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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNRPA Gene

protein-coding   GIFtS: 60
GCID: GC19P041256

small nuclear ribonucleoprotein polypeptide A
 Explore 9 diseases affiliated with
SNRPA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNRPA    

Aliases
for SNRPA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Small Nuclear Ribonucleoprotein Polypeptide A1 2     U1 SnRNP A2 3
U1-A1 2 3     U1 Small Nuclear Ribonucleoprotein A2
U1A1 2 3     U1 Small Nuclear RNP-Specific A2
Mud11 2     U1 SnRNP-Specific Protein A2

External Ids:    HGNC: 111511   Entrez Gene: 66262   Ensembl: ENSG000000773127   OMIM: 1822855   UniProtKB: P090123   

Export aliases for SNRPA gene to outside databases

Previous GC identifers: GC19P041896 GC19P041648 GC19P045932 GC19P045948 GC19P037690


Summaries
for SNRPA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SNRPA:
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds
the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by
polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing
and polyadenylation. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012
Function: Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required
for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in
coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro

Gene Wiki entry for SNRPA (Small nuclear ribonucleoprotein polypeptide A)


Genomic Views
for SNRPA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNRPA gene promoter:
         SRF   STAT1   SRF (504 AA)   ATF-2   STAT1beta   STAT1alpha   Max   c-Jun   Ik-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNRPA promoter sequence
   Search SABiosciences Chromatin IP Primers for SNRPA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

SNRPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041256:  view genomic region     (about GC identifiers)

Start:
 41,256,759 bp from pter      End:
 41,271,297 bp from pter
Size:
 14,539 bases      Orientation:
 plus strand

Proteins
for SNRPA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012 (See protein sequence)
Recommended Name: U1 small nuclear ribonucleoprotein A  
Size: 282 amino acids; 31280 Da
Subunit: Belongs to the spliceosome where it is associated with snRNP U1. Interacts with SFPQ. Also component of a
snRNP-free complex with SFPQ
Subcellular location: Nucleus
6/59 PDB 3D structures from and Proteopedia for SNRPA (see all 59):
1AUD (3D)        1CX0 (3D)        1DRZ (3D)        1DZ5 (3D)        1FHT (3D)        1M5K (3D)    

Explore the universe of human proteins at neXtProt for SNRPA: NX_P09012

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09012

    • SNRPA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004587.1  
    ENSEMBL proteins: 
     ENSP00000243563  
    Reactome Protein details: P09012
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: SNRPA
    OriGene Protein Over-expression Lysate: SNRPA
    OriGene Custom Protein Services for SNRPA 
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    Novus Biologicals SNRPA Protein
    Novus Biologicals SNRPA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SNRPA

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529


    SNRPA for ontologies           About GeneDecksing



    SNRPA Antibody Products: 
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    Uscn ELISAs and CLIAs for SNRPA

    Protein Domains /
    Families
    for SNRPA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNRPA for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR024888 U1_snRNP_A/U2_snRNP_B''
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry P09012

    ProtoNet protein and cluster: P09012

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012
    Similarity: Belongs to the RRM U1 A/B'' family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Function
    for SNRPA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012
    Function: Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required
    for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in
    coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro

         Genatlas biochemistry entry for SNRPA:
    samll ribonucleoprotein U1,A polypeptide

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPA
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPA:
    hsa-miR-644 hsa-miR-1231 hsa-miR-654-3p hsa-miR-106a* hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmid: SNRPA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRPA (see all 7)
    OriGene shRNA RFP: SNRPA
    OriGene siRNA: SNRPA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SNRPA

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA (see first 1)
    NM_004596 (human cat#: RC201818)  NM_001046637 (mouse cat#: MR203914)  NM_015782 (mouse cat#: MR203911)  NM_001008303 (rat cat#: RR207734)  
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA 

    Cell Line
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    Search LifeMap BioReagents cell lines for SNRPA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IDA19561594
    GO:0005515protein binding IPI9848648
    GO:0017069snRNA binding IEA--


    SNRPA for ontologies           About GeneDecksing



    Pathways & Interactions
    for SNRPA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA Splicing1.00
    		mRNA Processing0.82
    		mRNA Splicing - Major Pathway1.00
    		mRNA processing0.48
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    		Spliceosome0.31
    2Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SNRPA 
        mRNA processing

