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Aliases for SNRPB2 Gene

Aliases for SNRPB2 Gene

  • Small Nuclear Ribonucleoprotein Polypeptide B 2 3
  • Small Nuclear Ribonucleoprotein Polypeptide B2 2 3
  • U2 SnRNP B 3 4
  • U2 Small Nuclear Ribonucleoprotein B 3
  • Msl1 3

External Ids for SNRPB2 Gene

Previous GeneCards Identifiers for SNRPB2 Gene

  • GC20P016698
  • GC20P016705

Summaries for SNRPB2 Gene

Entrez Gene Summary for SNRPB2 Gene

  • The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNRPB2 Gene

SNRPB2 (Small Nuclear Ribonucleoprotein Polypeptide B) is a Protein Coding gene. Diseases associated with SNRPB2 include systemic lupus erythematosus. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include nucleotide binding and snRNA binding. An important paralog of this gene is SNRPA.

UniProtKB/Swiss-Prot for SNRPB2 Gene

  • Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A protein

Gene Wiki entry for SNRPB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPB2 Gene

Genomics for SNRPB2 Gene

Regulatory Elements for SNRPB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNRPB2 Gene

16,729,961 bp from pter
16,742,563 bp from pter
12,603 bases
Plus strand

Genomic View for SNRPB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNRPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPB2 Gene

Proteins for SNRPB2 Gene

  • Protein details for SNRPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U2 small nuclear ribonucleoprotein B
    Protein Accession:
    Secondary Accessions:
    • B2R7J3
    • D3DW21
    • Q9UJD4

    Protein attributes for SNRPB2 Gene

    225 amino acids
    Molecular mass:
    25486 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro, and composed of SNRPB2, HPRP8BP and CRNKL1.
    • Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins

    Three dimensional structures from OCA and Proteopedia for SNRPB2 Gene

neXtProt entry for SNRPB2 Gene

Proteomics data for SNRPB2 Gene at MOPED

Post-translational modifications for SNRPB2 Gene

  • Ubiquitination at Lys57, Lys77, Lys85, Lys93, and Lys219
  • Modification sites at PhosphoSitePlus

Other Protein References for SNRPB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SNRPB2 Gene

Domains for SNRPB2 Gene

Gene Families for SNRPB2 Gene

Suggested Antigen Peptide Sequences for SNRPB2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the RRM U1 A/B family.
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the RRM U1 A/B family.
genes like me logo Genes that share domains with SNRPB2: view

Function for SNRPB2 Gene

Molecular function for SNRPB2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A protein

Gene Ontology (GO) - Molecular Function for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 22365833
GO:0017069 snRNA binding IEA --
genes like me logo Genes that share ontologies with SNRPB2: view
genes like me logo Genes that share phenotypes with SNRPB2: view

miRNA for SNRPB2 Gene

miRTarBase miRNAs that target SNRPB2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNRPB2 Gene

Localization for SNRPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPB2 Gene

Subcellular locations from

Jensen Localization Image for SNRPB2 Gene COMPARTMENTS Subcellular localization image for SNRPB2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005686 U2 snRNP TAS 2951739
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SNRPB2: view

Pathways for SNRPB2 Gene

genes like me logo Genes that share pathways with SNRPB2: view

Pathways by source for SNRPB2 Gene

1 KEGG pathway for SNRPB2 Gene

Gene Ontology (GO) - Biological Process for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006397 mRNA processing TAS 2951739
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SNRPB2: view

Transcripts for SNRPB2 Gene

mRNA/cDNA for SNRPB2 Gene

Unigene Clusters for SNRPB2 Gene

Small nuclear ribonucleoprotein polypeptide B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPB2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for SNRPB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNRPB2 Gene

mRNA expression in normal human tissues for SNRPB2 Gene

Protein differential expression in normal tissues for SNRPB2 Gene

This gene is overexpressed in CD8 Tcells (7.7) and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNRPB2 Gene

