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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNRPG Gene

protein-coding   GIFtS: 54
GCID: GC02M070508

Small Nuclear Ribonucleoprotein Polypeptide G

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Small Nuclear Ribonucleoprotein Polypeptide G1 2     SMG2
Sm Protein G2 3     Small Nuclear Ribonucleoprotein G2
Sm-G2 3     PBSCG3
snRNP-G2 3     SmG3

External Ids:    HGNC: 111631   Entrez Gene: 66372   Ensembl: ENSG000001439777   OMIM: 6035425   UniProtKB: P623083   

Export aliases for SNRPG gene to outside databases

Previous GC identifers: GC02M070518 GC02M070719 GC02M070483 GC02M070420 GC02M070362 GC02M070245


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SNRPG Gene: 
SNRPG (small nuclear ribonucleoprotein polypeptide G) is a protein-coding gene. Diseases associated with SNRPG include spinal muscular atrophy, and muscular atrophy, and among its related super-pathways are mRNA Processing and Post-Elongation Processing of Intron-Containing pre-mRNA. GO annotations related to this gene include protein binding and RNA binding.

UniProtKB/Swiss-Prot: RUXG_HUMAN, P62308
Function: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated
with snRNP U1, U2, U4/U6 and U5

Gene Wiki entry for SNRPG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNRPG gene promoter:
         HOXA9   HOXA9B   AML1a   YY1   Meis-1b   AREB6   CREB   deltaCREB   Meis-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRPG promoter sequence
   Search SABiosciences Chromatin IP Primers for SNRPG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13.3

SNRPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPG gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M070508:  view genomic region     (about GC identifiers)

Start:
70,508,494 bp from pter      End:
70,520,903 bp from pter
Size:
12,410 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RUXG_HUMAN, P62308 (See protein sequence)
Recommended Name: Small nuclear ribonucleoprotein G  
Size: 76 amino acids; 8496 Da
Subunit: Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of
LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent
process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally,
the U7-specific LSM10 and LSM11 proteins. Identified in the spliceosome C complex. Component of the U11/U12
snRNPs that are part of the U12-type spliceosome. Interacts with TACC1
Subcellular location: Nucleus
6/10 PDB 3D structures from and Proteopedia for SNRPG (see all 10):
1VU2 (3D)        1VU3 (3D)        2Y9A (3D)        2Y9B (3D)        2Y9C (3D)        2Y9D (3D)    
Secondary accessions: D6W5G6 Q15357 Q6IB86

Explore the universe of human proteins at neXtProt for SNRPG: NX_P62308

Explore proteomics data for SNRPG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62308

  • SNRPG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNRPG Protein Expression
    REFSEQ proteins: NP_003087.1  
    ENSEMBL proteins: 
     ENSP00000272348   ENSP00000441332   ENSP00000402194   ENSP00000391403   ENSP00000416334  
     ENSP00000393388  
    Reactome Protein details: P62308
    Human Recombinant Protein Products for SNRPG: 
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    Novus Biologicals SNRPG Proteins
    Novus Biologicals SNRPG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SNRPG
    Cloud-Clone Corp. Proteins for SNRPG 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex TAS7744013
    GO:0005683U7 snRNP IDA11574479
    GO:0005689U12-type spliceosomal complex IDA15146077
    GO:0005829cytosol TAS--

    SNRPG for ontologies           About GeneDecksing



    SNRPG Antibody Products: 
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    Search for Antibodies for SNRPG at Abcam
    Cloud-Clone Corp. Antibodies for SNRPG 
    Search ThermoFisher Antibodies for SNRPG
    LSBio Antibodies in human, mouse, rat for SNRPG 

    Assay Products for SNRPG: 
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    Cloud-Clone Corp. CLIAs for SNRPG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001163 Ribonucl_LSM
     IPR010920 LSM_dom
     IPR006649 Ribonucl_LSM_euk/arc

    Graphical View of Domain Structure for InterPro Entry P62308

    ProtoNet protein and cluster: P62308

    1 Blocks protein domain: IPB010920 Like-Sm ribonucleoprotein-related

    UniProtKB/Swiss-Prot: RUXG_HUMAN, P62308
    Similarity: Belongs to the snRNP Sm proteins family


    SNRPG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RUXG_HUMAN, P62308
    Function: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated
    with snRNP U1, U2, U4/U6 and U5

