9 Ahn A.H.... Kunkel L.M. (1996)
- Characterization of the dystrophin-syntrophin interaction using the two-hybrid system in yeast. (PubMed id 8612778)1, 2, 3 Castello A.... Gilgenkrantz H. (1996)
- alpha-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption. (PubMed id 19684871)1, 2, 9 Wu G.... Vatta M. (2008)
- Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. (PubMed id 18591664)1, 2 Ueda K.... Makielski J.C. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins. (PubMed id 11163757)1, 2 Olalla L.... Marquez J. (2001)
- A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface. (PubMed id 10230395)1, 2 Fernandez-Larrea J....Arribas J. (1999)
|
External Searches for SNTA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNTA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNTA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNTA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNTA1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SNTA1 gene:
Search GeneIP for patents involving SNTA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SNTA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for SNTA1 | | OriGene shRNA RFP for SNTA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNTA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNTA1 | | | OriGene Protein Over-expression Lysate for SNTA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SNTA1 | | OriGene 3'-UTR Clone for SNTA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNTA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNTA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SNTA1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SNTA1 | | OriGene Custom Protein Services for SNTA1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNTA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNTA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNTA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNTA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNTA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNTA1 |
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| | | | Search Tocris compounds for SNTA1 |
| |  |  |  |  | | | | | | Recombinant Protein for SNTA1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNTA1 |
|  |  |  | | | | ThermoFisher Antibodies for SNTA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNTA1 |
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