Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SNRPB2 Gene

protein-coding   GIFtS: 57
GCID: GC20P016658

Small Nuclear Ribonucleoprotein Polypeptide B

(Previous names: small nuclear ribonucleoprotein polypeptide B2, small nuclear...)
  See SNRPB2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Small Nuclear Ribonucleoprotein Polypeptide B1 2
Small Nuclear Ribonucleoprotein Polypeptide B21 2
U2 SnRNP B''2 3
Small Nuclear Ribonucleoprotein Polypeptide B''1
Msl12
U2 Small Nuclear Ribonucleoprotein B''2

External Ids:    HGNC: 111551   Entrez Gene: 66292   Ensembl: ENSG000001258707   OMIM: 6035205   UniProtKB: P085793   

Export aliases for SNRPB2 gene to outside databases

Previous GC identifers: GC20P016698 GC20P016705


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SNRPB2 Gene:
The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in
the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients
with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants
encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SNRPB2 Gene:
SNRPB2 (small nuclear ribonucleoprotein polypeptide B) is a protein-coding gene. Diseases associated with SNRPB2 include systemic lupus erythematosus. GO annotations related to this gene include snRNA binding and nucleotide binding. An important paralog of this gene is SNRPA.

UniProtKB/Swiss-Prot: RU2B_HUMAN, P08579
Function: Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2
snRNA only in presence of the U2A' protein

Gene Wiki entry for SNRPB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNRPB2 gene promoter:
         p53   AP-1   Pax-6   FOXO3   FOXL1   MEF-2A   PPAR-gamma1   aMEF-2   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRPB2 promoter sequence
   Search Chromatin IP Primers for SNRPB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNRPB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12.1   Ensembl cytogenetic band:  20p12.1   HGNC cytogenetic band: 20p12.1

SNRPB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPB2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P016658:  view genomic region     (about GC identifiers)

Start:
16,710,606 bp from pter      End:
16,722,421 bp from pter
Size:
11,816 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RU2B_HUMAN, P08579 (See protein sequence)
Recommended Name: U2 small nuclear ribonucleoprotein B''  
Size: 225 amino acids; 25486 Da
Subunit: Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro, and
composed of SNRPB2, HPRP8BP and CRNKL1
Miscellaneous: Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins
1 PDB 3D structure from and Proteopedia for SNRPB2:
1A9N (3D)    
Secondary accessions: B2R7J3 D3DW21 Q9UJD4

Explore the universe of human proteins at neXtProt for SNRPB2: NX_P08579

Explore proteomics data for SNRPB2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys57, Lys77, Lys85, Lys93, Lys219
  • Modification sites at PhosphoSitePlus

  • See SNRPB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003083.1  NP_937863.1  

    ENSEMBL proteins: 
     ENSP00000367178   ENSP00000246071  
    Reactome Protein details: P08579

    SNRPB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SNRPB2
    OriGene Protein Over-expression Lysate for SNRPB2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SNRPB2
    GenScript Custom Purified and Recombinant Proteins Services for SNRPB2
    Novus Biologicals SNRPB2 Proteins
    Novus Biologicals SNRPB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SNRPB2
    Cloud-Clone Corp. Proteins for SNRPB2

     
    Search eBioscience for Proteins for SNRPB2 

    SNRPB2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SNRPB2
    Novus Biologicals SNRPB2 Antibody
    Abcam antibodies for SNRPB2
    Cloud-Clone Corp. Antibodies for SNRPB2
    Search ThermoFisher Antibodies for SNRPB2
    LSBio Antibodies in human, mouse, rat for SNRPB2

    SNRPB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SNRPB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNRPB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SNRPB2
    Cloud-Clone Corp. CLIAs for SNRPB2
    Search eBioscience for ELISAs for SNRPB2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR024888 U1_snRNP_A/U2_snRNP_B''
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry P08579

