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SNRPA Gene

protein-coding   GIFtS: 61
GCID: GC19P041256

Small Nuclear Ribonucleoprotein Polypeptide A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Small Nuclear Ribonucleoprotein Polypeptide A1 2     Mud12
U1-A2 3     U1 Small Nuclear Ribonucleoprotein A2
U1A2 3     U1 Small Nuclear RNP-Specific A2
U1 SnRNP A2 3     U1 SnRNP-Specific Protein A2

External Ids:    HGNC: 111511   Entrez Gene: 66262   Ensembl: ENSG000000773127   OMIM: 1822855   UniProtKB: P090123   

Export aliases for SNRPA gene to outside databases

Previous GC identifers: GC19P041896 GC19P041648 GC19P045932 GC19P045948 GC19P037690


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNRPA Gene:
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which
binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates
itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling
of splicing and polyadenylation. (provided by RefSeq, Oct 2010)

GeneCards Summary for SNRPA Gene:
SNRPA (small nuclear ribonucleoprotein polypeptide A) is a protein-coding gene. GO annotations related to this gene include RNA binding and snRNA binding. An important paralog of this gene is SNRPB2.

UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012
Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5'
splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with
pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA
binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and
polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs

Gene Wiki entry for SNRPA (Small nuclear ribonucleoprotein polypeptide A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNRPA gene promoter:
         SRF   STAT1   SRF (504 AA)   ATF-2   STAT1beta   STAT1alpha   Max   c-Jun   Ik-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRPA promoter sequence
   Search Chromatin IP Primers for SNRPA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNRPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

SNRPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041256:  view genomic region     (about GC identifiers)

Start:
41,256,542 bp from pter      End:
41,271,297 bp from pter
Size:
14,756 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012 (See protein sequence)
Recommended Name: U1 small nuclear ribonucleoprotein A  
Size: 282 amino acids; 31280 Da
Subunit: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that
assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at
least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SFPQ; component
of a snRNP-free complex with SFPQ
Selected PDB 3D structures from and Proteopedia for SNRPA (see all 59):
1AUD (3D)        1CX0 (3D)        1DRZ (3D)        1DZ5 (3D)        1FHT (3D)        1M5K (3D)    

Explore the universe of human proteins at neXtProt for SNRPA: NX_P09012

Explore proteomics data for SNRPA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys20, Lys60, Lys88, Lys96, Lys98, Lys268, Lys276
  • Modification sites at PhosphoSitePlus

  • See SNRPA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004587.1  
    ENSEMBL proteins: 
     ENSP00000470534   ENSP00000243563   ENSP00000469224   ENSP00000472449   ENSP00000472258  
     ENSP00000472355   ENSP00000471230  
    Reactome Protein details: P09012

    SNRPA Human Recombinant Protein Products:

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    Novus Biologicals SNRPA Protein
    Novus Biologicals SNRPA Lysates
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for SNRPA

     
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    SNRPA Assay Products:

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    Search eBioscience for ELISAs for SNRPA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR024888 U1_snRNP_A/U2_snRNP_B''
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry P09012

    ProtoNet protein and cluster: P09012

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012
    Similarity: Belongs to the RRM U1 A/B'' family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with SNRPA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNRPA_HUMAN, P09012
    Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5'
    splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with
    pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA
    binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and
    polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs

         Genatlas biochemistry entry for SNRPA:
    samll ribonucleoprotein U1,A polypeptide

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IDA19561594
    GO:0005515protein binding IPI10688667
    GO:0017069snRNA binding IEA--
         
    Find genes that share ontologies with SNRPA           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNRPA
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    miRNA
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    miRTarBase miRNAs that target SNRPA:
    hsa-mir-320c (MIRT036163), hsa-let-7b-5p (MIRT052317), hsa-mir-1307-3p (MIRT035815)

    Block miRNA regulation of human, mouse, rat SNRPA using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SNRPA:
    hsa-miR-644 hsa-miR-1231 hsa-miR-654-3p hsa-miR-106a* hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidSNRPA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNRPA
    Predesigned siRNA for gene silencing in human, mouse, rat SNRPA

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SNRPA (NM_004596)
    Sino Biological Human cDNA Clone for SNRPA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA
    Addgene plasmids for SNRPA 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNRPA_HUMAN, P09012: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005685U1 snRNP IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with SNRPA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNRPA About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome


    Find genes that share SuperPaths with SNRPA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNRPA
        mRNA processing


