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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SNRPA Gene

protein-coding GIFtS: 60
GCID: GC19P041256

small nuclear ribonucleoprotein polypeptide A

Explore 9 diseases affiliated with
SNRPA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Small Nuclear Ribonucleoprotein Polypeptide A¹ ²		U1 SnRNP A² ³
U1-A¹ ² ³		U1 Small Nuclear Ribonucleoprotein A²
U1A¹ ² ³		U1 Small Nuclear RNP-Specific A²
Mud1¹ ²		U1 SnRNP-Specific Protein A²

External Ids:	HGNC: 11151¹	Entrez Gene: 6626²	Ensembl: ENSG00000077312⁷	OMIM: 182285⁵	UniProtKB: P09012³

Export aliases for SNRPA gene to outside databases

Previous GC identifers: GC19P041896 GC19P041648 GC19P045932 GC19P045948 GC19P037690

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNRPA:

The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds

the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by

polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing

and polyadenylation. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012

Function: Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required

for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in

coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro

Gene Wiki entry for SNRPA (Small nuclear ribonucleoprotein polypeptide A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SNRPA gene promoter:
SRF STAT1 SRF (504 AA) ATF-2 STAT1beta STAT1alpha Max c-Jun Ik-1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNRPA promoter sequence

Search SABiosciences Chromatin IP Primers for SNRPA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1

SNRPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPA gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P041256: view genomic region (about GC identifiers)

Start:	41,256,759 bp from pter	End:	41,271,297 bp from pter
Size:	14,539 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012 (See protein sequence)

Recommended Name: U1 small nuclear ribonucleoprotein A

Size: 282 amino acids; 31280 Da

Subunit: Belongs to the spliceosome where it is associated with snRNP U1. Interacts with SFPQ. Also component of a

snRNP-free complex with SFPQ

Subcellular location: Nucleus

6/59 PDB 3D structures from and Proteopedia for SNRPA (see all 59):

1AUD (3D)

1CX0 (3D)

1DRZ (3D)

1DZ5 (3D)

1FHT (3D)

1M5K (3D)

Explore the universe of human proteins at neXtProt for SNRPA: NX_P09012

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09012

SNRPA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004587.1

ENSEMBL proteins:

ENSP00000243563

Reactome Protein details: P09012
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals SNRPA Protein Novus Biologicals SNRPA Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SNRPA

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005681	spliceosomal complex	IDA	9731529

SNRPA for ontologies About GeneDecksing

SNRPA Antibody Products:

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Assay Products for SNRPA:

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	Uscn ELISAs and CLIAs for SNRPA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SNRPA for domains About GeneDecksing

3 InterPro domains/families:

IPR024888 U1_snRNP_A/U2_snRNP_B''

IPR000504 RRM_dom

IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry P09012

ProtoNet protein and cluster: P09012

1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012

Similarity: Belongs to the RRM U1 A/B'' family

Similarity: Contains 2 RRM (RNA recognition motif) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012

Function: Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required

for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in

coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro

Genatlas biochemistry entry for SNRPA:

samll ribonucleoprotein U1,A polypeptide

miRNA Products:		OriGene 3'-UTR Clone: SNRPA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPA
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPA:
		hsa-miR-644 hsa-miR-1231 hsa-miR-654-3p hsa-miR-106a* hsa-miR-764
		SwitchGear 3'UTR luciferase reporter plasmid: SNRPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRPA (see all 7) OriGene shRNA RFP: SNRPA OriGene siRNA: SNRPA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPA

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SNRPA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA (see all 4) (see first 1) NM_004596 (human cat#: RC201818) NM_001046637 (mouse cat#: MR203914) NM_015782 (mouse cat#: MR203911) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SNRPA (NM_004596)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SNRPA
		Search LifeMap BioReagents cell lines for SNRPA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003723	RNA binding	IDA	19561594
GO:0005515	protein binding	IPI	9848648
GO:0017069	snRNA binding	IEA	--

SNRPA for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing	1.00	mRNA Processing	0.82
mRNA Splicing - Major Pathway	1.00	mRNA processing	0.48
Processing of Capped Intron-Containing Pre-mRNA	0.96	Spliceosome	0.31

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for SNRPA

mRNA processing

5 Reactome Pathways for SNRPA

	mRNA Splicing - Major Pathway
	mRNA Splicing
	Gene Expression
	mRNA Processing
	Processing of Capped Intron-Containing Pre-mRNA

