Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNRPB Gene

protein-coding   GIFtS: 62
GCID: GC20M002442

Small Nuclear Ribonucleoprotein Polypeptides B And B1


(Previous symbol: SNRPB1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Small Nuclear Ribonucleoprotein Polypeptides B And B11 2     SmB/SmB'2
SNRPB11 2 3     B Polypeptide Of Sm Protein2
COD2 3     sm-B/Sm-B'2
Sm-B/B'2 3     Small Nuclear Ribonucleoprotein Polypeptide B2
SmB/B'2 3     Small Nuclear Ribonucleoprotein Polypeptides B And B'2
Sm Protein B/B'2 3     Small Nuclear Ribonucleoprotein-Associated Proteins B And B'2
snRNP-B2 3     

External Ids:    HGNC: 111531   Entrez Gene: 66282   Ensembl: ENSG000001258357   OMIM: 1822825   UniProtKB: P146783   

Export aliases for SNRPB gene to outside databases

Previous GC identifers: GC20M002430 GC20M002390 GC20M002437 GC20M002392


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNRPB Gene:
The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6,
and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the
encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with
systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants
encoding different isoforms (B and B') have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SNRPB Gene: 
SNRPB (small nuclear ribonucleoprotein polypeptides B and B1) is a protein-coding gene. Diseases associated with SNRPB include mutism, and systemic lupus erythematosus, and among its related super-pathways are mRNA Processing and Post-Elongation Processing of Intron-Containing pre-mRNA. GO annotations related to this gene include protein binding and histone pre-mRNA DCP binding. An important paralog of this gene is SNRPN.

UniProtKB/Swiss-Prot: RSMB_HUMAN, P14678
Function: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated
with snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure. Binds
to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner (By similarity)

Gene Wiki entry for SNRPB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNRPB gene promoter:
         COUP-TF1   SRF   COUP-TF   SRF (504 AA)   COUP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRPB promoter sequence
   Search SABiosciences Chromatin IP Primers for SNRPB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

SNRPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPB gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M002442:  view genomic region     (about GC identifiers)

Start:
2,442,280 bp from pter      End:
2,451,499 bp from pter
Size:
9,220 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RSMB_HUMAN, P14678 (See protein sequence)
Recommended Name: Small nuclear ribonucleoprotein-associated proteins B and B'  
Size: 240 amino acids; 24610 Da
Subunit: Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1
(By similarity). Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least
composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an
ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and
additionally, the U7-specific LSM10 and LSM11 proteins. Identified in the spliceosome C complex. Component of the
U11/U12 snRNPs that are part of the U12-type spliceosome. Interacts with CLNS1A, DDX20, LSM11, TDRD3, SNUPN and
SMN1
Subcellular location: Nucleus
Miscellaneous: Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies
directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. B/b' bear
Sm epitopes
Sequence caution: Sequence=AAD54488.1; Type=Erroneous gene model prediction;
6/7 PDB 3D structures from and Proteopedia for SNRPB (see all 7):
1D3B (3D)        2Y9A (3D)        2Y9B (3D)        2Y9C (3D)        2Y9D (3D)        3CW1 (3D)    
Secondary accessions: Q15490 Q6IB35 Q9UIS5
Alternative splicing: 3 isoforms:  P14678-1   P14678-2   P14678-3   

Explore the universe of human proteins at neXtProt for SNRPB: NX_P14678

Explore proteomics data for SNRPB at MOPED 

Post-translational modifications:

  • UniProtKB: Methylated. Arg-108 and Arg-112 are dimethylated, probably to asymmetric dimethylarginine
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14678

  • SNRPB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNRPB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003082.1  NP_937859.1  

