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SNRPB Gene

protein-coding   GIFtS: 64
GCID: GC20M002442

Small Nuclear Ribonucleoprotein Polypeptides B And B1


(Previous symbol: SNRPB1)
  See SNRPB-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Small Nuclear Ribonucleoprotein Polypeptides B And B11 2     SmB/SmB'2
SNRPB11 2 3     B Polypeptide Of Sm Protein2
COD2 3     sm-B/Sm-B'2
Sm-B/B'2 3     Small Nuclear Ribonucleoprotein Polypeptide B2
SmB/B'2 3     Small Nuclear Ribonucleoprotein Polypeptides B And B'2
Sm Protein B/B'2 3     Small Nuclear Ribonucleoprotein-Associated Proteins B And B'2
snRNP-B2 3     

External Ids:    HGNC: 111531   Entrez Gene: 66282   Ensembl: ENSG000001258357   OMIM: 1822825   UniProtKB: P146783   

Export aliases for SNRPB gene to outside databases

Previous GC identifers: GC20M002430 GC20M002390 GC20M002437 GC20M002392


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNRPB Gene:
The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6,
and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the
encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with
systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants
encoding different isoforms (B and B') have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SNRPB Gene:
SNRPB (small nuclear ribonucleoprotein polypeptides B and B1) is a protein-coding gene. Diseases associated with SNRPB include systemic lupus erythematosus. GO annotations related to this gene include histone pre-mRNA DCP binding. An important paralog of this gene is SNRPN.

UniProtKB/Swiss-Prot: RSMB_HUMAN, P14678
Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the
building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As
part of the U7 snRNP it is involved in histone 3'-end processing

Gene Wiki entry for SNRPB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNRPB gene promoter:
         COUP-TF1   SRF   COUP-TF   SRF (504 AA)   COUP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRPB promoter sequence
   Search Chromatin IP Primers for SNRPB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNRPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

SNRPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPB gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M002442:  view genomic region     (about GC identifiers)

Start:
2,442,280 bp from pter      End:
2,451,499 bp from pter
Size:
9,220 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RSMB_HUMAN, P14678 (See protein sequence)
Recommended Name: Small nuclear ribonucleoprotein-associated proteins B and B'  
Size: 240 amino acids; 24610 Da
Subunit: U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF
and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core
snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the
U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or
U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA.
Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8,
STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs
assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like
structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1.
Interacts with TDRD3 and SNUPN
Miscellaneous: Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies
directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. B/b' bear
Sm epitopes
Sequence caution: Sequence=AAD54488.1; Type=Erroneous gene model prediction;
Selected PDB 3D structures from and Proteopedia for SNRPB (see all 7):
1D3B (3D)        2Y9A (3D)        2Y9B (3D)        2Y9C (3D)        2Y9D (3D)        3CW1 (3D)    
Secondary accessions: Q15490 Q6IB35 Q9UIS5
Alternative splicing: 3 isoforms:  P14678-1   P14678-2   P14678-3   

Explore the universe of human proteins at neXtProt for SNRPB: NX_P14678

Explore proteomics data for SNRPB at MOPED

Post-translational modifications: 

  • Methylated. Arg-108 and Arg-112 are dimethylated, probably to asymmetric dimethylarginine1
  • Ubiquitination2 at Lys5, Lys8, Lys32, Lys36, Lys88
  • Modification sites at PhosphoSitePlus

  • See SNRPB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003082.1  NP_937859.1  

    ENSEMBL proteins: 
     ENSP00000370746   ENSP00000412566   ENSP00000474579   ENSP00000342305  
    Reactome Protein details: P14678

    SNRPB Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. CLIAs for SNRPB
    Search eBioscience for ELISAs for SNRPB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001163 Ribonucl_LSM
     IPR017131 snRNP-assoc_SmB/SmN
     IPR010920 LSM_dom
     IPR006649 Ribonucl_LSM_euk/arc

