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Aliases for SNRPB2 Gene

Aliases for SNRPB2 Gene

  • Small Nuclear Ribonucleoprotein Polypeptide B2 2 3 5
  • Small Nuclear Ribonucleoprotein Polypeptide B 2 3
  • U2 SnRNP B 3 4
  • U2 Small Nuclear Ribonucleoprotein B 3
  • Msl1 3
  • U2B 3

External Ids for SNRPB2 Gene

Previous GeneCards Identifiers for SNRPB2 Gene

  • GC20P016698
  • GC20P016705

Summaries for SNRPB2 Gene

Entrez Gene Summary for SNRPB2 Gene

  • The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNRPB2 Gene

SNRPB2 (Small Nuclear Ribonucleoprotein Polypeptide B2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and snRNA binding. An important paralog of this gene is SNRPA.

UniProtKB/Swiss-Prot for SNRPB2 Gene

  • Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A protein.

Gene Wiki entry for SNRPB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPB2 Gene

Genomics for SNRPB2 Gene

Regulatory Elements for SNRPB2 Gene

Enhancers for SNRPB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F016760 0.8 ENCODE 11.3 +29.4 29350 0.2 ENSG00000228809 SNRPB2 OTOR ENSG00000236985
GH20F016541 0.8 Ensembl ENCODE 10.4 -188.5 -188483 0.2 NR2F2 YY1 KIF16B ENSG00000228809 SNRPB2 ENSG00000280240 GC20P016478
GH20F016538 1 Ensembl ENCODE 10.4 -190.6 -190550 1.4 KIF16B ENSG00000228809 SNRPB2 ENSG00000280240 GC20P016478
GH20F016578 0.8 Ensembl ENCODE 10.1 -149.7 -149738 2.6 PKNOX1 INSM2 OVOL3 FEZF1 TSHZ1 ZEB2 ZIC2 OSR2 POLR2A SMARCA4 KIF16B SNRPB2 ENSG00000228809 ENSG00000273998 ENSG00000275728
GH20F016532 0.2 ENCODE 9.7 -196.6 -196572 1.4 HLF PBX2 KIF16B ENSG00000228809 SNRPB2 ENSG00000280240 GC20P016478
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SNRPB2 on UCSC Golden Path with GeneCards custom track

Promoters for SNRPB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008450 240 2000 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for SNRPB2 Gene

Chromosome:
20
Start:
16,729,961 bp from pter
End:
16,742,563 bp from pter
Size:
12,603 bases
Orientation:
Plus strand

Genomic View for SNRPB2 Gene

Genes around SNRPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPB2 Gene

Proteins for SNRPB2 Gene

  • Protein details for SNRPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08579-RU2B_HUMAN
    Recommended name:
    U2 small nuclear ribonucleoprotein B
    Protein Accession:
    P08579
    Secondary Accessions:
    • B2R7J3
    • D3DW21
    • Q9UJD4

    Protein attributes for SNRPB2 Gene

    Size:
    225 amino acids
    Molecular mass:
    25486 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro, and composed of SNRPB2, HPRP8BP and CRNKL1.
    Miscellaneous:
    • Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins.

    Three dimensional structures from OCA and Proteopedia for SNRPB2 Gene

neXtProt entry for SNRPB2 Gene

Post-translational modifications for SNRPB2 Gene

  • Ubiquitination at Lys 57, Lys 77, Lys 85, Lys 93, and Lys 219
  • Modification sites at PhosphoSitePlus

Other Protein References for SNRPB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNRPB2 Gene

Domains & Families for SNRPB2 Gene

Gene Families for SNRPB2 Gene

Protein Domains for SNRPB2 Gene

Suggested Antigen Peptide Sequences for SNRPB2 Gene

Graphical View of Domain Structure for InterPro Entry

P08579

UniProtKB/Swiss-Prot:

RU2B_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the RRM U1 A/B family.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM U1 A/B family.
genes like me logo Genes that share domains with SNRPB2: view

Function for SNRPB2 Gene

Molecular function for SNRPB2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A protein.

