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SNRPF Gene

protein-coding   GIFtS: 59
GCID: GC12P096252

Small Nuclear Ribonucleoprotein Polypeptide F

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Small Nuclear Ribonucleoprotein Polypeptide F1 2     SMF2
Sm Protein F2 3     Small Nuclear Ribonucleoprotein F2
Sm-F2 3     PBSCF3
snRNP-F2 3     SmF3

External Ids:    HGNC: 111621   Entrez Gene: 66362   Ensembl: ENSG000001393437   OMIM: 6035415   UniProtKB: P623063   

Export aliases for SNRPF gene to outside databases

Previous GC identifers: GC12P095685 GC12P096616 GC12P096185 GC12P094755 GC12P094776 GC12P093317


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SNRPF Gene:
SNRPF (small nuclear ribonucleoprotein polypeptide F) is a protein-coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is LSM6.

UniProtKB/Swiss-Prot: RUXF_HUMAN, P62306
Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the
building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As
part of the U7 snRNP it is involved in histone 3'-end processing

Gene Wiki entry for SNRPF (Small nuclear ribonucleoprotein polypeptide F) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNRPF gene promoter:
         Brachyury   Tal-1beta   CBF-C   E47   N-Myc   CBF-A   CBF-B   CP1C   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRPF promoter sequence
   Search Chromatin IP Primers for SNRPF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNRPF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.1   Ensembl cytogenetic band:  12q23.1   HGNC cytogenetic band: 12q23.1

SNRPF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPF gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P096252:  view genomic region     (about GC identifiers)

Start:
96,252,706 bp from pter      End:
96,297,606 bp from pter
Size:
44,901 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RUXF_HUMAN, P62306 (See protein sequence)
Recommended Name: Small nuclear ribonucleoprotein F  
Size: 86 amino acids; 9725 Da
Subunit: U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF
and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core
snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the
U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or
U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA.
Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8,
STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs
assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like
structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP
Selected PDB 3D structures from and Proteopedia for SNRPF (see all 11):
1VU2 (3D)        1VU3 (3D)        2Y9A (3D)        2Y9B (3D)        2Y9C (3D)        2Y9D (3D)    
Secondary accessions: A2VCR2 B2R498 Q15356 Q6IBQ1 Q6P4I0

Explore the universe of human proteins at neXtProt for SNRPF: NX_P62306

Explore proteomics data for SNRPF at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys17, Lys24
  • Modification sites at PhosphoSitePlus

  • See SNRPF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003086.1  
    ENSEMBL proteins: 
     ENSP00000266735   ENSP00000447751   ENSP00000447127  
    Reactome Protein details: P62306

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001163 Ribonucl_LSM
     IPR016487 snRNP_SmF
     IPR010920 LSM_dom
     IPR006649 Ribonucl_LSM_euk/arc

    Graphical View of Domain Structure for InterPro Entry P62306

    ProtoNet protein and cluster: P62306

    1 Blocks protein domain: IPB010920 Like-Sm ribonucleoprotein-related

    UniProtKB/Swiss-Prot: RUXF_HUMAN, P62306
    Similarity: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily


    Find genes that share domains with SNRPF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RUXF_HUMAN, P62306
    Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the
    building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
    spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
    that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As
    part of the U7 snRNP it is involved in histone 3'-end processing

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IMP7744013
    GO:0005515protein binding IPI18984161
         
    Find genes that share ontologies with SNRPF           About GenesLikeMe


    Phenotypes:
         8 GenomeRNAi human phenotypes for SNRPF:
     Cell cycle / mitosis defect  Cell division defect  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Decreased viability of wild-ty  Increased G2M DNA content  Increased number of mitotic ce  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNRPF
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNRPF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNRPF

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNRPF:
    hsa-mir-124-3p (MIRT022590), hsa-mir-877-3p (MIRT036917)

    Block miRNA regulation of human, mouse, rat SNRPF using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SNRPF:
    hsa-miR-3163 hsa-miR-495 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidSNRPF 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SNRPF

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SNRPF (NM_003095)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPF

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RUXF_HUMAN, P62306: Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the
    cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular3

