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SNRPA Gene

protein-coding   GIFtS: 61
GCID: GC19P041256

Small Nuclear Ribonucleoprotein Polypeptide A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Small Nuclear Ribonucleoprotein Polypeptide A1 2     Mud12
U1-A2 3     U1 Small Nuclear Ribonucleoprotein A2
U1A2 3     U1 Small Nuclear RNP-Specific A2
U1 SnRNP A2 3     U1 SnRNP-Specific Protein A2

External Ids:    HGNC: 111511   Entrez Gene: 66262   Ensembl: ENSG000000773127   OMIM: 1822855   UniProtKB: P090123   

Export aliases for SNRPA gene to outside databases

Previous GC identifers: GC19P041896 GC19P041648 GC19P045932 GC19P045948 GC19P037690


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNRPA Gene:
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which
binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates
itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling
of splicing and polyadenylation. (provided by RefSeq, Oct 2010)

GeneCards Summary for SNRPA Gene:
SNRPA (small nuclear ribonucleoprotein polypeptide A) is a protein-coding gene. GO annotations related to this gene include RNA binding and snRNA binding. An important paralog of this gene is SNRPB2.

UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012
Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5'
splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with
pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA
binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and
polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs

Gene Wiki entry for SNRPA (Small nuclear ribonucleoprotein polypeptide A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNRPA gene promoter:
         SRF   STAT1   SRF (504 AA)   ATF-2   STAT1beta   STAT1alpha   Max   c-Jun   Ik-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRPA promoter sequence
   Search Chromatin IP Primers for SNRPA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNRPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

SNRPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041256:  view genomic region     (about GC identifiers)

Start:
41,256,542 bp from pter      End:
41,271,297 bp from pter
Size:
14,756 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012 (See protein sequence)
Recommended Name: U1 small nuclear ribonucleoprotein A  
Size: 282 amino acids; 31280 Da
Subunit: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that
assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at
least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SFPQ; component
of a snRNP-free complex with SFPQ
Selected PDB 3D structures from and Proteopedia for SNRPA (see all 59):
1AUD (3D)        1CX0 (3D)        1DRZ (3D)        1DZ5 (3D)        1FHT (3D)        1M5K (3D)    

Explore the universe of human proteins at neXtProt for SNRPA: NX_P09012

Explore proteomics data for SNRPA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys20, Lys60, Lys88, Lys96, Lys98, Lys268, Lys276
  • Modification sites at PhosphoSitePlus

  • See SNRPA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004587.1  
    ENSEMBL proteins: 
     ENSP00000470534   ENSP00000243563   ENSP00000469224   ENSP00000472449   ENSP00000472258  
     ENSP00000472355   ENSP00000471230  
    Reactome Protein details: P09012

    SNRPA Human Recombinant Protein Products:

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    OriGene Purified Protein for SNRPA
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    OriGene MassSpec for SNRPA
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    Novus Biologicals SNRPA Protein
    Novus Biologicals SNRPA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNRPA

     
    Search eBioscience for Proteins for SNRPA 

     
    antibodies-online proteins for SNRPA (8 products) 

     
    antibodies-online peptides for SNRPA

    SNRPA Antibody Products:

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    antibodies-online antibodies for SNRPA (61 products) 

    SNRPA Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SNRPA
    Cloud-Clone Corp. CLIAs for SNRPA
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    antibodies-online kits for SNRPA (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR024888 U1_snRNP_A/U2_snRNP_B''
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry P09012

    ProtoNet protein and cluster: P09012

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012
    Similarity: Belongs to the RRM U1 A/B'' family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with SNRPA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNRPA_HUMAN, P09012
    Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5'
    splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with
    pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA
    binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and
    polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs

         Genatlas biochemistry entry for SNRPA:
    samll ribonucleoprotein U1,A polypeptide

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IDA19561594
    GO:0005515protein binding IPI10688667
    GO:0017069snRNA binding IEA--
         
    Find genes that share ontologies with SNRPA           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNRPA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNRPA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNRPA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNRPA

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNRPA:
    hsa-mir-320c (MIRT036163), hsa-let-7b-5p (MIRT052317), hsa-mir-1307-3p (MIRT035815)

    Block miRNA regulation of human, mouse, rat SNRPA using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SNRPA:
    hsa-miR-644 hsa-miR-1231 hsa-miR-654-3p hsa-miR-106a* hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidSNRPA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNRPA
    Predesigned siRNA for gene silencing in human, mouse, rat SNRPA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNRPA

    Clone
    Products:
         
    OriGene clones in human, mouse for SNRPA (see all 7)
    OriGene ORF clones in mouse, rat for SNRPA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNRPA (NM_004596)
    Sino Biological Human cDNA Clone for SNRPA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA
    Addgene plasmids for SNRPA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SNRPA
    Browse ESI BIO Cell Lines and PureStem Progenitors for SNRPA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNRPA_HUMAN, P09012: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529
    GO:0005685U1 snRNP IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with SNRPA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNRPA About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome


    Find genes that share SuperPaths with SNRPA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNRPA
        mRNA processing


