SNRPA Gene

Aliases
for SNRPA gene

Previous GC identifers: GC19P041896 GC19P041648 GC19P045932 GC19P045948 GC19P037690

Summaries
for SNRPA gene

Genomic Views
for SNRPA gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmid: SNRPA promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPA

SNRPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041256:  view genomic region     (about GC identifiers)

Proteins
for SNRPA gene

6/59 PDB 3D structures from and Proteopedia for SNRPA (see all 59):

1AUD (3D)        1CX0 (3D)        1DRZ (3D)        1DZ5 (3D)        1FHT (3D)        1M5K (3D)    

Explore the universe of human proteins at neXtProt for SNRPA: NX_P09012

Post-translational modifications:

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	Uscn Proteins for SNRPA

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

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	Abcam antibodies for SNRPA
	Uscn Antibodies for SNRPA
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	Uscn ELISAs and CLIAs for SNRPA

Protein Domains /
Families
for SNRPA gene

ProtoNet protein and cluster: P09012

Function
for SNRPA gene

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SNRPA

miRNA Products:		OriGene 3'-UTR Clone: SNRPA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPA
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPA:
		hsa-miR-644 hsa-miR-1231 hsa-miR-654-3p hsa-miR-106a* hsa-miR-764
		SwitchGear 3'UTR luciferase reporter plasmid: SNRPA 3' UTR sequence

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			Sirion Biotech Customized adenovirus for overexpression of SNRPA  Sirion Biotech Customized adenovirus for potent knockdown of SNRPA

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA

Pathways & Interactions
for SNRPA gene

	Super-pathway	contained gene-specific pathways
1	mRNA Splicing - Major Pathway	mRNA Splicing 1.00 mRNA Processing 0.82 mRNA Splicing - Major Pathway 1.00 mRNA processing 0.48 Processing of Capped Intron-Containing Pre-mRNA 0.96 Spliceosome 0.31
2	Generic Transcription Pathway	Gene Expression 0.46

1 BioSystems Pathway for SNRPA

mRNA processing

5        Reactome Pathways for SNRPA

	mRNA Splicing - Major Pathway
	mRNA Splicing
	Gene Expression
	mRNA Processing
	Processing of Capped Intron-Containing Pre-mRNA

1         Kegg Pathway  (Kegg details for SNRPA)

Spliceosome

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for SNRPA gene

Transcripts
for SNRPA gene

Expression
for SNRPA gene

SNRPA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGCCCCTT

About this image
See SNRPA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNRPA

SOURCE GeneReport for Unigene cluster: Hs.466775
    SABiosciences Custom PCR Arrays for SNRPA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNRPA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SNRPA
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA

Orthologs
for SNRPA gene

Paralogs
for SNRPA gene

Paralogs for SNRPA gene

SNRPB2²  

1 SIMAP similar gene for SNRPA using alignment to 7 protein entries:     SNRPA_HUMAN (see all proteins):

SNRPB2

SNRPA for paralogs           About GeneDecksing

Genomic Variants
for SNRPA gene

10/287 NCBI SNPs in SNRPA are shown (see all 287)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1851921141,2		--	41254942(+)	CCAGGA/CTGGAG	2	--	int1 us2k1		0	--	--	--	--
rs1896103781,2		--	41255167(+)	CTGGGA/TTTACA	2	--	us2k1 int1		0	--	--	--	--
rs761773091,2	F	--	41255191(+)	GCACCC/TGGACT	2	--	us2k1 int1		1		NA	120
rs1476061061,2		--	41255310(+)	GGGAA-/CCCCCC	2	--	us2k1 int1		0	--	--	--	--
rs48020881,2	C,F,H	--	41255768(+)	TCCAAC/TGGAGA	2	--	ut51 us2k1		10		NS EA NA	1102
rs1888958001,2		--	41255823(+)	CAGAAC/TCTGGG	2	--	ut51 us2k1		0	--	--	--	--
rs1381015341,2		--	41255877(+)	CCACGA/GGAGCA	2	--	us2k1		0	--	--	--	--
rs22543261,2	C,F,O,H	--	41255889(-)	CCTCGC/AAATTC	2	--	us2k1		21		EA NS NA WA	3972
rs1929095971,2		--	41255907(+)	AAGTCA/CTAAGG	2	--	us2k1		0	--	--	--	--
rs48033641,2	C,F,H	--	41255920(+)	CCTGAC/TGGTTA	2	--	us2k1		8		NS EA NA	888

