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Aliases for SNRPA1 Gene

Aliases for SNRPA1 Gene

  • Small Nuclear Ribonucleoprotein Polypeptide A' 2
  • Small Nuclear Ribonucleoprotein Polypeptide A 2 3
  • U2 SnRNP A 3 4
  • U2 Small Nuclear Ribonucleoprotein Polypeptide A 3
  • U2 Small Nuclear Ribonucleoprotein A 3
  • Lea1 3

External Ids for SNRPA1 Gene

Previous GeneCards Identifiers for SNRPA1 Gene

  • GC15M098673
  • GC15M095663
  • GC15M099414
  • GC15M099556
  • GC15M099553
  • GC15M099639
  • GC15M101821
  • GC15M077944

Summaries for SNRPA1 Gene

GeneCards Summary for SNRPA1 Gene

SNRPA1 (Small Nuclear Ribonucleoprotein Polypeptide A') is a Protein Coding gene. Diseases associated with SNRPA1 include pasteurellosis. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for SNRPA1 Gene

  • This protein is associated with sn-RNP U2. It helps the A protein to bind stem loop IV of U2 snRNA

Gene Wiki entry for SNRPA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPA1 Gene

Genomics for SNRPA1 Gene

Regulatory Elements for SNRPA1 Gene

Genomic Location for SNRPA1 Gene

Start:
101,281,510 bp from pter
End:
101,295,282 bp from pter
Size:
13,773 bases
Orientation:
Minus strand

Genomic View for SNRPA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNRPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPA1 Gene

Proteins for SNRPA1 Gene

  • Protein details for SNRPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09661-RU2A_HUMAN
    Recommended name:
    U2 small nuclear ribonucleoprotein A
    Protein Accession:
    P09661
    Secondary Accessions:
    • B2R5I6
    • Q8TBD2

    Protein attributes for SNRPA1 Gene

    Size:
    255 amino acids
    Molecular mass:
    28416 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B.

    Three dimensional structures from OCA and Proteopedia for SNRPA1 Gene

neXtProt entry for SNRPA1 Gene

Proteomics data for SNRPA1 Gene at MOPED

Post-translational modifications for SNRPA1 Gene

  • Ubiquitination at Lys149, Lys179, Lys205, and Lys221
  • Modification sites at PhosphoSitePlus

Other Protein References for SNRPA1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SNRPA1 Gene

Domains for SNRPA1 Gene

Protein Domains for SNRPA1 Gene

Graphical View of Domain Structure for InterPro Entry

P09661

UniProtKB/Swiss-Prot:

RU2A_HUMAN :
  • P09661
Domain:
  • Contains 1 LRRCT domain.
Family:
  • Belongs to the U2 small nuclear ribonucleoprotein A family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SNRPA1: view

No data available for Gene Families for SNRPA1 Gene

Function for SNRPA1 Gene

Molecular function for SNRPA1 Gene

UniProtKB/Swiss-Prot Function: This protein is associated with sn-RNP U2. It helps the A protein to bind stem loop IV of U2 snRNA

Gene Ontology (GO) - Molecular Function for SNRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22365833
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with SNRPA1: view
genes like me logo Genes that share phenotypes with SNRPA1: view

miRNA for SNRPA1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNRPA1 Gene

Localization for SNRPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRPA1 Gene COMPARTMENTS Subcellular localization image for SNRPA1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SNRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005686 U2 snRNP TAS 2928112
GO:0019013 viral nucleocapsid --
genes like me logo Genes that share ontologies with SNRPA1: view

Pathways for SNRPA1 Gene

genes like me logo Genes that share pathways with SNRPA1: view

Pathways by source for SNRPA1 Gene

1 KEGG pathway for SNRPA1 Gene

Gene Ontology (GO) - Biological Process for SNRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SNRPA1: view

Transcripts for SNRPA1 Gene

Unigene Clusters for SNRPA1 Gene

Small nuclear ribonucleoprotein polypeptide A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPA1 Gene

No ASD Table

Relevant External Links for SNRPA1 Gene

GeneLoc Exon Structure for
SNRPA1
ECgene alternative splicing isoforms for
SNRPA1

Expression for SNRPA1 Gene

mRNA expression in normal human tissues for SNRPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNRPA1 Gene

SOURCE GeneReport for Unigene cluster for SNRPA1 Gene Hs.528763

genes like me logo Genes that share expressions with SNRPA1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNRPA1 Gene

