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SNRPG Gene

protein-coding   GIFtS: 56
GCID: GC02M070508

Small Nuclear Ribonucleoprotein Polypeptide G

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Small Nuclear Ribonucleoprotein Polypeptide G1 2     SMG2
Sm Protein G2 3     Small Nuclear Ribonucleoprotein G2
Sm-G2 3     PBSCG3
snRNP-G2 3     SmG3

External Ids:    HGNC: 111631   Entrez Gene: 66372   Ensembl: ENSG000001439777   OMIM: 6035425   UniProtKB: P623083   
ORGUL members:         

Export aliases for SNRPG gene to outside databases

Previous GC identifers: GC02M070518 GC02M070719 GC02M070483 GC02M070420 GC02M070362 GC02M070245


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SNRPG Gene:
SNRPG (small nuclear ribonucleoprotein polypeptide G) is a protein-coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: RUXG_HUMAN, P62308
Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the
building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.
Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing

Gene Wiki entry for SNRPG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNRPG gene promoter:
         HOXA9   HOXA9B   AML1a   YY1   Meis-1b   AREB6   CREB   deltaCREB   Meis-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRPG promoter sequence
   Search Chromatin IP Primers for SNRPG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNRPG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13.3

SNRPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPG gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M070508:  view genomic region     (about GC identifiers)

Start:
70,508,494 bp from pter      End:
70,520,903 bp from pter
Size:
12,410 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RUXG_HUMAN, P62308 (See protein sequence)
Recommended Name: Small nuclear ribonucleoprotein G  
Size: 76 amino acids; 8496 Da
Subunit: U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF
and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core
snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the
U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or
U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA.
Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8,
STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs
assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like
structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
Interacts with TACC1
Selected PDB 3D structures from and Proteopedia for SNRPG (see all 11):
1VU2 (3D)        1VU3 (3D)        2Y9A (3D)        2Y9B (3D)        2Y9C (3D)        2Y9D (3D)    
Secondary accessions: D6W5G6 Q15357 Q6IB86

Explore the universe of human proteins at neXtProt for SNRPG: NX_P62308

Explore proteomics data for SNRPG at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys10, Lys11, Lys20
  • Modification sites at PhosphoSitePlus

  • See SNRPG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003087.1  
    ENSEMBL proteins: 
     ENSP00000272348   ENSP00000441332   ENSP00000402194   ENSP00000391403   ENSP00000416334  
     ENSP00000393388  
    Reactome Protein details: P62308

    SNRPG Human Recombinant Protein Products:

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    Novus Biologicals SNRPG Proteins
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    Cloud-Clone Corp. Proteins for SNRPG

     
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    antibodies-online proteins for SNRPG (10 products) 

     
    Search antibodies-online for peptides for SNRPG

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    antibodies-online antibodies for SNRPG (21 products) 

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    antibodies-online kits for SNRPG (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001163 Ribonucl_LSM
     IPR010920 LSM_dom
     IPR006649 Ribonucl_LSM_euk/arc

    Graphical View of Domain Structure for InterPro Entry P62308

    ProtoNet protein and cluster: P62308

    1 Blocks protein domain: IPB010920 Like-Sm ribonucleoprotein-related

    UniProtKB/Swiss-Prot: RUXG_HUMAN, P62308
    Similarity: Belongs to the snRNP Sm proteins family


    Find genes that share domains with SNRPG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RUXG_HUMAN, P62308
    Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the
    building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
    spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
    that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.
    Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI12165861
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SNRPG           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SNRPG:
     Decreased viability  Decreased viability of wild-ty  Increased G2M DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SNRPG

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNRPG:
    hsa-mir-320a (MIRT044593)

    Block miRNA regulation of human, mouse, rat SNRPG using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SNRPG:
    hsa-miR-495 hsa-miR-493* hsa-miR-7-1* hsa-miR-7-2* hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidSNRPG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNRPG
    Predesigned siRNA for gene silencing in human, mouse, rat SNRPG

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SNRPG (NM_003096)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPG

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RUXG_HUMAN, P62308: Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the
    cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex TAS7744013
    GO:0005683U7 snRNP IDA11574479
    GO:0005685U1 snRNP IDA--
    GO:0005687U4 snRNP IDA--