    1 Reactome Pathway for SNRPA
        mRNA Splicing - Major Pathway


    1 Kegg Pathway  (Kegg details for SNRPA):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNRPA
    Interactions:

        GeneGlobe Interaction Network for SNRPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNRPA (P090121, 2, 3 ENSP000002435634) via UniProtKB, MINT, STRING, and/or I2D (see all 741) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN2Q166372, 3, ENSP000003701194MINT-14308 MINT-7947479 I2D: score=1 STRING: ENSP00000370119
    PTBP1P265992, 3, ENSP000003494284MINT-8332987 MINT-7947479 I2D: score=3 STRING: ENSP00000349428
    SF3A2Q154282, 3, ENSP000002214944MINT-5205386 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    SMN1Q166372, 3MINT-14308 MINT-7947479 I2D: score=1 
    C19orf43Q9BQ612, 3, ENSP000002427844MINT-8332954 I2D: score=4 STRING: ENSP00000242784
    SMAD5Q997172, 3MINT-61830 I2D: score=3 
    NSFP464592, 3MINT-7947479 I2D: score=1 
    U2AF2P263681, 2, ENSP000003078634EBI-607085,EBI-742339 MINT-8332559 MINT-7947479 MINT-8332943 STRING: ENSP00000307863
    SFPQP232461, 2, 3, ENSP000003497484EBI-607085,EBI-355453 MINT-7947479 I2D: score=3 STRING: ENSP00000349748
    PTBP2Q9UKA92, ENSP000004127884MINT-7947479 MINT-8332998 STRING: ENSP00000412788
    CDC5LQ994592, 3, ENSP000003605324MINT-7947479 I2D: score=1 STRING: ENSP00000360532
    CD2BP2O954002, 3, ENSP000003049034MINT-62838 I2D: score=1 STRING: ENSP00000304903
    GIGYF2Q6Y7W62, 3, ENSP000003871704MINT-65909 I2D: score=1 STRING: ENSP00000387170
    SF3A3Q128742, 3, ENSP000003621104MINT-7947479 I2D: score=1 STRING: ENSP00000362110
    CDKN2AP427713, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
    WBP4O755542, 3, ENSP000003688014MINT-73055 I2D: score=3 STRING: ENSP00000368801
    HNRNPKP619782, ENSP000003654394MINT-8332965 MINT-7947479 STRING: ENSP00000365439
    SNRPA1P096612, ENSP000002541934MINT-7947479 MINT-8332932 STRING: ENSP00000254193
    PAPOLAP510033, ENSP000002162774I2D: score=2 STRING: ENSP00000216277
    KIAA1429Q69YN43, ENSP000002975914I2D: score=1 STRING: ENSP00000297591
    RBM42Q9BTD82, ENSP000002626334MINT-8332976 STRING: ENSP00000262633
    HNRNPA2B1P226262, ENSP000003466944MINT-7947479 STRING: ENSP00000346694
    HNRNPCP079102, ENSP000003196904MINT-7947479 STRING: ENSP00000319690
    HNRNPFP525972, ENSP000003384774MINT-7947479 STRING: ENSP00000338477
    HNRNPMP522722, ENSP000003253764MINT-7947479 STRING: ENSP00000325376
    HNRNPUQ008392, ENSP000002831794MINT-7947479 STRING: ENSP00000283179
    SRSF1Q079552, ENSP000002589624MINT-7947479 STRING: ENSP00000258962
    SRSF4Q081702, ENSP000003629004MINT-7947479 STRING: ENSP00000362900
    U2AF1Q010812, ENSP000002915524MINT-7947479 STRING: ENSP00000291552
    CPSF7Q8N6842, ENSP000003454124MINT-7947479 STRING: ENSP00000345412
    SMC1AQ146832, ENSP000003234214MINT-7947479 STRING: ENSP00000323421
    NONOQ152332, ENSP000002760794MINT-7947479 STRING: ENSP00000276079
    TADA2AO754783, ENSP000002253964I2D: score=1 STRING: ENSP00000225396
    DARSP148683, ENSP000002641614I2D: score=1 STRING: ENSP00000264161
    KPNB1Q149742, ENSP000002901584MINT-7947479 STRING: ENSP00000290158
    UPF1Q929002, ENSP000002628034MINT-7947479 STRING: ENSP00000262803
    SF3B3Q153932, ENSP000003057904MINT-7947479 STRING: ENSP00000305790
    DDB1Q165312, ENSP000003017644MINT-7947479 STRING: ENSP00000301764
    DDX3XO005712, ENSP000003828404MINT-7947479 STRING: ENSP00000382840
    SMARCC1Q929222, ENSP000002544804MINT-7947479 STRING: ENSP00000254480
    SMARCC2Q8TAQ22, ENSP000002670644MINT-7947479 STRING: ENSP00000267064
    ATICP319393, ENSP000002369594I2D: score=2 STRING: ENSP00000236959
    RNPS1Q152873, ENSP000003158594I2D: score=2 STRING: ENSP00000315859
    RBBP7Q165762, ENSP000003694274MINT-7947479 STRING: ENSP00000369427
    CDC20Q128342, ENSP000003084504MINT-7947479 STRING: ENSP00000308450
    BUB3O436842, ENSP000003578584MINT-7947479 STRING: ENSP00000357858
    CPSF2Q9P2I02, ENSP000002988754MINT-7947479 STRING: ENSP00000298875
    CPSF3Q9UKF62, ENSP000002381124MINT-7947479 STRING: ENSP00000238112
    CSTF3Q129962, ENSP000003157914MINT-7947479 STRING: ENSP00000315791
    FUSP356372, ENSP000002541084MINT-7947479 STRING: ENSP00000254108
    HDAC1Q135472, ENSP000003626494MINT-7947479 STRING: ENSP00000362649
    KPNA2P522922, ENSP000003324554MINT-7947479 STRING: ENSP00000332455
    NUDT21O438092, ENSP000003002914MINT-7947479 STRING: ENSP00000300291
    PCBP1Q153652, ENSP000003055564MINT-7947479 STRING: ENSP00000305556
    PCBP2Q153662, ENSP000003524384MINT-7947479 STRING: ENSP00000352438
    PLRG1O436602, ENSP000003031914MINT-7947479 STRING: ENSP00000303191
    PRPF19Q9UMS42, ENSP000002275244MINT-7947479 STRING: ENSP00000227524
