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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNRPG Gene

protein-coding   GIFtS: 55
GCID: GC02M070508

small nuclear ribonucleoprotein polypeptide G
 Explore 5 diseases affiliated with
SNRPG via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNRPG    

Aliases
for SNRPG gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Small Nuclear Ribonucleoprotein Polypeptide G1 2     SMG2
Sm-G1 2 3     Small Nuclear Ribonucleoprotein G2
Sm Protein G2 3     PBSCG3
SnRNP-G1     SmG3

External Ids:    HGNC: 111631   Entrez Gene: 66372   Ensembl: ENSG000001439777   OMIM: 6035425   UniProtKB: P623083   

Export aliases for SNRPG gene to outside databases

Previous GC identifers: GC02M070518 GC02M070719 GC02M070483 GC02M070420 GC02M070362 GC02M070245


Summaries
for SNRPG gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RUXG_HUMAN, P62308
Function: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with
snRNP U1, U2, U4/U6 and U5

Gene Wiki entry for SNRPG


Genomic Views
for SNRPG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNRPG gene promoter:
         HOXA9   HOXA9B   AML1a   YY1   Meis-1b   AREB6   CREB   deltaCREB   Meis-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNRPG promoter sequence
   Search SABiosciences Chromatin IP Primers for SNRPG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13.3

SNRPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPG gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M070508:  view genomic region     (about GC identifiers)

Start:
 70,508,494 bp from pter      End:
 70,520,903 bp from pter
Size:
 12,410 bases      Orientation:
 minus strand

Proteins
for SNRPG gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RUXG_HUMAN, P62308 (See protein sequence)
Recommended Name: Small nuclear ribonucleoprotein G  
Size: 76 amino acids; 8496 Da
Subunit: Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10,
LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated
by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10
and LSM11 proteins. Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the
U12-type spliceosome. Interacts with TACC1
Subcellular location: Nucleus
6/7 PDB 3D structures from and Proteopedia for SNRPG (see all 7):
2Y9A (3D)        2Y9B (3D)        2Y9C (3D)        2Y9D (3D)        3CW1 (3D)        3PGW (3D)    
Secondary accessions: D6W5G6 Q15357 Q6IB86

Explore the universe of human proteins at neXtProt for SNRPG: NX_P62308

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62308

    • SNRPG Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003087.1  
    ENSEMBL proteins: 
     ENSP00000272348   ENSP00000441332   ENSP00000402194   ENSP00000391403   ENSP00000416334  
     ENSP00000393388  
    Reactome Protein details: P62308
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: SNRPG
    OriGene Protein Over-expression Lysate: SNRPG
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    Novus Biologicals SNRPG Proteins
    Novus Biologicals SNRPG Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SNRPG
    Uscn Proteins for SNRPG

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex TAS7744013
    GO:0005683U7 snRNP IDA11574479
    GO:0005689U12-type spliceosomal complex IDA15146077
    GO:0005829cytosol TAS--


    SNRPG for ontologies           About GeneDecksing



    SNRPG Antibody Products: 
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    Search ThermoFisher Antibodies for SNRPG

    Assay Products for SNRPG: 
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    Uscn ELISAs and CLIAs for SNRPG

    Protein Domains /
    Families
    for SNRPG gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNRPG for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001163 Ribonucl_LSM
     IPR006649 Ribonucl_LSM_euk/arc
     IPR010920 LSM_dom

    Graphical View of Domain Structure for InterPro Entry P62308

    ProtoNet protein and cluster: P62308

    1 Blocks protein family: IPB010920 Like-Sm ribonucleoprotein-related

    UniProtKB/Swiss-Prot: RUXG_HUMAN, P62308
    Similarity: Belongs to the snRNP Sm proteins family


    Function
    for SNRPG gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RUXG_HUMAN, P62308
    Function: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with
    snRNP U1, U2, U4/U6 and U5

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SNRPG
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPG
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPG:
    hsa-miR-495 hsa-miR-493* hsa-miR-7-1* hsa-miR-7-2* hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmid: SNRPG 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRPG (see all 7)
    OriGene shRNA RFP: SNRPG
    OriGene siRNA: SNRPG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPG

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SNRPG

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPG (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SNRPG (NM_003096)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPG 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SNRPG
    Search LifeMap BioReagents cell lines for SNRPG

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SNRPG

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI14603251


    SNRPG for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for SNRPG:
     Decreased viability  Decreased viability of wild-ty  Increased G2M DNA content 


