Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SNRPD3 Gene

protein-coding   GIFtS: 60
GCID: GC22P024951

Small Nuclear Ribonucleoprotein D3 Polypeptide 18kDa

(Previous name: small nuclear ribonucleoprotein D3 polypeptide (18kD))
  Search for SNRPD3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Small Nuclear Ribonucleoprotein D3 Polypeptide 18kDa1 2
Sm-D32 3
SnRNP Core Protein D32 3
Small Nuclear Ribonucleoprotein D3 Polypeptide (18kD)1
SMD32
Small Nuclear Ribonucleoprotein Sm D32

External Ids:    HGNC: 111601   Entrez Gene: 66342   Ensembl: ENSG000001000287   OMIM: 6010625   UniProtKB: P623183   

Export aliases for SNRPD3 gene to outside databases

Previous GC identifers: GC22P021648 GC22P023275 GC22P023276 GC22P007901


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SNRPD3 Gene:
This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions
in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul
2013)

GeneCards Summary for SNRPD3 Gene:
SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide 18kDa) is a protein-coding gene. GO annotations related to this gene include histone pre-mRNA DCP binding and enzyme binding.

UniProtKB/Swiss-Prot: SMD3_HUMAN, P62318
Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the
building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As
part of the U7 snRNP it is involved in histone 3'-end processing

Gene Wiki entry for SNRPD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNRPD3 gene promoter:
         CUTL1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRPD3 promoter sequence
   Search Chromatin IP Primers for SNRPD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNRPD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

SNRPD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPD3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P024951:  view genomic region     (about GC identifiers)

Start:
24,951,471 bp from pter      End:
25,005,947 bp from pter
Size:
54,477 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SMD3_HUMAN, P62318 (See protein sequence)
Recommended Name: Small nuclear ribonucleoprotein Sm D3  
Size: 126 amino acids; 13916 Da
Subunit: U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF
and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core
snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the
U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the U7 snRNP complex, or U7 Sm protein
core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Part of the
SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP
and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms
a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where
CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP
Miscellaneous: In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with
Sm specificity
Selected PDB 3D structures from and Proteopedia for SNRPD3 (see all 8):
1D3B (3D)        2Y9A (3D)        2Y9B (3D)        2Y9C (3D)        2Y9D (3D)        3CW1 (3D)    
Secondary accessions: B5BU13 P43331

Explore the universe of human proteins at neXtProt for SNRPD3: NX_P62318

Explore proteomics data for SNRPD3 at MOPED

Post-translational modifications: 

  • Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for
    assembly and biogenesis of snRNPs1
  • Ubiquitination2 at Lys8, Lys78
  • Modification sites at PhosphoSitePlus

  • See SNRPD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265585.1  NP_004166.1  

    ENSEMBL proteins: 
     ENSP00000215829   ENSP00000385266   ENSP00000456090   ENSP00000456969  
    Reactome Protein details: P62318

    SNRPD3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SNRPD3
    GenScript Custom Purified and Recombinant Proteins Services for SNRPD3
    Novus Biologicals SNRPD3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SNRPD3
    Cloud-Clone Corp. Proteins for SNRPD3

     
    Search eBioscience for Proteins for SNRPD3 

    SNRPD3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SNRPD3
    OriGene Custom Antibody Services for SNRPD3
    Novus Biologicals SNRPD3 Antibodies
    Abcam antibodies for SNRPD3
    Cloud-Clone Corp. Antibodies for SNRPD3
    ThermoFisher Antibody for SNRPD3
    LSBio Antibodies in human, mouse, rat for SNRPD3

    SNRPD3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SNRPD3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNRPD3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SNRPD3
    Cloud-Clone Corp. CLIAs for SNRPD3
    Search eBioscience for ELISAs for SNRPD3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR001163 Ribonucl_LSM
     IPR027141 LSm4/Sm_D1/D3
     IPR010920 LSM_dom
     IPR006649 Ribonucl_LSM_euk/arc

    Graphical View of Domain Structure for InterPro Entry P62318

    ProtoNet protein and cluster: P62318

    1 Blocks protein domain: IPB010920 Like-Sm ribonucleoprotein-related

    UniProtKB/Swiss-Prot: SMD3_HUMAN, P62318
    Similarity: Belongs to the snRNP core protein family