    1 Reactome Pathway for SNRPA
        mRNA Splicing - Major Pathway


    1 Kegg Pathway  (Kegg details for SNRPA):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNRPA
    Interactions:

        GeneGlobe Interaction Network for SNRPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNRPA (P090121, 2, 3 ENSP000002435634) via UniProtKB, MINT, STRING, and/or I2D (see all 741)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN2Q166372, 3, ENSP000003701194MINT-14308 MINT-7947479 I2D: score=1 STRING: ENSP00000370119
    PTBP1P265992, 3, ENSP000003494284MINT-8332987 MINT-7947479 I2D: score=3 STRING: ENSP00000349428
    SF3A2Q154282, 3, ENSP000002214944MINT-5205386 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    SMN1Q166372, 3MINT-14308 MINT-7947479 I2D: score=1 
    C19orf43Q9BQ612, 3, ENSP000002427844MINT-8332954 I2D: score=4 STRING: ENSP00000242784
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with SNRPA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNRPA

    1 DrugBank Compound for SNRPA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Malonic acidMalonate (see all 2)141-82-2target----

    7 Novoseek inferred chemical compound relationships for SNRPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 41.5 21 12670951 (4), 16943419 (2), 10742179 (2), 11839494 (1) (see all 8)
    hydrogen 27.4 8 11788718 (2), 12466552 (2), 16407334 (1), 16738410 (1) (see all 6)
    adenine 19.3 6 12466552 (3), 15491147 (1), 16278830 (1)
    guanidine hydrochloride 17.1 1 15476390 (1)
    cysteine 0.481 1 10852733 (1)
    atp 0 2 10648562 (1)
    iron 0 4 1584791 (1)



    Find genes that share compounds with SNRPA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SNRPA gene: 
    NM_004596.4  

    Unigene Cluster for SNRPA:

    Small nuclear ribonucleoprotein polypeptide A
    Hs.466775  [show with all ESTs]
    Unigene Representative Sequence: NM_004596
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601545 ENST00000243563(uc002ooz.3) ENST00000601253 ENST00000597353
    ENST00000599362 ENST00000599570 ENST00000601393 ENST00000598923 ENST00000600456
    ENST00000598452 ENST00000596860
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate SNRPA:
    hsa-miR-644 hsa-miR-1231 hsa-miR-654-3p hsa-miR-106a* hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidSNRPA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SNRPA
    Clone
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    GenScript: all cDNA clones in your preferred vector: SNRPA (NM_004596)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA
    Addgene plasmids for SNRPA 
    Primer
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    OriGene qPCR primer pairs and template standards for SNRPA
    OriGene qSTAR qPCR primer pairs in human, mouse for SNRPA
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SNRPA
      QuantiTect SYBR Green Assays in human, mouse, rat SNRPA
      QuantiFast Probe-based Assays in human, mouse, rat SNRPA

    Additional mRNA sequence: 

    AK293140.1 AK313182.1 BC000405.2 BC008290.1 X06347.1 

    17 DOTS entries:

    DT.97854609  DT.100827444  DT.80102050  DT.100827448  DT.121436155  DT.100647055  DT.100827455  DT.305096 
    DT.100750095  DT.121436170  DT.100827445  DT.100827454  DT.121436208  DT.100719490  DT.100827446  DT.100827447 
    DT.95206669 

    Selected AceView cDNA sequences (see all 488):

    CA313815 CR620163 BC000405 CR622302 CR597345 CF128304 AI870262 BM478204 
    BI907674 BQ447022 AW848338 CR609533 BQ671697 BQ689851 BX417996 BQ182227 
    BQ650463 BI768440 BC008290 AI949381 BQ068261 CR611939 CA306578 CR606390 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SNRPA (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9
    SP1:                                                  -                       -                       -                 -               
    SP2:        -     -     -     -     -     -     -     -                       -                       -                 -               
    SP3:                          -     -     -           -                       -                       -                                 
    SP4:                          -     -     -           -                       -     -                                                   
    SP5:                    -     -     -     -           -                       -                                                         


    ECgene alternative splicing isoforms for SNRPA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SNRPA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCCCCTT
    SNRPA Expression
    About this image

