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Aliases for SNRPF Gene

Aliases for SNRPF Gene

  • Small Nuclear Ribonucleoprotein Polypeptide F 2 3 5
  • Sm Protein F 3 4
  • SnRNP-F 3 4
  • Sm-F 3 4
  • SMF 3 4
  • PBSCF 4

External Ids for SNRPF Gene

Previous GeneCards Identifiers for SNRPF Gene

  • GC12P095685
  • GC12P096616
  • GC12P096185
  • GC12P094755
  • GC12P094776
  • GC12P093317
  • GC12P096252

Summaries for SNRPF Gene

GeneCards Summary for SNRPF Gene

SNRPF (Small Nuclear Ribonucleoprotein Polypeptide F) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of Glucokinase by Glucokinase Regulatory Protein. GO annotations related to this gene include RNA binding. An important paralog of this gene is LSM6.

UniProtKB/Swiss-Prot for SNRPF Gene

  • Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3-end processing.

Gene Wiki entry for SNRPF Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPF Gene

Genomics for SNRPF Gene

Regulatory Elements for SNRPF Gene

Promoters for SNRPF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNRPF on UCSC Golden Path with GeneCards custom track

Genomic Location for SNRPF Gene

Chromosome:
12
Start:
95,858,928 bp from pter
End:
95,903,828 bp from pter
Size:
44,901 bases
Orientation:
Plus strand

Genomic View for SNRPF Gene

Genes around SNRPF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRPF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRPF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPF Gene

Proteins for SNRPF Gene

  • Protein details for SNRPF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62306-RUXF_HUMAN
    Recommended name:
    Small nuclear ribonucleoprotein F
    Protein Accession:
    P62306
    Secondary Accessions:
    • A2VCR2
    • B2R498
    • Q15356
    • Q6IBQ1
    • Q6P4I0

    Protein attributes for SNRPF Gene

    Size:
    86 amino acids
    Molecular mass:
    9725 Da
    Quaternary structure:
    • U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.

    Three dimensional structures from OCA and Proteopedia for SNRPF Gene

neXtProt entry for SNRPF Gene

Proteomics data for SNRPF Gene at MOPED

Post-translational modifications for SNRPF Gene

  • Ubiquitination at Lys 17 and Lys 24
  • Modification sites at PhosphoSitePlus

Other Protein References for SNRPF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SNRPF Gene

Domains & Families for SNRPF Gene

Protein Domains for SNRPF Gene

Suggested Antigen Peptide Sequences for SNRPF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62306

UniProtKB/Swiss-Prot:

RUXF_HUMAN :
  • Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
Family:
  • Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
genes like me logo Genes that share domains with SNRPF: view

No data available for Gene Families for SNRPF Gene

Function for SNRPF Gene

Molecular function for SNRPF Gene

UniProtKB/Swiss-Prot Function:
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3-end processing.
genes like me logo Genes that share phenotypes with SNRPF: view

Animal Model Products

CRISPR Products

miRNA for SNRPF Gene

miRTarBase miRNAs that target SNRPF

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRPF Gene

Localization for SNRPF Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPF Gene

Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRPF Gene COMPARTMENTS Subcellular localization image for SNRPF gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 3

Gene Ontology (GO) - Cellular Components for SNRPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005685 U1 snRNP IDA 21113136
GO:0005689 U12-type spliceosomal complex IDA 15146077
GO:0034709 methylosome IDA 18984161
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with SNRPF: view

Pathways & Interactions for SNRPF Gene

genes like me logo Genes that share pathways with SNRPF: view

Pathways by source for SNRPF Gene

1 KEGG pathway for SNRPF Gene

Gene Ontology (GO) - Biological Process for SNRPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with SNRPF: view

No data available for SIGNOR curated interactions for SNRPF Gene

Drugs & Compounds for SNRPF Gene

No Compound Related Data Available

Transcripts for SNRPF Gene

Unigene Clusters for SNRPF Gene

Small nuclear ribonucleoprotein polypeptide F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPF Gene

No ASD Table

Relevant External Links for SNRPF Gene

GeneLoc Exon Structure for
SNRPF
ECgene alternative splicing isoforms for
SNRPF

Expression for SNRPF Gene

mRNA expression in normal human tissues for SNRPF Gene

Protein differential expression in normal tissues from HIPED for SNRPF Gene

This gene is overexpressed in Nasal epithelium (8.3) and Adrenal (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNRPF Gene



SOURCE GeneReport for Unigene cluster for SNRPF Gene Hs.105465

genes like me logo Genes that share expression patterns with SNRPF: view

Protein tissue co-expression partners for SNRPF Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNRPF Gene

Orthologs for SNRPF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNRPF 35
  • 94.19 (n)
  • 100 (a)
SNRPF 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRPF 35
  • 93.02 (n)
  • 100 (a)
SNRPF 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snrpf 35
  • 90.31 (n)
  • 100 (a)
Snrpf 16
Snrpf 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNRPF 35
  • 100 (n)
  • 100 (a)
SNRPF 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snrpf 35
  • 93.41 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia SNRPF 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNRPF 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNRPF 35
  • 84.11 (n)
  • 100 (a)
SNRPF 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNRPF 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snrpf 35
  • 82.56 (n)
  • 100 (a)
Str.2969 35
zebrafish
(Danio rerio)
Actinopterygii snrpf 35
  • 80 (n)
  • 97.33 (a)
snrpf 36
  • 95 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta DebB 37
  • 79 (a)
SmF 36
  • 75 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea snr-5 36
  • 66 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMX3 36
  • 49 (a)
OneToMany
SMX3 38
soybean
(Glycine max)
eudicotyledons Gma.8349 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8951 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4735 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01614 35
  • 58.22 (n)
  • 59.15 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes smf1 35
  • 63.81 (n)
  • 68.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.865 36
  • 84 (a)
OneToOne
Species with no ortholog for SNRPF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNRPF Gene

ENSEMBL:
Gene Tree for SNRPF (if available)
TreeFam:
Gene Tree for SNRPF (if available)

Paralogs for SNRPF Gene

Paralogs for SNRPF Gene

genes like me logo Genes that share paralogs with SNRPF: view

Variants for SNRPF Gene

Sequence variations from dbSNP and Humsavar for SNRPF Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs703693 -- 95,866,214(-) AGTTC(A/C/G/T)GTGAG utr-variant-3-prime
rs1036430 -- 95,866,538(-) TAGCT(A/G)CAATA downstream-variant-500B
rs1052953 -- 95,866,086(+) TGGGG(A/G)ATTTT utr-variant-3-prime
rs3751264 -- 95,861,529(-) GTGTC(C/T)GAGCT intron-variant
rs3764036 -- 95,857,715(-) CTACT(A/G)TGTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNRPF Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv455693 CNV Loss 19166990

Variation tolerance for SNRPF Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNRPF Gene

HapMap Linkage Disequilibrium report
SNRPF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRPF Gene

Disorders for SNRPF Gene

Relevant External Links for SNRPF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNRPF

No disorders were found for SNRPF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRPF Gene

Publications for SNRPF Gene

  1. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. (PMID: 7744013) Hermann H. … Luehrmann R. (EMBO J. 1995) 2 3 4 67
  2. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for SNRPF Gene

Sources for SNRPF Gene

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