    ProtoNet protein and cluster: P08579

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RU2B_HUMAN, P08579
    Similarity: Belongs to the RRM U1 A/B'' family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with SNRPB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RU2B_HUMAN, P08579
    Function: Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2
    snRNA only in presence of the U2A' protein

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI--
    GO:0017069snRNA binding IEA--
         
    Find genes that share ontologies with SNRPB2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for SNRPB2:
     Increased G1 DNA content  Increased cell size  Increased circadian period len  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNRPB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNRPB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNRPB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNRPB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNRPB2:
    hsa-mir-16-5p (MIRT031432), hsa-mir-24-3p (MIRT030365), hsa-mir-193a-3p (MIRT044882)

    Block miRNA regulation of human, mouse, rat SNRPB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNRPB2 (see all 11):
    hsa-miR-21* hsa-miR-495 hsa-miR-561 hsa-let-7a-2* hsa-miR-4282 hsa-miR-3142 hsa-miR-493* hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidSNRPB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNRPB2
    Predesigned siRNA for gene silencing in human, mouse, rat SNRPB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNRPB2

    Clone
    Products:
         
    OriGene clones in human, mouse for SNRPB2 (see all 12)
    OriGene ORF clones in mouse, rat for SNRPB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SNRPB2 (NM_198220)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SNRPB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SNRPB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RU2B_HUMAN, P08579: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005686U2 snRNP TAS2951739
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with SNRPB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SNRPB2 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome


    Find genes that share SuperPaths with SNRPB2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNRPB2
        mRNA processing

    1 Reactome Pathway for SNRPB2
        mRNA Splicing - Major Pathway


    1 Kegg Pathway  (Kegg details for SNRPB2):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNRPB2
    Interactions:

        Search GeneGlobe Interaction Network for SNRPB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNRPB2 (P085791, 2, 3 ENSP000002460714) via UniProtKB, MINT, STRING, and/or I2D (see all 739)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNRPA1P096611, 2, 3, ENSP000002541934EBI-1053651,EBI-876439 MINT-8332592 MINT-8333350 I2D: score=4 STRING: ENSP00000254193
    SMN2Q166372, 3, ENSP000003701194MINT-7945693 I2D: score=1 STRING: ENSP00000370119
    DHX9Q082112, 3, ENSP000003565204MINT-7945693 I2D: score=2 STRING: ENSP00000356520
    SF3A2Q154282, 3, ENSP000002214944MINT-5205431 I2D: score=2 STRING: ENSP00000221494
    SNRNP40Q96DI72, 3, ENSP000002636944MINT-7945693 I2D: score=2 STRING: ENSP00000263694
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing TAS2951739
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with SNRPB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNRPB2 (RU2B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SNRPB2 gene (2 alternative transcripts): 
    NM_003092.4  NM_198220.2  

    Unigene Cluster for SNRPB2:

    Small nuclear ribonucleoprotein polypeptide B
    Hs.280378  [show with all ESTs]
    Unigene Representative Sequence: AK095316
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377943(uc002wpi.2) ENST00000246071(uc002wph.2) ENST00000478522

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SNRPB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNRPB2 (see all 11):
    hsa-miR-21* hsa-miR-495 hsa-miR-561 hsa-let-7a-2* hsa-miR-4282 hsa-miR-3142 hsa-miR-493* hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidSNRPB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SNRPB2
    Predesigned siRNA for gene silencing in human, mouse, rat SNRPB2
    Clone
    Products:
         
    OriGene clones in human, mouse for SNRPB2 (see all 12)
    OriGene ORF clones in mouse, rat for SNRPB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SNRPB2 (NM_198220)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPB2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNRPB2
    OriGene qSTAR qPCR primer pairs in human, mouse for SNRPB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNRPB2
      QuantiTect SYBR Green Assays in human, mouse, rat SNRPB2
      QuantiFast Probe-based Assays in human, mouse, rat SNRPB2

    Additional mRNA sequence: 