    SNRPA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNRPA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466775
        Custom PCR Arrays for SNRPA
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SNRPA
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    QuantiTect SYBR Green Assays in human, mouse, rat SNRPA
    QuantiFast Probe-based Assays in human, mouse, rat SNRPA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRPA gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrpa5 small nuclear ribonucleoprotein polypeptide A   --   7 (15.84 cM) 27187005 
    lizard
    (Anolis carolinensis)
    Reptilia SNRPA6
    small nuclear ribonucleoprotein polypeptide A
    90(a)
    1 ↔ 1
    LGf(2806296-2810905)
    African clawed frog
    (Xenopus laevis)
    Amphibia snf-prov2 sans fille 77.7(n)    X57953.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC064308.12   -- 80.27(n)   324121  BC064308.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta snf1 sans fille 75.08(n)
    77.78(a)
      31442  NM_078490.3  NP_511045.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rnp-21 rnp-2 60.03(n)
    56.22(a)
      177181  NM_068103.3  NP_500504.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSL1(YIR009W)4 U2B component of U2 snRNP, involved in splicing, binds more   --   9(374525-374860) 854826  NP_012274.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons U1A1 U1A 54.99(n)
    54.7(a)
      819371  NM_130326.2  NP_182280.1 
    rice
    (Oryza sativa)
    Liliopsida Os.97662 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.96(n)    AK102716.1 


    ENSEMBL Gene Tree for SNRPA (if available)
    TreeFam Gene Tree for SNRPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNRPA gene
    SNRPB22  
    2 SIMAP similar genes for SNRPA using alignment to 7 protein entries:     SNRPA_HUMAN (see all proteins):
    SNRPB2    RBMX

    Find genes that share paralogs with SNRPA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SNRPA (see all 301)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1853428231,2
    --41257861(+) GGTCTA/GTGTGC 1 -- int10--------
    rs667432821,2
    C--41257952(+) AAGAAA/GCTGGG 1 -- int13Minor allele frequency- G:0.12WA NA 240
    rs1472987521,2
    --41258008(+) GAGGCC/TGAGGC 1 -- int10--------
    rs1399281031,2
    C--41258090(+) ATACAA/GAATTA 1 -- int10--------
    rs1897604541,2
    --41258215(+) ACAGCC/TTGGGC 1 -- int10--------
    rs1806876521,2
    --41258223(+) GGCAAC/GAAGAG 1 -- int10--------
    rs1859435221,2
    --41258238(+) ACTCCC/GTCTCA 1 -- int10--------
    rs104084521,2
    C,F,H--41258355(+) TAGGAA/GCCCAA 1 -- int111Minor allele frequency- G:0.05NS EA NA WA 1312
    rs1120469261,2
    F--41258381(+) GGTGGT/CTCAGG 1 -- int12Minor allele frequency- C:0.04CSA WA 120
    rs597057651,2
    C--41258485(+) AAAAA-/AAGGCTG 1 -- int11Minor allele frequency- AA:0.00NA 2

    HapMap Linkage Disequilibrium report for SNRPA (41256542 - 41271297 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SNRPA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833832CNV Loss17160897
    esv21537CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNRPA
    DNA2.0 Custom Variant and Variant Library Synthesis for SNRPA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 182285    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for SNRPA:
    Mixed connective tissue disease     Lupus erythematosus

    Find genes that share disorders with SNRPA           About GenesLikeMe

    3 Novoseek inferred disease relationships for SNRPA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mixed connective tissue disease 47.7 1 7930595 (1)
    lupus erythematosus systemic 41 5 7930595 (1), 9342149 (1), 8605931 (1), 9328587 (1) (see all 5)
    autoimmune diseases 17.4 1 7687615 (1)


