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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNRPF Gene

protein-coding   GIFtS: 58
GCID: GC12P096252

Small Nuclear Ribonucleoprotein Polypeptide F

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Small Nuclear Ribonucleoprotein Polypeptide F1 2     SMF2
Sm Protein F2 3     Small Nuclear Ribonucleoprotein F2
Sm-F2 3     PBSCF3
snRNP-F2 3     SmF3

External Ids:    HGNC: 111621   Entrez Gene: 66362   Ensembl: ENSG000001393437   OMIM: 6035415   UniProtKB: P623063   

Export aliases for SNRPF gene to outside databases

Previous GC identifers: GC12P095685 GC12P096616 GC12P096185 GC12P094755 GC12P094776 GC12P093317


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SNRPF Gene: 
SNRPF (small nuclear ribonucleoprotein polypeptide F) is a protein-coding gene. Diseases associated with SNRPF include spinal muscular atrophy, and muscular atrophy, and among its related super-pathways are mRNA Processing and Post-Elongation Processing of Intron-Containing pre-mRNA. GO annotations related to this gene include RNA binding. An important paralog of this gene is LSM6.

UniProtKB/Swiss-Prot: RUXF_HUMAN, P62306
Function: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated
with snRNP U1, U2, U4/U6 and U5

Gene Wiki entry for SNRPF (Small nuclear ribonucleoprotein polypeptide F) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNRPF gene promoter:
         Brachyury   Tal-1beta   CBF-C   E47   N-Myc   CBF-A   CBF-B   CP1C   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRPF promoter sequence
   Search SABiosciences Chromatin IP Primers for SNRPF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.1   Ensembl cytogenetic band:  12q23.1   HGNC cytogenetic band: 12q23.1

SNRPF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPF gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P096252:  view genomic region     (about GC identifiers)

Start:
96,252,706 bp from pter      End:
96,297,606 bp from pter
Size:
44,901 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RUXF_HUMAN, P62306 (See protein sequence)
Recommended Name: Small nuclear ribonucleoprotein F  
Size: 86 amino acids; 9725 Da
Subunit: Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of
LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent
process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally,
the U7-specific LSM10 and LSM11 proteins. Identified in the spliceosome C complex. Component of the U11/U12
snRNPs that are part of the U12-type spliceosome
Subcellular location: Nucleus
6/10 PDB 3D structures from and Proteopedia for SNRPF (see all 10):
1VU2 (3D)        1VU3 (3D)        2Y9A (3D)        2Y9B (3D)        2Y9C (3D)        2Y9D (3D)    
Secondary accessions: A2VCR2 B2R498 Q15356 Q6IBQ1 Q6P4I0

Explore the universe of human proteins at neXtProt for SNRPF: NX_P62306

Explore proteomics data for SNRPF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62306

  • SNRPF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNRPF Protein Expression
    REFSEQ proteins: NP_003086.1  
    ENSEMBL proteins: 
     ENSP00000266735   ENSP00000447751   ENSP00000447127  
    Reactome Protein details: P62306
    Human Recombinant Protein Products for SNRPF: 
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    OriGene Protein Over-expression Lysate for SNRPF
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    Novus Biologicals SNRPF Proteins
    Novus Biologicals SNRPF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SNRPF
    Cloud-Clone Corp. Proteins for SNRPF 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA7744013
    GO:0005683U7 snRNP IDA11574479
    GO:0005689U12-type spliceosomal complex IDA15146077

    SNRPF for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for SNRPF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001163 Ribonucl_LSM
     IPR016487 snRNP_SmF
     IPR010920 LSM_dom
     IPR006649 Ribonucl_LSM_euk/arc

    Graphical View of Domain Structure for InterPro Entry P62306

    ProtoNet protein and cluster: P62306

    1 Blocks protein domain: IPB010920 Like-Sm ribonucleoprotein-related

    UniProtKB/Swiss-Prot: RUXF_HUMAN, P62306
    Similarity: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily


    SNRPF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RUXF_HUMAN, P62306
    Function: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated
    with snRNP U1, U2, U4/U6 and U5

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IMP7744013
    GO:0005515protein binding IPI18984161
         
