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SNRPA1 Gene

protein-coding   GIFtS: 63
GCID: GC15M101821

Small Nuclear Ribonucleoprotein Polypeptide A'

  See SNRPA1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Small Nuclear Ribonucleoprotein Polypeptide A'1 2
U2 SnRNP A'2 3
Lea12
U2 Small Nuclear Ribonucleoprotein A'2
U2 Small Nuclear Ribonucleoprotein Polypeptide A'2

External Ids:    HGNC: 111521   Entrez Gene: 66272   Ensembl: ENSG000001318767   OMIM: 6035215   UniProtKB: P096613   
ORGUL members:         

Export aliases for SNRPA1 gene to outside databases

Previous GC identifers: GC15M098673 GC15M095663 GC15M099414 GC15M099556 GC15M099553 GC15M099639 GC15M077944


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SNRPA1 Gene:
SNRPA1 (small nuclear ribonucleoprotein polypeptide A') is a protein-coding gene. Diseases associated with SNRPA1 include pasteurellosis. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: RU2A_HUMAN, P09661
Function: This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA

Gene Wiki entry for SNRPA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNRPA1 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   AREB6   IRF-2   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRPA1 promoter sequence
   Search Chromatin IP Primers for SNRPA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNRPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

SNRPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPA1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M101821:  view genomic region     (about GC identifiers)

Start:
101,821,715 bp from pter      End:
101,835,487 bp from pter
Size:
13,773 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RU2A_HUMAN, P09661 (See protein sequence)
Recommended Name: U2 small nuclear ribonucleoprotein A'  
Size: 255 amino acids; 28416 Da
Subunit: Identified in the spliceosome C complex. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70,
SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1
and TRA2B
1 PDB 3D structure from and Proteopedia for SNRPA1:
1A9N (3D)    
Secondary accessions: B2R5I6 Q8TBD2

Explore the universe of human proteins at neXtProt for SNRPA1: NX_P09661

Explore proteomics data for SNRPA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys149, Lys179, Lys205, Lys221
  • Modification sites at PhosphoSitePlus

  • See SNRPA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003081.2  
    ENSEMBL proteins: 
     ENSP00000254193   ENSP00000452836   ENSP00000453309   ENSP00000453521  
    Reactome Protein details: P09661

    SNRPA1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SNRPA1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SNRPA1
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    Novus Biologicals SNRPA1 Proteins
    Novus Biologicals SNRPA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SNRPA1
    Cloud-Clone Corp. Proteins for SNRPA1

     
    Search eBioscience for Proteins for SNRPA1 

    SNRPA1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for SNRPA1

    SNRPA1 Assay Products:

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    Cloud-Clone Corp. ELISAs for SNRPA1
    Cloud-Clone Corp. CLIAs for SNRPA1
    Search eBioscience for ELISAs for SNRPA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003603 U2A'_phosphoprotein32A_C
     IPR001611 Leu-rich_rpt

    Graphical View of Domain Structure for InterPro Entry P09661

    ProtoNet protein and cluster: P09661

    1 Blocks protein domain: IPB003603 Leucine-rich-associated

    UniProtKB/Swiss-Prot: RU2A_HUMAN, P09661
    Similarity: Belongs to the U2 small nuclear ribonucleoprotein A family
    Similarity: Contains 4 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain


    Find genes that share domains with SNRPA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RU2A_HUMAN, P09661
    Function: This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SNRPA1           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SNRPA1:
     Cell division defect  Decreased Salmonella enterica   Increased G2M DNA content  Increased gamma-H2AX phosphory 
     Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNRPA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNRPA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNRPA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNRPA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNRPA1:
    hsa-mir-375 (MIRT019817), hsa-mir-34a-5p (MIRT047363), hsa-mir-98-5p (MIRT027521), hsa-mir-16-5p (MIRT031694), hsa-mir-182-5p (MIRT047183)

    Block miRNA regulation of human, mouse, rat SNRPA1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SNRPA1:
    hsa-miR-607 hsa-miR-520d-5p hsa-miR-3674 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidSNRPA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNRPA1
    Predesigned siRNA for gene silencing in human, mouse, rat SNRPA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNRPA1

    Clone
    Products:
         
    OriGene clones in human, mouse for SNRPA1 (see all 6)
    OriGene ORF clones in mouse, rat for SNRPA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNRPA1 (NM_003090)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SNRPA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SNRPA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RU2A_HUMAN, P09661: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005686U2 snRNP TAS2928112
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with SNRPA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNRPA1 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome


    Find genes that share SuperPaths with SNRPA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNRPA1
        mRNA processing

    1 Reactome Pathway for SNRPA1
        mRNA Splicing - Major Pathway


    1 Kegg Pathway  (Kegg details for SNRPA1):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNRPA1
    Interactions:

        Search GeneGlobe Interaction Network for SNRPA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNRPA1 (P096611, 2, 3 ENSP000002541934) via UniProtKB, MINT, STRING, and/or I2D (see all 768)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNRPB2P085791, 2, 3, ENSP000002460714EBI-876439,EBI-1053651 MINT-8332592 MINT-8333350 I2D: score=4 STRING: ENSP00000246071
    SF3A2Q154282, 3, ENSP000002214944MINT-5205422 MINT-7947479 I2D: score=2 STRING: ENSP00000221494
    SMN1Q166372, 3, ENSP000003700834MINT-7947479 I2D: score=2 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7947479 I2D: score=2 STRING: ENSP00000370119
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7947479 I2D: score=1 STRING: ENSP00000326261
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with SNRPA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNRPA1 (RU2A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SNRPA1 gene: 
    NM_003090.2  

    Unigene Cluster for SNRPA1:

    Small nuclear ribonucleoprotein polypeptide A'
    Hs.528763  [show with all ESTs]
    Unigene Representative Sequence: AK090986
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254193(uc002bww.3 uc002bwx.3 uc010bpc.3) ENST00000560307
    ENST00000559309 ENST00000558036 ENST00000560433 ENST00000394082 ENST00000540017
    ENST00000560496 ENST00000559686 ENST00000560383 ENST00000558059 ENST00000560987
    ENST00000560856 ENST00000558020 ENST00000561187
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SNRPA1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SNRPA1:
    hsa-miR-607 hsa-miR-520d-5p hsa-miR-3674 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidSNRPA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SNRPA1
    Predesigned siRNA for gene silencing in human, mouse, rat SNRPA1
    Clone
    Products:
         
    OriGene clones in human, mouse for SNRPA1 (see all 6)
    OriGene ORF clones in mouse, rat for SNRPA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNRPA1 (NM_003090)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNRPA1
    OriGene qSTAR qPCR primer pairs in human, mouse for SNRPA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNRPA1
      QuantiTect SYBR Green Assays in human, mouse, rat SNRPA1
      QuantiFast Probe-based Assays in human, mouse, rat SNRPA1

    Additional mRNA sequence: 

    AJ130971.1 AJ130972.1 AK090986.1 AK223070.1 AK223110.1 AK290078.1 AK312200.1 BC022816.1 
    BC067846.1 BC071717.1 X13482.1 

    23 DOTS entries:

    DT.316304  DT.102819753  DT.100821393  DT.75103673  DT.100773186  DT.120946756  DT.207204  DT.95287459 
    DT.100028428  DT.100821397  DT.121014148  DT.92439890  DT.95287446  DT.95287471  DT.121014134  DT.121014138 
    DT.91935841  DT.91973037  DT.95287447  DT.95287463  DT.102819752  DT.120946761  DT.95235756 

    Selected AceView cDNA sequences (see all 242):

    AI354841 CB107988 BI520025 BE674941 BM847072 BM846187 CA420435 AA344438 
    AA894407 BG260905 CR605454 W58098 BX102197 BQ427874 CD251339 BM717368 
    NM_003090 BM702193 BU678792 AA908433 CA771934 AV715754 BM972100 BQ001692 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNRPA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATAATAGC
    SNRPA1 Expression
    About this image