    Graphical View of Domain Structure for InterPro Entry P14678

    ProtoNet protein and cluster: P14678

    2 Blocks protein domains:
    IPB001163 Small nuclear ribonucleoprotein (Sm protein)
    IPB010920 Like-Sm ribonucleoprotein-related


    UniProtKB/Swiss-Prot: RSMB_HUMAN, P14678
    Similarity: Belongs to the snRNP SmB/SmN family


    Find genes that share domains with SNRPB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RSMB_HUMAN, P14678
    Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the
    building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
    spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
    that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As
    part of the U7 snRNP it is involved in histone 3'-end processing

         Genatlas biochemistry entry for SNRPB:
    small nuclear ribonucleoprotein,polypeptides B and B1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11714716
    GO:0044822poly(A) RNA binding IDA--
    GO:0071208histone pre-mRNA DCP binding IEA--
         
    Find genes that share ontologies with SNRPB           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for SNRPB:
     Cell division defect  Decreased homologous recombina  Decreased influenza A virus in  Decreased viability of wild-ty 
     Increased cell number in G2M,   Increased gamma-H2AX phosphory  Metaphase cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNRPB
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNRPB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNRPB

    miRNA
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    miRTarBase miRNAs that target SNRPB:
    hsa-mir-125b-5p (MIRT045972), hsa-mir-320a (MIRT044720), hsa-mir-124-3p (MIRT022383), hsa-mir-193b-3p (MIRT041541)

    Block miRNA regulation of human, mouse, rat SNRPB using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SNRPB:
    hsa-miR-495 hsa-let-7g* hsa-let-7a-2* hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidSNRPB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNRPB
    Predesigned siRNA for gene silencing in human, mouse, rat SNRPB

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SNRPB (NM_003091)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPB
    Addgene plasmids for SNRPB 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RSMB_HUMAN, P14678: Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the
    cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex TAS2531083
    GO:0005683U7 snRNP IDA11574479
    GO:0005685U1 snRNP IDA--

    Find genes that share ontologies with SNRPB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNRPB About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA processing0.44
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    mRNA Splicing0.78
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs0.00
    Cleavage of Growing Transcript in the Termination Region0.80
    SLBP independent Processing of Histone Pre-mRNAs0.00
    Processing of Capped Intronless Pre-mRNA0.52
    3Regulation of Glucokinase by Glucokinase Regulatory Protein
    Metabolism of non-coding RNA0.54
    snRNP Assembly0.54
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with SNRPB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNRPB
        mRNA processing

    Selected Reactome Pathways for SNRPB (see all 6)
        mRNA Splicing - Major Pathway
    SLBP independent Processing of Histone Pre-mRNAs
    snRNP Assembly
    Cleavage of Growing Transcript in the Termination Region
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs


    2 Kegg Pathways  (Kegg details for SNRPB):
        Spliceosome
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNRPB
    Interactions:

        Search GeneGlobe Interaction Network for SNRPB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNRPB (P146781, 2, 3 ENSP000004125664) via UniProtKB, MINT, STRING, and/or I2D (see all 238)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD2BP2O954002, 3, ENSP000003049034MINT-62827 MINT-62831 MINT-62664 MINT-62853 MINT-62655 MINT-62852 MINT-62851 MINT-62850 MINT-62849 MINT-62833 MINT-62652 I2D: score=2 STRING: ENSP00000304903
    CLNS1AP541051, 2, 3, ENSP000002633094EBI-372458,EBI-724693 MINT-8332646 I2D: score=3 STRING: ENSP00000263309
    SMN1Q166372, 3, ENSP000003700834MINT-14172 MINT-14173 MINT-14174 I2D: score=6 STRING: ENSP00000370083
    GIGYF2Q6Y7W62, 3, ENSP000003871704MINT-65887 MINT-65884 MINT-65888 MINT-65907 I2D: score=2 STRING: ENSP00000387170
    GEMIN4P576782, 3, ENSP000003217064MINT-15055 MINT-15056 I2D: score=5 STRING: ENSP00000321706
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    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0008334histone mRNA metabolic process TAS--