    SNRPF for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for SNRPF:
     Cell cycle / mitosis defect  Cell division defect  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Decreased viability of wild-ty  Increased G2M DNA content  Increased number of mitotic ce  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SNRPF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SNRPF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNRPF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNRPF 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPF
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPF:
    hsa-miR-3163 hsa-miR-495 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidSNRPF 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SNRPF About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA processing0.46
    mRNA Processing0.85
    mRNA Splicing - Minor Pathway0.40
    mRNA Splicing - Major Pathway0.82
    Spliceosome0.31
    mRNA Splicing0.82
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.79
    Post-Elongation Processing of the Transcript0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    3SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
    SLBP independent Processing of Histone Pre-mRNAs0.91
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs0.91
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Post-Elongation Processing of Intronless pre-mRNA
    Post-Elongation Processing of Intronless pre-mRNA0.61
    Processing of Capped Intronless Pre-mRNA0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNRPF
        mRNA processing

    5/18        Reactome Pathways for SNRPF (see all 18)
        mRNA Splicing
    RNA Polymerase II Transcription
    snRNP Assembly
    Cleavage of Growing Transcript in the Termination Region
    Metabolism of non-coding RNA


    1         Kegg Pathway  (Kegg details for SNRPF):
        Spliceosome


    SNRPF for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNRPF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/177 Interacting proteins for SNRPF (P623062, 3 ENSP000002667354) via UniProtKB, MINT, STRING, and/or I2D (see all 177)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNRPD2P623162, 3, ENSP000003423744MINT-49763 MINT-8332690 I2D: score=12 STRING: ENSP00000342374
    SNRPEP623042, 3, ENSP000004005914MINT-49760 MINT-8332778 I2D: score=11 STRING: ENSP00000400591
    SF3A2Q154282, 3, ENSP000002214944MINT-5205359 I2D: score=2 STRING: ENSP00000221494
    SNRPGP623082, 3, ENSP000002723484MINT-8332789 I2D: score=2 STRING: ENSP00000272348
    MAP3K1Q132332, 3MINT-48357 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006396RNA processing ----

    SNRPF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNRPF (RUXF)

    Search CenterWatch for drugs/clinical trials and news about SNRPF / RUXF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNRPF gene: 
    NM_003095.2  

    Unigene Cluster for SNRPF:

    Small nuclear ribonucleoprotein polypeptide F
    Hs.105465  [show with all ESTs]
    Unigene Representative Sequence: CD388516
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266735(uc001tej.3) ENST00000551316 ENST00000553192 ENST00000552085
    ENST00000549580
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPF:
    hsa-miR-3163 hsa-miR-495 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidSNRPF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SNRPF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPF
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    OriGene clones in human, mouse for SNRPF (see all 8)
    OriGene ORF clones in mouse, rat for SNRPF
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    GenScript: all cDNA clones in your preferred vector: SNRPF (NM_003095)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPF
    Sirion Biotech Customized lentivirus for stable overexpression of SNRPF 
                         Customized lentivirus expression plasmids for stable overexpression of SNRPF 
    Primer
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    OriGene qPCR primer pairs and template standards for SNRPF
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPF

    Additional mRNA sequence: 

    AK311752.1 BC002505.2 BC063397.1 BC128452.1 BC128453.1 CR456751.1 X85372.1 

    8 DOTS entries:

    DT.100668416  DT.92442627  DT.121211444  DT.92442631  DT.99996090  DT.100685752  DT.100842550  DT.95347974 

    24/225 AceView cDNA sequences (see all 225):

    AV703743 BQ882115 BU931026 AI347053 AW873105 BQ647236 BE408562 AW327621 
    AA514837 BM554302 AA612722 BE269077 BC002505 BQ645489 BQ648155 BQ647431 
    AI274390 BQ650411 CB998801 AA668189 BE792256 AA524133 BM423489 BM701732 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNRPF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTTGCAA
    SNRPF Expression
    About this image