    PRPF6O949062, ENSP000002660794MINT-7947479 STRING: ENSP00000266079
    PRPF8Q6P2Q92, ENSP000003043504MINT-7947479 STRING: ENSP00000304350
    RBBP4Q090282, ENSP000003625924MINT-7947479 STRING: ENSP00000362592
    RBM39Q144982, ENSP000002533634MINT-7947479 STRING: ENSP00000253363
    SART1O432902, ENSP000003104484MINT-7947479 STRING: ENSP00000310448
    SF3A1Q154592, ENSP000002157934MINT-7947479 STRING: ENSP00000215793
    SF3B1O755332, ENSP000003353214MINT-7947479 STRING: ENSP00000335321
    SF3B2Q134352, ENSP000003188614MINT-7947479 STRING: ENSP00000318861
    SF3B6Q9Y3B42, ENSP000002334684MINT-7947479 STRING: ENSP00000233468
    SNRNP200O756432, ENSP000003171234MINT-7947479 STRING: ENSP00000317123
    SNRNP40Q96DI72, ENSP000002636944MINT-7947479 STRING: ENSP00000263694
    SNRNP70P086212, ENSP000002214484MINT-7947479 STRING: ENSP00000221448
    SNRPD1P623142, ENSP000003004134MINT-7947479 STRING: ENSP00000300413
    SNRPD3P623182, ENSP000002158294MINT-7947479 STRING: ENSP00000215829
    SNRPEP623042, ENSP000004005914MINT-7947479 STRING: ENSP00000400591
    SRRM1Q8IYB32, ENSP000003262614MINT-7947479 STRING: ENSP00000326261
    SRSF7Q166292, ENSP000003259054MINT-7947479 STRING: ENSP00000325905
    UPF2Q9HAU52, ENSP000003487084MINT-7947479 STRING: ENSP00000348708
    USP10Q146942, ENSP000002194734MINT-7947479 STRING: ENSP00000219473
    WDR18Q9BV382, ENSP000002512894MINT-7947479 STRING: ENSP00000251289
    XRN2Q9H0D62, ENSP000003663964MINT-7947479 STRING: ENSP00000366396
    THG1LQ9NWX63I2D: score=5 
    ATG14Q6ZNE53I2D: score=1 
    GABARAPO951663I2D: score=1 
    KLHDC10Q6PID83I2D: score=1 
    NSMAFQ926363I2D: score=1 
    ULK2Q8IYT83I2D: score=1 
    VCLP182063I2D: score=1 
    WDR45Q9Y4843I2D: score=1 
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    ACTBP607092MINT-7947479
    ACTL6AO960192MINT-7947479
    ACTR1AP611632MINT-7947479
    ACTR2P611602MINT-7947479
    ADNPQ9H2P02MINT-7947479
    AHNAKQ096662MINT-7947479
    AKAP8O438232MINT-7947479
    ANAPC1Q9H1A42MINT-7947479
    ANAPC2Q9UJX62MINT-7947479
    ANAPC7Q9UJX32MINT-7947479
    ANLNQ9NQW62MINT-7947479
    ANXA11P509952MINT-7947479
    AP1B1Q105672MINT-7947479
    ARCN1P484442MINT-7947479
    ARGLU1Q9NWB62MINT-7947479
    ARHGEF1Q928882MINT-7947479
    ARHGEF2Q929742MINT-7947479
    ARID1AO144972MINT-7947479
    AURKBQ96GD42MINT-7947479
    BAZ1AQ9NRL22MINT-7947479
    BCAS2O759342MINT-7947479
    BCLAF1Q9NYF82MINT-7947479
    BIDP559572MINT-7947479
    BRD2P254402MINT-7947479
    BRD4O608852MINT-7947479
    BRD7Q9NPI12MINT-7947479
    BRD8Q9H0E92MINT-7947479
    BTAF1O149812MINT-7947479
    BUB1O436832MINT-7947479
    BUB1BO605662MINT-7947479
    BZW1Q7L1Q62MINT-7947479
    C7orf13Q8NI282MINT-7947479
    CAPGP401212MINT-7947479
    CAPZA1P529072MINT-7947479
    CARD10Q9BWT72MINT-7947479
    CASC5Q8NG312MINT-7947479
    CCNB1P146352MINT-7947479
    CCT2P783712MINT-7947479
    CCT3P493682MINT-7947479
    CCT4P509912MINT-7947479
    CCT5P486432MINT-7947479
    CCT6AP402272MINT-7947479
    CCT7Q998322MINT-7947479
    CCT8P509902MINT-7947479
    CDC16Q130422MINT-7947479
    CDC23Q9UJX22MINT-7947479
    CDC27P302602MINT-7947479
    CDC73Q6P1J92MINT-7947479
    CDK9P507502MINT-7947479
    CDKN2AIPQ9NXV62MINT-7947479
    CHD1LQ86WJ12MINT-7947479
    CHD8Q9HCK82MINT-7947479
    CHEK1O147572MINT-7947479
    CKAP5Q140082MINT-7947479
    CLASP1Q7Z4602MINT-7947479
    CLINT1Q146772MINT-7947479
    CNOT10Q9H9A52MINT-7947479
    CNOT3O751752MINT-7947479
    COPAP536212MINT-7947479
    COPB1P536182MINT-7947479
    COPB2P356062MINT-7947479
    COPG1Q9Y6782MINT-7947479
    COPG2Q9UBF22MINT-7947479
    COPS5Q929052MINT-7947479
    CSE1LP550602MINT-7947479
    CTNND1O607162MINT-7947479
    CUL1Q136162MINT-7947479
    CWC15Q9P0132MINT-7947479
    DCTN2Q135612MINT-7947479
    DDX17Q928412MINT-7947479
    DDX19AQ9NUU72MINT-7947479
    DDX19BQ9UMR22MINT-7947479
    DDX39AO001482MINT-7947479
    DDX39BQ138382MINT-7947479
    DDX41Q9UJV92MINT-7947479
    DDX42Q86XP32MINT-7947479
    DDX47Q9H0S42MINT-7947479
    DDX5P178442MINT-7947479
    DDX6P261962MINT-7947479
    DEPDC7Q96QD52MINT-7947479
    DFNA5O604432MINT-7947479
    DIAPH1O606102MINT-7947479
    DIDO1Q9BTC02MINT-7947479
    DMAP1Q9NPF52MINT-7947479
    DNAJA1P316892MINT-7947479
    DNM1LO004292MINT-7947479
    DNM2P505702MINT-7947479
    DOCK5Q9H7D02MINT-7947479
    DOCK8Q8NF502MINT-7947479
    DRG1Q9Y2952MINT-7947479
    DSPP159242MINT-7947479
    DTYMKP239192MINT-7947479
    DYNC1H1Q142042MINT-7947479
    DYNC1LI1Q9Y6G92MINT-7947479
    DYNC1LI2O432372MINT-7947479
    ECT2Q9H8V32MINT-7947479
    EDC4Q6P2E92MINT-7947479
    EEF1A1P681042MINT-7947479
    EFTUD2Q150292MINT-7947479