    ENSEMBL proteins: 
     ENSP00000370746   ENSP00000412566   ENSP00000474579   ENSP00000342305  
    Reactome Protein details: P14678
    Human Recombinant Protein Products for SNRPB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SNRPB
    OriGene Protein Over-expression Lysate for SNRPB
    OriGene MassSpec for SNRPB 
    OriGene Custom Protein Services for SNRPB
    GenScript Custom Purified and Recombinant Proteins Services for SNRPB
    Novus Biologicals SNRPB Protein
    Novus Biologicals SNRPB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNRPB 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex TAS2531083
    GO:0005683U7 snRNP IDA11574479
    GO:0005689U12-type spliceosomal complex IDA15146077

    SNRPB for ontologies           About GeneDecksing



    SNRPB Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SNRPB
    GenScript Custom Superior Antibodies Services for SNRPB
    Novus Biologicals SNRPB Antibodies
    Abcam antibodies for SNRPB
    Cloud-Clone Corp. Antibodies for SNRPB 
    ThermoFisher Antibody for SNRPB
    LSBio Antibodies in human, mouse, rat for SNRPB 

    Assay Products for SNRPB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SNRPB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNRPB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SNRPB 
    Cloud-Clone Corp. CLIAs for SNRPB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001163 Ribonucl_LSM
     IPR017131 snRNP-assoc_SmB/SmN
     IPR010920 LSM_dom
     IPR006649 Ribonucl_LSM_euk/arc

    Graphical View of Domain Structure for InterPro Entry P14678

    ProtoNet protein and cluster: P14678

    2 Blocks protein domains:
    IPB001163 Small nuclear ribonucleoprotein (Sm protein)
    IPB010920 Like-Sm ribonucleoprotein-related


    UniProtKB/Swiss-Prot: RSMB_HUMAN, P14678
    Similarity: Belongs to the snRNP SmB/SmN family


    SNRPB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RSMB_HUMAN, P14678
    Function: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated
    with snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure. Binds
    to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner (By similarity)

         Genatlas biochemistry entry for SNRPB:
    small nuclear ribonucleoprotein,polypeptides B and B1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11714716
    GO:0071208histone pre-mRNA DCP binding IEA--
         
    SNRPB for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for SNRPB:
     Cell division defect  Decreased homologous recombina  Decreased influenza A virus in  Decreased viability of wild-ty 
     Increased cell number in G2M,   Increased gamma-H2AX phosphory  Metaphase cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SNRPB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SNRPB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNRPB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNRPB 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPB
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPB:
    hsa-miR-495 hsa-let-7g* hsa-let-7a-2* hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidSNRPB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SNRPB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNRPB
    Sirion Biotech Customized adenovirus for overexpression of SNRPB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SNRPB (see all 13)
    OriGene ORF clones in mouse, rat for SNRPB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SNRPB (NM_003091)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPB
    Sirion Biotech Customized lentivirus for stable overexpression of SNRPB 
                         Customized lentivirus expression plasmids for stable overexpression of SNRPB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SNRPB
    Search LifeMap BioReagents cell lines for SNRPB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SNRPB About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA processing0.46
    mRNA Processing0.85
    mRNA Splicing - Minor Pathway0.40
    mRNA Splicing - Major Pathway0.82
    Spliceosome0.31
    mRNA Splicing0.82
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.79
    Post-Elongation Processing of the Transcript0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    3SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
    SLBP independent Processing of Histone Pre-mRNAs0.91
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs0.91
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Post-Elongation Processing of Intronless pre-mRNA
    Post-Elongation Processing of Intronless pre-mRNA0.61
    Processing of Capped Intronless Pre-mRNA0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNRPB
        mRNA processing

    5/18        Reactome Pathways for SNRPB (see all 18)
        mRNA Splicing
    RNA Polymerase II Transcription
    snRNP Assembly
    Cleavage of Growing Transcript in the Termination Region
    Metabolism of non-coding RNA