    Pathways & Interactions
    for SNRPG gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA Splicing1.00
    		mRNA processing0.48
    		mRNA Splicing - Major Pathway1.00
    		mRNA Splicing - Minor Pathway0.40
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    		Spliceosome0.31
    		mRNA Processing0.82
    2SLBP independent Processing of Histone Pre-mRNAs
    		SLBP independent Processing of Histone Pre-mRNAs1.00
    		snRNP Assembly0.28
    		SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs0.91
    		Metabolism of non-coding RNA0.28
    3RNA Polymerase II Transcription Termination
    		RNA Polymerase II Transcription Termination1.00
    		Cleavage of Growing Transcript in the Termination Region 1.00
    		Post-Elongation Processing of the Transcript1.00
    4Transcription
    		Transcription1.00
    		RNA Polymerase II Transcription0.69
    5Post-Elongation Processing of Intronless pre-mRNA
    		Processing of Capped Intronless Pre-mRNA1.00
    		Post-Elongation Processing of Intronless pre-mRNA1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SNRPG 
        mRNA processing

    5/18        Reactome Pathways for SNRPG (see all 18)
        mRNA Splicing
    RNA Polymerase II Transcription
    snRNP Assembly
    Cleavage of Growing Transcript in the Termination Region
    Metabolism of non-coding RNA


    1         Kegg Pathway  (Kegg details for SNRPG):
        Spliceosome


    SNRPG for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNRPG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/198 Interacting proteins for SNRPG (P623081, 2, 3 ENSP000002723484) via UniProtKB, MINT, STRING, and/or I2D (see all 198)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-13669 MINT-13668 I2D: score=5 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-13669 MINT-13668 I2D: score=5 STRING: ENSP00000370119
    SNRPEP623042, 3, ENSP000004005914MINT-49757 MINT-49761 I2D: score=6 STRING: ENSP00000400591
    SF3A2Q154282, 3, ENSP000002214944MINT-5205368 I2D: score=2 STRING: ENSP00000221494
    SNRPFP623062, 3, ENSP000002667354MINT-8332789 I2D: score=2 STRING: ENSP00000266735
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000245spliceosomal complex assembly NAS7744013
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--


    SNRPG for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNRPG gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNRPG
    Search CenterWatch for drugs/clinical trials and news about SNRPG / RUXG 

    Transcripts
    for SNRPG gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNRPG gene: 
    NM_003096.2  

    Unigene Clusters for SNRPG:

    Small nuclear ribonucleoprotein polypeptide G
    Hs.465167  [show with all ESTs], Hs.516076  [show with all ESTs], Hs.631639  [show with all ESTs], Hs.654528  [show with all ESTs]
    Unigene Representative Sequences: BU517151, BM543095, BU534134, BU198589
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272348(uc002sgp.3) ENST00000429728 ENST00000482975(uc002sgo.3)
    ENST00000438261 ENST00000449935 ENST00000413456 ENST00000454893 ENST00000480370
    ENST00000488400

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SNRPG
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPG
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPG:
    hsa-miR-495 hsa-miR-493* hsa-miR-7-1* hsa-miR-7-2* hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmid: SNRPG 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRPG (see all 7)
    OriGene shRNA RFP: SNRPG
    OriGene siRNA: SNRPG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPG
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPG (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPG
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SNRPG (NM_003096)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPG 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNRPG
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPG

    Additional cDNA sequence: 

    CR456918.1 X85373.1 

    20 DOTS entries:

    DT.120974615  DT.97861380  DT.91905000  DT.100032481  DT.91815834  DT.100827773  DT.120974604  DT.86855875 
    DT.121454965  DT.95081625  DT.121089586  DT.100038488  DT.120974624  DT.100774842  DT.120974601  DT.120974642 
    DT.86844929  DT.95324761  DT.120974663  DT.95081630 

    24/389 AceView cDNA sequences (see all 389):

    AI241354 AA923564 BM738725 AI468221 AA983328 BQ707873 BC000070 CB109315 
    AW083157 AI268598 AW274299 D57762 AI573211 AI471452 BG153462 AV712010 
    AV691391 AV709468 AI500328 W96021 CB160382 BM844274 AA258524 AA235102 

    GeneLoc Exon Structure


    Expression
    for SNRPG gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNRPG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACATTTTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SNRPG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNRPG

    SOURCE GeneReport for Unigene clusters: Hs.465167 Hs.516076 Hs.631639 Hs.654528
        SABiosciences Custom PCR Arrays for SNRPG
    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SNRPG

