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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNRPC Gene

protein-coding   GIFtS: 54
GCID: GC06P035771

small nuclear ribonucleoprotein polypeptide C
 Explore 6 diseases affiliated with
SNRPC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNRPC    

Aliases
for SNRPC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Small Nuclear Ribonucleoprotein Polypeptide C1 2     U1 SnRNP C2 3
Yhc11 2     U1 Small Nuclear Ribonucleoprotein C2
U1-C1 3     U1 Small Nuclear RNP Specific C2
U1C2 3     U1 SnRNP Protein C2

External Ids:    HGNC: 111571   Entrez Gene: 66312   Ensembl: ENSG000001245627   OMIM: 6035225   UniProtKB: P092343   
ORGUL members:         
NONCODE:n408379    

Export aliases for SNRPC gene to outside databases

Previous GC identifers: GC06P034727 GC06P034772 GC06P034833 GC06P034725 GC06P034447 GC06P034826


Summaries
for SNRPC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SNRPC:
This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle
required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor
messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective
tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a
non-coding transcript variant.(provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: RU1C_HUMAN, P09234
Function: Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the
subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both
constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing
between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of
the U1 snRNA and the 5' splice-site region

Gene Wiki entry for SNRPC (Small nuclear ribonucleoprotein polypeptide C)


Genomic Views
for SNRPC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNRPC gene promoter:
         PPAR-gamma1   CP2   FOXC1   POU2F1a   c-Myb   PPAR-gamma2   LCR-F1   Evi-1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNRPC promoter sequence
   Search SABiosciences Chromatin IP Primers for SNRPC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21

SNRPC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPC gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P035771:  view genomic region     (about GC identifiers)

Start:
 34,724,871 bp from pter      End:
 34,741,634 bp from pter
Size:
 16,764 bases      Orientation:
 plus strand

Proteins
for SNRPC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RU1C_HUMAN, P09234 (See protein sequence)
Recommended Name: U1 small nuclear ribonucleoprotein C  
Size: 159 amino acids; 17394 Da
Subunit: Component of the U1 snRNP particle, a subcomplex of the spliceosome. U1 snRNP is composed of the 7 core Sm
proteins B/B', D1, D2, D3, E, F and G common to all spliceosomal snRNPs, and at least 3 particle-specific proteins
U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA
Subcellular location: Nucleus
Sequence caution: Sequence=CAI20351.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for SNRPC:
2VRD (3D)        3CW1 (3D)    
Secondary accessions: Q5TAL3

Explore the universe of human proteins at neXtProt for SNRPC: NX_P09234

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09234

    • SNRPC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003084.1  
    ENSEMBL proteins: 
     ENSP00000244520   ENSP00000363130   ENSP00000363129  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SNRPC
    OriGene Protein Over-expression Lysate: SNRPC
    OriGene Custom Protein Services for SNRPC 
    GenScript Custom Purified and Recombinant Proteins Services for SNRPC
    Novus Biologicals SNRPC Proteins
    Novus Biologicals SNRPC Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SNRPC
    Uscn Proteins for SNRPC

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005685U1 snRNP IDA15312772
    GO:0015030Cajal body IDA10068039
    GO:0030529ribonucleoprotein complex ----


    SNRPC for ontologies           About GeneDecksing



    SNRPC Antibody Products: 
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    Uscn Antibodies for SNRPC
    ThermoFisher Antibodies for SNRPC

    Assay Products for SNRPC: 
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    Uscn ELISAs and CLIAs for SNRPC

    Protein Domains /
    Families
    for SNRPC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNRPC for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003604 Znf_U1
     IPR000690 Znf_C2H2_matrin
     IPR017340 U1_snRNP-C
     IPR013085 Znf_U1-C

    Graphical View of Domain Structure for InterPro Entry P09234

    ProtoNet protein and cluster: P09234

    1 Blocks protein family: IPB003604 Zn-finger

    UniProtKB/Swiss-Prot: RU1C_HUMAN, P09234
    Similarity: Belongs to the U1 small nuclear ribonucleoprotein C family
    Similarity: Contains 1 matrin-type zinc finger


    Function
    for SNRPC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RU1C_HUMAN, P09234
    Function: Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the
    subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both
    constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing
    between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of
    the U1 snRNA and the 5' splice-site region

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SNRPC
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPC
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPC:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmid: SNRPC 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRPC (see all 4)
    OriGene shRNA RFP: SNRPC
    OriGene siRNA: SNRPC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SNRPC

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPC (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPC
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SNRPC (NM_003093)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPC 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SNRPC
    Search LifeMap BioReagents cell lines for SNRPC

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SNRPC

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003727single-stranded RNA binding IDA8798632
    GO:0005515protein binding IPI8076607
    GO:0008270zinc ion binding IDA15312772
    GO:0030619NOT U1 snRNA binding IDA1826349