    Export disorders for SNRPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SNRPA gene, integrated from 10 sources (see all 155) (see top 10):
    (articles sorted by number of sources associating them with SNRPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. (PubMed id 9848648)1, 2, 9 Lutz C.S.... Alwine J.C. (RNA 1998)
    2. Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy. (PubMed id 9265619)1, 2, 9 Lu J. and Hall K.B. (Biochemistry 1997)
    3. Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding. (PubMed id 8609632)1, 2, 9 Avis J.M....Neuhaus D. (J. Mol. Biol. 1996)
    4. Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein. (PubMed id 1831431)1, 2, 9 Nelissen R.L.H.... van Venrooij W.J. (Gene 1991)
    5. Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. (PubMed id 2147232)1, 2, 9 Nagai K.... Evans P.R. (Nature 1990)
    6. Structural basis of the RNA-binding specificity of human U1A protein. (PubMed id 9312034)1, 2, 9 Allain F.H.-T.... Varani G. (EMBO J. 1997)
    7. NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein. (PubMed id 8070414)1, 2, 9 Howe P.W.A.... Varani G. (EMBO J. 1994)
    8. Crystal structure at 1.92-A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PubMed id 7984237)1, 2, 9 Oubridge C.... Nagai K. (Nature 1994)
    9. Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA. (PubMed id 1833186)1, 2, 9 Jessen T.-H.... Nagai K. (EMBO J. 1991)
    10. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. (PubMed id 19561594)1, 2 Ray D.... Hughes T.R. (Nat. Biotechnol. 2009)
    11. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    12. Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation. (PubMed id 8602269)1, 2 Allain F.H.-T....Varani G. (Nature 1996)
    13. RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins. (PubMed id 1826055)1, 2 Hoffman D.W.... Keene J.D. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    14. Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region. (PubMed id 1701111)1, 3 Schonk D....Geurts van Kessel A. (Cytogenet. Cell Genet. 1990)
    15. cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins. (PubMed id 2962859)1, 2 Sillekens P.T.G.... van Venrooij W.J. (EMBO J. 1987)
    16. The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. (PubMed id 10742179)1, 9 Varani L....Varani G. (Nat. Struct. Biol. 2000)
    17. Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation. (PubMed id 10688667)1, 9 Klein Gunnewiek J.M....Gunderson S.I. (Mol. Cell. Biol. 2000)
    18. An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B&quot; spliceosome proteins. (PubMed id 10648562)1, 9 Hetzer M. and Mattaj I.W. (J. Cell Biol. 2000)
    19. A bipartite U1 site represses U1A expression by synergizing with PIE to inhibit nuclear polyadenylation. (PubMed id 17942741)1, 9 Guan F....Gunderson S.I. (RNA 2007)
    20. 13C NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein. (PubMed id 15890361)1, 9 Shajani Z. and Varani G. (J. Mol. Biol. 2005)
    21. Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR. (PubMed id 17507659)1, 9 Hall-Pogar T....Lutz C.S. (RNA 2007)
    22. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    23. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)
    24. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    25. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    26. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    27. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    28. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    29. Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF. (PubMed id 21566083)1 Liu L....Dong X. (Mol. Endocrinol. 2011)
    30. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PubMed id 21642987)1 Pichlmair A....Superti-Furga G. (Nat. Immunol. 2011)
    31. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)
    32. The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus. (PubMed id 21298455)1 Bronzoni R.V....Nogueira M.L. (Arch. Virol. 2011)
    33. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    34. U1A protein-stem loop 2 RNA recognition: prediction of structural differences from protein mutations. (PubMed id 21384338)1 Kormos B.L....Baranger A.M. (Biopolymers 2011)
    35. Multistep kinetics of the U1A-SL2 RNA complex dissociation. (PubMed id 21419778)1 Anunciado D....Baranger A.M. (J. Mol. Biol. 2011)