1 Kegg Pathway (Kegg details for SNRPA):

Spliceosome

SNRPA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SNRPA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/617 Interacting proteins for SNRPA (P09012^{1, 2, 3} ENSP00000243563⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 617)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMN2	Q16637²^,³, ENSP00000370119⁴	MINT-14308 MINT-7947479 I2D: score=1 STRING: ENSP00000370119
PTBP1	P26599²^,³, ENSP00000349428⁴	MINT-8332987 MINT-7947479 I2D: score=3 STRING: ENSP00000349428
SF3A2	Q15428²^,³, ENSP00000221494⁴	MINT-5205386 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
SMN1	Q16637²^,³	MINT-14308 MINT-7947479 I2D: score=1
C19orf43	Q9BQ61²^,³, ENSP00000242784⁴	MINT-8332954 I2D: score=4 STRING: ENSP00000242784

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0008380	RNA splicing	TAS	--
GO:0010467	gene expression	TAS	--

SNRPA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SNRPA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SNRPA

1 DrugBank Compound for SNRPA About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Malonic acid	Malonate (see all 2)	141-82-2	target	--	--

7 Novoseek chemical compound relationships for SNRPA gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adenylate	41.5	21	12670951 (4), 16943419 (2), 10742179 (2), 11839494 (1) (see all 8)
hydrogen	27.4	8	11788718 (2), 12466552 (2), 16407334 (1), 16738410 (1) (see all 6)
adenine	19.3	6	12466552 (3), 15491147 (1), 16278830 (1)
guanidine hydrochloride	17.1	1	15476390 (1)
cysteine	0.481	1	10852733 (1)
atp	0	2	10648562 (1)
iron	0	4	1584791 (1)

Search CenterWatch for drugs/clinical trials and news about SNRPA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SNRPA gene:

NM_004596.4

Unigene Cluster for SNRPA:

Small nuclear ribonucleoprotein polypeptide A

Hs.466775 [show with all ESTs]

Unigene Representative Sequence: NM_004596

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000243563(uc002ooz.3)

miRNA Products:		OriGene 3'-UTR Clone: SNRPA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPA
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPA:
		hsa-miR-644 hsa-miR-1231 hsa-miR-654-3p hsa-miR-106a* hsa-miR-764
		SwitchGear 3'UTR luciferase reporter plasmid: SNRPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRPA (see all 7) OriGene shRNA RFP: SNRPA OriGene siRNA: SNRPA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPA

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SNRPA (NM_004596)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNRPA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat SNRPA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPA

Additional cDNA sequence:

AK293140.1 AK313182.1 BC000405.2 BC008290.1 X06347.1

17 DOTS entries:

DT.97854609 DT.100827444 DT.80102050 DT.100827448 DT.121436155 DT.100647055 DT.100827455 DT.305096

DT.100750095 DT.121436170 DT.100827445 DT.100827454 DT.121436208 DT.100719490 DT.100827446 DT.100827447

DT.95206669

24/488 AceView cDNA sequences (see all 488):

CA306578 BC008290 CA420448 CR612581 CR613649 BE501622 CR606390 CR620634

CR607723 CR595370 BP871078 BI768440 CR591403 AI188213 CR611065 BM682690

BX417996 CR597793 CR593045 BM740167 BM718224 CR614107 CR597345 CR622302

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SNRPA (see all 10) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	^	8	^	9
SP1:																	-								-								-						-
SP2:			-		-		-		-		-		-		-		-								-								-						-
SP3:									-		-		-				-								-								-
SP4:									-		-		-				-								-		-
SP5:							-		-		-		-				-								-

ECgene alternative splicing isoforms for SNRPA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SNRPA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGCCCCTT

About this image
See SNRPA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNRPA

SOURCE GeneReport for Unigene cluster: Hs.466775

SABiosciences Custom PCR Arrays for SNRPA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNRPA Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPA gene from 8/35 species (see all 35) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Snrpa^{1 , 5}	small nuclear ribonucleoprotein polypeptide A^{1, 5}	88.97(n)¹ 96.44(a)¹		7 (15.84 cM)⁵ 53607¹ NM_001046637.1¹ NP_001040102.1¹ 27187005⁵
lizard (Anolis carolinensis)	Reptilia	SNRPA⁶	--	84(a)	1 ↔ 1	LGf(2806307-2809992)
African clawed frog (Xenopus laevis)	Amphibia	snf-prov²	sans fille	77.7(n)		X57953.1
zebrafish (Danio rerio)	Actinopterygii	BC064308.1²	--	80.27(n)		324121 BC064308.1
fruit fly (Drosophila melanogaster)	Insecta	snf¹	sans fille	69.22(n) 70.27(a)		31442 NM_078490.3 NP_511045.1
worm (Caenorhabditis elegans)	Secernentea	rnp-2¹	Protein RNP-2	60.03(n) 56.22(a)		177181 NM_068103.2 NP_500504.1
thale cress (Arabidopsis thaliana)	eudicotyledons	U1A¹	spliceosomal protein U1A	54.99(n) 54.7(a)		819371 NM_130326.2 NP_182280.1
rice (Oryza sativa)	Liliopsida	Os.9766²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	74.96(n)		AK102716.1

