Aliases for SNRPA Gene
Aliases for SNRPA Gene
External Ids for SNRPA Gene
- HGNC: 11151
- Entrez Gene: 6626
- Ensembl: ENSG00000077312
- OMIM: 182285
- UniProtKB: P09012
Previous GeneCards Identifiers for SNRPA Gene
- GC19P041896
- GC19P041648
- GC19P045932
- GC19P045948
- GC19P041256
- GC19P037690
Summaries for SNRPA Gene
-
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]
GeneCards Summary for SNRPA Gene
SNRPA (Small Nuclear Ribonucleoprotein Polypeptide A) is a Protein Coding gene. Diseases associated with SNRPA include Connective Tissue Disease. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SNRPB2.
UniProtKB/Swiss-Prot for SNRPA Gene
-
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5 splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5-UGCAC-3 motif on RNAs.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPA Gene
Genomics for SNRPA Gene
GeneHancer (GH) Regulatory Elements for SNRPA Gene
- Top Transcription factor binding sites by QIAGEN in the SNRPA gene promoter:
Regulatory Element Products
Genomic Locations for SNRPA Gene
- chr19:40,750,637-40,765,392
- (GRCh38/hg38)
- Size:
- 14,756 bases
- Orientation:
- Plus strand
- chr19:41,256,542-41,271,297
- (GRCh37/hg19)
Genomic View for SNRPA Gene
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.1 by HGNC


RefSeq DNA sequence for SNRPA Gene
Proteins for SNRPA Gene
-
Protein details for SNRPA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09012-SNRPA_HUMAN
- Recommended name:
- U1 small nuclear ribonucleoprotein A
- Protein Accession:
- P09012
Protein attributes for SNRPA Gene
- Size:
- 282 amino acids
- Molecular mass:
- 31280 Da
- Quaternary structure:
-
- U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SFPQ; component of a snRNP-free complex with SFPQ.
Protein Expression for SNRPA Gene
Post-translational modifications for SNRPA Gene
- Ubiquitination at isoforms=20, posLast=6060, isoforms=88, isoforms=96, posLast=9898, posLast=268268, and posLast=276276
Other Protein References for SNRPA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for SNRPA
- Invitrogen Antibodies for SNRPA
- GeneTex SNRPA antibody for SNRPA
-
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Protein Products
-
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- Search GeneTex for Proteins for SNRPA
-
Abcam proteins for SNRPA
Assay Products
- antibodies-online: Search results for 4 available SNRPA Elisa Kits ranked by validation data
- Compare Top SNRPA Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SNRPA Gene
Domains & Families for SNRPA Gene
Gene Families for SNRPA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SNRPA Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SNRPA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P09012- Family:
-
- Belongs to the RRM U1 A/B family.
Function for SNRPA Gene
Molecular function for SNRPA Gene
- GENATLAS Biochemistry:
- samll ribonucleoprotein U1,A polypeptide
- UniProtKB/Swiss-Prot Function:
- Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5 splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5-UGCAC-3 motif on RNAs.
Phenotypes From GWAS Catalog for SNRPA Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IEA,IDA | 19561594 |
GO:0005515 | protein binding | IPI | 9848648 |
GO:0030619 | U1 snRNA binding | IBA | -- |
GO:0035614 | snRNA stem-loop binding | IBA | -- |
Phenotypes for SNRPA Gene
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-
-
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- Search ViGene Biosciences for SNRPA
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-
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-
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miRNA for SNRPA Gene
- miRTarBase miRNAs that target SNRPA
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SNRPA
- genomics-online: cdna clones - Search results for available SNRPA gene related products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SNRPA gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRPA Gene
Localization for SNRPA Gene
Subcellular locations from UniProtKB/Swiss-Prot for SNRPA Gene
- Nucleus.
