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Aliases for SNRPC Gene

Aliases for SNRPC Gene

  • Small Nuclear Ribonucleoprotein Polypeptide C 2 3 5
  • U1 SnRNP C 3 4
  • U1-C 3 4
  • U1C 3 4
  • U1 Small Nuclear Ribonucleoprotein C 3
  • U1 Small Nuclear RNP Specific C 3
  • U1 SnRNP Protein C 3
  • Yhc1 3

External Ids for SNRPC Gene

Previous GeneCards Identifiers for SNRPC Gene

  • GC06P034727
  • GC06P034772
  • GC06P034833
  • GC06P034725
  • GC06P034447
  • GC06P034826
  • GC06P035771
  • GC06P036301
  • GC06P037287
  • GC06P034928
  • GC06P035510
  • GC06P037746
  • GC06P038320

Summaries for SNRPC Gene

Entrez Gene Summary for SNRPC Gene

  • This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.[provided by RefSeq, Oct 2009]

GeneCards Summary for SNRPC Gene

SNRPC (Small Nuclear Ribonucleoprotein Polypeptide C) is a Protein Coding gene. Diseases associated with SNRPC include Chondrosarcoma, Extraskeletal Myxoid. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and protein homodimerization activity.

UniProtKB/Swiss-Prot for SNRPC Gene

  • Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5 splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5 splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5 splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5 end of the U1 snRNA and the 5 splice-site region.

Gene Wiki entry for SNRPC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPC Gene

Genomics for SNRPC Gene

Regulatory Elements for SNRPC Gene

Enhancers for SNRPC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F034951 1.1 Ensembl ENCODE 14.4 +196.9 196884 4.4 MLX ARID4B YY1 ZNF121 FOS ZHX2 MIER2 PPARG KAT8 SMARCA4 TAF11 UHRF1BP1 SNRPC ANKS1A SCUBE3 GC06P039581 PIR53548
GH06F034723 0.5 Ensembl ENCODE 12.3 -33.5 -33490 0.6 ESRRA ZNF146 SAP130 BACH1 THRB RARA ZNF316 ZNF547 NFE2 NR2F6 SNRPC C6orf106 ENSG00000220643 LOC105375029 RPS10P13
GH06F034722 0.6 ENCODE 12.3 -34.2 -34159 0.6 ESRRA SAP130 ZNF384 THRB RARA GATA3 GATA2 SOX5 GATAD2A RNF2 UHRF1BP1 SNRPC C6orf106 ENSG00000220643 LOC105375029 RPS10P13
GH06F034694 0.2 ENCODE 11.3 -60.8 -60838 3.4 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 UHRF1BP1 LEMD2 SNRPC ENSG00000272374 ENSG00000219023 FANCE RPL10A LOC101929243 LOC105375028
GH06F035359 0.9 Ensembl ENCODE 11.2 +603.6 603607 2.6 HDGF PKNOX1 MLX ARID4B FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SNRPC DEF6 C6orf106 PPARD GC06P040019
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SNRPC on UCSC Golden Path with GeneCards custom track

Promoters for SNRPC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001494762 406 2201 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for SNRPC Gene

Chromosome:
6
Start:
34,757,094 bp from pter
End:
34,773,857 bp from pter
Size:
16,764 bases
Orientation:
Plus strand

Genomic View for SNRPC Gene

Genes around SNRPC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRPC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPC Gene

Proteins for SNRPC Gene

  • Protein details for SNRPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09234-RU1C_HUMAN
    Recommended name:
    U1 small nuclear ribonucleoprotein C
    Protein Accession:
    P09234
    Secondary Accessions:
    • Q5TAL3

    Protein attributes for SNRPC Gene

    Size:
    159 amino acids
    Molecular mass:
    17394 Da
    Quaternary structure:
    • U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5 splice-site region of the pre-mRNA.
    SequenceCaution:
    • Sequence=CAI20351.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SNRPC Gene

neXtProt entry for SNRPC Gene

Post-translational modifications for SNRPC Gene

  • Ubiquitination at Lys 3 and Lys 40
  • Modification sites at PhosphoSitePlus

Other Protein References for SNRPC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNRPC Gene

Domains & Families for SNRPC Gene

Protein Domains for SNRPC Gene

Graphical View of Domain Structure for InterPro Entry

P09234

UniProtKB/Swiss-Prot:

RU1C_HUMAN :
  • Belongs to the U1 small nuclear ribonucleoprotein C family.
  • Contains 1 matrin-type zinc finger.
Family:
  • Belongs to the U1 small nuclear ribonucleoprotein C family.
Similarity:
  • Contains 1 matrin-type zinc finger.
genes like me logo Genes that share domains with SNRPC: view

No data available for Gene Families for SNRPC Gene

Function for SNRPC Gene

Molecular function for SNRPC Gene

UniProtKB/Swiss-Prot Function:
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5 splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5 splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5 splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5 end of the U1 snRNA and the 5 splice-site region.