Gene Ontology (GO) - Molecular Function for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 9716128
GO:0035614 snRNA stem-loop binding IBA --
genes like me logo Genes that share ontologies with SNRPB2: view
genes like me logo Genes that share phenotypes with SNRPB2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRPB2 Gene

Localization for SNRPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRPB2 Gene COMPARTMENTS Subcellular localization image for SNRPB2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005681 spliceosomal complex IEA,IDA 9731529
GO:0005686 U2 snRNP IDA 2951739
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SNRPB2: view

Pathways & Interactions for SNRPB2 Gene

genes like me logo Genes that share pathways with SNRPB2: view

Pathways by source for SNRPB2 Gene

1 KEGG pathway for SNRPB2 Gene

Gene Ontology (GO) - Biological Process for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA,TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SNRPB2: view

No data available for SIGNOR curated interactions for SNRPB2 Gene

Transcripts for SNRPB2 Gene

mRNA/cDNA for SNRPB2 Gene

Unigene Clusters for SNRPB2 Gene

Small nuclear ribonucleoprotein polypeptide B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPB2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1:
SP2: - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for SNRPB2 Gene

GeneLoc Exon Structure for
SNRPB2
ECgene alternative splicing isoforms for
SNRPB2

Expression for SNRPB2 Gene

mRNA expression in normal human tissues for SNRPB2 Gene

Protein differential expression in normal tissues from HIPED for SNRPB2 Gene

This gene is overexpressed in CD8 Tcells (7.7) and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNRPB2 Gene



Protein tissue co-expression partners for SNRPB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNRPB2 Gene:

SNRPB2

SOURCE GeneReport for Unigene cluster for SNRPB2 Gene:

Hs.280378
genes like me logo Genes that share expression patterns with SNRPB2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNRPB2 Gene

Orthologs for SNRPB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRPB2 34 35
  • 99.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SNRPB2 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRPB2 34 35
  • 93.63 (n)
-- 35
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SNRPB2 34 35
  • 93.58 (n)
rat
(Rattus norvegicus)
Mammalia Snrpb2 34
  • 90.67 (n)
mouse
(Mus musculus)
Mammalia Snrpb2 34 16 35
  • 89.63 (n)
oppossum
(Monodelphis domestica)
Mammalia SNRPB2 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNRPB2 34 35
  • 79.41 (n)
lizard
(Anolis carolinensis)
Reptilia SNRPB2 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snrpb2 34
  • 74.14 (n)
zebrafish
(Danio rerio)
Actinopterygii snrpb2 34 35
  • 71.67 (n)
Dr.14007 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8470 34
fruit fly
(Drosophila melanogaster)
Insecta snf 36 35
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea rnp-3 34 35
  • 54.72 (n)
rnp-2 35
  • 48 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSL1 35
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06960 34
  • 59.39 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1622 34
rice
(Oryza sativa)
Liliopsida Os03g0298800 34
  • 60.61 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.9408 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10455 35
  • 52 (a)
OneToMany
Species where no ortholog for SNRPB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SNRPB2 Gene

ENSEMBL:
Gene Tree for SNRPB2 (if available)
TreeFam:
Gene Tree for SNRPB2 (if available)

Paralogs for SNRPB2 Gene

Paralogs for SNRPB2 Gene

(1) SIMAP similar genes for SNRPB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNRPB2: view

Variants for SNRPB2 Gene

Sequence variations from dbSNP and Humsavar for SNRPB2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_035487 A colorectal cancer sample
rs1051179 -- 16,741,247(+) CCATC(G/T)CCCTA utr-variant-3-prime
rs111258155 -- 16,737,741(+) TCACT(C/T)AAAGT intron-variant
rs111326736 -- 16,736,910(+) AAGCC(C/T)GCTGG intron-variant
rs111482615 -- 16,732,863(+) ACATA(A/G)TGAGA intron-variant

Variation tolerance for SNRPB2 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNRPB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNRPB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SNRPB2 Gene

Disorders for SNRPB2 Gene

Relevant External Links for SNRPB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNRPB2

No disorders were found for SNRPB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRPB2 Gene

Publications for SNRPB2 Gene

  1. Analysis of a cDNA clone expressing a human autoimmune antigen: full- length sequence of the U2 small nuclear RNA-associated B' antigen. (PMID: 2951739) Habets W.J. … van Venrooij W.J. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3 4 64
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4 64
  5. Crooked neck is a component of the human spliceosome and implicated in the splicing process. (PMID: 12084575) Chung S. … Rymond B.C. (Biochim. Biophys. Acta 2002) 3 4 64

Products for SNRPB2 Gene

Sources for SNRPB2 Gene

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