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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SNRPD2 Gene

protein-coding GIFtS: 57
GCID: GC19M046190

small nuclear ribonucleoprotein D2 polypeptide 16.5kDa

(Previous name: small nuclear ribonucleoprotein D2 polypeptide (16.5kD)...)
(Previous symbol: SNRPD1)

Explore 7 diseases affiliated with
SNRPD2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Small Nuclear Ribonucleoprotein D2 Polypeptide 16.5kDa¹ ²		Small Nuclear Ribonucleoprotein D2 Polypeptide (16.5kD)¹
SNRPD1¹ ² ³		SMD2²
Sm-D2¹ ² ³		Small Nuclear Ribonucleoprotein Sm D2²
SnRNP Core Protein D2² ³

External Ids:	HGNC: 11159¹	Entrez Gene: 6633²	Ensembl: ENSG00000125743⁷	OMIM: 601061⁵	UniProtKB: P62316³

Export aliases for SNRPD2 gene to outside databases

Previous GC identifers: GC19M046834 GC19M046581 GC19M050866 GC19M050882 GC19M042619

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNRPD2:

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for

pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different

isoforms have been found for this gene. (provided by RefSeq, May 2009)

UniProtKB/Swiss-Prot: SMD2_HUMAN, P62316

Function: Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity)

Gene Wiki entry for SNRPD2 (Small nuclear ribonucleoprotein D2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SNRPD2 gene promoter:
AML1a p300 CUTL1 AP-2gamma GATA-1 AREB6 PPAR-gamma1 SREBP-1a CP2 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNRPD2 promoter sequence

Search SABiosciences Chromatin IP Primers for SNRPD2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPD2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.2-q13.3

SNRPD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPD2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M046190: view genomic region (about GC identifiers)

Start:	46,190,712 bp from pter	End:	46,195,827 bp from pter
Size:	5,116 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SMD2_HUMAN, P62316 (See protein sequence)

Recommended Name: Small nuclear ribonucleoprotein Sm D2

Size: 118 amino acids; 13527 Da

Subunit: Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type

spliceosome

Subcellular location: Nucleus

Miscellaneous: In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm

specificity

6/8 PDB 3D structures from and Proteopedia for SNRPD2 (see all 8):

1B34 (3D)

2Y9A (3D)

2Y9B (3D)

2Y9C (3D)

2Y9D (3D)

3CW1 (3D)

Secondary accessions: A8K797 J3KPM5 P43330

Alternative splicing: 2 isoforms: P62316-1 P62316-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SNRPD2: NX_P62316

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P62316

SNRPD2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004588.1 NP_808210.2

ENSEMBL proteins:

ENSP00000342374 ENSP00000465101 ENSP00000465952 ENSP00000466152 ENSP00000375798

ENSP00000465216 ENSP00000468247

Reactome Protein details: P62316
Human Recombinant Protein Products for SNRPD2:

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	Novus Biologicals SNRPD2 Proteins Novus Biologicals SNRPD2 Lysates
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	ProSpec Recombinant Protein for SNRPD2
	Uscn Proteins for SNRPD2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005681	spliceosomal complex	TAS	1701240
GO:0005689	U12-type spliceosomal complex	IDA	15146077
GO:0005829	cytosol	TAS	--
GO:0030532	small nuclear ribonucleoprotein complex	TAS	1701240

SNRPD2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SNRPD2 for domains About GeneDecksing

4 InterPro domains/families:

IPR027248 Sm_D2

IPR001163 Ribonucl_LSM

IPR006649 Ribonucl_LSM_euk/arc

IPR010920 LSM_dom

Graphical View of Domain Structure for InterPro Entry P62316

ProtoNet protein and cluster: P62316

1 Blocks protein family: IPB010920 Like-Sm ribonucleoprotein-related

UniProtKB/Swiss-Prot: SMD2_HUMAN, P62316

Similarity: Belongs to the snRNP core protein family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SMD2_HUMAN, P62316

Function: Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11748230

SNRPD2 for ontologies About GeneDecksing

Phenotypes:
7 GenomeRNAi human phenotypes for SNRPD2:

Decreased influenza A virus in	Decreased viability	Decreased viability of wild-ty	Increased G2M DNA content
Increased gamma-H2AX phosphory	Metaphase cells	S arrest

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SNRPD2

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SNRPD2 Browse MicroRNA Expression Plasmids
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		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SNRPD2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPD2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing	1.00	mRNA processing	0.48
mRNA Splicing - Major Pathway	1.00	mRNA Splicing - Minor Pathway	0.40
Processing of Capped Intron-Containing Pre-mRNA	0.96	Spliceosome	0.31
mRNA Processing	0.82