    36. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    37. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    38. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. (PubMed id 20508642)1 Krebs A.R....Tora L. (EMBO Rep. 2010)
    39. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    40. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    41. Identification of DeltaNp63alpha protein interactions by mass spectrometry. (PubMed id 20085233)1 Amoresano A....CalabrA^ V. (J. Proteome Res. 2010)
    42. Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. (PubMed id 19373254)1 Komander D....Barford D. (EMBO Rep. 2009)
    43. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    44. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. (PubMed id 19738201)1 Humphries J.D....Humphries M.J. (Sci Signal 2009)
    45. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    46. Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry. (PubMed id 18457437)1 Forsman A....Rymo L. (J. Proteome Res. 2008)
    47. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PubMed id 18854154)1 KAPnig R....Chanda S.K. (Cell 2008)
    48. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    49. Proteomic analysis of p16ink4a-binding proteins. (PubMed id 17955473)1 Souza-RodrA-gues E....Jaumot M. (Proteomics 2007)
    50. Composition and three-dimensional EM structure of double affinity- purified, human prespliceosomal A complexes. (PubMed id 17332742)1 Behzadnia N.... Luehrmann R. (EMBO J. 2007)
    51. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    52. 14-3-3sigma controls mitotic translation to facilitate cytokinesis. (PubMed id 17361185)1 Wilker E.W....Yaffe M.B. (Nature 2007)
    53. Nucleolar proteome dynamics. (PubMed id 15635413)1 Andersen J.S.... Mann M. (Nature 2005)
    54. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    55. WW domains provide a platform for the assembly of multiprotein networks. (PubMed id 16055720)1 Ingham R.J....Pawson T. (Mol. Cell. Biol. 2005)
    56. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    57. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (Genome Res. 2004)
    58. Comprehensive proteomic analysis of the human spliceosome. (PubMed id 12226669)1 Zhou Z.... Reed R. (Nature 2002)
    59. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    60. Nef triggers a transcriptional program in T cells imitating single- signal T cell activation and inducing HIV virulence mediators. (PubMed id 11420046)1 Simmons A.... McMichael A. (Immunity 2001)
    61. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. (PubMed id 11101529)1 Ajuh P....Lamond A.I. (EMBO J. 2000)
    62. Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. (PubMed id 9731529)1 Neubauer G.... Mann M. (Nat. Genet. 1998)
    63. Crystal structure of a hepatitis delta virus ribozyme. (PubMed id 9783582)1 FerrAc-D'AmarAc A.R....Doudna J.A. (Nature 1998)
    64. Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA. (PubMed id 1696729)1 Lutz-Freyermuth C....Keene J.D. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    65. Severe axial bending of RNA induced by the U1A binding element present in the 3' untranslated region of the U1A mRNA. (PubMed id 9367748)9 Grainger R.J....Lilley D.M. (J. Mol. Biol. 1997)
    66. The snRNP-associated U1A levels change following IL-6 stimulation of human B-cells. (PubMed id 12617996)9 Milcarek C....Lutz C.S. (Mol. Immunol. 2003)
    67. Sequences adjacent to the 5' splice site control U1A binding upstream of the IgM heavy chain secretory poly(A) site. (PubMed id 12670951)9 Phillips C. and Gunderson S. (J. Biol. Chem. 2003)
    68. Molecular characterization of the spliceosomal proteins U1A and U2B&quot; from higher plants. (PubMed id 7556097)9 Simpson G.G....Brown J.W. (EMBO J. 1995)
    69. Analysis of in vitro binding of U1-A protein mutants to U1 snRNA. (PubMed id 1832492)9 Boelens W....van Venrooij W.J. (Nucleic Acids Res. 1991)
    70. Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA. (PubMed id 12203842)9 Lutz C.S....James J.A. (J. Mol. Recognit. 2002)
    71. Spatial orientation and dynamics of the U1A proteins in the U1A-UTR complex. (PubMed id 10852733)9 Clerte C. and Hall K.B. (Biochemistry 2000)
    72. Heavy chain CDR3 optimization of a germline encoded recombinant antibody fragment predisposed to bind the U1A protein. (PubMed id 9342149)9 de Wildt R.M....Hoet R.M. (Protein Eng. 1997)
    73. Probing the 3' UTR structure of U1A mRNA and footprinting analysis of its complex with U1A protein. (PubMed id 9048562)9 Teunissen S.W....van Venrooij W.J. (Biochemistry 1997)