    Find genes that share domains with SNRPD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMD3_HUMAN, P62318
    Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the
    building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
    spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
    that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As
    part of the U7 snRNP it is involved in histone 3'-end processing

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11714716
    GO:0019899enzyme binding IPI17709427
    GO:0044822poly(A) RNA binding IDA--
    GO:0071208histone pre-mRNA DCP binding ISS--
         
    Find genes that share ontologies with SNRPD3           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SNRPD3:
     Decreased cell number, increas  Decreased homologous recombina  Decreased influenza A virus in  Decreased viability of wild-ty 
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNRPD3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNRPD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNRPD3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNRPD3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNRPD3:
    hsa-mir-193b-3p (MIRT041313), hsa-mir-183-5p (MIRT024990), hsa-mir-500a-5p (MIRT037997), hsa-mir-363-3p (MIRT044049), hsa-mir-124-3p (MIRT023211), hsa-mir-330-3p (MIRT043833), hsa-mir-24-3p (MIRT030561)

    Block miRNA regulation of human, mouse, rat SNRPD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNRPD3 (see all 9):
    hsa-miR-148b* hsa-miR-4311 hsa-miR-513c hsa-miR-4282 hsa-miR-371-5p hsa-miR-3160-3p hsa-miR-330-3p hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidSNRPD3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNRPD3
    Predesigned siRNA for gene silencing in human, mouse, rat SNRPD3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNRPD3

    Clone
    Products:
         
    OriGene clones in human, mouse for SNRPD3 (see all 6)
    OriGene ORF clones in mouse, rat for SNRPD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNRPD3 (NM_004175)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPD3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SNRPD3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SNRPD3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SMD3_HUMAN, P62318: Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the
    cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex TAS7527560
    GO:0005683U7 snRNP IDA11574479
    GO:0005685U1 snRNP IDA--

    Find genes that share ontologies with SNRPD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SNRPD3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA processing0.44
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    mRNA Splicing0.78
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs0.00
    Cleavage of Growing Transcript in the Termination Region0.80
    SLBP independent Processing of Histone Pre-mRNAs0.00
    Processing of Capped Intronless Pre-mRNA0.52
    3Regulation of Glucokinase by Glucokinase Regulatory Protein
    Metabolism of non-coding RNA0.54
    snRNP Assembly0.54
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with SNRPD3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNRPD3
        mRNA processing

    Selected Reactome Pathways for SNRPD3 (see all 6)
        mRNA Splicing - Major Pathway
    SLBP independent Processing of Histone Pre-mRNAs
    snRNP Assembly
    Cleavage of Growing Transcript in the Termination Region
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs


    2 Kegg Pathways  (Kegg details for SNRPD3):
        Spliceosome
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNRPD3
    Interactions:

        Search GeneGlobe Interaction Network for SNRPD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNRPD3 (P623181, 2, 3 ENSP000002158294) via UniProtKB, MINT, STRING, and/or I2D (see all 993)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000370119
    PRPF8Q6P2Q92, 3, ENSP000003043504MINT-7945693 MINT-7947479 I2D: score=6 STRING: ENSP00000304350
    PRPF6O949062, 3, ENSP000002660794MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000266079
    SNRNP200O756432, 3, ENSP000003171234MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000317123
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0008334histone mRNA metabolic process TAS--

    Find genes that share ontologies with SNRPD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNRPD3 (SMD3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SNRPD3 gene (2 alternative transcripts): 
    NM_001278656.1  NM_004175.4  

    Unigene Cluster for SNRPD3:

    Small nuclear ribonucleoprotein D3 polypeptide 18kDa
    Hs.356549  [show with all ESTs]
    Unigene Representative Sequence: AK296173
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215829(uc003aam.1 uc011aju.2) ENST00000468770 ENST00000402849
    ENST00000404603 ENST00000439775
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SNRPD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNRPD3 (see all 9):
    hsa-miR-148b* hsa-miR-4311 hsa-miR-513c hsa-miR-4282 hsa-miR-371-5p hsa-miR-3160-3p hsa-miR-330-3p hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidSNRPD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SNRPD3
    Predesigned siRNA for gene silencing in human, mouse, rat SNRPD3
    Clone
    Products:
         