ENSEMBL Gene Tree for SNRPA (if available)
TreeFam Gene Tree for SNRPA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SNRPA gene

SNRPB2²

1 SIMAP similar gene for SNRPA using alignment to 7 protein entries: SNRPA_HUMAN (see all proteins):

SNRPB2

SNRPA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185192114^1,2		--	41254942(+)	`CCAGGA/CTGGAG`	2	--	int¹ us2k¹		0	--	--	--	--
rs189610378^1,2		--	41255167(+)	`CTGGGA/TTTACA`	2	--	us2k¹ int¹		0	--	--	--	--
rs76177309^1,2	F,	--	41255191(+)	`GCACCC/TGGACT`	2	--	us2k¹ int¹		1		NA	120
rs147606106^1,2		--	41255310(+)	`GGGAA-/CCCCCC`	2	--	us2k¹ int¹		0	--	--	--	--
rs4802088^1,2	C,F,H,	--	41255768(+)	`TCCAAC/TGGAGA`	2	--	ut5¹ us2k¹		10		NS EA NA	1102
rs188895800^1,2		--	41255823(+)	`CAGAAC/TCTGGG`	2	--	ut5¹ us2k¹		0	--	--	--	--
rs138101534^1,2		--	41255877(+)	`CCACGA/GGAGCA`	2	--	us2k¹		0	--	--	--	--
rs2254326^1,2	C,F,O,H,	--	41255889(-)	`CCTCGC/AAATTC`	2	--	us2k¹		21		EA NS NA WA	3972
rs192909597^1,2		--	41255907(+)	`AAGTCA/CTAAGG`	2	--	us2k¹		0	--	--	--	--
rs4803364^1,2	C,F,H,	--	41255920(+)	`CCTGAC/TGGTTA`	2	--	us2k¹		8		NS EA NA	888

HapMap Linkage Disequilibrium report for SNRPA (41256759 - 41271297 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SNRPA
1 CNV: 5100
1 Indel: 67545

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNRPA

DNA2.0 Custom Variant and Variant Library Synthesis for SNRPA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SNRPA for disorders           About GeneDecksing

OMIM gene information: 182285    OMIM disorders: --

9 diseases for SNRPA:    About MalaCards

mixed connective tissue disease connective tissue disease yellow fever lupus erythematosus

systemic lupus erythematosus myotonic dystrophy cervicitis hepatitis

malaria

2 diseases from the University of Copenhagen DISEASES database for SNRPA:

Mixed connective tissue disease Systemic lupus erythematosus

3 Novoseek disease relationships for SNRPA gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mixed connective tissue disease	47.7	1	7930595 (1)
lupus erythematosus systemic	41	5	7930595 (1), 9342149 (1), 8605931 (1), 9328587 (1) (see all 5)
autoimmune diseases	17.4	1	7687615 (1)

Export disorders for SNRPA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SNRPA gene, integrated from 9 sources (see all 147):
(articles sorted by number of sources associating them with SNRPA)

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The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. (PubMed id 9848648)^{1, 2, 9} Lutz C.S.... Alwine J.C. (1998)
Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy. (PubMed id 9265619)^{1, 2, 9} Lu J. and Hall K.B. (1997)
Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding. (PubMed id 8609632)^{1, 2, 9} Avis J.M....Neuhaus D. (1996)
Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein. (PubMed id 1831431)^{1, 2, 9} Nelissen R.L.H.... van Venrooij W.J. (1991)
Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. (PubMed id 2147232)^{1, 2, 9} Nagai K.... Evans P.R. (1990)
Structural basis of the RNA-binding specificity of human U1A protein. (PubMed id 9312034)^{1, 2, 9} Allain F.H.-T.... Varani G. (1997)
NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein. (PubMed id 8070414)^{1, 2, 9} Howe P.W.A.... Varani G. (1994)
Crystal structure at 1.92-A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PubMed id 7984237)^{1, 2, 9} Oubridge C.... Nagai K. (1994)
Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA. (PubMed id 1833186)^{1, 2, 9} Jessen T.-H.... Nagai K. (1991)
Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. (PubMed id 19561594)^{1, 2} Ray D....Hughes T.R. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6626	HGNC: 11151	AceView: SNRPA	Ensembl:ENSG00000077312	euGenes: HUgn6626
ECgene: SNRPA	Kegg: 6626	H-InvDB: SNRPA

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SNRPA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SNRPA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SNRPA gene:
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small nuclear ribonucleoprotein polypeptide A

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small nuclear ribonucleoprotein polypeptide A

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