HapMap Linkage Disequilibrium report for SNRPA (41256759 - 41271297 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SNRPA
     1 CNV: 5100
     1 Indel: 67545

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNRPA

DNA2.0 Custom Variant and Variant Library Synthesis for SNRPA

Disorders / Diseases
for SNRPA gene

9 diseases for SNRPA

3 Novoseek disease relationships for SNRPA gene    About this table

Publications
for SNRPA gene

PubMed articles for SNRPA gene, integrated from 9 sources (see all 147) (see top 10): (articles sorted by number of sources associating them with SNRPA)

Utopia: connect your pdf to the dynamic world of online information

1. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. (PubMed id 9848648)^{1, 2, 9} Lutz C.S.... Alwine J.C. (1998)
2. Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy. (PubMed id 9265619)^{1, 2, 9} Lu J. and Hall K.B. (1997)
3. Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding. (PubMed id 8609632)^{1, 2, 9} Avis J.M....Neuhaus D. (1996)
4. Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein. (PubMed id 1831431)^{1, 2, 9} Nelissen R.L.H.... van Venrooij W.J. (1991)
5. Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. (PubMed id 2147232)^{1, 2, 9} Nagai K.... Evans P.R. (1990)
6. Structural basis of the RNA-binding specificity of human U1A protein. (PubMed id 9312034)^{1, 2, 9} Allain F.H.-T.... Varani G. (1997)
7. NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein. (PubMed id 8070414)^{1, 2, 9} Howe P.W.A.... Varani G. (1994)
8. Crystal structure at 1.92-A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PubMed id 7984237)^{1, 2, 9} Oubridge C.... Nagai K. (1994)
9. Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA. (PubMed id 1833186)^{1, 2, 9} Jessen T.-H.... Nagai K. (1991)
10. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. (PubMed id 19561594)^{1, 2} Ray D....Hughes T.R. (2009)
11. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
12. Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation. (PubMed id 8602269)^{1, 2} Allain F.H.-T....Varani G. (1996)
13. RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins. (PubMed id 1826055)^{1, 2} Hoffman D.W.... Keene J.D. (1991)
14. Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region. (PubMed id 1701111)^{1, 3} Schonk D....Geurts van Kessel A. (1990)
15. cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins. (PubMed id 2962859)^{1, 2} Sillekens P.T.G.... van Venrooij W.J. (1987)
16. The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. (PubMed id 10742179)^{1, 9} Varani L....Varani G. (2000)
17. Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation. (PubMed id 10688667)^{1, 9} Klein Gunnewiek J.M....Gunderson S.I. (2000)
18. An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B' spliceosome proteins. (PubMed id 10648562)^{1, 9} Hetzer M. and Mattaj I.W. (2000)
19. A bipartite U1 site represses U1A expression by synergizing with PIE to inhibit nuclear polyadenylation. (PubMed id 17942741)^{1, 9} Guan F....Gunderson S.I. (2007)
20. 13C NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein. (PubMed id 15890361)^{1, 9} Shajani Z. and Varani G. (2005)
21. Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR. (PubMed id 17507659)^{1, 9} Hall-Pogar T....Lutz C.S. (2007)
22. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
23. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
24. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
25. Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor c oregulators, p54nrb and PSF. (PubMed id 21566083)¹ Liu L....Dong X. (2011)
26. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)¹ Emanuele M.J....Elledge S.J. (2011)
27. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)¹ Neganova I....Lako M. (2011)
28. The small nuclear ribonucleoprotein U1A interacts wit h NS5 from yellow fever virus. (PubMed id 21298455)¹ Bronzoni R.V....Nogueira M.L. (2011)
29. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