    OriGene clones in human, mouse for SNRPD3 (see all 6)
    OriGene ORF clones in mouse, rat for SNRPD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNRPD3 (NM_004175)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPD3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNRPD3
    OriGene qSTAR qPCR primer pairs in human, mouse for SNRPD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNRPD3
      QuantiTect SYBR Green Assays in human, mouse, rat SNRPD3
      QuantiFast Probe-based Assays in human, mouse, rat SNRPD3

    Additional mRNA sequence: 

    AB451249.1 AB451373.1 AK296173.1 BC000457.2 BC003150.1 BC034447.1 CR456583.1 U15009.1 

    15 DOTS entries:

    DT.316341  DT.100669185  DT.97822264  DT.40244599  DT.95267470  DT.87016250  DT.91726177  DT.100667157 
    DT.111160  DT.120642645  DT.120642906  DT.400578  DT.91746242  DT.100770361  DT.120642746 

    Selected AceView cDNA sequences (see all 367):

    BE266867 BE295476 BC065921 NM_004175 BE560199 L20494 AI050789 BG944859 
    AU077341 BC025927 AA310856 BM668578 AI929243 CR591143 BU164348 BQ649885 
    W23739 CR600958 BM928709 BE298745 BU626240 L20490 AW612875 BF219926 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SNRPD3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4
    SP1:                                          
    SP2:                    -                     
    SP3:                                -         


    ECgene alternative splicing isoforms for SNRPD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SNRPD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SNRPD3 Expression
    About this image


    SNRPD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    SNRPD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNRPD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356549
        Custom PCR Arrays for SNRPD3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SNRPD3
    OriGene qSTAR qPCR primer pairs in human, mouse for SNRPD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNRPD3
    QuantiTect SYBR Green Assays in human, mouse, rat SNRPD3
    QuantiFast Probe-based Assays in human, mouse, rat SNRPD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRPD3 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrpd31 , 5 small nuclear ribonucleoprotein D31, 5 91.8(n)1
    100(a)1
      10 (38.55 cM)5
    673321  NM_026095.41  NP_080371.11 
     755180425 
    chicken
    (Gallus gallus)
    Aves SNRPD31 small nuclear ribonucleoprotein D3 polypeptide 18kDa 85.71(n)
    100(a)
      416947  NM_001007838.1  NP_001007839.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNRPD36
    small nuclear ribonucleoprotein D3 polypeptide 18k...
    91(a)
    1 ↔ 1
    GL343947.1(83657-85469)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ031709.12   -- 82.86(n)    BJ031709.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa18f042 wufa18f04 85.14(n)   327011  BC045929.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SmD31 , 3 mRNA splicing3
    Small ribonucleoprotein particle protein SmD31
    91(a)3
    70.72(n)1
    83.18(a)1
      2 48E43
    363061  NM_165866.21  NP_725106.11 
    worm
    (Caenorhabditis elegans)
    Secernentea snr-11 snr-1 64.13(n)
    69.57(a)
      178483  NM_070626.4  NP_503027.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMD3(YLR147C)4 Core Sm protein Sm D3; part of heteroheptameric complex more   --   12(434463-434158) 850839  NP_013248.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G205801 AT1G20580 60.07(n)
    58.42(a)
      838647  NM_101909.3  NP_564119.1 
    rice
    (Oryza sativa)
    Liliopsida AK121552.12   -- 73.03(n)    AK121552.1 


    ENSEMBL Gene Tree for SNRPD3 (if available)
    TreeFam Gene Tree for SNRPD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SNRPD3 gene
    2 SIMAP similar genes for SNRPD3 using alignment to 3 protein entries:     SMD3_HUMAN (see all proteins):
    LSM4    SNRPD1