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI12165861
         
    SNRPG for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SNRPG:
     Decreased viability  Decreased viability of wild-ty  Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SNRPG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SNRPG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNRPG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNRPG 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPG
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPG:
    hsa-miR-495 hsa-miR-493* hsa-miR-7-1* hsa-miR-7-2* hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidSNRPG 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SNRPG

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SNRPG (see all 7)
    OriGene ORF clones in mouse, rat for SNRPG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNRPG (NM_003096)
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                         Customized lentivirus expression plasmids for stable overexpression of SNRPG 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SNRPG About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA processing0.46
    mRNA Processing0.85
    mRNA Splicing - Minor Pathway0.40
    mRNA Splicing - Major Pathway0.82
    Spliceosome0.31
    mRNA Splicing0.82
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.79
    Post-Elongation Processing of the Transcript0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    3SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
    SLBP independent Processing of Histone Pre-mRNAs0.91
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs0.91
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Post-Elongation Processing of Intronless pre-mRNA
    Post-Elongation Processing of Intronless pre-mRNA0.61
    Processing of Capped Intronless Pre-mRNA0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNRPG
        mRNA processing

    5/18        Reactome Pathways for SNRPG (see all 18)
        mRNA Splicing
    RNA Polymerase II Transcription
    snRNP Assembly
    Cleavage of Growing Transcript in the Termination Region
    Metabolism of non-coding RNA


    1         Kegg Pathway  (Kegg details for SNRPG):
        Spliceosome


    SNRPG for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNRPG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/198 Interacting proteins for SNRPG (P623081, 2, 3 ENSP000002723484) via UniProtKB, MINT, STRING, and/or I2D (see all 198)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-13669 MINT-13668 I2D: score=5 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-13669 MINT-13668 I2D: score=5 STRING: ENSP00000370119
    SNRPEP623042, 3, ENSP000004005914MINT-49757 MINT-49761 I2D: score=6 STRING: ENSP00000400591
    SF3A2Q154282, 3, ENSP000002214944MINT-5205368 I2D: score=2 STRING: ENSP00000221494
    SNRPFP623062, 3, ENSP000002667354MINT-8332789 I2D: score=2 STRING: ENSP00000266735
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000245spliceosomal complex assembly NAS7744013
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--

    SNRPG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNRPG (RUXG)

    Search CenterWatch for drugs/clinical trials and news about SNRPG / RUXG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNRPG gene: 
    NM_003096.2  

    Unigene Clusters for SNRPG:

    Small nuclear ribonucleoprotein polypeptide G
    Hs.465167  [show with all ESTs], Hs.516076  [show with all ESTs], Hs.631639  [show with all ESTs], Hs.654528  [show with all ESTs]
    Unigene Representative Sequences: BU517151, BM543095, BU534134, BU198589
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272348(uc002sgp.3) ENST00000429728 ENST00000482975(uc002sgo.3)
    ENST00000438261 ENST00000449935 ENST00000413456 ENST00000454893 ENST00000480370
    ENST00000488400
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPG:
    hsa-miR-495 hsa-miR-493* hsa-miR-7-1* hsa-miR-7-2* hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidSNRPG 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPG
    Sirion Biotech Customized lentivirus for stable overexpression of SNRPG 
                         Customized lentivirus expression plasmids for stable overexpression of SNRPG 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNRPG
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPG

    Additional mRNA sequence: 

    CR456918.1 X85373.1 

    20 DOTS entries:

    DT.120974615  DT.97861380  DT.91905000  DT.100032481  DT.91815834  DT.100827773  DT.120974604  DT.86855875 
    DT.121454965  DT.95081625  DT.121089586  DT.100038488  DT.120974624  DT.100774842  DT.120974601  DT.120974642 
    DT.86844929  DT.95324761  DT.120974663  DT.95081630 

    24/389 AceView cDNA sequences (see all 389):

    AI468221 BG153462 AA954582 AA931157 BE766353 BE254686 AA910206 CB110665 
    CB109399 BM817715 CB107252 CB109330 H20602 BQ050818 AI290354 AI808583 
    BM762211 AI123998 BM702629 T31409 AA835048 AI223007 BM843255 AA479079 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNRPG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACATTTTCA
    SNRPG Expression
    About this image