    See SNRPF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNRPF

    SOURCE GeneReport for Unigene cluster: Hs.105465
        SABiosciences Custom PCR Arrays for SNRPF
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRPF gene from 10/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrpf1 , 5 small nuclear ribonucleoprotein polypeptide F1, 5 90.31(n)1
    100(a)1
      10 (48.57 cM)5
    698781  NM_027246.11  NP_081522.11 
     935830295 
    chicken
    (Gallus gallus)
    Aves SNRPF1 small nuclear ribonucleoprotein polypeptide F 84.11(n)
    100(a)
      417916  XM_416157.3  XP_416157.2 
    lizard
    (Anolis carolinensis)
    Reptilia SNRPF6
    Uncharacterized protein
    97(a)
    1 ↔ 1
    5(30641445-30643258)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056127.12   -- 84.53(n)    BC056127.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ076957.12   -- 82.64(n)    BQ076957.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DebB3
    SmF1
    mRNA splicing3
    Small ribonucleoprotein particle protein SmF1
    79(a)3
    71.83(n)1
    78.57(a)1
      48E63
    363141  NM_078984.31  NP_523708.21 
    worm
    (Caenorhabditis elegans)
    Secernentea snr-51 Protein SNR-5 65.37(n)
    72.73(a)
      176103  NM_066307.3  NP_498708.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMX3(YPR182W)4 Core Sm protein Sm F; part of heteroheptameric complex more   --   16(900194-900454) 856312  NP_015508.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RUXF1 small nuclear ribonucleoprotein F 70.04(n)
    77.22(a)
      829145  NM_119168.3  NP_194751.1 
    rice
    (Oryza sativa)
    Liliopsida AK062752.12   -- 72.48(n)    AK062752.1 


    ENSEMBL Gene Tree for SNRPF (if available)
    TreeFam Gene Tree for SNRPF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNRPF gene
    LSM62  
    18/84 SIMAP similar genes for SNRPF using alignment to 2 protein entries:     RUXF_HUMAN (see all proteins) (see all similar genes):
    TNNT1    FBLN5    ARL6IP5    NDC80    C3orf33    MYL10
    ASCC1    HEXDC    MRPL45    SEC14L3    ZNF415    COQ5
    NLRC5    pp12301    EIF3G    GNB2L1    TP63    GCDH

    SNRPF for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for SNRPF (see all 6)
    PGOHUM00000248429 PGOHUM00000246843 PGOHUM00000246857 PGOHUM00000244640 PGOHUM00000247558


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/165 SNPs in SNRPF are shown (see all 165)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857941071,2
    --96250745(+) GGCTGC/TAGTAA 1 -- us2k10--------
    rs801563121,2
    C,F--96250818(+) AAAAAA/TATTTA 1 -- us2k11Minor allele frequency- T:0.19NA 120
    rs786888991,2
    --96250838(+) GAAAAA/TCCAAC 1 -- us2k10--------
    rs1896534261,2
    --96250906(+) GAGAAA/TACAGC 1 -- us2k10--------
    rs79701331,2
    C,F,A,H--96250933(+) TAAAAC/TACATA 1 -- us2k132Minor allele frequency- T:0.30NS EA NA WA 3402
    rs1823271691,2
    --96251057(+) TAGGGC/TCCATC 1 -- us2k10--------
    rs1887260561,2
    --96251259(+) CCAGGC/TGGTGC 1 -- us2k10--------
    rs1408250101,2
    --96251278(+) TAGAGC/TGTACT 1 -- us2k10--------
    rs557081881,2
    C,F--96251472(+) CACGAT/CTGTTG 1 -- us2k12Minor allele frequency- C:0.05WA 120
    rs37640361,2
    C,F,A,H--96251493(-) CTACTA/GTGTGT 1 -- us2k126Minor allele frequency- G:0.21EA NS NA WA CSA 4247

    HapMap Linkage Disequilibrium report for SNRPF (96252706 - 96297606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SNRPF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv455693CNV Loss19166990
    nsv7234OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603541    OMIM disorders: --

    3 diseases for SNRPF:    About MalaCards
    spinal muscular atrophy    muscular atrophy    neuronitis


    SNRPF for disorders           About GeneDecksing


    Export disorders for SNRPF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNRPF gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with SNRPF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. (PubMed id 7744013)1, 2, 3 Hermann H....Luehrmann R. (1995)
    2. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    5. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. (PubMed id 11574479)1, 2 Pillai R.S.... Mueller B. (2001)
    6. Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
    7. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (2013)
    8. Cleavage and polyadenylation specificity factor 1 (CPS F1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6636 HGNC: 11162 AceView: SNRPF Ensembl:ENSG00000139343 euGenes: HUgn6636
    ECgene: SNRPF Kegg: 6636 H-InvDB: SNRPF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNRPF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNRPF gene:
    Search GeneIP for patents involving SNRPF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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