    AB451234.1 AB451359.1 AK095316.1 AK313004.1 BC008311.1 BC018022.1 BC022311.1 BC036737.2 
    M15841.1 

    12 DOTS entries:

    DT.91680366  DT.100814268  DT.100814275  DT.100814276  DT.100814271  DT.91747710  DT.95357212  DT.91901252 
    DT.95263130  DT.92444476  DT.95157907  DT.95157908 

    Selected AceView cDNA sequences (see all 362):

    AA055460 M15841 AI283364 NM_003092 CR620323 CR595063 BP380141 BM903941 
    BU741000 BM772256 Z41577 BQ014214 CR592015 AI476780 AA165066 BU162080 
    AI884607 BM799655 BC018022 BM849557 BP354415 CR612578 BM453785 BM723584 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SNRPB2    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
    SP1:                                                                                          
    SP2:                          -                 -     -                                       
    SP3:                                            -     -                                       
    SP4:                          -                                                               
    SP5:                                                                                          


    ECgene alternative splicing isoforms for SNRPB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SNRPB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATGAGGG
    SNRPB2 Expression
    About this image

    SNRPB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNRPB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.280378
        Custom PCR Arrays for SNRPB2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SNRPB2
    OriGene qSTAR qPCR primer pairs in human, mouse for SNRPB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNRPB2
    QuantiTect SYBR Green Assays in human, mouse, rat SNRPB2
    QuantiFast Probe-based Assays in human, mouse, rat SNRPB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRPB2 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrpb21 , 5 U2 small nuclear ribonucleoprotein B1, 5 89.63(n)1
    96(a)1
      2 (70.89 cM)5
    206391  NM_021335.31  NP_067310.11 
     1430630395 
    chicken
    (Gallus gallus)
    Aves SNRPB21 small nuclear ribonucleoprotein polypeptide B 79.41(n)
    90.22(a)
      421261  XM_419331.4  XP_419331.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNRPB26
    small nuclear ribonucleoprotein polypeptide B
    87(a)
    1 ↔ 1
    1(127301548-127313812)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD327097.12   -- 76.73(n)    CD327097.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.140072 Danio rerio, clone IMAGE5776900, mRNA 75.49(n)    BC049068.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta snf3 mRNA splicing RNA binding 67(a)   1 4F4   --
    worm
    (Caenorhabditis elegans)
    Secernentea rnp-31 rnp-3 54.72(n)
    50(a)
      177182  NM_068104.5  NP_500505.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSL16
    U2B component of U2 snRNP, involved in splicing, b...
    23(a)
    1 → many
    IX(374525-374860) YIR009W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G069601 AT1G06960 59.39(n)
    56.36(a)
      837206  NM_100569.3  NP_172177.3 
    rice
    (Oryza sativa)
    Liliopsida Os03g02988001 Os03g0298800 60.61(n)
    54.55(a)
      4332557  NM_001056381.1  NP_001049846.1 


    ENSEMBL Gene Tree for SNRPB2 (if available)
    TreeFam Gene Tree for SNRPB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SNRPB2 gene
    SNRPA2  
    1 SIMAP similar gene for SNRPB2 using alignment to 2 protein entries:     RU2B_HUMAN (see all proteins):
    SNRPA

    Find genes that share paralogs with SNRPB2           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for SNRPB2
    PGOHUM00000238629 PGOHUM00000238045 PGOHUM00000235229 PGOHUM00000243413 PGOHUM00000249253