    Find genes that share ontologies with SNRPG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNRPG About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA processing0.44
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    mRNA Splicing0.78
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs0.00
    Cleavage of Growing Transcript in the Termination Region0.80
    SLBP independent Processing of Histone Pre-mRNAs0.00
    Processing of Capped Intronless Pre-mRNA0.52
    3Regulation of Glucokinase by Glucokinase Regulatory Protein
    Metabolism of non-coding RNA0.54
    snRNP Assembly0.54
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with SNRPG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNRPG
        mRNA processing

    Selected Reactome Pathways for SNRPG (see all 6)
        mRNA Splicing - Major Pathway
    SLBP independent Processing of Histone Pre-mRNAs
    snRNP Assembly
    Cleavage of Growing Transcript in the Termination Region
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs


    1 Kegg Pathway  (Kegg details for SNRPG):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNRPG
    Interactions:

        Search GeneGlobe Interaction Network for SNRPG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNRPG (P623081, 2, 3 ENSP000002723484) via UniProtKB, MINT, STRING, and/or I2D (see all 237)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNRPEP623041, 2, 3, ENSP000004005914EBI-624585,EBI-348082 MINT-49757 MINT-49761 I2D: score=6 STRING: ENSP00000400591
    SMN1Q166372, 3, ENSP000003700834MINT-13669 MINT-13668 I2D: score=5 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-13669 MINT-13668 I2D: score=5 STRING: ENSP00000370119
    SF3A2Q154282, 3, ENSP000002214944MINT-5205368 I2D: score=2 STRING: ENSP00000221494
    SNRPFP623062, 3, ENSP000002667354MINT-8332789 I2D: score=2 STRING: ENSP00000266735
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000245spliceosomal complex assembly NAS7744013
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--

    Find genes that share ontologies with SNRPG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNRPG (RUXG)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SNRPG gene: 
    NM_003096.2  

    Unigene Clusters for SNRPG:

    Small nuclear ribonucleoprotein polypeptide G
    Hs.465167  [show with all ESTs], Hs.516076  [show with all ESTs], Hs.631639  [show with all ESTs], Hs.654528  [show with all ESTs]
    Unigene Representative Sequences: BU517151, BM543095, BU534134, BU198589
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272348(uc002sgp.3) ENST00000429728 ENST00000482975(uc002sgo.3)
    ENST00000438261 ENST00000449935 ENST00000413456 ENST00000454893 ENST00000480370
    ENST00000488400
    miRNA
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    hsa-miR-495 hsa-miR-493* hsa-miR-7-1* hsa-miR-7-2* hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidSNRPG 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SNRPG (NM_003096)
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    Primer
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    OriGene qPCR primer pairs and template standards for SNRPG
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      QuantiTect SYBR Green Assays in human, mouse, rat SNRPG
      QuantiFast Probe-based Assays in human, mouse, rat SNRPG

    Additional mRNA sequence: 

    CR456918.1 X85373.1 

    20 DOTS entries:

    DT.120974615  DT.97861380  DT.91905000  DT.100032481  DT.91815834  DT.100827773  DT.120974604  DT.86855875 
    DT.121454965  DT.95081625  DT.121089586  DT.100038488  DT.120974624  DT.100774842  DT.120974601  DT.120974642 
    DT.86844929  DT.95324761  DT.120974663  DT.95081630 

    Selected AceView cDNA sequences (see all 389):

    AV691391 AV712010 AV709468 W96021 AI500328 CB160382 BM844274 AA235102 
    AA258524 AW016461 AA307064 AA862849 BQ890481 AA314119 AW949447 BG778072 
    AI498975 CB110672 AA936414 AA911677 BQ644405 CB111360 AA954582 AA931157 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNRPG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACATTTTCA
    SNRPG Expression
    About this image