SLBP independent Processing of Histone Pre-mRNAs

snRNP Assembly

0.28

Metabolism of non-coding RNA

0.28

EGFR1 Signaling Pathway

EGFR1 Signaling Pathway

1.00

Metabolism of mRNA

Metabolism of RNA

0.92

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for SNRPD2

	EGFR1 Signaling Pathway
	mRNA processing

5/9 Reactome Pathways for SNRPD2 (see all 9)

	mRNA Splicing - Major Pathway
	mRNA Splicing
	snRNP Assembly
	Metabolism of non-coding RNA
	Metabolism of RNA

1 Kegg Pathway (Kegg details for SNRPD2):

Spliceosome

SNRPD2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SNRPD2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/236 Interacting proteins for SNRPD2 (P62316^{2, 3} ENSP00000342374⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 236)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LSM2	Q9Y333²^,³, ENSP00000364813⁴	MINT-62594 MINT-62768 MINT-8332701 MINT-62692 I2D: score=12 STRING: ENSP00000364813
SNRPD1	P62314²^,³, ENSP00000300413⁴	MINT-49764 MINT-49765 I2D: score=4 STRING: ENSP00000300413
CLNS1A	P54105²^,³, ENSP00000263309⁴	MINT-8332723 I2D: score=2 STRING: ENSP00000263309
GRB2	P62993²^,³, ENSP00000339007⁴	MINT-61562 I2D: score=2 STRING: ENSP00000339007
SF3A2	Q15428²^,³, ENSP00000221494⁴	MINT-5205332 I2D: score=2 STRING: ENSP00000221494

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000245	spliceosomal complex assembly	TAS	7527560
GO:0000387	spliceosomal snRNP assembly	TAS	--
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0008380	RNA splicing	TAS	--
GO:0010467	gene expression	TAS	--

SNRPD2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SNRPD2
Search CenterWatch for drugs/clinical trials and news about SNRPD2 / SMD2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SNRPD2 gene (2 alternative transcripts):

NM_004597.5 NM_177542.2

Unigene Cluster for SNRPD2:

Small nuclear ribonucleoprotein D2 polypeptide 16.5kDa

Hs.515472 [show with all ESTs]

Unigene Representative Sequence: BE901089

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000342669(uc002pcw.3) ENST00000585392 ENST00000587367 ENST00000588599

ENST00000391932(uc002pcv.3) ENST00000588301 ENST00000590212 ENST00000587579

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SNRPD2 Browse OriGene MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRPD2 (see all 7) OriGene shRNA RFP: SNRPD2 OriGene siRNA: SNRPD2
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPD2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPD2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SNRPD2 (NM_004597)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPD2

Additional cDNA sequence:

AK291912.1 BC000486.2 BC001930.2 U15008.1

20 DOTS entries:

DT.450533 DT.100039393 DT.91901967 DT.91766629 DT.100890815 DT.91657907 DT.91766627 DT.91766633

DT.100039391 DT.100890804 DT.91766607 DT.95261072 DT.97837580 DT.95261649 DT.100643171 DT.100826159

DT.100890790 DT.100890800 DT.100890812 DT.87009937

24/705 AceView cDNA sequences (see all 705):

AI141094 BG107836 BM856819 BE856397 BG207294 T31452 AI750163 BI862286

BM550355 BE616029 BF220098 T32569 BU194550 BU145744 BM709054 BM853581

BI857394 AJ714212 AL697723 BQ219882 W16770 BM721941 AA323350 BQ439169

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SNRPD2 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e
SP1:							-		-		-						-
SP2:							-				-						-
SP3:							-		-								-
SP4:							-		-		-
SP5:							-		-		-		-				-

ECgene alternative splicing isoforms for SNRPD2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SNRPD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCTGGAGA

About this image

SNRPD2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Primary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