    Find genes that share paralogs with SNRPD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SNRPD3 (see all 334)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22983881,2
    C,F,H--24953279(+) TTCCAA/GTCCCC 1 -- int115Minor allele frequency- G:0.15EA NS NA WA CSA 1799
    rs1510293621,2
    --24953340(+) GGGACA/GTAGGG 1 -- int10--------
    rs1409925861,2
    --24953344(+) CATAGA/GGTAGC 1 -- int10--------
    rs22983891,2
    C,F,A,H--24953349(+) GGTAGT/CGGGGA 1 -- int125Minor allele frequency- C:0.15EA NS NA WA CSA 4015
    rs1497877651,2
    --24953421(+) TTCCTC/TCTCAC 1 -- int10--------
    rs1875945201,2
    --24953448(+) ATTTGC/TCAGAT 1 -- int10--------
    rs2011019121,2
    C--24953496(-) TCTACA/CAAGGA 1 -- int10--------
    rs57604721,2
    C,F,H--24953571(+) GTGCCG/ACATGC 1 -- int113Minor allele frequency- A:0.11NA WA CSA EA 379
    rs1450304871,2
    C--24953595(+) GAAAGA/GTGAAC 1 -- int10--------
    rs2016975201,2
    --24953606(+) TGACTA/GTTGTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SNRPD3 (24951471 - 25005947 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SNRPD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724068CNV Deletion23290073
    esv2724041CNV Deletion23290073
    nsv914629CNV Gain21882294
    nsv526567CNV Gain19592680
    nsv914599CNV Gain21882294
    nsv9884CNV Gain+Loss18304495
    nsv7350OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNRPD3
    DNA2.0 Custom Variant and Variant Library Synthesis for SNRPD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601062    OMIM disorders: --


    Find genes that share disorders with SNRPD3           About GenesLikeMe


    Export disorders for SNRPD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SNRPD3 gene, integrated from 10 sources (see all 89):
    (articles sorted by number of sources associating them with SNRPD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction. (PubMed id 7527560)1, 2, 3 Lehmeier T.... Luehrmann R. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis. (PubMed id 21516107)1, 2 Leung A.K....Li J. (Nature 2011)
    3. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PubMed id 18984161)1, 2 Chari A....Fischer U. (Cell 2008)
    4. Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. (PubMed id 17709427)1, 2 Gonsalvez G.B....Matera A.G. (J. Cell Biol. 2007)
    5. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (RNA 2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    9. Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln. (PubMed id 11747828)1, 2 Meister G.... Fischer U. (Curr. Biol. 2001)
    10. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. (PubMed id 11574479)1, 2 Pillai R.S.... Mueller B. (EMBO J. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6634 HGNC: 11160 AceView: SNRPD3andGGT1 Ensembl:ENSG00000100028 euGenes: HUgn6634
    ECgene: SNRPD3 Kegg: 6634 H-InvDB: SNRPD3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SNRPD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SNRPD3 gene:
    Search GeneIP for patents involving SNRPD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SNRPD3   OriGene RNAi products in human, mouse, rat for SNRPD3  
     OriGene qPCR primer pairs and template standards for SNRPD3   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SNRPD3  
     OriGene qSTAR qPCR primer pairs in human, mouse for SNRPD3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SNRPD3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SNRPD3   OriGene Custom Protein Services for SNRPD3  

     
     
     Block miRNA regulation of human, mouse, rat SNRPD3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SNRPD3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNRPD3 Predesigned siRNA for gene silencing in human, mouse, rat SNRPD3
     QuantiFast Probe-based Assays in human, mouse, rat SNRPD3 QuantiTect SYBR Green Assays in human, mouse, rat SNRPD3
     Custom PCR Arrays for SNRPD3 Search Chromatin IP Primers for SNRPD3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNRPD3  Search GeneGlobe Interaction Network for SNRPD3
     Regulatory tfbs in SNRPD3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SNRPD3 GenScript cDNA clones with any tag delivered in your preferred vector for SNRPD3
     GenScript Custom Assay Services for SNRPD3 GenScript Custom overexpressing Cell Line Services for SNRPD3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SNRPD3 (SMD3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SNRPD3 antibodies
     SNRPD3 proteins
     Antibodies for SNRPD3
     See all of Abcam's Antibodies, Kits and Proteins for SNRPD3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SNRPD3
     Proteins for SNRPD3
     Antibodies for SNRPD3
     ELISAs for SNRPD3
     CLIAs for SNRPD3



     Browse ESI BIO Cell Lines and PureStem Progenitors for SNRPD3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPD3
     SwitchGear 3'UTR luciferase reporter plasmids for SNRPD3
     SwitchGear Promoter luciferase reporter plasmids for SNRPD3
     ThermoFisher Antibody for SNRPD3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPD3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNRPD3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNRPD3
     LSBio Antibodies in human, mouse, rat for SNRPD3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SNRPD3
      Search eBioscience for proteins for SNRPD3
      Search eBioscience for elisas for SNRPD3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SNRPD3 gene at Home site.
    Version: 3.12.216 30 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4