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA7744013
    GO:0005683U7 snRNP IDA11574479
    GO:0005685U1 snRNP IDA--

    Find genes that share ontologies with SNRPF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNRPF About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA processing0.44
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    mRNA Splicing0.78
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs0.00
    Cleavage of Growing Transcript in the Termination Region0.80
    SLBP independent Processing of Histone Pre-mRNAs0.00
    Processing of Capped Intronless Pre-mRNA0.52
    3Regulation of Glucokinase by Glucokinase Regulatory Protein
    Metabolism of non-coding RNA0.54
    snRNP Assembly0.54
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with SNRPF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNRPF
        mRNA processing

    Selected Reactome Pathways for SNRPF (see all 6)
        mRNA Splicing - Major Pathway
    SLBP independent Processing of Histone Pre-mRNAs
    snRNP Assembly
    Cleavage of Growing Transcript in the Termination Region
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs


    1 Kegg Pathway  (Kegg details for SNRPF):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNRPF
    Interactions:

        Search GeneGlobe Interaction Network for SNRPF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNRPF (P623061, 2, 3 ENSP000002667354) via UniProtKB, MINT, STRING, and/or I2D (see all 229)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNRPEP623041, 2, 3, ENSP000004005914EBI-356900,EBI-348082 MINT-49760 MINT-8332778 I2D: score=11 STRING: ENSP00000400591
    SNRPD2P623162, 3, ENSP000003423744MINT-49763 MINT-8332690 I2D: score=12 STRING: ENSP00000342374
    SF3A2Q154282, 3, ENSP000002214944MINT-5205359 I2D: score=2 STRING: ENSP00000221494
    SNRPGP623082, 3, ENSP000002723484MINT-8332789 I2D: score=2 STRING: ENSP00000272348
    MAP3K1Q132332, 3MINT-48357 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006396RNA processing ----

    Find genes that share ontologies with SNRPF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNRPF (RUXF)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SNRPF gene: 
    NM_003095.2  

    Unigene Cluster for SNRPF:

    Small nuclear ribonucleoprotein polypeptide F
    Hs.105465  [show with all ESTs]
    Unigene Representative Sequence: CD388516
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266735(uc001tej.3) ENST00000551316 ENST00000553192 ENST00000552085
    ENST00000549580
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate SNRPF:
    hsa-miR-3163 hsa-miR-495 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidSNRPF 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SNRPF (NM_003095)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPF
    Primer
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    OriGene qPCR primer pairs and template standards for SNRPF
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      QuantiTect SYBR Green Assays in human, mouse, rat SNRPF
      QuantiFast Probe-based Assays in human, mouse, rat SNRPF

    Additional mRNA sequence: 

    AK311752.1 BC002505.2 BC063397.1 BC128452.1 BC128453.1 CR456751.1 X85372.1 

    8 DOTS entries:

    DT.100668416  DT.92442627  DT.121211444  DT.92442631  DT.99996090  DT.100685752  DT.100842550  DT.95347974 

    Selected AceView cDNA sequences (see all 225):

    AW327621 AA514837 BM712034 BC002505 BQ647236 AW873105 BQ647431 AI347053 
    BM554302 BM701732 BE269077 BQ650411 AA524133 CB998801 BM423489 BQ882115 
    AI199012 AA612722 AA668189 BE408562 BU931026 AI274390 BQ648155 AW327351 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNRPF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTTGCAA
    SNRPF Expression
    About this image

