Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SNRPB2 Gene

Aliases for SNRPB2 Gene

  • Small Nuclear Ribonucleoprotein Polypeptide B 2 3
  • Small Nuclear Ribonucleoprotein Polypeptide B2 2 3
  • U2 SnRNP B 3 4
  • U2 Small Nuclear Ribonucleoprotein B 3
  • Msl1 3

External Ids for SNRPB2 Gene

Summaries for SNRPB2 Gene

Entrez Gene Summary for SNRPB2 Gene

  • The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNRPB2 Gene

SNRPB2 (Small Nuclear Ribonucleoprotein Polypeptide B) is a Protein Coding gene. Diseases associated with SNRPB2 include systemic lupus erythematosus. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include nucleotide binding and snRNA binding. An important paralog of this gene is SNRPA.

UniProtKB/Swiss-Prot for SNRPB2 Gene

  • Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A protein

Gene Wiki entry for SNRPB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPB2 Gene

Genomics for SNRPB2 Gene

Genomic Location for SNRPB2 Gene

Start:
16,729,961 bp from pter
End:
16,742,563 bp from pter
Size:
12,603 bases
Orientation:
Plus strand

Genomic View for SNRPB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNRPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPB2 Gene

Regulatory Elements for SNRPB2 Gene

Proteins for SNRPB2 Gene

  • Protein details for SNRPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08579-RU2B_HUMAN
    Recommended name:
    U2 small nuclear ribonucleoprotein B
    Protein Accession:
    P08579
    Secondary Accessions:
    • B2R7J3
    • D3DW21
    • Q9UJD4

    Protein attributes for SNRPB2 Gene

    Size:
    225 amino acids
    Molecular mass:
    25486 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro, and composed of SNRPB2, HPRP8BP and CRNKL1.
    Miscellaneous:
    • Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins

    Three dimensional structures from OCA and Proteopedia for SNRPB2 Gene

neXtProt entry for SNRPB2 Gene

Proteomics data for SNRPB2 Gene at MOPED

Post-translational modifications for SNRPB2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys57, Lys77, Lys85, Lys93, and Lys219

Other Protein References for SNRPB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SNRPB2 Gene

Domains for SNRPB2 Gene

Gene Families for SNRPB2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

UniProtKB/Swiss-Prot:

RU2B_HUMAN
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.:
    • P08579
Family:
  • Belongs to the RRM U1 A/B family.:
    • P08579
genes like me logo Genes that share domains with SNRPB2: view

Function for SNRPB2 Gene

Molecular function for SNRPB2 Gene

UniProtKB/Swiss-Prot Function: Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A protein

Gene Ontology (GO) - Molecular Function for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 22365833
GO:0017069 snRNA binding IEA --
genes like me logo Genes that share ontologies with SNRPB2: view
genes like me logo Genes that share phenotypes with SNRPB2: view

miRNA for SNRPB2 Gene

miRTarBase miRNAs that target SNRPB2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNRPB2 Gene

Localization for SNRPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRPB2 Gene COMPARTMENTS Subcellular localization image for SNRPB2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005686 U2 snRNP TAS 2951739
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SNRPB2: view

Pathways for SNRPB2 Gene

genes like me logo Genes that share pathways with SNRPB2: view

Pathways by source for SNRPB2 Gene

1 KEGG pathway for SNRPB2 Gene

Gene Ontology (GO) - Biological Process for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006397 mRNA processing TAS 2951739
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SNRPB2: view

Transcripts for SNRPB2 Gene

mRNA/cDNA for SNRPB2 Gene

Unigene Clusters for SNRPB2 Gene

Small nuclear ribonucleoprotein polypeptide B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPB2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1:
SP2: - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for SNRPB2 Gene

GeneLoc Exon Structure for
SNRPB2
ECgene alternative splicing isoforms for
SNRPB2

Expression for SNRPB2 Gene

mRNA expression in normal human tissues for SNRPB2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNRPB2 Gene

SOURCE GeneReport for Unigene cluster for SNRPB2 Gene Hs.280378

genes like me logo Genes that share expressions with SNRPB2: view

Orthologs for SNRPB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRPB2 36
  • 99.11 (n)
  • 99.56 (a)
SNRPB2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNRPB2 36
  • 93.58 (n)
  • 99.08 (a)
SNRPB2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 89 (a)
OneToMany
SNRPB2 36
  • 93.63 (n)
  • 98.67 (a)
SNRPB2 37
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Snrpb2 36
  • 89.63 (n)
  • 96 (a)
Snrpb2 16
Snrpb2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNRPB2 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNRPB2 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snrpb2 36
  • 90.67 (n)
  • 96.89 (a)
chicken
(Gallus gallus)
Aves SNRPB2 36
  • 79.41 (n)
  • 90.22 (a)
SNRPB2 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNRPB2 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snrpb2 36
  • 74.14 (n)
  • 83.86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8470 36
zebrafish
(Danio rerio)
Actinopterygii Dr.14007 36
snrpb2 36
  • 71.67 (n)
  • 80 (a)
snrpb2 37
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta snf 37
  • 68 (a)
OneToMany
snf 38
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea rnp-2 37
  • 48 (a)
ManyToMany
rnp-3 36
  • 54.72 (n)
  • 50 (a)
rnp-3 37
  • 47 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSL1 37
  • 23 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1622 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06960 36
  • 59.39 (n)
  • 56.36 (a)
rice
(Oryza sativa)
Liliopsida Os03g0298800 36
  • 60.61 (n)
  • 54.55 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9408 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10455 37
  • 52 (a)
OneToMany
Species with no ortholog for SNRPB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SNRPB2 Gene

ENSEMBL:
Gene Tree for SNRPB2 (if available)
TreeFam:
Gene Tree for SNRPB2 (if available)

Paralogs for SNRPB2 Gene

Paralogs for SNRPB2 Gene

Selected SIMAP similar genes for SNRPB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNRPB2: view

Variants for SNRPB2 Gene

Sequence variations from dbSNP and Humsavar for SNRPB2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs879880 -- 16,729,003(+) CAGTA(G/T)AACCA upstream-variant-2KB
rs1051179 -- 16,741,247(+) CCATC(G/T)CCCTA utr-variant-3-prime
rs1131480 -- 16,731,677(+) TTTAC(G/T)GTCTC utr-variant-5-prime
rs1804873 -- 16,741,008(+) TAACA(C/T)TTGGG utr-variant-3-prime
rs2073054 -- 16,730,285(-) ACCTT(C/T)GCCCA intron-variant

Relevant External Links for SNRPB2 Gene

HapMap Linkage Disequilibrium report
SNRPB2

No data available for Structural Variations from Database of Genomic Variants (DGV) for SNRPB2 Gene

Disorders for SNRPB2 Gene

genes like me logo Genes that share disorders with SNRPB2: view

No data available for UniProtKB/Swiss-Prot for SNRPB2 Gene

Publications for SNRPB2 Gene

  1. Analysis of a cDNA clone expressing a human autoimmune antigen: full- length sequence of the U2 small nuclear RNA-associated B' antigen. (PMID: 2951739) Habets W.J. … van Venrooij W.J. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3 4
  2. Crystal structure of the spliceosomal U2B'-U2A' protein complex bound to a fragment of U2 small nuclear RNA. (PMID: 9716128) Price S.R. … Nagai K. (Nature 1998) 3 4
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  4. Crooked neck is a component of the human spliceosome and implicated in the splicing process. (PMID: 12084575) Chung S. … Rymond B.C. (Biochim. Biophys. Acta 2002) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for SNRPB2 Gene

Sources for SNRPB2 Gene

Back to Top

Content