- Nucleoplasm (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS,IDA | -- |
GO:0005681 | spliceosomal complex | IDA | 9731529 |
GO:0005685 | U1 snRNP | IDA,IEA | 21113136 |
GO:0030529 | intracellular ribonucleoprotein complex | IEA | -- |
Pathways & Interactions for SNRPA Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | mRNA Splicing - Major Pathway |
.79
|
.50
.41
|
2 | Gene Expression |
.48
|
Pathways by source for SNRPA Gene
1 BioSystems pathway for SNRPA Gene
4 Reactome pathways for SNRPA Gene
1 KEGG pathway for SNRPA Gene
Interacting Proteins for SNRPA Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
GO:0006397 | mRNA processing | IEA | -- |
GO:0008380 | RNA splicing | IEA | -- |
GO:1900363 | regulation of mRNA polyadenylation | IEA | -- |
No data available for SIGNOR curated interactions for SNRPA Gene
Drugs & Compounds for SNRPA Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Malonic acid | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for SNRPA Gene
mRNA/cDNA for SNRPA Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (488) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SNRPA Gene
CRISPR Products
-
OriGene CRISPR knockouts for SNRPA
- genomics-online: gRNA clones - Search results for available SNRPA gene related products
- Applied Biological Materials CRISPR for SNRPA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SNRPA
- GenScript: Design CRISPR guide RNA sequences for SNRPA
miRNA Products
- Search ViGene Biosciences for SNRPA
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SNRPA
- Browse OriGene Inhibitory RNA Products For SNRPA
- genomics-online: shRNA clones - Search results for available SNRPA gene related products
-
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Clone Products
- Sino Biological Human cDNA Clone for SNRPA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SNRPA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SNRPA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SNRPA
- genomics-online: cdna clones - Search results for available SNRPA gene related products
- orf clones - Search results for available SNRPA gene related products
- Applied Biological Materials Clones for SNRPA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP10: | - |
Expression for SNRPA Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNRPA Gene
NURSA nuclear receptor signaling pathways regulating expression of SNRPA Gene:
SNRPASOURCE GeneReport for Unigene cluster for SNRPA Gene:
Hs.466775Evidence on tissue expression from TISSUES for SNRPA Gene
- Liver(4.5)
- Lung(4.5)
- Nervous system(4)
- Muscle(2.8)
- Heart(2.4)
- Kidney(2.3)
- Blood(2.2)
- Intestine(2.2)
- Eye(2.1)
- Skin(2.1)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs for SNRPA
-
OriGene qPCR primer pairs and template standards for SNRPA
- genomics-online: primer clones - Search results for available SNRPA gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNRPA Gene
Orthologs for SNRPA Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SNRPA 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | SNRPA 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Snrpa 34 |
|
OneToMany | |
Gm5145 34 |
|
OneToMany | |||
dog (Canis familiaris) |
Mammalia | SNRPA 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | SNRPA 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Snrpa 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | SNRPA 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | SNRPA 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | snrpa 33 |
|
||
Str.3059 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | snf-prov 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | snrpa 33 34 |
|
||
-- 33 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | snf 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011637 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | rnp-2 33 34 |
|
||
rnp-3 34 |
|
ManyToMany | |||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MSL1 34 36 |
|
OneToMany | |
thale cress (Arabidopsis thaliana) |
eudicotyledons | U1A 33 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7167 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os05g0154800 33 |
|
||
Os.9766 33 |
|
||||
barley (Hordeum vulgare) |
Liliopsida | Hv.1400 33 |
|
||
wheat (Triticum aestivum) |
Liliopsida | Ta.5442 33 |
|
||
corn (Zea mays) |
Liliopsida | Zm.3121 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10455 34 |
|
OneToMany | |
bread mold (Neurospora crassa) |
Ascomycetes | NCU08034 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | usp102 33 |
|
- Species where no ortholog for SNRPA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for SNRPA Gene
(2) SIMAP similar genes for SNRPA Gene using alignment to 7 proteins:
Variants for SNRPA Gene
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000077433 | -- | 40,754,194(+) | C/G | intron_variant | |
rs1000302033 | -- | 40,760,104(+) | A/C/G | intron_variant | |
rs1000377746 | -- | 40,749,653(+) | G/C | upstream_transcript_variant | |
rs1000434082 | -- | 40,765,592(+) | G/A | downstream_transcript_variant | |
rs1000571615 | -- | 40,764,434(+) | G/A | intron_variant |
Additional Variant Information for SNRPA Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SNRPA
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRPA Gene
Disorders for SNRPA Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
connective tissue disease |
|
|
Additional Disease Information for SNRPA
No data available for UniProtKB/Swiss-Prot and Genatlas for SNRPA Gene
Publications for SNRPA Gene
- The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. (PMID: 9848648) Lutz CS … Alwine JC (RNA (New York, N.Y.) 1998) 3 4 22 58
- Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy. (PMID: 9265619) Lu J … Hall KB (Biochemistry 1997) 3 4 22 58
- Structural basis of the RNA-binding specificity of human U1A protein. (PMID: 9312034) Allain FH … Varani G (The EMBO journal 1997) 3 4 22 58
- Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding. (PMID: 8609632) Avis JM … Neuhaus D (Journal of molecular biology 1996) 3 4 22 58
- Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PMID: 7984237) Oubridge C … Nagai K (Nature 1994) 3 4 22 58
Products for SNRPA Gene
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- Invitrogen Antibodies for SNRPA
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- Cyagen custom Knockout/knockin (KOKI) mouse models for SNRPA
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SNRPA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SNRPA
- antibodies-online: Search results for 101 available SNRPA Antibodies ranked by validation data
- Compare Top SNRPA Antibodies
- antibodies-online: Search results for 4 available SNRPA Elisa Kits ranked by validation data
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- antibodies-online: Search results for 18 available SNRPA Proteins ranked by validation data
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- GeneTex SNRPA antibody for SNRPA
- Search GeneTex for Proteins for SNRPA
- ViGene Biosciences adenoviral particle packaged cDNA for SNRPA gene
- ViGene Biosciences lentiviral particle packaged cDNA for SNRPA gene
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- Search ViGene Biosciences for SNRPA
- Santa Cruz Biotechnology (SCBT) Antibodies for SNRPA
- Search Santa Cruz Biotechnology (SCBT) for SNRPA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SNRPA
- genomics-online: cdna clones - Search results for available SNRPA gene related products
- orf clones - Search results for available SNRPA gene related products
- genomics-online: gRNA clones - Search results for available SNRPA gene related products
- genomics-online: primer clones - Search results for available SNRPA gene related products
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Sources for SNRPA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
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- (60) TGDB
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- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
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- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
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- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
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- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
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- (133) ENCODE
- (134) ProSci
- (135)