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Aliases for SNRPA Gene

Aliases for SNRPA Gene

  • Small Nuclear Ribonucleoprotein Polypeptide A 2 3
  • U1 SnRNP A 3 4
  • U1-A 3 4
  • U1A 3 4
  • U1 Small Nuclear Ribonucleoprotein A 3
  • U1 Small Nuclear RNP-Specific A 3
  • U1 SnRNP-Specific Protein A 3
  • Mud1 3

External Ids for SNRPA Gene

Summaries for SNRPA Gene

Entrez Gene Summary for SNRPA Gene

  • The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]

GeneCards Summary for SNRPA Gene

SNRPA (Small Nuclear Ribonucleoprotein Polypeptide A) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include RNA binding and snRNA binding. An important paralog of this gene is SNRPB2.

UniProtKB/Swiss-Prot for SNRPA Gene

  • Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5 splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5-UGCAC-3 motif on RNAs.

Gene Wiki entry for SNRPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPA Gene

Genomics for SNRPA Gene

Genomic Location for SNRPA Gene

Start:
40,750,637 bp from pter
End:
40,765,392 bp from pter
Size:
14,756 bases
Orientation:
Plus strand

Genomic View for SNRPA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNRPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPA Gene

Regulatory Elements for SNRPA Gene

Proteins for SNRPA Gene

  • Protein details for SNRPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09012-SNRPA_HUMAN
    Recommended name:
    U1 small nuclear ribonucleoprotein A
    Protein Accession:
    P09012
    Secondary Accessions:

    Protein attributes for SNRPA Gene

    Size:
    282 amino acids
    Molecular mass:
    31280 Da
    Quaternary structure:
    • U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SFPQ; component of a snRNP-free complex with SFPQ.

    Three dimensional structures from OCA and Proteopedia for SNRPA Gene

neXtProt entry for SNRPA Gene

Proteomics data for SNRPA Gene at MOPED

Post-translational modifications for SNRPA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys20, Lys60, Lys88, Lys96, Lys98, Lys268, and Lys276

Other Protein References for SNRPA Gene

No data available for DME Specific Peptides for SNRPA Gene

Domains for SNRPA Gene

Gene Families for SNRPA Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

UniProtKB/Swiss-Prot:

SNRPA_HUMAN
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.:
    • P09012
Family:
  • Belongs to the RRM U1 A/B family.:
    • P09012
genes like me logo Genes that share domains with SNRPA: view

Function for SNRPA Gene

Molecular function for SNRPA Gene

GENATLAS Biochemistry: samll ribonucleoprotein U1,A polypeptide
UniProtKB/Swiss-Prot Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5 splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5-UGCAC-3 motif on RNAs.

Gene Ontology (GO) - Molecular Function for SNRPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IDA 19561594
GO:0005515 protein binding IPI 10688667
GO:0017069 snRNA binding IEA --
genes like me logo Genes that share ontologies with SNRPA: view

miRNA for SNRPA Gene

miRTarBase miRNAs that target SNRPA

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNRPA Gene

Localization for SNRPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRPA Gene COMPARTMENTS Subcellular localization image for SNRPA gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SNRPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005685 U1 snRNP IDA 21113136
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SNRPA: view

Pathways for SNRPA Gene

genes like me logo Genes that share pathways with SNRPA: view

Pathways by source for SNRPA Gene

1 KEGG pathway for SNRPA Gene

Gene Ontology (GO) - Biological Process for SNRPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SNRPA: view

Compounds for SNRPA Gene

(1) Drugbank Compounds for SNRPA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Malonic acid
  • Malonate
141-82-2 target

(7) Novoseek inferred chemical compound relationships for SNRPA Gene

Compound -log(P) Hits PubMed IDs
adenylate 41.5 13
hydrogen 27.4 8
adenine 19.3 5
guanidine hydrochloride 17.1 1
cysteine 0.481 1
genes like me logo Genes that share compounds with SNRPA: view

Transcripts for SNRPA Gene

Unigene Clusters for SNRPA Gene

Small nuclear ribonucleoprotein polypeptide A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPA Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9
SP1: - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - -
SP8: -
SP9: - -
SP10: -

Relevant External Links for SNRPA Gene

GeneLoc Exon Structure for
SNRPA
ECgene alternative splicing isoforms for
SNRPA

Expression for SNRPA Gene

mRNA expression in normal human tissues for SNRPA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNRPA Gene

