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Aliases for SNRPC Gene

Aliases for SNRPC Gene

  • Small Nuclear Ribonucleoprotein Polypeptide C 2 3
  • U1 SnRNP C 3 4
  • U1-C 3 4
  • U1C 3 4
  • U1 Small Nuclear Ribonucleoprotein C 3
  • U1 Small Nuclear RNP Specific C 3
  • U1 SnRNP Protein C 3
  • Yhc1 3

External Ids for SNRPC Gene

Summaries for SNRPC Gene

Entrez Gene Summary for SNRPC Gene

  • This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.[provided by RefSeq, Oct 2009]

GeneCards Summary for SNRPC Gene

SNRPC (Small Nuclear Ribonucleoprotein Polypeptide C) is a Protein Coding gene. Among its related pathways are Spliceosome. GO annotations related to this gene include protein homodimerization activity and single-stranded RNA binding.

UniProtKB/Swiss-Prot for SNRPC Gene

  • Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5 splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5 splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5 splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5 end of the U1 snRNA and the 5 splice-site region.

Gene Wiki entry for SNRPC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPC Gene

Genomics for SNRPC Gene

Genomic Location for SNRPC Gene

Start:
34,757,094 bp from pter
End:
34,773,857 bp from pter
Size:
16,764 bases
Orientation:
Plus strand

Genomic View for SNRPC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNRPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPC Gene

Regulatory Elements for SNRPC Gene

Proteins for SNRPC Gene

  • Protein details for SNRPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09234-RU1C_HUMAN
    Recommended name:
    U1 small nuclear ribonucleoprotein C
    Protein Accession:
    P09234
    Secondary Accessions:
    • Q5TAL3

    Protein attributes for SNRPC Gene

    Size:
    159 amino acids
    Molecular mass:
    17394 Da
    Quaternary structure:
    • U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5 splice-site region of the pre-mRNA.
    SequenceCaution:
    • Sequence=CAI20351.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SNRPC Gene

neXtProt entry for SNRPC Gene

Proteomics data for SNRPC Gene at MOPED

Post-translational modifications for SNRPC Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys3, Lys40, and Lys52

Other Protein References for SNRPC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNRPC Gene

Domains for SNRPC Gene

Protein Domains for SNRPC Gene

UniProtKB/Swiss-Prot:

RU1C_HUMAN
Family:
  • Belongs to the U1 small nuclear ribonucleoprotein C family.:
    • P09234
Similarity:
  • Contains 1 matrin-type zinc finger.:
    • P09234
genes like me logo Genes that share domains with SNRPC: view

No data available for Gene Families for SNRPC Gene

Function for SNRPC Gene

Molecular function for SNRPC Gene

UniProtKB/Swiss-Prot Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5 splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5 splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5 splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5 end of the U1 snRNA and the 5 splice-site region.

Gene Ontology (GO) - Molecular Function for SNRPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003727 single-stranded RNA binding IDA 8798632
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding IPI 12486009
GO:0008270 zinc ion binding IDA 15312772
genes like me logo Genes that share ontologies with SNRPC: view
genes like me logo Genes that share phenotypes with SNRPC: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNRPC Gene

Localization for SNRPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRPC Gene COMPARTMENTS Subcellular localization image for SNRPC gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SNRPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000243 commitment complex IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005685 U1 snRNP IDA 15312772
GO:0015030 Cajal body IDA 10068039
genes like me logo Genes that share ontologies with SNRPC: view

Pathways for SNRPC Gene

SuperPathways for SNRPC Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with SNRPC: view

Pathways by source for SNRPC Gene

1 KEGG pathway for SNRPC Gene

Gene Ontology (GO) - Biological Process for SNRPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly IDA 8972845
GO:0000395 mRNA 5-splice site recognition IEA --
GO:0000398 mRNA splicing, via spliceosome IDA 8972845
genes like me logo Genes that share ontologies with SNRPC: view

Compounds for SNRPC Gene

(1) Novoseek inferred chemical compound relationships for SNRPC Gene

Compound -log(P) Hits PubMed IDs
zinc 38.8 2
genes like me logo Genes that share compounds with SNRPC: view