Orthologs for SNRPA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRPA1 35
  • 99.74 (n)
  • 100 (a)
SNRPA1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNRPA1 35
  • 93.33 (n)
  • 99.22 (a)
SNRPA1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRPA1 35
  • 94.51 (n)
  • 100 (a)
SNRPA1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snrpa1 35
  • 91.5 (n)
  • 98.04 (a)
Snrpa1 16
Snrpa1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNRPA1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNRPA1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snrpa1 35
  • 92.42 (n)
  • 98.04 (a)
chicken
(Gallus gallus)
Aves SNRPA1 35
  • 82.09 (n)
  • 91.37 (a)
SNRPA1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNRPA1 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23786 35
tropical clawed frog
(Silurana tropicalis)
Amphibia snrpa1 35
  • 76.47 (n)
  • 81.96 (a)
zebrafish
(Danio rerio)
Actinopterygii snrpa1 35
  • 76.41 (n)
  • 84.75 (a)
snrpa1 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007670 35
  • 56.13 (n)
  • 58.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta U2A 35
  • 56.28 (n)
  • 55.84 (a)
U2A 36
  • 50 (a)
OneToOne
U2A 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea mog-2 35
  • 55.51 (n)
  • 50 (a)
mog-2 36
  • 47 (a)
OneToOne
H20J04.8 37
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEA1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons U2A 35
  • 54.26 (n)
  • 53.25 (a)
corn
(Zea mays)
Liliopsida Zm.15425 35
rice
(Oryza sativa)
Liliopsida Os02g0234800 35
  • 59.42 (n)
  • 55.65 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.22751 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06622 35
  • 48.39 (n)
  • 43.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes lea1 35
  • 49.64 (n)
  • 44.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4424 36
  • 58 (a)
OneToOne
Species with no ortholog for SNRPA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SNRPA1 Gene

ENSEMBL:
Gene Tree for SNRPA1 (if available)
TreeFam:
Gene Tree for SNRPA1 (if available)

Paralogs for SNRPA1 Gene

Pseudogenes.org Pseudogenes for SNRPA1 Gene

genes like me logo Genes that share paralogs with SNRPA1: view

No data available for Paralogs for SNRPA1 Gene

Variants for SNRPA1 Gene

Sequence variations from dbSNP and Humsavar for SNRPA1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1050845 -- 101,281,589(-) TGATA(A/G)TTTTG utr-variant-3-prime, nc-transcript-variant
rs1054887 -- 101,291,642(-) GTTGT(A/T)TTCTA intron-variant
rs1482918 -- 101,292,878(+) AAAAA(A/C)TATTT intron-variant
rs1545855 -- 101,291,473(+) caaaa(C/T)gttat intron-variant
rs2898864 -- 101,289,297(-) ACCCT(C/G)CTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNRPA1 Gene

Variant ID Type Subtype PubMed ID
esv34275 CNV Gain 17911159
nsv833110 CNV Gain+Loss 17160897
dgv786e1 CNV Complex 17122850
dgv787e1 CNV Complex 17122850
nsv428314 CNV Loss 18775914
nsv904598 CNV Loss 21882294
nsv904599 CNV Gain 21882294
dgv2450n71 CNV Loss 21882294

Relevant External Links for SNRPA1 Gene

HapMap Linkage Disequilibrium report
SNRPA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRPA1 Gene

Disorders for SNRPA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SNRPA1 Gene including...

Search for SNRPA1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SNRPA1 Gene

genes like me logo Genes that share disorders with SNRPA1: view

No data available for UniProtKB/Swiss-Prot for SNRPA1 Gene

Publications for SNRPA1 Gene

  1. Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein. (PMID: 2928112) Sillekens P.T.G. … van Venrooij W.J. (Nucleic Acids Res. 1989) 2 3 4
  2. The SRm160/300 splicing coactivator is required for exon-enhancer function. (PMID: 10339552) Eldridge A.G. … Blencowe B.J. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  4. A coactivator of pre-mRNA splicing. (PMID: 9531537) Blencowe B.J. … Sharp P.A. (Genes Dev. 1998) 3 4
  5. Crystal structure of the spliceosomal U2B'-U2A' protein complex bound to a fragment of U2 small nuclear RNA. (PMID: 9716128) Price S.R. … Nagai K. (Nature 1998) 3 4

Products for SNRPA1 Gene

Sources for SNRPA1 Gene

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