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Aliases for SNRPG Gene

Aliases for SNRPG Gene

  • Small Nuclear Ribonucleoprotein Polypeptide G 2 3 5
  • Sm Protein G 3 4
  • SnRNP-G 3 4
  • Sm-G 3 4
  • SMG 3 4
  • Small Nuclear Ribonucleoprotein G 3
  • PBSCG 4

External Ids for SNRPG Gene

Previous GeneCards Identifiers for SNRPG Gene

  • GC02M070518
  • GC02M070719
  • GC02M070483
  • GC02M070420
  • GC02M070362
  • GC02M070508
  • GC02M070245

Summaries for SNRPG Gene

Entrez Gene Summary for SNRPG Gene

  • The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for SNRPG Gene

SNRPG (Small Nuclear Ribonucleoprotein Polypeptide G) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Processing of Capped Intronless Pre-mRNA. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for SNRPG Gene

  • Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3-end processing.

Gene Wiki entry for SNRPG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPG Gene

Genomics for SNRPG Gene

Regulatory Elements for SNRPG Gene

Enhancers for SNRPG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G069945 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.7 +346.8 346839 4.3 PKNOX1 FOXA2 ATF1 ELK1 FOS DEK SP5 NCOA1 REST ZNF592 MXD1 SNRNP27 ASPRV1 PCBP1 GMCL1 SNRPG PIR33848
GH02G070291 1.2 ENCODE 0.7 +0.6 569 4.1 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 PCYOX1 PCBP1-AS1 CD207 TEX261 C2orf42 GMCL1 CLEC4F NAGK FAM136A SNRPG
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNRPG on UCSC Golden Path with GeneCards custom track

Promoters for SNRPG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000118680 71 2201 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1

Genomic Location for SNRPG Gene

Chromosome:
2
Start:
70,281,362 bp from pter
End:
70,293,771 bp from pter
Size:
12,410 bases
Orientation:
Minus strand

Genomic View for SNRPG Gene

Genes around SNRPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPG Gene

Proteins for SNRPG Gene

  • Protein details for SNRPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62308-RUXG_HUMAN
    Recommended name:
    Small nuclear ribonucleoprotein G
    Protein Accession:
    P62308
    Secondary Accessions:
    • D6W5G6
    • Q15357
    • Q6IB86

    Protein attributes for SNRPG Gene

    Size:
    76 amino acids
    Molecular mass:
    8496 Da
    Quaternary structure:
    • U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with TACC1.

    Three dimensional structures from OCA and Proteopedia for SNRPG Gene

neXtProt entry for SNRPG Gene

Post-translational modifications for SNRPG Gene

  • Ubiquitination at Lys11 and Lys20
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SNRPG Gene

Domains & Families for SNRPG Gene

Protein Domains for SNRPG Gene

Suggested Antigen Peptide Sequences for SNRPG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62308

UniProtKB/Swiss-Prot:

RUXG_HUMAN :
  • Belongs to the snRNP Sm proteins family.
Family:
  • Belongs to the snRNP Sm proteins family.
genes like me logo Genes that share domains with SNRPG: view

No data available for Gene Families for SNRPG Gene

Function for SNRPG Gene

Molecular function for SNRPG Gene

UniProtKB/Swiss-Prot Function:
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3-end processing.

Gene Ontology (GO) - Molecular Function for SNRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,IEA 22658674
GO:0005515 protein binding IPI 9417867
GO:1990446 U1 snRNP binding IEA --
genes like me logo Genes that share ontologies with SNRPG: view
genes like me logo Genes that share phenotypes with SNRPG: view

Animal Model Products

CRISPR Products

miRNA for SNRPG Gene

miRTarBase miRNAs that target SNRPG

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRPG Gene

Localization for SNRPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPG Gene

Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNRPG gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for SNRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005681 spliceosomal complex TAS,IEA 7744013
GO:0005682 U5 snRNP IBA --
GO:0005683 U7 snRNP IDA 11574479
genes like me logo Genes that share ontologies with SNRPG: view

Pathways & Interactions for SNRPG Gene

genes like me logo Genes that share pathways with SNRPG: view

Pathways by source for SNRPG Gene

Gene Ontology (GO) - Biological Process for SNRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly NAS 7744013
GO:0000387 spliceosomal snRNP assembly TAS,IEA --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with SNRPG: view