    74. Two structurally different RNA molecules are bound by the spliceosomal protein U1A using the same recognition strategy. (PubMed id 8736559)9 Jovine L....Nagai K. (Structure 1996)
    75. MHC class II gene associations with autoantibodies to U1A and SmD1 proteins. (PubMed id 10069423)9 Dumortier H....Muller S. (Int. Immunol. 1999)
    76. A complex secondary structure in U1A pre-mRNA that binds two molecules of U1A protein is required for regulation of polyadenylation. (PubMed id 8262062)9 van Gelder C.W....van Venrooij W.J. (EMBO J. 1993)
    77. Intracellular distribution of the U1A protein depends on active transport and nuclear binding to U1 snRNA. (PubMed id 1618898)9 Kambach C. and Mattaj I.W. (J. Cell Biol. 1992)
    78. The role of RNA structure in the interaction of U1A protein with U1 hairpin II RNA. (PubMed id 16738410)9 Law M.J....Laird-Offringa I.A. (RNA 2006)
    79. Determinants within an 18-amino-acid U1A autoregulatory domain that uncouple cooperative RNA binding, inhibition of polyadenylation, and homodimerization. (PubMed id 12697817)9 Guan F....Gunderson S.I. (Mol. Cell. Biol. 2003)
    80. Investigation of a conserved stacking interaction in target site recognition by the U1A protein. (PubMed id 11788718)9 Shiels J.C....Baranger A.M. (Nucleic Acids Res. 2002)
    81. Changes in side-chain and backbone dynamics identify determinants of specificity in RNA recognition by human U1A protein. (PubMed id 10588900)9 Mittermaier A....Varani G. (J. Mol. Biol. 1999)
    82. Target discrimination by RNA-binding proteins: role of the ancillary protein U2A' and a critical leucine residue in differentiating the RNA-binding specificity of spliceosomal proteins U1A and U2B&quot;. (PubMed id 9814759)9 Rimmele M.E. and Belasco J.G. (RNA 1998)
    83. An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicing. (PubMed id 8449403)9 Liao X.C....Rosbash M. (amp 1993)
    84. Induced fit or conformational selection for RNA/U1A folding. (PubMed id 20354153)9 Qin F....Chen H.F. (RNA 2010)
    85. Characterization of the dynamics of an essential helix in the U1A protein by time-resolved fluorescence measurements. (PubMed id 18293956)9 Anunciado D....Baranger A.M. (J Phys Chem B 2008)
    86. Role of Cajal bodies and nucleolus in the maturation of the U1 snRNP in Arabidopsis. (PubMed id 19098980)9 LorkoviA8 Z.J. and Barta A. (PLoS ONE 2008)
    87. Recognition of essential purines by the U1A protein. (PubMed id 17980039)9 Benitex Y. and Baranger A.M. (BMC Biochem. 2007)
    88. p54nrb is a component of the snRNP-free U1A (SF-A) complex that promotes pre-mRNA cleavage during polyadenylation. (PubMed id 16373496)9 Liang S. and Lutz C.S. (RNA 2006)
    89. Discriminatory RNP remodeling by the DEAD-box protein DED1. (PubMed id 16556937)9 Bowers H.A....Jankowsky E. (RNA 2006)
    90. Global and local dynamics of the U1A polyadenylation inhibition element (PIE) RNA and PIE RNA-U1A complexes. (PubMed id 15491147)9 Clerte C. and Hall K.B. (Biochemistry 2004)
    91. Molecular dynamics simulation studies of induced fit and conformational capture in U1A-RNA binding: do molecular substates code for specificity? (PubMed id 12434430)9 Pitici F....Baranger A.M. (Biopolymers 2002)
    92. Two functionally distinct steps mediate high affinity binding of U1A protein to U1 hairpin II RNA. (PubMed id 11297556)9 Katsamba P.S....Laird-Offringa I.A. (J. Biol. Chem. 2001)
    93. Global and local dynamics of the human U1A protein determined by tryptophan fluorescence. (PubMed id 10548057)9 Jean J.M....Hall K.B. (Protein Sci. 1999)
    94. Molecular dynamics simulations of the complex between human U1A protein and hairpin II of U1 small nuclear RNA and of free RNA in solution. (PubMed id 10465742)9 Tang Y. and Nilsson L. (Biophys. J. 1999)
    95. Characterization of human variable domain antibody fragments against the U1 RNA-associated A protein, selected from a synthetic and patient-derived combinatorial V gene library. (PubMed id 8605931)9 de Wildt R.M....Hoet R.M. (Eur. J. Immunol. 1996)
    96. The human U1 snRNP-specific U1A protein inhibits polyadenylation of its own pre-mRNA. (PubMed id 8458082)9 Boelens W.C....Gunderson S.I. (Cell 1993)
    97. Interaction of N-terminal domain of U1A protein with an RNA stem/loop. (PubMed id 1508720)9 Hall K.B. and Stump W.T. (Nucleic Acids Res. 1992)
    98. The U1 snRNA hairpin II as a RNA affinity tag for selecting snoRNP complexes. (PubMed id 17673090)9 Piekna-Przybylska D....Fournier M.J. (Meth. Enzymol. 2007)