    SNRPF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNRPF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.105465
        Custom PCR Arrays for SNRPF
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    QuantiFast Probe-based Assays in human, mouse, rat SNRPF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRPF gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrpf1 , 5 small nuclear ribonucleoprotein polypeptide F1, 5 90.31(n)1
    100(a)1
      10 (48.57 cM)5
    698781  NM_027246.11  NP_081522.11 
     935830295 
    chicken
    (Gallus gallus)
    Aves SNRPF1 small nuclear ribonucleoprotein polypeptide F 84.11(n)
    100(a)
      417916  NM_001277362.1  NP_001264291.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNRPF6
    small nuclear ribonucleoprotein polypeptide F
    97(a)
    1 ↔ 1
    5(30641445-30643258)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056127.12   -- 84.53(n)    BC056127.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ076957.12   -- 82.64(n)    BQ076957.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DebB3 mRNA splicing 79(a)   48E6   --
    worm
    (Caenorhabditis elegans)
    Secernentea snr-56
    Protein SNR-5 (snr-5) mRNA, complete cds
    66(a)
    1 ↔ 1
    III(7862070-7862576) WBGene00004918
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMX3(YPR182W)4 Core Sm protein Sm F; part of heteroheptameric complex more   --   16(900194-900454) 856312  NP_015508.1 
    soybean
    (Glycine max)
    eudicotyledons Gma.83492 Transcribed sequence with moderate similarity to protein more 77.07(n)  
    rice
    (Oryza sativa)
    Liliopsida AK062752.12   -- 72.48(n)    AK062752.1 


    ENSEMBL Gene Tree for SNRPF (if available)
    TreeFam Gene Tree for SNRPF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNRPF gene
    LSM62  
    Selected SIMAP similar genes for SNRPF using alignment to 2 protein entries:     RUXF_HUMAN (see all proteins) (see all similar genes):
    TNNT1    FBLN5    ARL6IP5    NDC80    C3orf33    MYL10
    ASCC1    HEXDC    MRPL45    SEC14L3    ZNF415    COQ5
    NLRC5    pp12301    EIF3G    GNB2L1    PGS1    TP63

    Find genes that share paralogs with SNRPF           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for SNRPF (see all 6)
    PGOHUM00000248429 PGOHUM00000246843 PGOHUM00000246857 PGOHUM00000244640 PGOHUM00000247558


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNRPF (see all 165)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857941071,2
    --96250745(+) GGCTGC/TAGTAA 1 -- us2k10--------
    rs801563121,2
    C,F--96250818(+) AAAAAA/TATTTA 1 -- us2k11Minor allele frequency- T:0.19NA 120
    rs786888991,2
    --96250838(+) GAAAAA/TCCAAC 1 -- us2k10--------
    rs1896534261,2
    --96250906(+) GAGAAA/TACAGC 1 -- us2k10--------
    rs79701331,2
    C,F,A,H--96250933(+) TAAAAC/TACATA 1 -- us2k132Minor allele frequency- T:0.30NS EA NA WA 3402
    rs1823271691,2
    --96251057(+) TAGGGC/TCCATC 1 -- us2k10--------
    rs1887260561,2
    --96251259(+) CCAGGC/TGGTGC 1 -- us2k10--------
    rs1408250101,2
    --96251278(+) TAGAGC/TGTACT 1 -- us2k10--------
    rs557081881,2
    C,F--96251472(+) CACGAT/CTGTTG 1 -- us2k12Minor allele frequency- C:0.05WA 120
    rs37640361,2
    C,F,A,H--96251493(-) CTACTA/GTGTGT 1 -- us2k126Minor allele frequency- G:0.21EA NS NA WA CSA 4247

    HapMap Linkage Disequilibrium report for SNRPF (96252706 - 96297606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SNRPF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv455693CNV Loss19166990
    nsv7234OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNRPF
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603541    OMIM disorders: --


    Find genes that share disorders with SNRPF           About GenesLikeMe


    Export disorders for SNRPF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNRPF gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with SNRPF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. (PubMed id 7744013)1, 2, 3 Hermann H....Luehrmann R. (EMBO J. 1995)
    2. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PubMed id 18984161)1, 2 Chari A....Fischer U. (Cell 2008)
    3. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (RNA 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    6. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. (PubMed id 11574479)1, 2 Pillai R.S.... Mueller B. (EMBO J. 2001)
    7. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    8. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    9. Structural basis of assembly chaperone-mediated snRNP formation. (PubMed id 23333303)2 Grimm C.... Fischer U. (Mol. Cell 2013)
    10. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6636 HGNC: 11162 AceView: SNRPF Ensembl:ENSG00000139343 euGenes: HUgn6636
    ECgene: SNRPF Kegg: 6636 H-InvDB: SNRPF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNRPF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNRPF gene:
    Search GeneIP for patents involving SNRPF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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