    EHD1Q9H4M92MINT-7947479
    EHD4Q9H2232MINT-7947479
    EHMT1Q9H9B12MINT-7947479
    EIF2B4Q9UI102MINT-7947479
    EIF2DP412142MINT-7947479
    EIF2S3P410912MINT-7947479
    EIF3BP558842MINT-7947479
    EIF3GO758212MINT-7947479
    EIF3IQ133472MINT-7947479
    EIF4A1P608422MINT-7947479
    EIF4A2Q142402MINT-7947479
    EIF4A3P389192MINT-7947479
    EIF4G2P783442MINT-7947479
    EIF5BO608412MINT-7947479
    ELAVL1Q157172MINT-7947479
    ELF2Q157232MINT-7947479
    ENAHQ8N8S72MINT-7947479
    ENSG00000183311P074372MINT-7947479
    ENSG00000206289P287022MINT-7947479
    ENSG00000206490Q8NE712MINT-7947479
    ENSG00000215077P254402MINT-7947479
    ENSG00000215425Q138382MINT-7947479
    ENSG00000224156P074372MINT-7947479
    ENSG00000225073Q138382MINT-7947479
    ENSG00000225859Q138382MINT-7947479
    ENSG00000225989Q8NE712MINT-7947479
    ENSG00000227322P287022MINT-7947479
    ENSG00000227739P074372MINT-7947479
    ENSG00000228333P287022MINT-7947479
    ENSG00000229496Q138382MINT-7947479
    ENSG00000229684P074372MINT-7947479
    ENSG00000230624Q138382MINT-7947479
    ENSG00000231129Q8NE712MINT-7947479
    ENSG00000231321P287022MINT-7947479
    ENSG00000232169Q8NE712MINT-7947479
    ENSG00000232421P074372MINT-7947479
    ENSG00000232575P074372MINT-7947479
    ENSG00000234507P254402MINT-7947479
    ENSG00000234704P254402MINT-7947479
    ENSG00000235067P074372MINT-7947479
    ENSG00000235307P254402MINT-7947479
    ENSG00000235439Q138382MINT-7947479
    ENSG00000235712P287022MINT-7947479
    ENSG00000236149Q8NE712MINT-7947479
    ENSG00000236342Q8NE712MINT-7947479
    EPB41L3Q9Y2J22MINT-7947479
    EPPK1P581072MINT-7947479
    EPS8L2Q9H6S32MINT-7947479
    ERAL1O756162MINT-7947479
    ERCC1P079922MINT-7947479
    ERCC6LQ2NKX82MINT-7947479
    ETF1P624952MINT-7947479
    ETV6P412122MINT-7947479
    EWSR1Q018442MINT-7947479
    EXOC2Q96KP12MINT-7947479
    EXOC4Q96A652MINT-7947479
    EXOC5O004712MINT-7947479
    EXOC7Q9UPT52MINT-7947479
    EXOSC10Q017802MINT-7947479
    FAF1Q9UNN52MINT-7947479
    FAM129BQ96TA12MINT-7947479
    FANCD2Q9BXW92MINT-7947479
    FANCIQ9NVI12MINT-7947479
    FASNP493272MINT-7947479
    FEN1P397482MINT-7947479
    FERMT1Q9BQL62MINT-7947479
    FHOD1Q9Y6132MINT-7947479
    GAPDHP044062MINT-7947479
    GATAD2AQ86YP42MINT-7947479
    GCN1L1Q926162MINT-7947479
    GEMIN4P576782MINT-7947479
    GEMIN6Q8WXD52MINT-7947479
    GMPSP499152MINT-7947479
    GNASP630922MINT-7947479
    GNB3P165202MINT-7947479
    GOLGB1Q147892MINT-7947479
    GPS2Q132272MINT-7947479
    GTF2IP783472MINT-7947479
    GTF3C2Q8WUA42MINT-7947479
    GTF3C5Q9Y5Q82MINT-7947479
    GTPBP1O001782MINT-7947479
    GULP1Q9UBP92MINT-7947479
    HAUS7Q998712MINT-7947479
    HBS1LQ9Y4502MINT-7947479
    HDAC2Q927692MINT-7947479
    HDLBPQ003412MINT-7947479
    HELLSQ9NRZ92MINT-7947479
    HIC2Q96JB32MINT-7947479
    HIP1RO751462MINT-7947479
    HIRAP541982MINT-7947479
    HLTFQ145272MINT-7947479
    HNRNPH1P319432MINT-7947479
    HSP90AA1P079002MINT-7947479
    HSP90AB1P082382MINT-7947479
    HSP90B1P146252MINT-7947479
    HSPA12AO433012MINT-7947479
    HSPA5P110212MINT-7947479
    HSPA6P170662MINT-7947479
    HSPA8P111422MINT-7947479
    HSPB1P047922MINT-7947479
    HSPD1P108092MINT-7947479
    HUWE1Q7Z6Z72MINT-7947479
    IKBKAPO951632MINT-7947479
    ILF2Q129052MINT-7947479
    INTS1Q8N2012MINT-7947479
    INTS3Q68E012MINT-7947479
    INTS6Q9UL032MINT-7947479
    INTS8Q75QN22MINT-7947479
    IPO5O004102MINT-7947479
    IPO7O953732MINT-7947479
    IPO9Q96P702MINT-7947479
    IQGAP1P469402MINT-7947479
    ITPK1Q135722MINT-7947479
    KANSL1Q7Z3B32MINT-7947479
    KDM1AO603412MINT-7947479
    KHDRBS1Q076662MINT-7947479
    KIF11P527322MINT-7947479
    KIF21AQ7Z4S62MINT-7947479
    KIF2CQ996612MINT-7947479
    KIF4AO952392MINT-7947479
    LAS1LQ9Y4W22MINT-7947479
    LENG9Q96B702MINT-7947479
    LIMS1P480592MINT-7947479
    LMNAP025452MINT-7947479
    LMO7Q8WWI12MINT-7947479
    LRRC1Q9BTT62MINT-7947479
    LRRC40Q9H9A62MINT-7947479
    LRWD1Q9UFC02MINT-7947479
    MAD1L1Q9Y6D92MINT-7947479
    MAGEE2Q8TD902MINT-7947479
    MAP2K4P459852MINT-7947479
    MAP2K7O147332MINT-7947479
    MAP7Q142442MINT-7947479
    MARK2Q7KZI72MINT-7947479
    MATR3P432432MINT-7947479
    MDN1Q9NU222MINT-7947479
    MED12Q930742MINT-7947479
    MED12LQ86YW92MINT-7947479
    MED16Q9Y2X02MINT-7947479
    MED4Q9NPJ62MINT-7947479
    MELKQ146802MINT-7947479
    MPP2Q141682MINT-7947479
    MRE11AP499592MINT-7947479
    MSH2P432462MINT-7947479
    MSH6P527012MINT-7947479
    MTA2O947762MINT-7947479
    MTA3Q9BTC82MINT-7947479
    MTCL1Q9Y4B52MINT-7947479
    MVPQ147642MINT-7947479
    MYBBP1AQ9BQG02MINT-7947479
    MYH9P355792MINT-7947479
    MYO15BQ96JP22MINT-7947479