    Find genes that share ontologies with SNRPB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNRPB (RSMB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SNRPB gene (2 alternative transcripts): 
    NM_003091.3  NM_198216.1  

    Unigene Cluster for SNRPB:

    Small nuclear ribonucleoprotein polypeptides B and B1
    Hs.83753  [show with all ESTs]
    Unigene Representative Sequence: BM564070
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381342(uc002wga.1) ENST00000438552(uc002wfz.1) ENST00000474384
    ENST00000339610(uc010zpv.2 uc002wgb.3 uc010gan.3)
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate SNRPB:
    hsa-miR-495 hsa-let-7g* hsa-let-7a-2* hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidSNRPB 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): SNRPB (NM_003091)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPB
    Addgene plasmids for SNRPB 
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      QuantiTect SYBR Green Assays in human, mouse, rat SNRPB
      QuantiFast Probe-based Assays in human, mouse, rat SNRPB

    Additional mRNA sequence: 

    AK301034.1 AK301206.1 AK307093.1 AK307266.1 AK312620.1 AY742712.1 BC080516.1 CR456969.1 
    J04564.1 M34081.1 M34082.1 X15893.1 X17567.1 X17568.1 

    Selected DOTS entries (see all 27):

    DT.100045354  DT.455957  DT.101985257  DT.100042501  DT.95325267  DT.99981347  DT.100880258  DT.95099492 
    DT.100880254  DT.95325250  DT.100880270  DT.102837046  DT.95325254  DT.100880269  DT.120829112  DT.100880264 
    DT.97862682  DT.100880257  DT.450384  DT.95325273  DT.95325431  DT.100880260  DT.120829127  DT.120829147 

    Selected AceView cDNA sequences (see all 1609):

    CR598745 BM511626 CR615802 X17567 W74721 BG681145 BQ055542 BQ071067 
    BQ944696 BG170745 AA378811 BG482242 BM765119 BM751847 AI969111 BE298492 
    BU070577 BI862124 BE256280 BQ069036 BE880916 BG775048 BM477491 BQ650671 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SNRPB (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b
    SP1:                          -     -     -           -     -     -     -     -                                                         
    SP2:                          -     -     -           -     -     -     -     -                                         -               
    SP3:                          -     -     -           -     -     -     -     -                                                         
    SP4:                                      -           -     -                                                                           
    SP5:                                      -           -     -     -     -     -                                                         


    ECgene alternative splicing isoforms for SNRPB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SNRPB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATTGTCTG
    SNRPB Expression
    About this image


    SNRPB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
     
     Thyroid (Endocrine System)
    SNRPB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNRPB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.83753
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SNRPB gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrpb1 , 5 small nuclear ribonucleoprotein B1, 5 91.85(n)1
    99.56(a)1
      2 (63.19 cM)5
    206381  NM_009225.21  NP_033251.11 
     1301714145 
    chicken
    (Gallus gallus)
    Aves SNRB'6
    small nuclear ribonucleoprotein-associated protein...
    49(a)
    1 → many
    20(11094571-11097691)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Small nuclear ribonucleoprotein-associated protein...
    96(a)
    1 → many
    GL343820.1(155984-166215)
    African clawed frog
    (Xenopus laevis)
    Amphibia snrpn-prov2 small nuclear ribonucleoparticle-associated protein more 76.29(n)    BC041275.1 
    zebrafish
    (Danio rerio)
    Actinopterygii snrpb6
    small nuclear ribonucleoprotein polypeptides B and...
    95(a)
    1 → many
    6(57428411-57435485) ENSDARG00000011125
    fruit fly
    (Drosophila melanogaster)
    Insecta SmB3 mRNA splicing 70(a)   31E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea snr-26
    Protein SNR-2 (snr-2) mRNA, complete cds
    58(a)
    1 → many
    I(13339397-13340227) WBGene00004915
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMB16
    Core Sm protein Sm B; part of heteroheptameric com...
    30(a)
    1 → many
    V(212587-213177) YER029C