30. U1A protein-stem loop 2 RNA recognition: prediction o f structural differences from protein mutations. (PubMed id 21384338)¹ Kormos B.L....Baranger A.M. (2011)
31. Multistep kinetics of the U1A-SL2 RNA complex dissoci ation. (PubMed id 21419778)¹ Anunciado D....Baranger A.M. (2011)
32. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
33. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
34. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. (PubMed id 20508642)¹ Krebs A.R....Tora L. (2010)
35. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
36. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
37. Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. (PubMed id 19373254)¹ Komander D....Barford D. (2009)
38. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)² Choudhary C.... Mann M. (2009)
39. Identification of intracellular proteins associated w ith the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-I CR mass spectrometry. (PubMed id 18457437)¹ Forsman A....Rymo L. (2008)
40. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
41. Proteomic analysis of p16ink4a-binding proteins. (PubMed id 17955473)¹ Souza-Rodrigues E....Jaumot M. (2007)
42. Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. (PubMed id 17332742)¹ Behzadnia N.... Luehrmann R. (2007)
43. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)¹ Ewing R.M.... Figeys D. (2007)
44. 14-3-3sigma controls mitotic translation to facilitate cytokinesis. (PubMed id 17361185)¹ Wilker E.W....Yaffe M.B. (2007)
45. Nucleolar proteome dynamics. (PubMed id 15635413)¹ Andersen J.S....Mann M. (2005)
46. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
47. WW domains provide a platform for the assembly of mul tiprotein networks. (PubMed id 16055720)¹ Ingham R.J....Pawson T. (2005)
48. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)
49. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)¹ Colland F....Gauthier J.M. (2004)
50. Comprehensive proteomic analysis of the human spliceosome. (PubMed id 12226669)¹ Zhou Z.... Reed R. (2002)
51. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
52. Nef triggers a transcriptional program in T cells imitating single- signal T cell activation and inducing HIV virulence mediators. (PubMed id 11420046)¹ Simmons A.... McMichael A. (2001)
53. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. (PubMed id 11101529)¹ Ajuh P....Lamond A.I. (2000)
54. Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. (PubMed id 9731529)¹ Neubauer G.... Mann M. (1998)
55. Crystal structure of a hepatitis delta virus ribozyme. (PubMed id 9783582)¹ Ferre-D'Amare A.R....Doudna J.A. (1998)
56. Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA. (PubMed id 1696729)¹ Lutz-Freyermuth C....Keene J.D. (1990)
57. Severe axial bending of RNA induced by the U1A binding element present in the 3' untranslated region of the U1A mRNA. (PubMed id 9367748)⁹ Grainger R.J....Lilley D.M. (1997)
58. The snRNP-associated U1A levels change following IL-6 stimulation of human B-cells. (PubMed id 12617996)⁹ Milcarek C....Lutz C.S. (2003)
59. Sequences adjacent to the 5' splice site control U1A binding upstream of the IgM heavy chain secretory poly(A) site. (PubMed id 12670951)⁹ Phillips C. and Gunderson S. (2003)
60. Molecular characterization of the spliceosomal proteins U1A and U2B' from higher plants. (PubMed id 7556097)⁹ Simpson G.G....Brown J.W. (1995)
61. Analysis of in vitro binding of U1-A protein mutants to U1 snRNA. (PubMed id 1832492)⁹ Boelens W....van Venrooij W.J. (1991)
62. Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA. (PubMed id 12203842)⁹ Lutz C.S....James J.A. (2002)
63. Spatial orientation and dynamics of the U1A proteins in the U1A-UTR complex. (PubMed id 10852733)⁹ Clerte C. and Hall K.B. (2000)
64. Heavy chain CDR3 optimization of a germline encoded recombinant antibody fragment predisposed to bind the U1A protein. (PubMed id 9342149)⁹ de Wildt R.M....Hoet R.M. (1997)
65. Probing the 3' UTR structure of U1A mRNA and footprinting analysis of its complex with U1A protein. (PubMed id 9048562)⁹ Teunissen S.W....van Venrooij W.J. (1997)