See SNRPD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNRPD2

SOURCE GeneReport for Unigene cluster: Hs.515472

SABiosciences Custom PCR Arrays for SNRPD2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPD2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPD2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPD2 gene from 9/38 species (see all 38) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Snrpd2^{1 , 5}	small nuclear ribonucleoprotein D2^{1, 5}	91.24(n)¹ 100(a)¹		7 (9.46 cM)⁵ 107686¹ NM_026943.1¹ NP_081219.1¹ 19149722⁵
lizard (Anolis carolinensis)	Reptilia	SNRPD2⁶	--	99(a)	1 ↔ 1	GL343568.1(107657-109328)
African clawed frog (Xenopus laevis)	Amphibia	Xl.4271²	Xenopus laevis transcribed sequence with strong similarity more	80.11(n)		BI444879.1
zebrafish (Danio rerio)	Actinopterygii	Dr.12513²	Transcribed sequence with strong similarity to protein more	84.36(n)		57060199
fruit fly (Drosophila melanogaster)	Insecta	CG1249³ SmD2¹	mRNA splicing³ Small ribonucleoprotein particle protein SmD2¹	88(a)³ 79.71(n)¹ 89.57(a)¹		83E4³ 40781¹ NM_141388.3¹ NP_649645.1¹
worm (Caenorhabditis elegans)	Secernentea	snr-4¹	Protein SNR-4	71.05(n) 81.58(a)		179639 NM_073603.4 NP_506004.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SMD2(YLR275W)⁴ SMD2¹	Core Sm protein Sm D2; part of heteroheptameric complex more⁴ Smd2p¹	55.87(n)¹ 56.19(a)¹		12(694378-694800)⁴ 850981^{1, 4} NP_013377.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G62840¹	small nuclear ribonucleoprotein D2	71.6(n) 81.48(a)		825459 NM_116149.3 NP_567134.3
rice (Oryza sativa)	Liliopsida	Os.24812²	Transcribed sequence with moderate similarity to protein more	75.38(n)		CA762705.1

ENSEMBL Gene Tree for SNRPD2 (if available)
TreeFam Gene Tree for SNRPD2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SNRPD2 gene

2 SIMAP similar genes for SNRPD2 using alignment to 3 protein entries: SMD2_HUMAN (see all proteins):

LOC645339 LSM3

SNRPD2 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for SNRPD2
PGOHUM00000238885 PGOHUM00000244478

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1964272^1,2	C,F,A	--	46190268(+)	`CGCCCA/GGCCAG`	2	--	ds500¹		4		NA	8
rs150350229^1,2		--	46190286(+)	`ATTTTC/TAGTAG`	2	--	ds500¹		0	--	--	--	--
rs112371824^1,2		--	46190299(+)	`ACAGCG/ATTTTA`	2	--	ds500¹		1		CSA	2
rs60281425^1,2	C	--	46190443(+)	`TCATTG/ATAAGA`	2	--	ds500¹		1		WA	2
rs7246757^1,2	C,F,H	--	46190531(+)	`CCACAA/GCTGGG`	2	--	ds500¹		19		NS EA NA WA	2344
rs146238526^1,2		--	46190549(+)	`TTCCAA/TGCAAA`	2	--	ds500¹		0	--	--	--	--
rs191891306^1,2		--	46190555(+)	`GCAAAC/GTGTTT`	2	--	ds500¹		0	--	--	--	--
rs141723220^1,2	F	--	46190961(+)	`TTCACG/ATTCTC`	4	/N	syn¹		1		NA	4552
rs77837925^1,2	C,F	--	46191008(+)	`GGGGAG/CGCACT`	2	--	int¹		1		WA	118
rs2075142^1,2	C,F,H	--	46191021(+)	`GCGTGA/GGGGGC`	2	--	int¹		13		EA NS NA WA	2270

HapMap Linkage Disequilibrium report for SNRPD2 (46190712 - 46195827 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SNRPD2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SNRPD2 for disorders           About GeneDecksing

OMIM gene information: 601061    OMIM disorders: --

7 diseases for SNRPD2:    About MalaCards

spinal muscular atrophy muscular atrophy agoraphobia intrahepatic cholangiocarcinoma

cholangiocarcinoma malaria neuronitis

Export disorders for SNRPD2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SNRPD2 gene, integrated from 9 sources (see all 65):
(articles sorted by number of sources associating them with SNRPD2)

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cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction. (PubMed id 7527560)^{1, 2, 3} Lehmeier T.... Luehrmann R. (1994)
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)^{1, 2} Will C.L.... Luehrmann R. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)^{1, 2} Jurica M.S.... Moore M.J. (2002)
Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. (PubMed id 10025403)^{1, 2} Kambach C.... Nagai K. (1999)
Evidence for three distinct D proteins, which react d ifferentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5. (PubMed id 1701240)^{1, 3} Lehmeier T....LA1hrmann R. (1990)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. (PubMed id 22446626)¹ Close P.... Svejstrup J.Q. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6633	HGNC: 11159	AceView: SNRPD2	Ensembl:ENSG00000125743	euGenes: HUgn6633
ECgene: SNRPD2	Kegg: 6633	H-InvDB: SNRPD2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SNRPD2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SNRPD2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SNRPD2 gene:
Search GeneIP for patents involving SNRPD2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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small nuclear ribonucleoprotein D2 polypeptide 16.5kDa

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SNRPD2 Gene

small nuclear ribonucleoprotein D2 polypeptide 16.5kDa

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