    SNRPC for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for SNRPC:
     Decreased viability  Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 


    Pathways & Interactions
    for SNRPC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		Spliceosome0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for SNRPC):
        Spliceosome


    SNRPC for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNRPC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/73 Interacting proteins for SNRPC (P092342, 3 ENSP000002445204) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIGYF2Q6Y7W62, 3, ENSP000003871704MINT-65890 I2D: score=3 STRING: ENSP00000387170
    SF3A2Q154282, 3, ENSP000002214944MINT-5205395 I2D: score=1 STRING: ENSP00000221494
    WDR83Q9BRX92, ENSP000002427964MINT-8332075 MINT-8333031 STRING: ENSP00000242796
    RBM10P981752, ENSP000003668294MINT-8332152 MINT-8333009 STRING: ENSP00000366829
    SNRNP70P086213, ENSP000002214484I2D: score=3 STRING: ENSP00000221448
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000387spliceosomal snRNP assembly IDA8972845
    GO:0000398mRNA splicing, via spliceosome IDA8972845


    SNRPC for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNRPC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SNRPC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNRPC
    1 Novoseek chemical compound relationship for SNRPC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 38.8 2 8532530 (1), 9588745 (1)

    Search CenterWatch for drugs/clinical trials and news about SNRPC / RU1C 

    Transcripts
    for SNRPC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNRPC gene: 
    NM_003093.2  

    Unigene Cluster for SNRPC:

    Small nuclear ribonucleoprotein polypeptide C
    Hs.1063  [show with all ESTs]
    Unigene Representative Sequence: BU603692
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000244520(uc003ojt.2 uc021yyv.1) ENST00000374018 ENST00000374017(uc021yyw.1)
    ENST00000474635

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SNRPC
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPC
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPC:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmid: SNRPC 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRPC (see all 4)
    OriGene shRNA RFP: SNRPC
    OriGene siRNA: SNRPC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPC
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPC (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPC
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SNRPC (NM_003093)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPC 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNRPC
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SNRPC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPC

    Additional cDNA sequence: 

    AK223098.1 AK311955.1 BC121082.1 BC121083.1 M18465.1 NR_029472.1 X12517.1 

    10 DOTS entries:

    DT.419516  DT.100678757  DT.91770583  DT.91770580  DT.95217217  DT.97782342  DT.100678761  DT.97859659 
    DT.80100501  DT.91923145 

    24/520 AceView cDNA sequences (see all 520):

    AI742714 CA442927 CB143558 AA381953 AA187992 CR625497 BM711501 BG474126 
    BU072195 BU150254 N83681 CF129377 CF593413 BU557048 BU508721 BM918534 
    BE887295 BM978049 BM353466 AW516571 BM840316 BM781747 AA165513 BM695493 

    GeneLoc Exon Structure


    Expression
    for SNRPC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNRPC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGCTGTGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SNRPC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNRPC

    SOURCE GeneReport for Unigene cluster: Hs.1063
        SABiosciences Custom PCR Arrays for SNRPC
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNRPC
    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPC
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SNRPC

    Orthologs
    for SNRPC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRPC gene from 9/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Snrpc1 , 5 U1 small nuclear ribonucleoprotein C1, 5 89.73(n)1
    99.37(a)1    		   17 (14.59 cM)5
    206301  NM_011432.21  NP_035562.11 
     278399745 
    chicken
    (Gallus gallus)    		 Aves E1C6F0_CHICK6
    		 U1 small nuclear ribonucleoprotein C
    		 98(a)
    		 1 ↔ 1
    		 26(4138328-4142298)
    lizard
    (Anolis carolinensis)    		 Reptilia SNRPC6
    		 --
    		 84(a)
    		 1 ↔ 1
    		 4(121155845-121161266)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.11582 X.laevis mRNA for snRNP C protein 80.65(n)    X63892.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii snrpc2 small nuclear ribonucleoprotein polypeptide C 77.92(n)   192330  AY099526.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta snRNP-U1-C6
    		 small ribonucleoprotein particle U1 subunit C
    		 59(a)
    		 1 ↔ 1
    		 3R(14808686-14809370)
    worm
    (Caenorhabditis elegans)    		 Secernentea F08B4.76
    		 U1 small nuclear ribonucleoprotein C
    		 50(a)
    		 1 ↔ 1
    		 IV(8686738-8687802)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G031206
    		 C2H2 and C2HC zinc finger-containing protein
    		 33(a)
    		 1 ↔ 1
    		 4(1385660-1387739)
    rice
    (Oryza sativa)    		 Liliopsida Os.56302 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.55(n)    AK060957.1 