SOURCE GeneReport for Unigene cluster for SNRPB2 Gene Hs.280378

genes like me logo Genes that share expressions with SNRPB2: view

Expression partners for SNRPB2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNRPB2 Gene

Orthologs for SNRPB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SNRPB2 35
  • 93.58 (n)
  • 99.08 (a)
  • 97 (a)
(Canis familiaris)
Mammalia SNRPB2 35
  • 93.63 (n)
  • 98.67 (a)
-- 36
  • 89 (a)
  • 98 (a)
(Mus musculus)
Mammalia Snrpb2 35
  • 89.63 (n)
  • 96 (a)
Snrpb2 16
Snrpb2 36
  • 96 (a)
(Pan troglodytes)
Mammalia SNRPB2 35
  • 99.11 (n)
  • 99.56 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Snrpb2 35
  • 90.67 (n)
  • 96.89 (a)
(Monodelphis domestica)
Mammalia SNRPB2 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia SNRPB2 36
  • 94 (a)
(Gallus gallus)
Aves SNRPB2 35
  • 79.41 (n)
  • 90.22 (a)
  • 88 (a)
(Anolis carolinensis)
Reptilia SNRPB2 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snrpb2 35
  • 74.14 (n)
  • 83.86 (a)
(Danio rerio)
Actinopterygii Dr.14007 35
snrpb2 35
  • 71.67 (n)
  • 80 (a)
snrpb2 36
  • 80 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8470 35
fruit fly
(Drosophila melanogaster)
Insecta snf 37
  • 67 (a)
snf 36
  • 68 (a)
(Caenorhabditis elegans)
Secernentea rnp-3 35
  • 54.72 (n)
  • 50 (a)
rnp-2 36
  • 48 (a)
rnp-3 36
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSL1 36
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06960 35
  • 59.39 (n)
  • 56.36 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1622 35
(Oryza sativa)
Liliopsida Os03g0298800 35
  • 60.61 (n)
  • 54.55 (a)
(Triticum aestivum)
Liliopsida Ta.9408 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10455 36
  • 52 (a)
Species with no ortholog for SNRPB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SNRPB2 Gene

Gene Tree for SNRPB2 (if available)
Gene Tree for SNRPB2 (if available)

Paralogs for SNRPB2 Gene

Paralogs for SNRPB2 Gene

(1) SIMAP similar genes for SNRPB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNRPB2: view

Variants for SNRPB2 Gene

Sequence variations from dbSNP and Humsavar for SNRPB2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs879880 -- 16,729,003(+) CAGTA(G/T)AACCA upstream-variant-2KB
rs1051179 -- 16,741,247(+) CCATC(G/T)CCCTA utr-variant-3-prime
rs1131480 -- 16,731,677(+) TTTAC(G/T)GTCTC utr-variant-5-prime
rs1804873 -- 16,741,008(+) TAACA(C/T)TTGGG utr-variant-3-prime
rs2073054 -- 16,730,285(-) ACCTT(C/T)GCCCA intron-variant

Relevant External Links for SNRPB2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SNRPB2 Gene

Disorders for SNRPB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SNRPB2 Gene in MalaCards »

(1) Disease for SNRPB2 Gene

genes like me logo Genes that share disorders with SNRPB2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SNRPB2 Gene

Publications for SNRPB2 Gene

  1. Analysis of a cDNA clone expressing a human autoimmune antigen: full- length sequence of the U2 small nuclear RNA-associated B' antigen. (PMID: 2951739) Habets W.J. … van Venrooij W.J. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3 4
  2. Crystal structure of the spliceosomal U2B'-U2A' protein complex bound to a fragment of U2 small nuclear RNA. (PMID: 9716128) Price S.R. … Nagai K. (Nature 1998) 3 4
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  4. Crooked neck is a component of the human spliceosome and implicated in the splicing process. (PMID: 12084575) Chung S. … Rymond B.C. (Biochim. Biophys. Acta 2002) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for SNRPB2 Gene

Sources for SNRPB2 Gene

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