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Aliases for SNRPG Gene

Aliases for SNRPG Gene

  • Small Nuclear Ribonucleoprotein Polypeptide G 2 3 5
  • Sm Protein G 3 4
  • SnRNP-G 3 4
  • Sm-G 3 4
  • SMG 3 4
  • PBSCG 4

External Ids for SNRPG Gene

Previous GeneCards Identifiers for SNRPG Gene

  • GC02M070518
  • GC02M070719
  • GC02M070483
  • GC02M070420
  • GC02M070362
  • GC02M070508
  • GC02M070245

Summaries for SNRPG Gene

Entrez Gene Summary for SNRPG Gene

  • The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for SNRPG Gene

SNRPG (Small Nuclear Ribonucleoprotein Polypeptide G) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of Glucokinase by Glucokinase Regulatory Protein. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for SNRPG Gene

  • Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3-end processing.

Gene Wiki entry for SNRPG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPG Gene

Genomics for SNRPG Gene

Regulatory Elements for SNRPG Gene

Promoters for SNRPG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNRPG on UCSC Golden Path with GeneCards custom track

Genomic Location for SNRPG Gene

Chromosome:
2
Start:
70,281,362 bp from pter
End:
70,293,771 bp from pter
Size:
12,410 bases
Orientation:
Minus strand

Genomic View for SNRPG Gene

Genes around SNRPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPG Gene

Proteins for SNRPG Gene

  • Protein details for SNRPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62308-RUXG_HUMAN
    Recommended name:
    Small nuclear ribonucleoprotein G
    Protein Accession:
    P62308
    Secondary Accessions:
    • D6W5G6
    • Q15357
    • Q6IB86

    Protein attributes for SNRPG Gene

    Size:
    76 amino acids
    Molecular mass:
    8496 Da
    Quaternary structure:
    • U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with TACC1.

    Three dimensional structures from OCA and Proteopedia for SNRPG Gene

neXtProt entry for SNRPG Gene

Proteomics data for SNRPG Gene at MOPED

Post-translational modifications for SNRPG Gene

  • Ubiquitination at Lys 11 and Lys 20
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SNRPG Gene

Domains & Families for SNRPG Gene

Protein Domains for SNRPG Gene

Suggested Antigen Peptide Sequences for SNRPG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62308

UniProtKB/Swiss-Prot:

RUXG_HUMAN :
  • Belongs to the snRNP Sm proteins family.
Family:
  • Belongs to the snRNP Sm proteins family.
genes like me logo Genes that share domains with SNRPG: view

No data available for Gene Families for SNRPG Gene

Function for SNRPG Gene

Molecular function for SNRPG Gene

UniProtKB/Swiss-Prot Function:
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3-end processing.
genes like me logo Genes that share phenotypes with SNRPG: view

Animal Model Products

CRISPR Products

miRNA for SNRPG Gene

miRTarBase miRNAs that target SNRPG

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRPG Gene

Localization for SNRPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPG Gene

Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRPG Gene COMPARTMENTS Subcellular localization image for SNRPG gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for SNRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005685 U1 snRNP IDA 21113136
GO:0005686 U2 snRNP IBA --
GO:0005689 U12-type spliceosomal complex IDA 15146077
GO:0034709 methylosome IDA 18984161
genes like me logo Genes that share ontologies with SNRPG: view

Pathways & Interactions for SNRPG Gene

genes like me logo Genes that share pathways with SNRPG: view

Pathways by source for SNRPG Gene

1 KEGG pathway for SNRPG Gene

Gene Ontology (GO) - Biological Process for SNRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly NAS 7744013
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with SNRPG: view

No data available for SIGNOR curated interactions for SNRPG Gene

Drugs & Compounds for SNRPG Gene

No Compound Related Data Available

Transcripts for SNRPG Gene

Unigene Clusters for SNRPG Gene

Small nuclear ribonucleoprotein polypeptide G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPG Gene

No ASD Table

Relevant External Links for SNRPG Gene

GeneLoc Exon Structure for
SNRPG
ECgene alternative splicing isoforms for
SNRPG

Expression for SNRPG Gene

mRNA expression in normal human tissues for SNRPG Gene

Protein differential expression in normal tissues from HIPED for SNRPG Gene

This gene is overexpressed in Pancreas (35.0), Lung (13.5), Breast (11.8), and Bone (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNRPG Gene



SOURCE GeneReport for Unigene cluster for SNRPG Gene Hs.465167

genes like me logo Genes that share expression patterns with SNRPG: view

Protein tissue co-expression partners for SNRPG Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNRPG Gene

Orthologs for SNRPG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNRPG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNRPG 35
  • 97.81 (n)
  • 100 (a)
SNRPG 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRPG 35
  • 93.86 (n)
  • 100 (a)
SNRPG 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100614811 35
  • 97.75 (n)
  • 94.59 (a)
SNRPG 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snrpgl2 35
  • 85.53 (n)
  • 92.11 (a)
oppossum
(Monodelphis domestica)
Mammalia SNRPG 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snrpg 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM136A 35
  • 81.14 (n)
  • 97.37 (a)
SNRPG 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNRPG 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snrpg 35
  • 78.95 (n)
  • 90.79 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14228 35
zgc:103688 35
  • 77.19 (n)
  • 89.47 (a)
SNRPG 36
  • 89 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.812 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002706 35
  • 67.98 (n)
  • 77.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta SmG 35
  • 62.72 (n)
  • 72.37 (a)
SmG 36
  • 72 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea snr-7 35
  • 59.21 (n)
  • 65.79 (a)
snr-7 36
  • 65 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMX2 36
  • 49 (a)
OneToOne
SMX2 38
Species with no ortholog for SNRPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNRPG Gene

ENSEMBL:
Gene Tree for SNRPG (if available)
TreeFam:
Gene Tree for SNRPG (if available)

Paralogs for SNRPG Gene

(4) SIMAP similar genes for SNRPG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SNRPG: view

No data available for Paralogs for SNRPG Gene

Variants for SNRPG Gene

Sequence variations from dbSNP and Humsavar for SNRPG Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs15656 -- 70,293,714(+) TCCCG(A/C/G/T)TGTAG utr-variant-5-prime
rs1961833 -- 70,291,653(-) TTCCT(C/T)TGCTT intron-variant
rs2272531 -- 70,281,741(+) ACTAT(A/G)ATGAT intron-variant
rs2272532 -- 70,293,366(+) GGGCC(A/G)GACCG intron-variant
rs2272533 -- 70,293,488(+) GGATC(C/T)CGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNRPG Gene

Variant ID Type Subtype PubMed ID
nsv518294 CNV Loss 19592680
esv2523050 CNV Deletion 19546169

Variation tolerance for SNRPG Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNRPG Gene

HapMap Linkage Disequilibrium report
SNRPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRPG Gene

Disorders for SNRPG Gene

Relevant External Links for SNRPG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNRPG

No disorders were found for SNRPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRPG Gene

Publications for SNRPG Gene

  1. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. (PMID: 7744013) Hermann H. … Luehrmann R. (EMBO J. 1995) 2 3 4 67
  2. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PMID: 12165861) Conte N. … Birnbaum D. (Oncogene 2002) 3 23
  3. Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro. (PMID: 1387914) Heinrichs V. … LA1hrmann R. (J. Mol. Biol. 1992) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for SNRPG Gene

Sources for SNRPG Gene

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