No data available for SIGNOR curated interactions for SNRPG Gene

Transcripts for SNRPG Gene

Unigene Clusters for SNRPG Gene

Small nuclear ribonucleoprotein polypeptide G:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPG Gene

No ASD Table

Relevant External Links for SNRPG Gene

GeneLoc Exon Structure for
SNRPG
ECgene alternative splicing isoforms for
SNRPG

Expression for SNRPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNRPG Gene

Protein differential expression in normal tissues from HIPED for SNRPG Gene

This gene is overexpressed in Pancreas (35.0), Lung (13.5), Breast (11.8), and Bone (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNRPG Gene



Protein tissue co-expression partners for SNRPG Gene

NURSA nuclear receptor signaling pathways regulating expression of SNRPG Gene:

SNRPG

SOURCE GeneReport for Unigene cluster for SNRPG Gene:

Hs.465167

Evidence on tissue expression from TISSUES for SNRPG Gene

  • Nervous system(4.6)
  • Pancreas(4.2)
  • Bone(4)
  • Liver(3.2)
genes like me logo Genes that share expression patterns with SNRPG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNRPG Gene

Orthologs for SNRPG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNRPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRPG 35
  • 100 (a)
OneToOne
LOC100614811 34
  • 97.75 (n)
mouse
(Mus musculus)
Mammalia Snrpg 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNRPG 34 35
  • 97.81 (n)
oppossum
(Monodelphis domestica)
Mammalia SNRPG 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRPG 34 35
  • 93.86 (n)
rat
(Rattus norvegicus)
Mammalia Snrpgl2 34
  • 85.53 (n)
chicken
(Gallus gallus)
Aves SNRPG 35
  • 97 (a)
OneToOne
FAM136A 34
  • 81.14 (n)
lizard
(Anolis carolinensis)
Reptilia SNRPG 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snrpg 34
  • 78.95 (n)
zebrafish
(Danio rerio)
Actinopterygii SNRPG 35
  • 89 (a)
OneToOne
zgc:103688 34
  • 77.19 (n)
Dr.14228 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.812 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002706 34
  • 67.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta SmG 34 35
  • 62.72 (n)
worm
(Caenorhabditis elegans)
Secernentea snr-7 34 35
  • 59.21 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMX2 35 37
  • 49 (a)
OneToOne
Species where no ortholog for SNRPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNRPG Gene

ENSEMBL:
Gene Tree for SNRPG (if available)
TreeFam:
Gene Tree for SNRPG (if available)

Paralogs for SNRPG Gene

No data available for Paralogs for SNRPG Gene

Variants for SNRPG Gene

Sequence variations from dbSNP and Humsavar for SNRPG Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000167915 -- 70,285,120(+) GTGAT(A/G)CTGGC intron-variant
rs1000579362 -- 70,283,835(+) GGGCA(C/G)ATAGC intron-variant
rs1000620261 -- 70,286,198(+) GCTGG(A/G)ATTAT intron-variant
rs1000686899 -- 70,284,909(+) ACATC(C/T)GTAAG intron-variant
rs1000928744 -- 70,283,474(+) ACTTA(-/TTC)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNRPG Gene

Variant ID Type Subtype PubMed ID
esv2523050 CNV deletion 19546169
esv2760537 CNV gain 21179565
nsv518294 CNV loss 19592680
nsv963614 CNV duplication 23825009
nsv979017 CNV duplication 23825009

Variation tolerance for SNRPG Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNRPG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNRPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRPG Gene

Disorders for SNRPG Gene

Relevant External Links for SNRPG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNRPG

No disorders were found for SNRPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRPG Gene

Publications for SNRPG Gene

  1. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PMID: 12165861) Conte N. … Birnbaum D. (Oncogene 2002) 3 4 22 64
  2. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. (PMID: 7744013) Hermann H. … Luehrmann R. (EMBO J. 1995) 2 3 4 64
  3. Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis. (PMID: 21516107) Leung A.K. … Li J. (Nature 2011) 3 4 64
  4. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PMID: 18984161) Chari A. … Fischer U. (Cell 2008) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SNRPG Gene

Sources for SNRPG Gene

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