    99. Binding of U1A protein changes RNA dynamics as observed by 13C NMR relaxation studies. (PubMed id 17469848)9 Shajani Z....Varani G. (Biochemistry 2007)
    100. Multiple features contribute to the use of the immunoglobulin M secretion-specific poly(A) signal but are not required for developmental regulation. (PubMed id 16943419)9 Peterson M.L....Cowan C. (Mol. Cell. Biol. 2006)
    101. The role of positively charged amino acids and electrostatic interactions in the complex of U1A protein and U1 hairpin II RNA. (PubMed id 16407334)9 Law M.J....Laird-Offringa I.A. (Nucleic Acids Res. 2006)
    102. Substitution of an essential adenine in the U1A-RNA complex with a non-polar isostere. (PubMed id 12466552)9 Tuite J.B....Baranger A.M. (Nucleic Acids Res. 2002)
    103. Complex role of the beta 2-beta 3 loop in the interaction of U1A with U1 hairpin II RNA. (PubMed id 12082087)9 Katsamba P.S....Laird-Offringa I.A. (J. Biol. Chem. 2002)
    104. Characterization of self-T-cell response and antigenic determinants of U1A protein with bone marrow-derived dendritic cells in NZB x NZW F1 mice. (PubMed id 11454059)9 Suen J.L....Chiang B.L. (Immunology 2001)
    105. Binding of U1A protein to the 3' untranslated region of its pre-mRNA. (PubMed id 10329165)9 Grainger R.J....Lilley D.M. (J. Mol. Biol. 1999)
    106. Severe helical distortion of the U1A mRNA 3' untranslated region induced by the U1A protein binding site. (PubMed id 9450069)9 Grainger R.J....Lilley D.M. (Biochem. Soc. Trans. 1997)
    107. Structure of the polyadenylation regulatory element of the human U1A pre-mRNA 3'-untranslated region and interaction with the U1A protein. (PubMed id 8652566)9 Gubser C.C. and Varani G. (Biochemistry 1996)
    108. The human U1A snRNP protein regulates polyadenylation via a direct interaction with poly(A) polymerase. (PubMed id 8313473)9 Gunderson S.I....Mattaj L.W. (Cell 1994)
    109. Coevolution of Drosophila snf protein and its snRNA targets. (PubMed id 20455544)9 Williams S.G. and Hall K.B. (Biochemistry 2010)
    110. Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion. (PubMed id 19447915)9 Netter C.... Wahl M.C. (RNA 2009)
    111. Prediction of salt and mutational effects on the association rate of U1A protein and U1 small nuclear RNA stem/loop II. (PubMed id 18154282)9 Qin S. and Zhou H.X. (J Phys Chem B 2008)
    112. High-resolution structural validation of the computational redesign of human U1A protein. (PubMed id 16698546)9 Dobson N....Varani G. (Structure 2006)
    113. Do collective atomic fluctuations account for cooperative effects? Molecular dynamics studies of the U1A-RNA complex. (PubMed id 16834346)9 Kormos B.L....Beveridge D.L. (J. Am. Chem. Soc. 2006)
    114. U1A RNA-binding domain at 1.8 A resolution. (PubMed id 12876372)9 Rupert P.B....FerrAc-D'AmarAc A.R. (Acta Crystallogr. D Biol. Crystallogr. 2003)
    115. A functional role for correlated motion in the N-terminal RNA-binding domain of human U1A protein. (PubMed id 12225747)9 Showalter S.A. and Hall K.B. (J. Mol. Biol. 2002)
    116. T7 phage display: a novel genetic selection system for cloning RNA-binding proteins from cDNA libraries. (PubMed id 11606722)9 Danner S. and Belasco J.G. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    117. Molecular dynamics and thermodynamics of protein-RNA interactions: mutation of a conserved aromatic residue modifies stacking interactions and structural adaptation in the U1A-stem loop 2 RNA complex. (PubMed id 11456923)9 Blakaj D.M....Baranger A.M. (J. Am. Chem. Soc. 2001)
    118. Molecular dynamics studies of U1A-RNA complexes. (PubMed id 10024175)9 Reyes C.M. and Kollman P.A. (RNA 1999)
    119. RNA recognition by the human U1A protein is mediated by a network of local cooperative interactions that create the optimal binding surface. (PubMed id 9878401)9 Kranz J.K. and Hall K.B. (J. Mol. Biol. 1999)
    120. Determination of the NMR structure of the complex between U1A protein and its RNA polyadenylation inhibition element. (PubMed id 9566313)9 Howe P.W....Neuhaus D. (J. Biomol. NMR 1998)
    121. Characterization of an anti-RNA recombinant autoantibody fragment (scFv) isolated from a phage display library and detailed analysis of its binding site on U1 snRNA. (PubMed id 9740130)9 Teunissen S.W....Hoet R.M. (RNA 1998)