    2         Kegg Pathways  (Kegg details for SNRPB):
        Spliceosome
    Systemic lupus erythematosus


    SNRPB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNRPB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/130 Interacting proteins for SNRPB (P146781, 2, 3 ENSP000004125664) via UniProtKB, MINT, STRING, and/or I2D (see all 130)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD2BP2O954002, 3, ENSP000003049034MINT-62827 MINT-62831 MINT-62664 MINT-62853 MINT-62655 MINT-62851 MINT-62852 MINT-62850 MINT-62849 MINT-62833 MINT-62652 I2D: score=2 STRING: ENSP00000304903
    SMN1Q166372, 3, ENSP000003700834MINT-14172 MINT-14173 MINT-14174 I2D: score=6 STRING: ENSP00000370083
    GIGYF2Q6Y7W62, 3, ENSP000003871704MINT-65887 MINT-65884 MINT-65888 MINT-65907 I2D: score=2 STRING: ENSP00000387170
    GEMIN4P576782, 3, ENSP000003217064MINT-15055 MINT-15056 I2D: score=5 STRING: ENSP00000321706
    COILP384322, 3, ENSP000002403164MINT-8052983 I2D: score=4 STRING: ENSP00000240316
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0008334histone mRNA metabolic process TAS--

    SNRPB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNRPB (RSMB)

    Search CenterWatch for drugs/clinical trials and news about SNRPB / RSMB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNRPB gene (2 alternative transcripts): 
    NM_003091.3  NM_198216.1  

    Unigene Cluster for SNRPB:

    Small nuclear ribonucleoprotein polypeptides B and B1
    Hs.83753  [show with all ESTs]
    Unigene Representative Sequence: BM564070
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381342(uc002wga.1) ENST00000438552(uc002wfz.1) ENST00000474384
    ENST00000339610(uc010zpv.2 uc002wgb.3 uc010gan.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPB
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPB:
    hsa-miR-495 hsa-let-7g* hsa-let-7a-2* hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidSNRPB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SNRPB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPB
    Clone
    Products:
         
    OriGene clones in human, mouse for SNRPB (see all 13)
    OriGene ORF clones in mouse, rat for SNRPB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SNRPB (NM_003091)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPB
    Sirion Biotech Customized lentivirus for stable overexpression of SNRPB 
                         Customized lentivirus expression plasmids for stable overexpression of SNRPB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNRPB
    OriGene qSTAR qPCR primer pairs in human, mouse for SNRPB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNRPB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPB

    Additional mRNA sequence: 

    AK301034.1 AK301206.1 AK307093.1 AK307266.1 AK312620.1 AY742712.1 BC080516.1 CR456969.1 
    J04564.1 M34081.1 M34082.1 X15893.1 X17567.1 X17568.1 

    24/27 DOTS entries (see all 27):

    DT.100045354  DT.455957  DT.101985257  DT.100042501  DT.95325267  DT.99981347  DT.100880258  DT.95099492 
    DT.100880254  DT.95325250  DT.100880270  DT.102837046  DT.95325254  DT.100880269  DT.120829112  DT.100880264 
    DT.97862682  DT.100880257  DT.450384  DT.95325273  DT.95325431  DT.100880260  DT.120829127  DT.120829147 

    24/1609 AceView cDNA sequences (see all 1609):

    BC080516 AW592867 AA305939 AI610628 AA313910 AI989770 CA448107 BQ212757 
    R31943 CR604766 BQ894673 AW949353 BE304414 CR598745 BM511626 CR615802 
    X17567 W74721 BG681145 BQ055542 BQ071067 BQ944696 BG170745 AA378811 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SNRPB (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b
    SP1:                          -     -     -           -     -     -     -     -                                                         
    SP2:                          -     -     -           -     -     -     -     -                                         -               
    SP3:                          -     -     -           -     -     -     -     -                                                         
    SP4:                                      -           -     -                                                                           
    SP5:                                      -           -     -     -     -     -                                                         


    ECgene alternative splicing isoforms for SNRPB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNRPB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATTGTCTG
    SNRPB Expression
    About this image