Transcripts for SNRPC Gene

Unigene Clusters for SNRPC Gene

Small nuclear ribonucleoprotein polypeptide C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPC Gene

No ASD Table

Relevant External Links for SNRPC Gene

GeneLoc Exon Structure for
SNRPC
ECgene alternative splicing isoforms for
SNRPC

Expression for SNRPC Gene

mRNA expression in normal human tissues for SNRPC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNRPC Gene

SOURCE GeneReport for Unigene cluster for SNRPC Gene Hs.1063

genes like me logo Genes that share expressions with SNRPC: view

Orthologs for SNRPC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRPC 36
  • 99.58 (n)
  • 100 (a)
SNRPC 37
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNRPC 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102153257 36
  • 96.23 (n)
  • 98.11 (a)
SNRPC 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snrpc 16
Snrpc 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 99 (a)
OneToMany
SNRPC 37
  • 87 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SNRPC 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC685273 36
  • 90.15 (n)
  • 98.74 (a)
chicken
(Gallus gallus)
Aves SNRPC 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNRPC 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1158 36
zebrafish
(Danio rerio)
Actinopterygii snrpc 36
snrpc 37
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta snRNP-U1-C 37
  • 59 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F08B4.7 37
  • 53 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YHC1 39
corn
(Zea mays)
Liliopsida Zm.5207 36
rice
(Oryza sativa)
Liliopsida Os.5630 36
wheat
(Triticum aestivum)
Liliopsida Ta.13756 36
Species with no ortholog for SNRPC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for SNRPC Gene

ENSEMBL:
Gene Tree for SNRPC (if available)
TreeFam:
Gene Tree for SNRPC (if available)

Paralogs for SNRPC Gene

genes like me logo Genes that share paralogs with SNRPC: view

No data available for Paralogs for SNRPC Gene

Variants for SNRPC Gene

Sequence variations from dbSNP and Humsavar for SNRPC Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1998702 -- 34,774,140(-) TTCTT(C/T)CCATT downstream-variant-500B
rs2038841 -- 34,770,426(-) ATGGA(A/G)CAAAC intron-variant
rs2236392 -- 34,773,398(-) AAATA(C/T)GATTT intron-variant
rs3736896 -- 34,768,106(-) TTACT(A/G)TCTAC intron-variant
rs3798350 -- 34,772,881(-) TTAGC(A/G)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNRPC Gene

Variant ID Type Subtype PubMed ID
dgv6831n71 CNV Gain 21882294
nsv885795 CNV Loss 21882294
nsv462905 CNV Gain 19166990
nsv885796 CNV Gain 21882294

Relevant External Links for SNRPC Gene

HapMap Linkage Disequilibrium report
SNRPC

Disorders for SNRPC Gene

(1) Novoseek inferred disease relationships for SNRPC Gene

Disease -log(P) Hits PubMed IDs
autoimmune diseases 21.7 1
genes like me logo Genes that share disorders with SNRPC: view

No data available for UniProtKB/Swiss-Prot for SNRPC Gene

Publications for SNRPC Gene

  1. Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals. (PMID: 2971157) Sillekens P.T.G. … van Venrooij W.J. (Nucleic Acids Res. 1988) 2 3 4
  2. Zinc finger-like structure in U1-specific protein C is essential for specific binding to U1 snRNP. (PMID: 1826349) Nelissen R.L.H. … van Venrooij W.J. (Nucleic Acids Res. 1991) 3 4 23
  3. Homodimerization of the human U1 snRNP-specific protein C. (PMID: 8532530) Gunnewiek J.M. … Nelissen R.L. (Nucleic Acids Res. 1995) 2 3 23
  4. Involvement of U1 small nuclear ribonucleoproteins (snRNP) in 5' splice site-U1 snRNP interaction. (PMID: 8798632) Rossi F. … Cathala G. (J. Biol. Chem. 1996) 3 4 23
  5. The structure and biochemical properties of the human spliceosomal protein U1C. (PMID: 15312772) Muto Y. … Nagai K. (J. Mol. Biol. 2004) 3 4 23

Products for SNRPC Gene

Sources for SNRPC Gene

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