    5        Reactome Pathways for SNRPA
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA


    1         Kegg Pathway  (Kegg details for SNRPA):
        Spliceosome


    SNRPA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNRPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/617 Interacting proteins for SNRPA (P090121, 2, 3 ENSP000002435634) via UniProtKB, MINT, STRING, and/or I2D (see all 617)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN2Q166372, 3, ENSP000003701194MINT-14308 MINT-7947479 I2D: score=1 STRING: ENSP00000370119
    PTBP1P265992, 3, ENSP000003494284MINT-8332987 MINT-7947479 I2D: score=3 STRING: ENSP00000349428
    SF3A2Q154282, 3, ENSP000002214944MINT-5205386 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    SMN1Q166372, 3MINT-14308 MINT-7947479 I2D: score=1 
    C19orf43Q9BQ612, 3, ENSP000002427844MINT-8332954 I2D: score=4 STRING: ENSP00000242784
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--


    SNRPA for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNRPA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SNRPA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNRPA

    1 DrugBank Compound for SNRPA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Malonic acidMalonate (see all 2)141-82-2target----

    7 Novoseek chemical compound relationships for SNRPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 41.5 21 12670951 (4), 16943419 (2), 10742179 (2), 11839494 (1) (see all 8)
    hydrogen 27.4 8 11788718 (2), 12466552 (2), 16407334 (1), 16738410 (1) (see all 6)
    adenine 19.3 6 12466552 (3), 15491147 (1), 16278830 (1)
    guanidine hydrochloride 17.1 1 15476390 (1)
    cysteine 0.481 1 10852733 (1)
    atp 0 2 10648562 (1)
    iron 0 4 1584791 (1)

    Search CenterWatch for drugs/clinical trials and news about SNRPA 

    Transcripts
    for SNRPA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNRPA gene: 
    NM_004596.4  

    Unigene Cluster for SNRPA:

    Small nuclear ribonucleoprotein polypeptide A
    Hs.466775  [show with all ESTs]
    Unigene Representative Sequence: NM_004596
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000243563(uc002ooz.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SNRPA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPA
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPA:
    hsa-miR-644 hsa-miR-1231 hsa-miR-654-3p hsa-miR-106a* hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmid: SNRPA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRPA (see all 7)
    OriGene shRNA RFP: SNRPA
    OriGene siRNA: SNRPA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPA
    Clone
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    GenScript: all cDNA clones in your preferred vector: SNRPA (NM_004596)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPA

    Additional cDNA sequence: 

    AK293140.1 AK313182.1 BC000405.2 BC008290.1 X06347.1 

    17 DOTS entries:

    DT.97854609  DT.100827444  DT.80102050  DT.100827448  DT.121436155  DT.100647055  DT.100827455  DT.305096 
    DT.100750095  DT.121436170  DT.100827445  DT.100827454  DT.121436208  DT.100719490  DT.100827446  DT.100827447 
    DT.95206669 

    24/488 AceView cDNA sequences (see all 488):

    CA306578 BC008290 CA420448 CR612581 CR613649 BE501622 CR606390 CR620634 
    CR607723 CR595370 BP871078 BI768440 CR591403 AI188213 CR611065 BM682690 
    BX417996 CR597793 CR593045 BM740167 BM718224 CR614107 CR597345 CR622302 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SNRPA (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9
    SP1:                                                  -                       -                       -                 -               
    SP2:        -     -     -     -     -     -     -     -                       -                       -                 -               
    SP3:                          -     -     -           -                       -                       -                                 
    SP4:                          -     -     -           -                       -     -                                                   
    SP5:                    -     -     -     -           -                       -                                                         


    ECgene alternative splicing isoforms for SNRPA

    Expression
    for SNRPA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNRPA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGCCCCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SNRPA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNRPA

    SOURCE GeneReport for Unigene cluster: Hs.466775
        SABiosciences Custom PCR Arrays for SNRPA
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for SNRPA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRPA gene from 8/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Snrpa1 , 5 small nuclear ribonucleoprotein polypeptide A1, 5 88.97(n)1
    96.44(a)1    		   7 (15.84 cM)5
    536071  NM_001046637.11  NP_001040102.11 
     271870055 
    lizard
    (Anolis carolinensis)    		 Reptilia SNRPA6
    		 --
    		 84(a)
    		 1 ↔ 1
    		 LGf(2806307-2809992)
    African clawed frog
    (Xenopus laevis)    		 Amphibia snf-prov2 sans fille 77.7(n)    X57953.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC064308.12   -- 80.27(n)   324121  BC064308.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta snf1 sans fille 69.22(n)
    70.27(a)    		   31442  NM_078490.3  NP_511045.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rnp-21 Protein RNP-2 60.03(n)
    56.22(a)    		   177181  NM_068103.2  NP_500504.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons U1A1 spliceosomal protein U1A 54.99(n)
    54.7(a)    		   819371  NM_130326.2  NP_182280.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.97662 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.96(n)    AK102716.1 


    ENSEMBL Gene Tree for SNRPA (if available)
    TreeFam Gene Tree for SNRPA (if available) 