Gene Ontology (GO) - Molecular Function for SNRPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003727 single-stranded RNA binding IDA 8798632
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding IPI 8076607
genes like me logo Genes that share ontologies with SNRPC: view
genes like me logo Genes that share phenotypes with SNRPC: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRPC Gene

Localization for SNRPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRPC Gene COMPARTMENTS Subcellular localization image for SNRPC gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SNRPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000243 commitment complex IBA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005685 U1 snRNP IEA,IDA 15312772
GO:0015030 Cajal body IDA 10068039
genes like me logo Genes that share ontologies with SNRPC: view

Pathways & Interactions for SNRPC Gene

genes like me logo Genes that share pathways with SNRPC: view

Pathways by source for SNRPC Gene

Gene Ontology (GO) - Biological Process for SNRPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly IEA,IDA 8972845
GO:0000395 mRNA 5-splice site recognition IEA,IBA --
GO:0000398 mRNA splicing, via spliceosome IEA,IDA 8972845
genes like me logo Genes that share ontologies with SNRPC: view

No data available for SIGNOR curated interactions for SNRPC Gene

Drugs & Compounds for SNRPC Gene

(1) Drugs for SNRPC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SNRPC: view

Transcripts for SNRPC Gene

Unigene Clusters for SNRPC Gene

Small nuclear ribonucleoprotein polypeptide C:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPC Gene

No ASD Table

Relevant External Links for SNRPC Gene

GeneLoc Exon Structure for
SNRPC
ECgene alternative splicing isoforms for
SNRPC

Expression for SNRPC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNRPC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNRPC Gene

This gene is overexpressed in Fetal Brain (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNRPC Gene



Protein tissue co-expression partners for SNRPC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNRPC Gene:

SNRPC

SOURCE GeneReport for Unigene cluster for SNRPC Gene:

Hs.1063
genes like me logo Genes that share expression patterns with SNRPC: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNRPC Gene

Orthologs for SNRPC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNRPC 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNRPC 34 35
  • 99.58 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
OneToMany
SNRPC 35
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Snrpc 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102153257 34
  • 96.23 (n)
SNRPC 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNRPC 35
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC685273 34
  • 90.15 (n)
chicken
(Gallus gallus)
Aves SNRPC 35
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNRPC 35
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1158 34
zebrafish
(Danio rerio)
Actinopterygii snrpc 34 35
  • 83 (a)
fruit fly
(Drosophila melanogaster)
Insecta snRNP-U1-C 35
  • 59 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F08B4.7 35
  • 53 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YHC1 37
rice
(Oryza sativa)
Liliopsida Os.5630 34
wheat
(Triticum aestivum)
Liliopsida Ta.13756 34
corn
(Zea mays)
Liliopsida Zm.5207 34
Species where no ortholog for SNRPC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for SNRPC Gene

ENSEMBL:
Gene Tree for SNRPC (if available)
TreeFam:
Gene Tree for SNRPC (if available)

Paralogs for SNRPC Gene

genes like me logo Genes that share paralogs with SNRPC: view

No data available for Paralogs for SNRPC Gene

Variants for SNRPC Gene

Sequence variations from dbSNP and Humsavar for SNRPC Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs111370028 -- 34,758,717(+) GAAAA(C/T)GTTGA intron-variant
rs111751632 -- 34,766,296(+) CCTGG(A/G)CTCAA intron-variant
rs111795547 -- 34,770,290(+) TTTCA(C/G)CGGGT splice-acceptor-variant
rs111811514 -- 34,766,235(+) TTACT(C/G)TGTCA intron-variant
rs111917822 -- 34,762,304(+) GTTAG(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNRPC Gene

Variant ID Type Subtype PubMed ID
dgv5955n100 CNV gain 25217958
esv2763967 CNV gain 21179565
nsv462905 CNV gain 19166990
nsv602906 CNV gain 21841781
nsv965714 CNV duplication 23825009

Variation tolerance for SNRPC Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.92; 87.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNRPC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNRPC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRPC Gene

Disorders for SNRPC Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNRPC Gene - From: DISEASES

Disorder Aliases PubMed IDs
chondrosarcoma, extraskeletal myxoid
  • extraskeletal myxoid chondrosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search SNRPC in MalaCards View complete list of genes associated with diseases

Relevant External Links for SNRPC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNRPC
genes like me logo Genes that share disorders with SNRPC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNRPC Gene

Publications for SNRPC Gene

  1. Protein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein: absolute quantification using isotope-coded tags and mass spectrometry. (PMID: 15525645) Hochleitner E.O. … Lottspeich F. (J. Biol. Chem. 2005) 3 4 22 64
  2. The structure and biochemical properties of the human spliceosomal protein U1C. (PMID: 15312772) Muto Y. … Nagai K. (J. Mol. Biol. 2004) 3 4 22 64
  3. Involvement of U1 small nuclear ribonucleoproteins (snRNP) in 5' splice site-U1 snRNP interaction. (PMID: 8798632) Rossi F. … Cathala G. (J. Biol. Chem. 1996) 3 4 22 64
  4. Homodimerization of the human U1 snRNP-specific protein C. (PMID: 8532530) Gunnewiek J.M. … Nelissen R.L. (Nucleic Acids Res. 1995) 2 3 22 64
  5. Zinc finger-like structure in U1-specific protein C is essential for specific binding to U1 snRNP. (PMID: 1826349) Nelissen R.L.H. … van Venrooij W.J. (Nucleic Acids Res. 1991) 3 4 22 64

Products for SNRPC Gene

Sources for SNRPC Gene

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