    See SNRPG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNRPG

    SOURCE GeneReport for Unigene clusters: Hs.465167 Hs.516076 Hs.631639 Hs.654528
        SABiosciences Custom PCR Arrays for SNRPG
    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SNRPG gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrpg1 , 5 small nuclear ribonucleoprotein polypeptide G1, 5 89.91(n)1
    100(a)1
      6 (37.69 cM)5
    680111  NM_026506.21  NP_080782.11 
     863715835 
    chicken
    (Gallus gallus)
    Aves FAM136A1 family with sequence similarity 136, member A 81.14(n)
    97.37(a)
      771344  XM_001233286.1  XP_001233287.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNRPG6
    small nuclear ribonucleoprotein polypeptide G
    86(a)
    1 ↔ 1
    AAWZ02037395(616-3484)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377270962   -- 81.05(n)    137727096 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.142282 Transcribed sequence with moderate similarity to protein more 78.28(n)    BM072215.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SmG1 Small ribonucleoprotein particle protein SmG 62.72(n)
    72.37(a)
      32636  NM_001144737.1  NP_001138209.1 
    worm
    (Caenorhabditis elegans)
    Secernentea snr-71 Protein SNR-7 59.21(n)
    65.79(a)
      171834  NM_058631.4  NP_491032.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMX2(YFL017W-A)4 Core Sm protein Sm G; part of heteroheptameric complex more   --   6(103699-103932) 850528  NP_116636.1 


    ENSEMBL Gene Tree for SNRPG (if available)
    TreeFam Gene Tree for SNRPG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNRPG gene
    4 SIMAP similar genes for SNRPG using alignment to 4 protein entries:     RUXG_HUMAN (see all proteins):
    LSM7    LSM6    LSM8    NAA38

    SNRPG for paralogs           About GeneDecksing


    5/20 Pseudogenes.org Pseudogenes for SNRPG (see all 20)
    PGOHUM00000238351 PGOHUM00000258505 PGOHUM00000238930 PGOHUM00000242330 PGOHUM00000242859


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/303 SNPs in SNRPG are shown (see all 303)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018056211,2
    C--70508835(+) AAATAA/CATTTG 1 -- int11Minor allele frequency- C:0.00EU 1301
    rs1814441931,2
    C--70508845(+) GAAAAA/GAACAA 1 -- int10--------
    rs22725311,2
    C,F,H--70508873(+) ACTATG/AATGAT 1 -- int16Minor allele frequency- A:0.01NS EA NA 684
    rs1910116161,2
    C--70508983(+) TTATAC/TGACAG 1 -- int10--------
    rs778120441,2
    C,F--70509071(+) TTTTTT/GGAGAC 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1498543061,2
    C--70509112(+) AGTGGC/TGCAAT 1 -- int10--------
    rs65465831,2
    C,F,A--70509158(+) GCAATC/TCTGCT 1 -- int111Minor allele frequency- T:0.43NA WA CSA EA 374
    rs75606541,2
    C,F--70509167(+) cttcaG/Acctcc 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs75605531,2
    C--70509169(+) tcagcC/Ttccca 1 -- int10--------
    rs1830875971,2
    --70509363(+) CTTCTA/GAAATG 1 -- int10--------

    HapMap Linkage Disequilibrium report for SNRPG (70508494 - 70520903 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SNRPG:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2523050CNV Deletion19546169
    nsv518294CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603542    OMIM disorders: --

    4 diseases for SNRPG:    About MalaCards
    spinal muscular atrophy    muscular atrophy    breast cancer    neuronitis


    SNRPG for disorders           About GeneDecksing


    Export disorders for SNRPG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNRPG gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with SNRPG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. (PubMed id 7744013)1, 2, 3 Hermann H....Luehrmann R. (1995)
    2. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PubMed id 12165861)1, 2, 9 Conte N.... Birnbaum D. (2002)
    3. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    6. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. (PubMed id 11574479)1, 2 Pillai R.S.... Mueller B. (2001)
    7. Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro. (PubMed id 1387914)1, 9 Heinrichs V....Luhrmann R. (1992)
    8. Cleavage and polyadenylation specificity factor 1 (CPS F1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (2013)
    9. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6637 HGNC: 11163 AceView: SNRPG Ensembl:ENSG00000143977 euGenes: HUgn6637
    ECgene: SNRPG Kegg: 6637 H-InvDB: SNRPG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNRPG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNRPG gene:
    Search GeneIP for patents involving SNRPG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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