    See SNRPB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNRPB

    SOURCE GeneReport for Unigene cluster: Hs.83753
        SABiosciences Custom PCR Arrays for SNRPB
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SNRPB
    OriGene qSTAR qPCR primer pairs in human, mouse for SNRPB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNRPB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRPB gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrpb1 , 5 small nuclear ribonucleoprotein B1, 5 91.85(n)1
    99.56(a)1
      2 (63.19 cM)5
    206381  NM_009225.21  NP_033251.11 
     1301714145 
    chicken
    (Gallus gallus)
    Aves SNRPB1 small nuclear ribonucleoprotein polypeptides B and more 80.28(n)
    96.25(a)
      395298  NM_204599.1  NP_989930.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Small nuclear ribonucleoprotein-associated protein...
    95(a)
    1 → many
    GL343820.1(155984-166215)
    African clawed frog
    (Xenopus laevis)
    Amphibia snrpn-prov2 small nuclear ribonucleoparticle-associated protein more 76.29(n)    BC041275.1 
    zebrafish
    (Danio rerio)
    Actinopterygii snrpb1 small nuclear ribonucleoprotein polypeptides B and more 77.12(n)
    95.76(a)
      402966  NM_205667.1  NP_991230.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SmB1 , 3 mRNA splicing3
    Small ribonucleoprotein particle protein SmB1
    70(a)3
    60.91(n)1
    67.01(a)1
      31E13
    344261  NM_001201851.11  NP_001188780.11 
    worm
    (Caenorhabditis elegans)
    Secernentea snr-26
    Probable small nuclear ribonucleoprotein-associate...
    56(a)
    1 → many
    I(13339395-13340227)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMB16
    Core Sm protein Sm B; part of heteroheptameric com...
    28(a)
    1 → many
    V(212587-213177)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons smB1 small nuclear ribonucleoprotein associated protein more 56.98(n)
    60.35(a)
      827792  NM_001160786.1  NP_001154258.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g01666001 hypothetical protein 57.45(n)
    60.43(a)
      9270807  NM_001188139.1  NP_001175068.1 


    ENSEMBL Gene Tree for SNRPB (if available)
    TreeFam Gene Tree for SNRPB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNRPB gene
    SNRPN2  
    3 SIMAP similar genes for SNRPB using alignment to 6 protein entries:     RSMB_HUMAN (see all proteins):
    SNRPN    NAA38    LSM8

    SNRPB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SNRPB
    PGOHUM00000246309


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/202 SNPs in SNRPB are shown (see all 202)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9267261,2
    C,F,O,A,H--2403482(-) agccaA/C/Gaactg 2 -- us2k124MN NS EA NA WA CSA 2669
    rs1869612801,2
    --2441866(+) CTGCTC/TAGTGA 2 -- ds50010--------
    rs1428409601,2
    --2441959(+) GCAGAA/TAGTTA 2 -- ds50010--------
    rs1460942741,2
    --2442016(+) GCTTCA/GTGGAG 2 -- ds50010--------
    rs60492121,2
    C,F,H--2442022(+) TGGAGG/AAGCTA 2 -- ds500122Minor allele frequency- A:0.05NS EA NA WA CSA 1870
    rs745409121,2
    F--2442096(+) ATCTGA/GTAAGT 2 -- ds50011Minor allele frequency- G:0.01EA 120
    rs1171547811,2
    C,F--2442149(+) ACAGAT/CGCAAA 2 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1487575681,2
    --2442252(+) TCAAAG/TATTTT 2 -- ds50010--------
    rs60492161,2
    C,F,A,H--2442273(+) AAGATA/CCATAG 2 -- ds500129Minor allele frequency- C:0.10NS EA NA WA CSA 2499
    rs1906421681,2
    C--2442363(+) CCTTAA/C/TGGGAA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for SNRPB (2442280 - 2451499 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SNRPB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912601CNV Loss21882294
    nsv470535CNV Gain18288195
    dgv1303e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SNRPB
    DNA2.0 Custom Variant and Variant Library Synthesis for SNRPB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182282    OMIM disorders: --