    Paralogs
    for SNRPA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNRPA gene
    SNRPB22  
    1 SIMAP similar gene for SNRPA using alignment to 7 protein entries:     SNRPA_HUMAN (see all proteins):
    SNRPB2

    SNRPA for paralogs           About GeneDecksing



    Genomic Variants
    for SNRPA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/287 NCBI SNPs in SNRPA are shown (see all 287)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1851921141,2
    		--41254942(+) CCAGGA/CTGGAG 2 -- int1 us2k10--------
    rs1896103781,2
    		--41255167(+) CTGGGA/TTTACA 2 -- us2k1 int10--------
    rs761773091,2
    		F,--41255191(+) GCACCC/TGGACT 2 -- us2k1 int11Minor allele frequency- T:0.02NA 120
    rs1476061061,2
    		--41255310(+) GGGAA-/CCCCCC 2 -- us2k1 int10--------
    rs48020881,2
    		C,F,H,--41255768(+) TCCAAC/TGGAGA 2 -- ut51 us2k110Minor allele frequency- T:0.02NS EA NA 1102
    rs1888958001,2
    		--41255823(+) CAGAAC/TCTGGG 2 -- ut51 us2k10--------
    rs1381015341,2
    		--41255877(+) CCACGA/GGAGCA 2 -- us2k10--------
    rs22543261,2
    		C,F,O,H,--41255889(-) CCTCGC/AAATTC 2 -- us2k121Minor allele frequency- A:0.17EA NS NA WA 3972
    rs1929095971,2
    		--41255907(+) AAGTCA/CTAAGG 2 -- us2k10--------
    rs48033641,2
    		C,F,H,--41255920(+) CCTGAC/TGGTTA 2 -- us2k18Minor allele frequency- T:0.02NS EA NA 888

    HapMap Linkage Disequilibrium report for SNRPA (41256759 - 41271297 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SNRPA
         1 CNV: 5100
         1 Indel: 67545

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNRPA
    DNA2.0 Custom Variant and Variant Library Synthesis for SNRPA

    Disorders / Diseases
    for SNRPA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNRPA for disorders           About GeneDecksing

    OMIM gene information: 182285    OMIM disorders: --

    9 diseases for SNRPA:    About MalaCards
    mixed connective tissue disease    connective tissue disease    yellow fever    lupus erythematosus
    systemic lupus erythematosus    myotonic dystrophy    cervicitis    hepatitis
    malaria

    2 diseases from the University of Copenhagen DISEASES database for SNRPA:
    Mixed connective tissue disease     Systemic lupus erythematosus

    3 Novoseek disease relationships for SNRPA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mixed connective tissue disease 47.7 1 7930595 (1)
    lupus erythematosus systemic 41 5 7930595 (1), 9342149 (1), 8605931 (1), 9328587 (1) (see all 5)
    autoimmune diseases 17.4 1 7687615 (1)


    Export disorders for SNRPA gene to outside databases

    Publications
    for SNRPA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNRPA gene, integrated from 9 sources (see all 147):
    (articles sorted by number of sources associating them with SNRPA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. (PubMed id 9848648)1, 2, 9 Lutz C.S.... Alwine J.C. (1998)
    2. Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy. (PubMed id 9265619)1, 2, 9 Lu J. and Hall K.B. (1997)
    3. Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding. (PubMed id 8609632)1, 2, 9 Avis J.M....Neuhaus D. (1996)
    4. Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein. (PubMed id 1831431)1, 2, 9 Nelissen R.L.H.... van Venrooij W.J. (1991)
    5. Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. (PubMed id 2147232)1, 2, 9 Nagai K.... Evans P.R. (1990)
    6. Structural basis of the RNA-binding specificity of human U1A protein. (PubMed id 9312034)1, 2, 9 Allain F.H.-T.... Varani G. (1997)
    7. NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein. (PubMed id 8070414)1, 2, 9 Howe P.W.A.... Varani G. (1994)
    8. Crystal structure at 1.92-A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PubMed id 7984237)1, 2, 9 Oubridge C.... Nagai K. (1994)
    9. Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA. (PubMed id 1833186)1, 2, 9 Jessen T.-H.... Nagai K. (1991)
    10. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. (PubMed id 19561594)1, 2 Ray D....Hughes T.R. (2009)

    External Searches for SNRPA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SNRPA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6626 HGNC: 11151 AceView: SNRPA Ensembl:ENSG00000077312 euGenes: HUgn6626
    ECgene: SNRPA Kegg: 6626 H-InvDB: SNRPA

    Other Databases showing SNRPA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SNRPA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNRPA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SNRPA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SNRPA gene:
    Search GeneIP for patents involving SNRPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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