    ENSEMBL Gene Tree for SNRPB (if available)
    TreeFam Gene Tree for SNRPB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNRPB gene
    SNRPN2  
    3 SIMAP similar genes for SNRPB using alignment to 7 protein entries:     RSMB_HUMAN (see all proteins):
    SNRPN    NAA38    LSM8

    Find genes that share paralogs with SNRPB           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SNRPB
    PGOHUM00000246309


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNRPB (see all 202)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9267261,2
    C,F,O,A,H--2403482(-) agccaA/C/Gaactg 2 -- us2k124MN NS EA NA WA CSA 2669
    rs1869612801,2
    --2441866(+) CTGCTC/TAGTGA 2 -- ds50010--------
    rs1428409601,2
    --2441959(+) GCAGAA/TAGTTA 2 -- ds50010--------
    rs1460942741,2
    --2442016(+) GCTTCA/GTGGAG 2 -- ds50010--------
    rs60492121,2
    C,F,H--2442022(+) TGGAGG/AAGCTA 2 -- ds500122Minor allele frequency- A:0.05NS EA NA WA CSA 1870
    rs745409121,2
    F--2442096(+) ATCTGA/GTAAGT 2 -- ds50011Minor allele frequency- G:0.01EA 120
    rs1171547811,2
    C,F--2442149(+) ACAGAT/CGCAAA 2 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1487575681,2
    --2442252(+) TCAAAG/TATTTT 2 -- ds50010--------
    rs60492161,2
    C,F,A,H--2442273(+) AAGATA/CCATAG 2 -- ds500129Minor allele frequency- C:0.10NS EA NA WA CSA 2499
    rs1906421681,2
    C--2442363(+) CCTTAA/C/TGGGAA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for SNRPB (2442280 - 2451499 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SNRPB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912601CNV Loss21882294
    nsv470535CNV Gain18288195
    dgv1303e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182282    OMIM disorders: --

    1 disease for SNRPB:    
    About MalaCards
    systemic lupus erythematosus


    Find genes that share disorders with SNRPB           About GenesLikeMe

    Genetic Association Database (GAD): SNRPB
    Human Genome Epidemiology (HuGE) Navigator: SNRPB (1 document)

    Export disorders for SNRPB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNRPB gene, integrated from 10 sources (see all 102):
    (articles sorted by number of sources associating them with SNRPB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. (PubMed id 20418484)1, 4 Wang X....Couch F.J. (Hum. Mol. Genet. 2010)
    2. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PubMed id 18984161)1, 2 Chari A....Fischer U. (Cell 2008)
    3. Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. (PubMed id 16087681)1, 2 Azzouz T.N.... Schuemperli D. (J. Biol. Chem. 2005)
    4. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (RNA 2004)
    5. Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. (PubMed id 12975319)1, 2 Pillai R.S.... Schuemperli D. (Genes Dev. 2003)
    6. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    7. SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. (PubMed id 12095920)1, 2 Narayanan U.... Matera A.G. (Hum. Mol. Genet. 2002)
    8. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. (PubMed id 11574479)1, 2 Pillai R.S.... Mueller B. (EMBO J. 2001)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    10. Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci. (PubMed id 10556313)1, 2 Gray T.A.... Nicholls R.D. (Nucleic Acids Res. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6628 HGNC: 11153 AceView: SNRPBandMGC10715 Ensembl:ENSG00000125835 euGenes: HUgn6628
    ECgene: SNRPB Kegg: 6628 H-InvDB: SNRPB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNRPB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNRPB gene:
    Search GeneIP for patents involving SNRPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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