    Orthologs
    for SNRPG gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRPG gene from 9/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Snrpg1 , 5 small nuclear ribonucleoprotein polypeptide G1, 5 89.91(n)1
    100(a)1    		   6 (37.69 cM)5
    680111  NM_026506.21  NP_080782.11 
     863715835 
    chicken
    (Gallus gallus)    		 Aves FAM136A1 family with sequence similarity 136, member A 81.14(n)
    97.37(a)    		   771344  XM_001233286.1  XP_001233287.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SNRPG6
    		 --
    		 86(a)
    		 1 ↔ 1
    		 AAWZ02037395(616-3484)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia 1377270962   -- 81.05(n)    137727096 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.142282 Transcribed sequence with moderate similarity to protein more 78.28(n)    BM072215.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta SmG1 Small ribonucleoprotein particle protein SmG 62.72(n)
    72.37(a)    		   32636  NM_001144737.1  NP_001138209.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea snr-71 Protein SNR-7 59.21(n)
    65.79(a)    		   171834  NM_058631.4  NP_491032.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G115006
    SNRNP-G6
    		 small nuclear ribonucleoprotein
    		 58(a)
    58(a)
    		 many → 1
    many → 1
    		 3(3621409-3622606)
    2(10182251-10183240)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 LSM domain containing protein, expressed
    		 55(a)
    51(a)
    		 many → 1
    many → 1
    		 3(16940020-16942201)
    7(25035631-25036762)


    ENSEMBL Gene Tree for SNRPG (if available)
    TreeFam Gene Tree for SNRPG (if available) 

    Paralogs
    for SNRPG gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNRPG gene
    LOC1001309322  
    4 SIMAP similar genes for SNRPG using alignment to 4 protein entries:     RUXG_HUMAN (see all proteins):
    LSM7    LSM6    LSM8    NAA38

    SNRPG for paralogs           About GeneDecksing


    5/20 Pseudogenes.org Pseudogenes for SNRPG (see all 20)
    PGOHUM00000238351 PGOHUM00000258505 PGOHUM00000238930 PGOHUM00000242330 PGOHUM00000242859


    Genomic Variants
    for SNRPG gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/258 NCBI SNPs in SNRPG are shown (see all 258)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs752358331,2
    		C,--70508040(+) ATCAC-/AAAAAA 2 -- int1 ut310--------
    rs1151205071,2
    		F,--70508124(+) CTCTCG/CTTTGA 2 -- int1 ut311Minor allele frequency- C:0.02WA 118
    rs1455840221,2
    		--70508187(+) CTCACA/TACCCC 2 -- ut31 int10--------
    rs1851952401,2
    		--70508313(+) TACATC/GATTAC 2 -- int1 ut310--------
    rs48534381,2
    		C,F,A,H,--70508379(+) GTCAGA/GCTAGA 2 -- ds5001 int127Minor allele frequency- G:0.27NS EA NA WA CSA 2524
    rs1894111951,2
    		--70508387(+) AGATCA/GAAGTT 2 -- ds5001 int10--------
    rs1477443401,2
    		--70508438(+) ACTCAC/TTCATG 2 -- int1 ds50010--------
    rs22725301,2
    		C,F,--70508559(+) ATCAAT/CGTCAA 2 -- ds5001 ut31 ese31Minor allele frequency- C:0.01EA 1474
    rs2018056211,2
    		C,--70508835(+) AAATAA/CATTTG 1 -- int11Minor allele frequency- C:0.00EU 1301
    rs1814441931,2
    		C,--70508845(+) GAAAAA/GAACAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SNRPG (70508494 - 70520903 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SNRPG
         1 CNV: 97879

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    Disorders / Diseases
    for SNRPG gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNRPG for disorders           About GeneDecksing

    OMIM gene information: 603542    OMIM disorders: --

    5 diseases for SNRPG:    About MalaCards
    spinal muscular atrophy    muscular atrophy    breast cancer    malaria
    neuronitis


    Export disorders for SNRPG gene to outside databases

    Publications
    for SNRPG gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNRPG gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with SNRPG)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. (PubMed id 7744013)1, 2, 3 Hermann H....Luehrmann R. (1995)
    2. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PubMed id 12165861)1, 2, 9 Conte N.... Birnbaum D. (2002)
    3. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    6. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. (PubMed id 11574479)1, 2 Pillai R.S.... Mueller B. (2001)
    7. Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro. (PubMed id 1387914)1, 9 Heinrichs V....Luhrmann R. (1992)
    8. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)

    External Searches for SNRPG gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SNRPG gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6637 HGNC: 11163 AceView: SNRPG Ensembl:ENSG00000143977 euGenes: HUgn6637
    ECgene: SNRPG Kegg: 6637 H-InvDB: SNRPG

    Other Databases showing SNRPG gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SNRPG gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNRPG Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SNRPG gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SNRPG gene:
    Search GeneIP for patents involving SNRPG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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