66. Two structurally different RNA molecules are bound by the spliceosomal protein U1A using the same recognition strategy. (PubMed id 8736559)⁹ Jovine L....Nagai K. (1996)
67. MHC class II gene associations with autoantibodies to U1A and SmD1 proteins. (PubMed id 10069423)⁹ Dumortier H....Muller S. (1999)
68. A complex secondary structure in U1A pre-mRNA that binds two molecules of U1A protein is required for regulation of polyadenylation. (PubMed id 8262062)⁹ van Gelder C.W....van Venrooij W.J. (1993)
69. Intracellular distribution of the U1A protein depends on active transport and nuclear binding to U1 snRNA. (PubMed id 1618898)⁹ Kambach C. and Mattaj I.W. (1992)
70. The role of RNA structure in the interaction of U1A protein with U1 hairpin II RNA. (PubMed id 16738410)⁹ Law M.J....Laird-Offringa I.A. (2006)
71. Determinants within an 18-amino-acid U1A autoregulatory domain that uncouple cooperative RNA binding, inhibition of polyadenylation, and homodimerization. (PubMed id 12697817)⁹ Guan F....Gunderson S.I. (2003)
72. Investigation of a conserved stacking interaction in target site recognition by the U1A protein. (PubMed id 11788718)⁹ Shiels J.C....Baranger A.M. (2002)
73. Changes in side-chain and backbone dynamics identify determinants of specificity in RNA recognition by human U1A protein. (PubMed id 10588900)⁹ Mittermaier A....Varani G. (1999)
74. Target discrimination by RNA-binding proteins: role of the ancillary protein U2A' and a critical leucine residue in differentiating the RNA-binding specificity of spliceosomal proteins U1A and U2B'. (PubMed id 9814759)⁹ Rimmele M.E. and Belasco J.G. (1998)
75. An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicing. (PubMed id 8449403)⁹ Liao X.C....Rosbash M. (1993)
76. Induced fit or conformational selection for RNA/U1A f olding. (PubMed id 20354153)⁹ Qin F....Chen H.F. (2010)
77. Characterization of the dynamics of an essential helix in the U1A protein by time-resolved fluorescence measurements. (PubMed id 18293956)⁹ Anunciado D....Baranger A.M. (2008)
78. Role of cajal bodies and nucleolus in the maturation of the U1 snRNP in arabidopsis. (PubMed id 19098980)⁹ LorkoviA8 Z.J. and Barta A. (2008)
79. Recognition of essential purines by the U1A protein. (PubMed id 17980039)⁹ Benitex Y. and Baranger A.M. (2007)
80. p54nrb is a component of the snRNP-free U1A (SF-A) complex that promotes pre-mRNA cleavage during polyadenylation. (PubMed id 16373496)⁹ Liang S. and Lutz C.S. (2006)
81. Discriminatory RNP remodeling by the DEAD-box protein DED1. (PubMed id 16556937)⁹ Bowers H.A....Jankowsky E. (2006)
82. Global and local dynamics of the U1A polyadenylation inhibition element (PIE) RNA and PIE RNA-U1A complexes. (PubMed id 15491147)⁹ Clerte C. and Hall K.B. (2004)
83. Molecular dynamics simulation studies of induced fit and conformational capture in U1A-RNA binding: do molecular substates code for specificity? (PubMed id 12434430)⁹ Pitici F....Baranger A.M. (2002)
84. Two functionally distinct steps mediate high affinity binding of U1A protein to U1 hairpin II RNA. (PubMed id 11297556)⁹ Katsamba P.S....Laird-Offringa I.A. (2001)
85. Global and local dynamics of the human U1A protein determined by tryptophan fluorescence. (PubMed id 10548057)⁹ Jean J.M....Hall K.B. (1999)
86. Molecular dynamics simulations of the complex between human U1A protein and hairpin II of U1 small nuclear RNA and of free RNA in solution. (PubMed id 10465742)⁹ Tang Y. and Nilsson L. (1999)
87. Characterization of human variable domain antibody fragments against the U1 RNA-associated A protein, selected from a synthetic and patient-derived combinatorial V gene library. (PubMed id 8605931)⁹ de Wildt R.M....Hoet R.M. (1996)
88. The human U1 snRNP-specific U1A protein inhibits polyadenylation of its own pre-mRNA. (PubMed id 8458082)⁹ Boelens W.C....Gunderson S.I. (1993)
89. Interaction of N-terminal domain of U1A protein with an RNA stem/loop. (PubMed id 1508720)⁹ Hall K.B. and Stump W.T. (1992)