    SNRPA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    SNRPA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNRPA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528763
        Custom PCR Arrays for SNRPA1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SNRPA1
    OriGene qSTAR qPCR primer pairs in human, mouse for SNRPA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNRPA1
    QuantiTect SYBR Green Assays in human, mouse, rat SNRPA1
    QuantiFast Probe-based Assays in human, mouse, rat SNRPA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRPA1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrpa11 , 5 small nuclear ribonucleoprotein polypeptide A'1, 5 91.5(n)1
    98.04(a)1
      7 (35.47 cM)5
    689811  NM_021336.41  NP_067311.41 
     660602995 
    chicken
    (Gallus gallus)
    Aves SNRPA11 small nuclear ribonucleoprotein polypeptide A' 82.09(n)
    91.37(a)
      415523  NM_001005823.1  NP_001005823.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNRPA16
    small nuclear ribonucleoprotein polypeptide A'
    88(a)
    1 ↔ 1
    GL343941.1(15879-26283)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237862 Xenopus laevis transcribed sequence with moderate similarity more 78.29(n)    CA983301.1 
    zebrafish
    (Danio rerio)
    Actinopterygii snrpa11 small nuclear ribonucleoprotein polypeptide A' 76.41(n)
    84.75(a)
      492511  NM_001007383.2  NP_001007384.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta U2A1 , 3 mRNA splicing RNA binding3
    U2A1
    53(a)3
    56.28(n)1
    55.84(a)1
      43E93
    357131  NM_136471.41  NP_610315.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H20J04.83
    mog-21
    mog-21 47(a)3
    55.51(n)1
    50(a)1
      II(4324365-4325865)3
    1737671  NM_062362.31  NP_494763.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons U2A'1 U2A' 54.26(n)
    53.25(a)
      837505  NM_100848.4  NP_172447.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g02348001 Os02g0234800 59.42(n)
    55.65(a)
      4328823  NM_001052918.1  NP_001046383.1 


    ENSEMBL Gene Tree for SNRPA1 (if available)
    TreeFam Gene Tree for SNRPA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNRPA1 gene

    Find genes that share paralogs with SNRPA1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SNRPA1
    PGOHUM00000246357


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNRPA1 (see all 450)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839096991,2
    C--101821371(+) TGGGAA/GGCCAA 1 -- int10--------
    rs1402370201,2
    C--101821457(+) GGTTTA/GGTGGG 1 -- int10--------
    rs1504502871,2
    C--101821516(+) AAGCCA/GGAGCG 1 -- int10--------
    rs80364131,2
    H--101821520(+) CGGAGC/TGACAG 1 -- int14Minor allele frequency- T:0.00NS EA 418
    rs1382844731,2
    C--101821568(+) AAAAGC/GCGGCC 1 -- int10--------
    rs49658151,2
    C,F,H--101821609(+) CCAGAC/TGCTAA 1 -- int120Minor allele frequency- T:0.11NS EA NA 2446
    rs1886817261,2
    --101821629(+) GGAAGC/GCTACC 1 -- int10--------
    rs1818055031,2
    --101821635(+) CTACCA/GAGAAA 1 -- int10--------
    rs10508451,2
    C,H--101821794(-) TGATAA/GTTTTG 1 -- ut313Minor allele frequency- G:0.01NS NA 226
    rs740419611,2
    C,F--101821912(+) TATTAT/CACATC 1 -- ut312Minor allele frequency- C:0.00WA EU 1325

    HapMap Linkage Disequilibrium report for SNRPA1 (101821715 - 101835487 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SNRPA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2450n71CNV Loss21882294
    nsv904598CNV Loss21882294
    nsv428314CNV Loss18775914
    esv34275CNV Gain17911159
    nsv904599CNV Gain21882294
    nsv833110CNV Gain+Loss17160897
    dgv787e1CNV Complex17122850
    dgv786e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603521    OMIM disorders: --

    1 disease for SNRPA1:    
    About MalaCards
    pasteurellosis

    1 disease from the University of Copenhagen DISEASES database for SNRPA1:
    Pasteurellosis

    Find genes that share disorders with SNRPA1           About GenesLikeMe


    Export disorders for SNRPA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNRPA1 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with SNRPA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein. (PubMed id 2928112)1, 2, 3 Sillekens P.T.G.... van Venrooij W.J. (Nucleic Acids Res. 1989)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    5. The SRm160/300 splicing coactivator is required for exon-enhancer function. (PubMed id 10339552)1, 2 Eldridge A.G.... Blencowe B.J. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    6. Crystal structure of the spliceosomal U2B'-U2A' protein complex bound to a fragment of U2 small nuclear RNA. (PubMed id 9716128)1, 2 Price S.R.... Nagai K. (Nature 1998)
    7. A coactivator of pre-mRNA splicing. (PubMed id 9531537)1, 2 Blencowe B.J.... Sharp P.A. (Genes Dev. 1998)
    8. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    9. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    10. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6627 HGNC: 11152 AceView: SNRPA1 Ensembl:ENSG00000131876 euGenes: HUgn6627
    ECgene: SNRPA1 Kegg: 6627 H-InvDB: SNRPA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNRPA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SNRPA1 gene:
    Search GeneIP for patents involving SNRPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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