    9 diseases for SNRPB:    About MalaCards
    mutism    systemic lupus erythematosus    lupus erythematosus    spinal muscular atrophy
    muscular atrophy    celiac disease    herpes simplex    breast cancer
    neuronitis


    SNRPB for disorders           About GeneDecksing

    Genetic Association Database (GAD): SNRPB
    Human Genome Epidemiology (HuGE) Navigator: SNRPB (1 document)

    Export disorders for SNRPB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNRPB gene, integrated from 9 sources (see all 99):
    (articles sorted by number of sources associating them with SNRPB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common variants associated with breast cancer in geno me-wide association studies are modifiers of breast cancer risk in BRCA1 and BR CA2 mutation carriers. (PubMed id 20418484)1, 4 Wang X....Couch F.J. (2010)
    2. Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. (PubMed id 16087681)1, 2 Azzouz T.N.... Schuemperli D. (2005)
    3. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (2004)
    4. Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. (PubMed id 12975319)1, 2 Pillai R.S.... Schuemperli D. (2003)
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    6. SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. (PubMed id 12095920)1, 2 Narayanan U.... Matera A.G. (2002)
    7. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. (PubMed id 11574479)1, 2 Pillai R.S.... Mueller B. (2001)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    9. Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci. (PubMed id 10556313)1, 2 Gray T.A.... Nicholls R.D. (1999)
    10. Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs. (PubMed id 10025403)1, 2 Kambach C.... Nagai K. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6628 HGNC: 11153 AceView: SNRPBandMGC10715 Ensembl:ENSG00000125835 euGenes: HUgn6628
    ECgene: SNRPB Kegg: 6628 H-InvDB: SNRPB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNRPB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNRPB gene:
    Search GeneIP for patents involving SNRPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SNRPB  
     OriGene qPCR primer pairs and template standards for SNRPB   OriGene Protein Over-expression Lysate for SNRPB  
     OriGene MassSpec something-or-other for SNRPB   OriGene clones in human, mouse for SNRPB  
     OriGene qSTAR qPCR primer pairs in human, mouse for SNRPB   OriGene Purified Protein for SNRPB  
     OriGene ORF clones in mouse, rat for SNRPB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SNRPB   OriGene Custom Protein Services for SNRPB  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNRPB
     QIAGEN SeqTarget long-range PCR primers for resequencing SNRPB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPB
     GenScript Custom Purified and Recombinant Proteins Services for SNRPB GenScript cDNA clones with any tag delivered in your preferred vector for SNRPB
     GenScript Custom Assay Services for SNRPB GenScript Custom Superior Antibodies Services for SNRPB
     GenScript Custom overexpressing Cell Line Services for SNRPB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SNRPB promoter
     Search Chromatin IP Primers for SNRPB
     RT2 qPCR Primer Assay in human, mouse, rat SNRPB
     Search GNC Networks for SNRPB
     SABiosciences Custom PCR Arrays for SNRPB
     Search Tocris compounds for SNRPB (RSMB)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SNRPB antibodies
     SNRPB proteins
     SNRPB lysates
     Antibodies for SNRPB
     See all of Abcam's Antibodies, Kits and Proteins for SNRPB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SNRPB
     Antibodies for SNRPB
     ELISAs for SNRPB
     CLIAs for SNRPB
     Search LifeMap BioReagents cell lines for SNRPB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPB
     SwitchGear 3'UTR luciferase reporter plasmids for SNRPB
     SwitchGear Promoter luciferase reporter plasmids for SNRPB
     ThermoFisher Antibody for SNRPB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SNRPB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SNRPB
    Customized:
     lentivirus for stable overexpression of SNRPB
     lentivirus expression plasmids for stable overexpression of SNRPB
     adenovirus for overexpression of SNRPB
     LSBio Antibodies in human, mouse, rat for SNRPB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SNRPB gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4