90. The U1 snRNA hairpin II as a RNA affinity tag for selecting snoRNP complexes. (PubMed id 17673090)⁹ Piekna-Przybylska D....Fournier M.J. (2007)
91. Binding of U1A protein changes RNA dynamics as observed by 13C NMR relaxation studies. (PubMed id 17469848)⁹ Shajani Z....Varani G. (2007)
92. Multiple features contribute to the use of the immunoglobulin M secretion-specific poly(A) signal but are not required for developmental regulation. (PubMed id 16943419)⁹ Peterson M.L....Cowan C. (2006)
93. The role of positively charged amino acids and electrostatic interactions in the complex of U1A protein and U1 hairpin II RNA. (PubMed id 16407334)⁹ Law M.J....Laird-Offringa I.A. (2006)
94. Substitution of an essential adenine in the U1A-RNA complex with a non-polar isostere. (PubMed id 12466552)⁹ Tuite J.B....Baranger A.M. (2002)
95. Complex role of the beta 2-beta 3 loop in the interaction of U1A with U1 hairpin II RNA. (PubMed id 12082087)⁹ Katsamba P.S....Laird-Offringa I.A. (2002)
96. Characterization of self-T-cell response and antigenic determinants of U1A protein with bone marrow-derived dendritic cells in NZB x NZW F1 mice. (PubMed id 11454059)⁹ Suen J.L....Chiang B.L. (2001)
97. Binding of U1A protein to the 3' untranslated region of its pre-mRNA. (PubMed id 10329165)⁹ Grainger R.J....Lilley D.M. (1999)
98. Severe helical distortion of the U1A mRNA 3' untranslated region induced by the U1A protein binding site. (PubMed id 9450069)⁹ Grainger R.J....Lilley D.M. (1997)
99. Structure of the polyadenylation regulatory element o f the human U1A pre-mRNA 3'-untranslated region and interaction with the U1A pr otein. (PubMed id 8652566)⁹ Gubser C.C. and Varani G. (1996)
100. The human U1A snRNP protein regulates polyadenylation via a direct interaction with poly(A) polymerase. (PubMed id 8313473)⁹ Gunderson S.I....Mattaj L.W. (1994)
101. Coevolution of Drosophila snf protein and its snRNA t argets. (PubMed id 20455544)⁹ Williams S.G. and Hall K.B. (2010)
102. Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion. (PubMed id 19447915)⁹ Netter C....Wahl M.C. (2009)
103. Prediction of salt and mutational effects on the association rate of U1A protein and U1 small nuclear RNA stem/loop II. (PubMed id 18154282)⁹ Qin S. and Zhou H.X. (2008)
104. High-resolution structural validation of the computational redesign of human U1A protein. (PubMed id 16698546)⁹ Dobson N....Varani G. (2006)
105. Do collective atomic fluctuations account for cooperative effects? Molecular dynamics studies of the U1A-RNA complex. (PubMed id 16834346)⁹ Kormos B.L....Beveridge D.L. (2006)
106. U1A RNA-binding domain at 1.8 A resolution. (PubMed id 12876372)⁹ Rupert P.B....Ferre-D'Amare A.R. (2003)
107. A functional role for correlated motion in the N-terminal RNA-binding domain of human U1A protein. (PubMed id 12225747)⁹ Showalter S.A. and Hall K.B. (2002)
108. T7 phage display: a novel genetic selection system for cloning RNA-binding proteins from cDNA libraries. (PubMed id 11606722)⁹ Danner S. and Belasco J.G. (2001)
109. Molecular dynamics and thermodynamics of protein-RNA interactions: mutation of a conserved aromatic residue modifies stacking interactions and structural adaptation in the U1A-stem loop 2 RNA complex. (PubMed id 11456923)⁹ Blakaj D.M....Baranger A.M. (2001)
110. Molecular dynamics studies of U1A-RNA complexes. (PubMed id 10024175)⁹ Reyes C.M. and Kollman P.A. (1999)
111. RNA recognition by the human U1A protein is mediated by a network of local cooperative interactions that create the optimal binding surface. (PubMed id 9878401)⁹ Kranz J.K. and Hall K.B. (1999)
112. Determination of the NMR structure of the complex bet ween U1A protein and its RNA polyadenylation inhibition element. (PubMed id 9566313)⁹ Howe P.W....Neuhaus D. (1998)
113. Characterization of an anti-RNA recombinant autoantib ody fragment (scFv) isolated from a phage display library and detailed analysis of its binding site on U1 snRNA. (PubMed id 9740130)⁹ Teunissen S.W....Hoet R.M. (1998)