    NACC1Q96RE72MINT-7947479
    NAT10Q9H0A02MINT-7947479
    NBNO609342MINT-7947479
    NCAPD2Q150212MINT-7947479
    NCAPHQ150032MINT-7947479
    NCOR1O753762MINT-7947479
    NDC80O147772MINT-7947479
    NELFBQ8WX922MINT-7947479
    NF1P213592MINT-7947479
    NIPBLQ6KC792MINT-7947479
    NPM1P067482MINT-7947479
    NRG1Q022972MINT-7947479
    NSUN5Q96P112MINT-7947479
    NUDCQ9Y2662MINT-7947479
    NUF2Q9BZD42MINT-7947479
    NUP107P577402MINT-7947479
    NUP155O756942MINT-7947479
    NUP93Q8N1F72MINT-7947479
    ORC2Q134162MINT-7947479
    ORC3Q9UBD52MINT-7947479
    OXSR1O957472MINT-7947479
    PAK4O960132MINT-7947479
    PARP1P098742MINT-7947479
    PARVAQ9NVD72MINT-7947479
    PARVBQ9HBI12MINT-7947479
    PCNTO956132MINT-7947479
    PDLIM7Q9NR122MINT-7947479
    PELOQ9BRX22MINT-7947479
    PFKMP082372MINT-7947479
    PFKPQ018132MINT-7947479
    PHGDHO431752MINT-7947479
    PICALMQ134922MINT-7947479
    PKN2Q165132MINT-7947479
    PLECQ151492MINT-7947479
    PLK1P533502MINT-7947479
    PNNQ9H3072MINT-7947479
    POLD1P283402MINT-7947479
    POLR1CO151602MINT-7947479
    POLR3DP054232MINT-7947479
    POLR3EQ9NVU02MINT-7947479
    PPFIA1Q131362MINT-7947479
    PPM1DO152972MINT-7947479
    PPP1CAP621362MINT-7947479
    PPP2R1AP301532MINT-7947479
    PRCCQ927332MINT-7947479
    PRKDCP785272MINT-7947479
    PRPF3O433952MINT-7947479
    PRPF4BQ135232MINT-7947479
    PSMC1P621912MINT-7947479
    PSMC2P359982MINT-7947479
    PSMC3P179802MINT-7947479
    PSMC4P436862MINT-7947479
    PSMC5P621952MINT-7947479
    PSMC6P623332MINT-7947479
    PSMD1Q994602MINT-7947479
    PSMD11O002312MINT-7947479
    PSMD12O002322MINT-7947479
    PSMD13Q9UNM62MINT-7947479
    PSMD2Q132002MINT-7947479
    PSMD3O432422MINT-7947479
    PSTPIP2Q9H9392MINT-7947479
    PTBP3O957582MINT-7947479
    PUM1Q146712MINT-7947479
    RACGAP1Q9H0H52MINT-7947479
    RAD18Q9NS912MINT-7947479
    RAD50Q928782MINT-7947479
    RALYQ9UKM92MINT-7947479
    RANBP2P497922MINT-7947479
    RANGAP1P460602MINT-7947479
    RAVER1Q8IY672MINT-7947479
    RBBP5Q152912MINT-7947479
    RBM17Q96I252MINT-7947479
    RBM4Q9BWF32MINT-7947479
    RBM45Q8IUH32MINT-7947479
    RBM7Q9Y5802MINT-7947479
    RBMXP381592MINT-7947479
    RCOR1Q9UKL02MINT-7947479
    RFC2P352502MINT-7947479
    RFC3P409382MINT-7947479
    RFC4P352492MINT-7947479
    RFC5P409372MINT-7947479
    RFX1P226702MINT-7947479
    RFX5P483822MINT-7947479
    RIF1Q5UIP02MINT-7947479
    RNF130Q86XS82MINT-7947479
    RNF17Q9BXT82MINT-7947479
    ROCK2O751162MINT-7947479
    RPL13P263732MINT-7947479
    RPL22P352682MINT-7947479
    RPL24P837312MINT-7947479
    RPL31P628992MINT-7947479
    RPLP0P053882MINT-7947479
    RPS13P622772MINT-7947479
    RPS6KA4O756762MINT-7947479
    RPS6KB2Q9UBS02MINT-7947479
    RTCBQ9Y3I02MINT-7947479
    RUVBL1Q9Y2652MINT-7947479
    RUVBL2Q9Y2302MINT-7947479
    RXRBP287022MINT-7947479
    SCAF8Q9UPN62MINT-7947479
    SCRIBQ141602MINT-7947479
    SCYL2Q6P3W72MINT-7947479
    SEC23AQ154362MINT-7947479
    SEC24CP539922MINT-7947479
    SEH1LQ96EE32MINT-7947479
    SENP3Q9H4L42MINT-7947479
    SEPT9Q9UHD82MINT-7947479
    SETXQ7Z3332MINT-7947479
    SHC1P293532MINT-7947479
    SHROOM3Q8TF722MINT-7947479
    SIN3AQ96ST32MINT-7947479
    SKIV2L2P422852MINT-7947479
    SMARCA5O602642MINT-7947479
    SMARCAD1Q9H4L72MINT-7947479
    SMARCB1Q128242MINT-7947479
    SMARCD1Q96GM52MINT-7947479
    SMARCE1Q969G32MINT-7947479
    SMC2O953472MINT-7947479
    SMC3Q9UQE72MINT-7947479
    SMC4Q9NTJ32MINT-7947479
    SMCHD1A6NHR92MINT-7947479
    SNAPC4Q5SXM22MINT-7947479
    SNRPAP090122MINT-68459
    SNW1Q135732MINT-7947479
    SNX12Q9UMY42MINT-7947479
    SNX2O607492MINT-7947479
    SPATA5Q8NB902MINT-7947479
    SPENQ96T582MINT-7947479
    SPTAN1Q138132MINT-7947479
    SPTBN1Q010822MINT-7947479
    SREK1Q8WXA92MINT-7947479
    SRP54P610112MINT-7947479
    SRP68Q9UHB92MINT-7947479
    SRP72O760942MINT-7947479
    SSUH2Q9Y2M22MINT-7947479
    STAB1Q9NY152MINT-7947479
    STAG2Q8N3U42MINT-7947479
    STAT3P407632MINT-7947479
    STK24Q9Y6E02MINT-7947479
    SUGT1Q9Y2Z02MINT-7947479
    SUMO1P631652MINT-7947479
    SUPT16HQ9Y5B92MINT-7947479
    SYMPKQ927972MINT-7947479
    TAF15Q928042MINT-7947479
    TAF5LO755292MINT-7947479
    TANC2Q9HCD62MINT-7947479
    TARDBPQ131482MINT-7947479
    TBL1XR1Q9BZK72MINT-7947479
    TCP1P179872MINT-7947479
    THAP1Q9NVV92MINT-7947479
    THRAP3Q9Y2W12MINT-7947479
    TIAL1Q010852MINT-7947479
    TLN1Q9Y4902MINT-7947479
    TLN2Q9Y4G62MINT-7947479
    TMOD3Q9NYL92MINT-7947479
    TMPOP421662MINT-7947479
    TNFAIP2Q031692MINT-7947479
    TNKS1BP1Q9C0C22MINT-7947479
    TNPO1Q929732MINT-7947479
    TPRP122702MINT-7947479
    TPX2Q9ULW02MINT-7947479