    SNRPG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNRPG Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.465167 Hs.516076 Hs.631639 Hs.654528
        Custom PCR Arrays for SNRPG
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SNRPG gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrpg5 small nuclear ribonucleoprotein polypeptide G   --   6 (37.69 cM) 86371583 
    chicken
    (Gallus gallus)
    Aves FAM136A1 family with sequence similarity 136, member A 81.14(n)
    97.37(a)
      771344  XM_001233286.2  XP_001233287.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNRPG6
    small nuclear ribonucleoprotein polypeptide G
    84(a)
    1 ↔ 1
    AAWZ02037395(616-3484)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377270962   -- 81.05(n)    137727096 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.142282 Transcribed sequence with moderate similarity to protein more 78.28(n)    BM072215.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SmG1 Small ribonucleoprotein particle protein SmG 62.72(n)
    72.37(a)
      32636  NM_132911.2  NP_573139.1 
    worm
    (Caenorhabditis elegans)
    Secernentea snr-71 snr-7 59.21(n)
    65.79(a)
      171834  NM_058631.5  NP_491032.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMX2(YFL017W-A)4 Core Sm protein Sm G; part of heteroheptameric complex more   --   6(103699-103932) 850528  NP_116636.1 


    ENSEMBL Gene Tree for SNRPG (if available)
    TreeFam Gene Tree for SNRPG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNRPG gene
    4 SIMAP similar genes for SNRPG using alignment to 4 protein entries:     RUXG_HUMAN (see all proteins):
    LSM7    LSM6    LSM8    NAA38

    Find genes that share paralogs with SNRPG           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for SNRPG (see all 20)
    PGOHUM00000238351 PGOHUM00000258505 PGOHUM00000238930 PGOHUM00000242330 PGOHUM00000242859


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNRPG (see all 303)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018056211,2
    C--70508835(+) AAATAA/CATTTG 1 -- int11Minor allele frequency- C:0.00EU 1301
    rs1814441931,2
    C--70508845(+) GAAAAA/GAACAA 1 -- int10--------
    rs22725311,2
    C,F,H--70508873(+) ACTATG/AATGAT 1 -- int16Minor allele frequency- A:0.01NS EA NA 684
    rs1910116161,2
    C--70508983(+) TTATAC/TGACAG 1 -- int10--------
    rs778120441,2
    C,F--70509071(+) TTTTTT/GGAGAC 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1498543061,2
    C--70509112(+) AGTGGC/TGCAAT 1 -- int10--------
    rs65465831,2
    C,F,A--70509158(+) GCAATC/TCTGCT 1 -- int111Minor allele frequency- T:0.43NA WA CSA EA 374
    rs75606541,2
    C,F--70509167(+) cttcaG/Acctcc 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs75605531,2
    C--70509169(+) tcagcC/Ttccca 1 -- int10--------
    rs1830875971,2
    --70509363(+) CTTCTA/GAAATG 1 -- int10--------

    HapMap Linkage Disequilibrium report for SNRPG (70508494 - 70520903 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SNRPG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2523050CNV Deletion19546169
    nsv518294CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNRPG
    DNA2.0 Custom Variant and Variant Library Synthesis for SNRPG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603542    OMIM disorders: --


    Find genes that share disorders with SNRPG           About GenesLikeMe


    Export disorders for SNRPG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNRPG gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with SNRPG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. (PubMed id 7744013)1, 2, 3 Hermann H....Luehrmann R. (EMBO J. 1995)
    2. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PubMed id 12165861)1, 2, 9 Conte N.... Birnbaum D. (Oncogene 2002)
    3. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PubMed id 18984161)1, 2 Chari A....Fischer U. (Cell 2008)
    4. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (RNA 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    7. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. (PubMed id 11574479)1, 2 Pillai R.S.... Mueller B. (EMBO J. 2001)
    8. Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro. (PubMed id 1387914)1, 9 Heinrichs V....LA1hrmann R. (J. Mol. Biol. 1992)
    9. Structural basis of assembly chaperone-mediated snRNP formation. (PubMed id 23333303)2 Grimm C.... Fischer U. (Mol. Cell 2013)
    10. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6637 HGNC: 11163 AceView: SNRPG Ensembl:ENSG00000143977 euGenes: HUgn6637
    ECgene: SNRPG Kegg: 6637 H-InvDB: SNRPG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SNRPG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNRPG gene:
    Search GeneIP for patents involving SNRPG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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