    ENSEMBL Gene Tree for SNRPC (if available)
    TreeFam Gene Tree for SNRPC (if available) 

    Paralogs
    for SNRPC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNRPC gene
    SF3A22  ZNF2072  WBP112  

    SNRPC for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for SNRPC
    PGOHUM00000247291 PGOHUM00000234972 PGOHUM00000237820 PGOHUM00000235661 PGOHUM00000236008


    Genomic Variants
    for SNRPC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/321 NCBI SNPs in SNRPC are shown (see all 321)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs94698591,2
    		C,F,H,--34722902(+) TATAGC/ACTATC 2 -- us2k122Minor allele frequency- A:0.49NS EA NA WA CSA 2337
    rs614079261,2
    		F,--34723104(+) AAAAAT/ATAAAA 2 -- us2k12Minor allele frequency- A:0.11WA EA 238
    rs728922381,2
    		C,--34723136(+) CAGGTG/ACCTGT 2 -- us2k14Minor allele frequency- A:0.12NA WA EA 360
    rs1397124201,2
    		--34723536(+) TATGAC/GATAGT 2 -- us2k10--------
    rs69414531,2
    		C,F,A,H,--34723895(+) CGGGCG/ACGGTG 2 -- us2k1 tfbs316Minor allele frequency- A:0.15NS EA NA 2222
    rs1452102161,2
    		--34724023(+) AAAATC/TAGCCG 2 -- us2k10--------
    rs734157791,2
    		C,--34724095(+) GAACCC/AGGGAG 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1446089091,2
    		--34724194(+) AAAAC-/AAAAAT
                AAATT     		2 -- us2k10--------
    rs1162923541,2
    		F,--34724354(+) GCAGTG/CGTGCG 2 -- us2k11Minor allele frequency- C:0.06WA 118
    rs1914819981,2
    		--34724663(+) CACCAC/GGTTGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SNRPC (34724871 - 34741634 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SNRPC: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNRPC
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    Disorders / Diseases
    for SNRPC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNRPC for disorders           About GeneDecksing

    OMIM gene information: 603522    OMIM disorders: --

    6 diseases for SNRPC:    About MalaCards
    connective tissue disease    systemic lupus erythematosus    lupus erythematosus    herpes simplex
    malaria    neuronitis

    1 Novoseek disease relationship for SNRPC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 21.7 1 8960101 (1)


    Export disorders for SNRPC gene to outside databases

    Publications
    for SNRPC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNRPC gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with SNRPC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals. (PubMed id 2971157)1, 2, 3 Sillekens P.T.G.... van Venrooij W.J. (1988)
    2. The structure and biochemical properties of the human spliceosomal protein U1C. (PubMed id 15312772)1, 2, 9 Muto Y....Nagai K. (2004)
    3. Homodimerization of the human U1 snRNP-specific protein C. (PubMed id 8532530)1, 3, 9 Gunnewiek J.M....Nelissen R.L. (1995)
    4. Zinc finger-like structure in U1-specific protein C is essential for specific binding to U1 snRNP. (PubMed id 1826349)1, 2, 9 Nelissen R.L....van Venrooij W.J. (1991)
    5. Protein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein: absolute quantification using isotope-coded tags and mass spectrometry. (PubMed id 15525645)1, 2, 9 Hochleitner E.O....Lottspeich F. (2005)
    6. Involvement of U1 small nuclear ribonucleoproteins (snRNP) in 5' splice site-U1 snRNP interaction. (PubMed id 8798632)1, 2, 9 Rossi F....Cathala G. (1996)
    7. Isolation and characterization of a complementary DNA expressing human U1 small nuclear ribonucleoprotein C polypeptide. (PubMed id 2961811)1, 2 Yamamoto K....Miyamoto T. (1988)
    8. Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C. (PubMed id 9031639)1, 9 Nelissen R.L....Van Venrooij W.J. (1997)
    9. Human monoclonal autoantibody fragments from combinatorial antibody libraries directed to the U1snRNP associated U1C protein; epitope mapping, immunolocalization and V-gene usage. (PubMed id 10068039)1, 9 Hoet R.M....van Venrooij W.J. (1998)
    10. At least three linear regions but not the zinc-finger domain of U1C protein are exposed at the surface of the protein in solution and on the human spliceosomal U1 snRNP particle. (PubMed id 9826776)1, 9 Dumortier H....Muller S. (1998)

    External Searches for SNRPC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing SNRPC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6631 HGNC: 11157 AceView: SNRPC Ensembl:ENSG00000124562 euGenes: HUgn6631
    ECgene: SNRPC Kegg: 6631 H-InvDB: SNRPC

    Other Databases showing SNRPC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SNRPC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNRPC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SNRPC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SNRPC gene:
    Search GeneIP for patents involving SNRPC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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