SOURCE GeneReport for Unigene cluster for SNRPA Gene Hs.466775

genes like me logo Genes that share expressions with SNRPA: view

Orthologs for SNRPA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRPA 36
  • 99.65 (n)
  • 99.65 (a)
SNRPA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNRPA 36
  • 91.13 (n)
  • 98.23 (a)
SNRPA 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRPA 36
  • 91.61 (n)
  • 98.94 (a)
SNRPA 37
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5145 37
  • 90 (a)
OneToMany
Snrpa 16
Snrpa 37
  • 94 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SNRPA 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNRPA 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snrpa 36
  • 89.44 (n)
  • 98.93 (a)
lizard
(Anolis carolinensis)
Reptilia SNRPA 37
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia snf-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia snrpa 36
  • 73.78 (n)
  • 82.92 (a)
Str.3059 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
snrpa 36
  • 76.22 (n)
  • 84.23 (a)
snrpa 37
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011637 36
  • 70.51 (n)
  • 73.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta snf 36
  • 75.08 (n)
  • 77.78 (a)
snf 37
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rnp-2 36
  • 60.03 (n)
  • 56.22 (a)
rnp-2 37
  • 52 (a)
ManyToMany
rnp-3 37
  • 50 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSL1 37
  • 27 (a)
OneToMany
MSL1 39
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7167 36
thale cress
(Arabidopsis thaliana)
eudicotyledons U1A 36
  • 54.99 (n)
  • 54.7 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1400 36
corn
(Zea mays)
Liliopsida Zm.3121 36
rice
(Oryza sativa)
Liliopsida Os.9766 36
Os05g0154800 36
  • 60.78 (n)
  • 59.48 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5442 36
bread mold
(Neurospora crassa)
Ascomycetes NCU08034 36
  • 48.24 (n)
  • 35.77 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes usp102 36
  • 45.68 (n)
  • 39.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10455 37
  • 55 (a)
OneToMany
Species with no ortholog for SNRPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SNRPA Gene

ENSEMBL:
Gene Tree for SNRPA (if available)
TreeFam:
Gene Tree for SNRPA (if available)

Paralogs for SNRPA Gene

Paralogs for SNRPA Gene

Selected SIMAP similar genes for SNRPA Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SNRPA: view

Variants for SNRPA Gene

Sequence variations from dbSNP and Humsavar for SNRPA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs13108 -- 40,765,199(+) TCCCC(C/T)GTTCT utr-variant-3-prime
rs736625 -- 40,759,296(+) CTGCT(C/T)GCTTT intron-variant
rs897810 -- 40,759,866(+) GTTTC(A/G)CTCTC intron-variant
rs1058852 -- 40,765,266(+) GCCTT(C/T)TTGGA utr-variant-3-prime
rs2076808 -- 40,759,278(+) ctcct(A/G)gcctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNRPA Gene

Variant ID Type Subtype PubMed ID
esv21537 CNV Loss 19812545
nsv833832 CNV Loss 17160897

Relevant External Links for SNRPA Gene

HapMap Linkage Disequilibrium report
SNRPA

Disorders for SNRPA Gene

(2) University of Copenhagen DISEASES for SNRPA Gene

(3) Novoseek inferred disease relationships for SNRPA Gene

Disease -log(P) Hits PubMed IDs
mixed connective tissue disease 47.7 1
lupus erythematosus systemic 41 5
autoimmune diseases 17.4 1
genes like me logo Genes that share disorders with SNRPA: view

No data available for UniProtKB/Swiss-Prot for SNRPA Gene

Publications for SNRPA Gene

  1. Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein. (PMID: 1831431) Nelissen R.L.H. … van Venrooij W.J. (Gene 1991) 3 4 23
  2. Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA. (PMID: 1833186) Jessen T.-H. … Nagai K. (EMBO J. 1991) 3 4 23
  3. Crystal structure at 1.92-A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PMID: 7984237) Oubridge C. … Nagai K. (Nature 1994) 3 4 23
  4. NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein. (PMID: 8070414) Howe P.W.A. … Varani G. (EMBO J. 1994) 3 4 23
  5. Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding. (PMID: 8609632) Avis J.M. … Neuhaus D. (J. Mol. Biol. 1996) 3 4 23

Products for SNRPA Gene

  • Addgene plasmids for SNRPA

Sources for SNRPA Gene

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