    TRAP1Q129312MINT-7947479
    TRIM21P194742MINT-7947479
    TRIM28Q132632MINT-7947479
    TRIP13Q156452MINT-7947479
    TRMT1LQ7Z2T52MINT-7947479
    TRRAPQ9Y4A52MINT-7947479
    TRUB1Q8WWH52MINT-7947479
    TSG101Q998162MINT-7947479
    TUBA1CQ9BQE32MINT-7947479
    TUBA4AP683662MINT-7947479
    TUBBP074372MINT-7947479
    TUBB4BP683712MINT-7947479
    TUBG1P232582MINT-7947479
    TUBGCP2Q9BSJ22MINT-7947479
    TUBGCP3Q96CW52MINT-7947479
    TUBGCP4Q9UGJ12MINT-7947479
    TWF1Q127922MINT-7947479
    U2SURPO150422MINT-7947479
    UBA5Q9GZZ92MINT-7947479
    UBE2MP610812MINT-7947479
    UBE2NP610882MINT-7947479
    UBE2SQ167632MINT-7947479
    UBL4AP114412MINT-7947479
    UBN1Q9NPG32MINT-7947479
    UCHL5Q9Y5K52MINT-7947479
    UMPSP111722MINT-7947479
    UNC45AQ9H3U12MINT-7947479
    USO1O607632MINT-7947479
    USP24Q9UPU52MINT-7947479
    USP39Q53GS92MINT-7947479
    VIMP086702MINT-7947479
    VPS33AQ96AX12MINT-7947479
    VPS33BQ9H2672MINT-7947479
    VPS36Q86VN12MINT-7947479
    VPS51Q9UID32MINT-7947479
    WDR33Q9C0J82MINT-7947479
    WRNIP1Q96S552MINT-7947479
    XPO5Q9HAV42MINT-7947479
    YEATS4O956192MINT-7947479
    YLPM1P497502MINT-7947479
    YWHAEP622582MINT-7947479
    ZBTB7CA1YPR02MINT-7947479
    ZC3HC1Q86WB02MINT-7947479
    ZNF638Q149662MINT-7947479
    ALYREFENSP000003318174STRING: ENSP00000331817
    CPSF1ENSP000003393534STRING: ENSP00000339353
    CSTF2ENSP000003620634STRING: ENSP00000362063
    DHX9ENSP000003565204STRING: ENSP00000356520
    DNAJC8ENSP000002636974STRING: ENSP00000263697
    GTF2F1ENSP000003779694STRING: ENSP00000377969
    HNRNPA0ENSP000003160424STRING: ENSP00000316042
    HNRNPDENSP000003131994STRING: ENSP00000313199
    HNRNPLENSP000002214194STRING: ENSP00000221419
    HNRNPUL1ENSP000003758634STRING: ENSP00000375863
    NHP2L1ENSP000002159564STRING: ENSP00000215956
    PABPN1ENSP000002167274STRING: ENSP00000216727
    PCF11ENSP000002982814STRING: ENSP00000298281
    PHF5AENSP000002162524STRING: ENSP00000216252
    POLR2AENSP000003149494STRING: ENSP00000314949
    POLR2BENSP000003127354STRING: ENSP00000312735
    POLR2CENSP000002192524STRING: ENSP00000219252
    POLR2DENSP000002726454STRING: ENSP00000272645
    POLR2EENSP000002155874STRING: ENSP00000215587
    POLR2FENSP000004038524STRING: ENSP00000403852
    POLR2GENSP000003017884STRING: ENSP00000301788
    POLR2HENSP000002962234STRING: ENSP00000296223
    POLR2IENSP000002218594STRING: ENSP00000221859
    POLR2LENSP000003241244STRING: ENSP00000324124
    RBM5ENSP000003430544STRING: ENSP00000343054
    SF3B4ENSP000002716284STRING: ENSP00000271628
    SF3B5ENSP000003565414STRING: ENSP00000356541
    SNRPBENSP000004125664STRING: ENSP00000412566
    SNRPB2ENSP000002460714STRING: ENSP00000246071
    SNRPD2ENSP000003423744STRING: ENSP00000342374
    SNRPFENSP000002667354STRING: ENSP00000266735
    SNRPGENSP000002723484STRING: ENSP00000272348
    SRSF11ENSP000003599884STRING: ENSP00000359988
    SRSF2ENSP000003508774STRING: ENSP00000350877
    SRSF5ENSP000003778924STRING: ENSP00000377892
    SRSF6ENSP000002440204STRING: ENSP00000244020
    SRSF9ENSP000002293904STRING: ENSP00000229390
    TXNL4AENSP000002696014STRING: ENSP00000269601
    YBX1ENSP000003616264STRING: ENSP00000361626
    CCAR1ENSP000002658724STRING: ENSP00000265872
    CLP1ENSP000003047044STRING: ENSP00000304704
    GTF2F2ENSP000003408234STRING: ENSP00000340823
    HNRNPRENSP000003637454STRING: ENSP00000363745
    NFX1ENSP000003688564STRING: ENSP00000368856
    SUGP1ENSP000002470014STRING: ENSP00000247001
    UBCENSP000003448184STRING: ENSP00000344818
    PPM1GENSP000002647144STRING: ENSP00000264714
    TP63ENSP000002647314STRING: ENSP00000264731
    S100A4ENSP000003462944STRING: ENSP00000346294
    IFIT1ENSP000003608694STRING: ENSP00000360869
    IFIT2ENSP000003608914STRING: ENSP00000360891
    IFIT3ENSP000003608764STRING: ENSP00000360876
    DHX37ENSP000003111354STRING: ENSP00000311135
    DKC1ENSP000003585634STRING: ENSP00000358563
    EIF4EENSP000002808924STRING: ENSP00000280892
    FBLENSP000002218014STRING: ENSP00000221801
    LARP7ENSP000003143114STRING: ENSP00000314311
    LSM12ENSP000002934064STRING: ENSP00000293406
    NAF1ENSP000002740544STRING: ENSP00000274054
    NCBP1ENSP000003642894STRING: ENSP00000364289
    NCBP2ENSP000003268064STRING: ENSP00000326806
    PRPF31ENSP000003241224STRING: ENSP00000324122
    PRPF39ENSP000003480104STRING: ENSP00000348010
    SETD2ENSP000003867594STRING: ENSP00000386759
    SF1ENSP000003666074STRING: ENSP00000366607
    SNRPCENSP000002445204STRING: ENSP00000244520
    TRNAU1APENSP000003629364STRING: ENSP00000362936
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with SNRPA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNRPA

    1 DrugBank Compound for SNRPA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Malonic acidMalonate (see all 2)141-82-2target----

    7 Novoseek inferred chemical compound relationships for SNRPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 41.5 21 12670951 (4), 16943419 (2), 10742179 (2), 11839494 (1) (see all 8)
    hydrogen 27.4 8 11788718 (2), 12466552 (2), 16407334 (1), 16738410 (1) (see all 6)
    adenine 19.3 6 12466552 (3), 15491147 (1), 16278830 (1)
    guanidine hydrochloride 17.1 1 15476390 (1)
    cysteine 0.481 1 10852733 (1)
    atp 0 2 10648562 (1)
    iron 0 4 1584791 (1)



    Find genes that share compounds with SNRPA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SNRPA gene: 
    NM_004596.4  

    Unigene Cluster for SNRPA:

    Small nuclear ribonucleoprotein polypeptide A
    Hs.466775  [show with all ESTs]
    Unigene Representative Sequence: NM_004596
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601545 ENST00000243563(uc002ooz.3) ENST00000601253 ENST00000597353
    ENST00000599362 ENST00000599570 ENST00000601393 ENST00000598923 ENST00000600456
    ENST00000598452 ENST00000596860
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate SNRPA:
    hsa-miR-644 hsa-miR-1231 hsa-miR-654-3p hsa-miR-106a* hsa-miR-764
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    Additional mRNA sequence: 

    AK293140.1 AK313182.1 BC000405.2 BC008290.1 X06347.1 

    17 DOTS entries:

    DT.97854609  DT.100827444  DT.80102050  DT.100827448  DT.121436155  DT.100647055  DT.100827455  DT.305096 
    DT.100750095  DT.121436170  DT.100827445  DT.100827454  DT.121436208  DT.100719490  DT.100827446  DT.100827447 
    DT.95206669 

    Selected AceView cDNA sequences (see all 488):