114. Thermal unfolding of the N-terminal RNA binding domai n of the human U1A protein studied by differential scanning calorimetry. (PubMed id 9127942)⁹ Lu J. and Hall K.B. (1997)
115. RNA hairpins with non-nucleotide spacers bind efficie ntly to the human U1A protein. (PubMed id 8609622)⁹ Williams D.J. and Hall K.B. (1996)
116. Drosophila SNF/D25 combines the functions of the two snRNP proteins U1A and U2B' that are encoded separately in human, potato, and yeast. (PubMed id 8846293)⁹ Polycarpou-Schwarz M....Mattaj I.W. (1996)
117. An RBD that does not bind RNA: NMR secondary structur e determination and biochemical properties of the C-terminal RNA binding domain from the human U1A protein. (PubMed id 7723028)⁹ Lu J. and Hall K.B. (1995)
118. Crystal structure of the U1A spliceosomal protein complexed with its cognate RNA hairpin. (PubMed id 8841523)⁹ Nagai K....Evans P. (1995)
119. Isolation of RNA from cell lines and cervical cytology specimens stored in BD SurePath preservative fluid and downstream detection of housekeeping gene and HPV E6 expression using real time RT-PCR. (PubMed id 19095009)⁹ Murphy P.G....Malinowski D.P. (2009)
120. NELF-E RRM undergoes major structural changes in flexible protein regions on target RNA binding. (PubMed id 18303858)⁹ Rao J.N....Rosch P. (2008)
121. Cellular siRNA delivery mediated by a cell-permeant RNA-binding protein and photoinduced RNA interference. (PubMed id 18442282)⁹ Endoh T....Ohtsuki T. (2008)
122. Molecular dynamics simulation studies of a protein-RNA complex with a selectively modified binding interface. (PubMed id 16278830)⁹ Zhao Y....Baranger A.M. (2006)
123. Correspondence between anomalous m- and DeltaCp-values in protein folding. (PubMed id 15557266)⁹ Otzen D.E. and Oliveberg M. (2004)
124. Transient aggregation and stable dimerization induced by introducing an Alzheimer sequence into a water-soluble protein. (PubMed id 15476390)⁹ Otzen D.E....Oliveberg M. (2004)
125. Activity of hybrid type I interferons in cells lacking Tyk2: a common region of IFN-alpha 8 induces a response, but IFN-alpha2/8 hybrids can behave like IFN-beta. (PubMed id 14651780)⁹ Platis D. and Foster G.R. (2003)
126. Novel specificity of anti-U1A autoimmune patient sera. (PubMed id 12542801)⁹ Faig O.Z. and Lutz C.S. (2003)
127. Automated selection of aptamers against protein targets translated in vitro: from gene to aptamer. (PubMed id 12384610)⁹ Cox J.C....Ellington A.D. (2002)
128. Poly(A) tail synthesis and regulation: recent structu ral insights. (PubMed id 11839494)⁹ Hall T.M. (2002)
129. Inhibition of the U1A-RNA complex by an aminoacridine derivative. (PubMed id 12270158)⁹ Gayle A.Y. and Baranger A.M. (2002)
130. Regulation of nuclear poly(A) addition controls the expression of immunoglobulin M secretory mRNA. (PubMed id 11707415)⁹ Phillips C....Gunderson S.I. (2001)
131. Functional analysis of SNF, the Drosophila U1A/U2B' homolog: identification of dispensable and indispensable motifs for both snRNP assembly and function in vivo. (PubMed id 10580472)⁹ Stitzinger S.M....Salz H.K. (1999)
132. Human monoclonal autoantibody fragments from combinatorial antibody libraries directed to the U1snRNP associated U1C protein; epitope mapping, immunolocalization and V-gene usage. (PubMed id 10068039)⁹ Hoet R.M....van Venrooij W.J. (1998)
133. Crystal structure of the spliceosomal U2B'-U2A' protein complex bound to a fragment of U2 small nuclear RNA. (PubMed id 9716128)⁹ Price S.R.... Nagai K. (1998)
134. Protein-RNA recognition. (PubMed id 10333745)⁹ De Guzman R.N....Summers M.F. (1998)
135. A new method for the analysis and production of monoc lonal antibody fragments originating from single human B cells. (PubMed id 9328587)⁹ de Wildt R.M....Hoet R.M. (1997)
136. Identification and characterization of a yeast gene encoding the U2 small nuclear ribonucleoprotein particle B' protein. (PubMed id 8649387)⁹ Tang J....Rosbash M. (1996)

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