    122. Thermal unfolding of the N-terminal RNA binding domain of the human U1A protein studied by differential scanning calorimetry. (PubMed id 9127942)9 Lu J. and Hall K.B. (Biophys. Chem. 1997)
    123. RNA hairpins with non-nucleotide spacers bind efficiently to the human U1A protein. (PubMed id 8609622)9 Williams D.J. and Hall K.B. (J. Mol. Biol. 1996)
    124. Drosophila SNF/D25 combines the functions of the two snRNP proteins U1A and U2B' that are encoded separately in human, potato, and yeast. (PubMed id 8846293)9 Polycarpou-Schwarz M....Mattaj I.W. (RNA 1996)
    125. An RBD that does not bind RNA: NMR secondary structure determination and biochemical properties of the C-terminal RNA binding domain from the human U1A protein. (PubMed id 7723028)9 Lu J. and Hall K.B. (J. Mol. Biol. 1995)
    126. Crystal structure of the U1A spliceosomal protein complexed with its cognate RNA hairpin. (PubMed id 8841523)9 Nagai K....Evans P. (Nucleic Acids Symp. Ser. 1995)
    127. Isolation of RNA from cell lines and cervical cytology specimens stored in BD SurePath preservative fluid and downstream detection of housekeeping gene and HPV E6 expression using real time RT-PCR. (PubMed id 19095009)9 Murphy P.G....Malinowski D.P. (J. Virol. Methods 2009)
    128. NELF-E RRM undergoes major structural changes in flexible protein regions on target RNA binding. (PubMed id 18303858)9 Rao J.N....RAPsch P. (Biochemistry 2008)
    129. Cellular siRNA delivery mediated by a cell-permeant RNA-binding protein and photoinduced RNA interference. (PubMed id 18442282)9 Endoh T....Ohtsuki T. (Bioconjug. Chem. 2008)
    130. Molecular dynamics simulation studies of a protein-RNA complex with a selectively modified binding interface. (PubMed id 16278830)9 Zhao Y....Baranger A.M. (Biopolymers 2006)
    131. Correspondence between anomalous m- and DeltaCp-values in protein folding. (PubMed id 15557266)9 Otzen D.E. and Oliveberg M. (Protein Sci. 2004)
    132. Transient aggregation and stable dimerization induced by introducing an Alzheimer sequence into a water-soluble protein. (PubMed id 15476390)9 Otzen D.E....Oliveberg M. (Biochemistry 2004)
    133. Activity of hybrid type I interferons in cells lacking Tyk2: a common region of IFN-alpha 8 induces a response, but IFN-alpha2/8 hybrids can behave like IFN-beta. (PubMed id 14651780)9 Platis D. and Foster G.R. (amp 2003)
    134. Novel specificity of anti-U1A autoimmune patient sera. (PubMed id 12542801)9 Faig O.Z. and Lutz C.S. (Scand. J. Immunol. 2003)
    135. Automated selection of aptamers against protein targets translated in vitro: from gene to aptamer. (PubMed id 12384610)9 Cox J.C....Ellington A.D. (Nucleic Acids Res. 2002)
    136. Poly(A) tail synthesis and regulation: recent structural insights. (PubMed id 11839494)9 Hall T.M. (Curr. Opin. Struct. Biol. 2002)
    137. Inhibition of the U1A-RNA complex by an aminoacridine derivative. (PubMed id 12270158)9 Gayle A.Y. and Baranger A.M. (amp 2002)
    138. Regulation of nuclear poly(A) addition controls the expression of immunoglobulin M secretory mRNA. (PubMed id 11707415)9 Phillips C....Gunderson S.I. (EMBO J. 2001)
    139. Functional analysis of SNF, the Drosophila U1A/U2B&quot; homolog: identification of dispensable and indispensable motifs for both snRNP assembly and function in vivo. (PubMed id 10580472)9 Stitzinger S.M....Salz H.K. (RNA 1999)
    140. Human monoclonal autoantibody fragments from combinatorial antibody libraries directed to the U1snRNP associated U1C protein; epitope mapping, immunolocalization and V-gene usage. (PubMed id 10068039)9 Hoet R.M....van Venrooij W.J. (Mol. Immunol. 1998)
    141. Crystal structure of the spliceosomal U2B'-U2A' protein complex bound to a fragment of U2 small nuclear RNA. (PubMed id 9716128)9 Price S.R.... Nagai K. (Nature 1998)
    142. Protein-RNA recognition. (PubMed id 10333745)9 De Guzman R.N....Summers M.F. (Biopolymers 1998)
    143. A new method for the analysis and production of monoclonal antibody fragments originating from single human B cells. (PubMed id 9328587)9 de Wildt R.M....Hoet R.M. (J. Immunol. Methods 1997)

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    Entrez Gene: 6626 HGNC: 11151 AceView: SNRPA Ensembl:ENSG00000077312 euGenes: HUgn6626
    ECgene: SNRPA Kegg: 6626 H-InvDB: SNRPA

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNRPA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNRPA gene:
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    GeneCards and IP:
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