    CA313815 CR620163 BC000405 CR622302 CR597345 CF128304 AI870262 BM478204 
    BI907674 BQ447022 AW848338 CR609533 BQ671697 BQ689851 BX417996 BQ182227 
    BQ650463 BI768440 BC008290 AI949381 BQ068261 CR611939 CA306578 CR606390 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SNRPA (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9
    SP1:                                                  -                       -                       -                 -               
    SP2:        -     -     -     -     -     -     -     -                       -                       -                 -               
    SP3:                          -     -     -           -                       -                       -                                 
    SP4:                          -     -     -           -                       -     -                                                   
    SP5:                    -     -     -     -           -                       -                                                         


    ECgene alternative splicing isoforms for SNRPA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SNRPA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCCCCTT
    SNRPA Expression
    About this image

    SNRPA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNRPA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466775
        Custom PCR Arrays for SNRPA
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRPA gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrpa5 small nuclear ribonucleoprotein polypeptide A   --   7 (15.84 cM) 27187005 
    lizard
    (Anolis carolinensis)
    Reptilia SNRPA6
    small nuclear ribonucleoprotein polypeptide A
    90(a)
    1 ↔ 1
    LGf(2806296-2810905)
    African clawed frog
    (Xenopus laevis)
    Amphibia snf-prov2 sans fille 77.7(n)    X57953.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC064308.12   -- 80.27(n)   324121  BC064308.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta snf1 sans fille 75.08(n)
    77.78(a)
      31442  NM_078490.3  NP_511045.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rnp-21 rnp-2 60.03(n)
    56.22(a)
      177181  NM_068103.3  NP_500504.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSL1(YIR009W)4 U2B component of U2 snRNP, involved in splicing, binds more   --   9(374525-374860) 854826  NP_012274.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons U1A1 U1A 54.99(n)
    54.7(a)
      819371  NM_130326.2  NP_182280.1 
    rice
    (Oryza sativa)
    Liliopsida Os.97662 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.96(n)    AK102716.1 


    ENSEMBL Gene Tree for SNRPA (if available)
    TreeFam Gene Tree for SNRPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNRPA gene
    SNRPB22  
    2 SIMAP similar genes for SNRPA using alignment to 7 protein entries:     SNRPA_HUMAN (see all proteins):
    SNRPB2    RBMX

    Find genes that share paralogs with SNRPA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNRPA (see all 301)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1853428231,2
    --41257861(+) GGTCTA/GTGTGC 1 -- int10--------
    rs667432821,2
    C--41257952(+) AAGAAA/GCTGGG 1 -- int13Minor allele frequency- G:0.12WA NA 240
    rs1472987521,2
    --41258008(+) GAGGCC/TGAGGC 1 -- int10--------
    rs1399281031,2
    C--41258090(+) ATACAA/GAATTA 1 -- int10--------
    rs1897604541,2
    --41258215(+) ACAGCC/TTGGGC 1 -- int10--------
    rs1806876521,2
    --41258223(+) GGCAAC/GAAGAG 1 -- int10--------
    rs1859435221,2
    --41258238(+) ACTCCC/GTCTCA 1 -- int10--------
    rs104084521,2
    C,F,H--41258355(+) TAGGAA/GCCCAA 1 -- int111Minor allele frequency- G:0.05NS EA NA WA 1312
    rs1120469261,2
    F--41258381(+) GGTGGT/CTCAGG 1 -- int12Minor allele frequency- C:0.04CSA WA 120
    rs597057651,2
    C--41258485(+) AAAAA-/AAGGCTG 1 -- int11Minor allele frequency- AA:0.00NA 2

    HapMap Linkage Disequilibrium report for SNRPA (41256542 - 41271297 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SNRPA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833832CNV Loss17160897
    esv21537CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNRPA
    DNA2.0 Custom Variant and Variant Library Synthesis for SNRPA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182285    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for SNRPA:
    Mixed connective tissue disease     Lupus erythematosus

    Find genes that share disorders with SNRPA           About GenesLikeMe

    3 Novoseek inferred disease relationships for SNRPA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mixed connective tissue disease 47.7 1 7930595 (1)
    lupus erythematosus systemic 41 5 7930595 (1), 9342149 (1), 8605931 (1), 9328587 (1) (see all 5)
    autoimmune diseases 17.4 1 7687615 (1)


    Export disorders for SNRPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNRPA gene, integrated from 10 sources (see all 155):
    (articles sorted by number of sources associating them with SNRPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. (PubMed id 9848648)1, 2, 9 Lutz C.S.... Alwine J.C. (RNA 1998)
    2. Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy. (PubMed id 9265619)1, 2, 9 Lu J. and Hall K.B. (Biochemistry 1997)
    3. Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding. (PubMed id 8609632)1, 2, 9 Avis J.M....Neuhaus D. (J. Mol. Biol. 1996)
    4. Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein. (PubMed id 1831431)1, 2, 9 Nelissen R.L.H.... van Venrooij W.J. (Gene 1991)
    5. Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. (PubMed id 2147232)1, 2, 9 Nagai K.... Evans P.R. (Nature 1990)
    6. Structural basis of the RNA-binding specificity of human U1A protein. (PubMed id 9312034)1, 2, 9 Allain F.H.-T.... Varani G. (EMBO J. 1997)
    7. NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein. (PubMed id 8070414)1, 2, 9 Howe P.W.A.... Varani G. (EMBO J. 1994)
    8. Crystal structure at 1.92-A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PubMed id 7984237)1, 2, 9 Oubridge C.... Nagai K. (Nature 1994)
    9. Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA. (PubMed id 1833186)1, 2, 9 Jessen T.-H.... Nagai K. (EMBO J. 1991)
    10. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. (PubMed id 19561594)1, 2 Ray D.... Hughes T.R. (Nat. Biotechnol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6626 HGNC: 11151 AceView: SNRPA Ensembl:ENSG00000077312 euGenes: HUgn6626
    ECgene: SNRPA Kegg: 6626 H-InvDB: SNRPA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SNRPA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNRPA gene:
    Search GeneIP for patents involving SNRPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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