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SNRPB2 (see all 324)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354874
    A colorectal cancer sample4--see VAR_0354872 K Q mis40--------
    rs1876235471,2
    --16708621(+) TATTCG/TATCCT 2 -- us2k10--------
    rs1422296341,2
    --16708640(+) CCTTCC/TTGTAC 2 -- us2k10--------
    rs779431641,2
    C,F--16708655(+) CTCAAT/AAACTG 2 -- us2k11Minor allele frequency- A:0.13WA 118
    rs782760501,2
    F--16708659(+) ATAACT/AGGCTT 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs113231671,2
    C--16708755(+) GGCTCT/-TTTTA 2 -- us2k1 tfbs31Minor allele frequency- -:0.50NA 2
    rs1511852221,2
    --16708775(+) GGAAAA/CGTGCA 2 -- us2k10--------
    rs1928586731,2
    --16708790(+) GACCAC/TTGCGG 2 -- us2k10--------
    rs169981291,2
    C,F--16708793(+) CATTGC/AGGCTG 2 -- us2k14Minor allele frequency- A:0.02NA WA 260
    rs1403010991,2
    --16708826(+) TCTCAA/CAGTGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SNRPB2 (16710606 - 16722421 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SNRPB2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNRPB2
    DNA2.0 Custom Variant and Variant Library Synthesis for SNRPB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603520    OMIM disorders: --

    1 disease for SNRPB2:    
    About MalaCards
    systemic lupus erythematosus


    Find genes that share disorders with SNRPB2           About GenesLikeMe


    Export disorders for SNRPB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SNRPB2 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with SNRPB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of a cDNA clone expressing a human autoimmune antigen: full- length sequence of the U2 small nuclear RNA-associated B' antigen. (PubMed id 2951739)1, 2, 3 Habets W.J.... van Venrooij W.J. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    5. Crooked neck is a component of the human spliceosome and implicated in the splicing process. (PubMed id 12084575)1, 2 Chung S.... Rymond B.C. (Biochim. Biophys. Acta 2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Crystal structure of the spliceosomal U2B'-U2A' protein complex bound to a fragment of U2 small nuclear RNA. (PubMed id 9716128)1, 2 Price S.R.... Nagai K. (Nature 1998)
    8. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6629 HGNC: 11155 AceView: SNRPB2 Ensembl:ENSG00000125870 euGenes: HUgn6629
    ECgene: SNRPB2 Kegg: 6629 H-InvDB: SNRPB2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SNRPB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SNRPB2 gene:
    Search GeneIP for patents involving SNRPB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SNRPB2  
     OriGene qPCR primer pairs and template standards for SNRPB2   OriGene Protein Over-expression Lysate for SNRPB2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SNRPB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SNRPB2   OriGene Purified Protein for SNRPB2  
     OriGene ORF clones in mouse, rat for SNRPB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SNRPB2   OriGene Custom Protein Services for SNRPB2  

     
     
     Block miRNA regulation of human, mouse, rat SNRPB2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SNRPB2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNRPB2 Predesigned siRNA for gene silencing in human, mouse, rat SNRPB2
     QuantiFast Probe-based Assays in human, mouse, rat SNRPB2 QuantiTect SYBR Green Assays in human, mouse, rat SNRPB2
     Custom PCR Arrays for SNRPB2 Search Chromatin IP Primers for SNRPB2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNRPB2  Search GeneGlobe Interaction Network for SNRPB2
     Regulatory tfbs in SNRPB2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SNRPB2 GenScript cDNA clones with any tag delivered in your preferred vector for SNRPB2
     GenScript Custom Assay Services for SNRPB2 GenScript Custom overexpressing Cell Line Services for SNRPB2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SNRPB2 (RU2B)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SNRPB2 antibodies
     SNRPB2 proteins
     SNRPB2 lysates
     Antibodies for SNRPB2
     See all of Abcam's Antibodies, Kits and Proteins for SNRPB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SNRPB2
     Proteins for SNRPB2
     Antibodies for SNRPB2
     ELISAs for SNRPB2
     CLIAs for SNRPB2



     Browse ESI BIO Cell Lines and PureStem Progenitors for SNRPB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPB2
     SwitchGear 3'UTR luciferase reporter plasmids for SNRPB2
     SwitchGear Promoter luciferase reporter plasmids for SNRPB2
     Search ThermoFisher Antibodies for SNRPB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPB2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNRPB2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNRPB2
     LSBio Antibodies in human, mouse, rat for SNRPB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SNRPB2
      Search eBioscience for proteins for SNRPB2
      Search eBioscience for elisas for SNRPB2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SNRPB2 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4