SNRPA Gene
protein-coding GIFtS: 60
GCID: GC19P041256
|
|
small nuclear ribonucleoprotein polypeptide A
| |
Aliases
for SNRPA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Small Nuclear Ribonucleoprotein Polypeptide A1 2 | | U1 SnRNP A2 3 | | U1-A1 2 3 | | U1 Small Nuclear Ribonucleoprotein A2 | | U1A1 2 3 | | U1 Small Nuclear RNP-Specific A2 | | Mud11 2 | | U1 SnRNP-Specific Protein A2 |
Export aliases for SNRPA gene to outside databasesPrevious GC identifers: GC19P041896 GC19P041648 GC19P045932 GC19P045948 GC19P037690 |
Summaries
for SNRPA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SNRPA:
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which bindsthe 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself bypolyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicingand polyadenylation. (provided by RefSeq, Oct 2010)
UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012Function: Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is requiredfor the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved incoupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro
Gene Wiki entry for SNRPA (Small nuclear ribonucleoprotein polypeptide A)
|
Genomic Views
for SNRPA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNRPA gene promoter:
SRF STAT1 SRF (504 AA) ATF-2 STAT1beta STAT1alpha Max c-Jun Ik-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNRPA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1SNRPA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P041256: view genomic region
(about GC identifiers)
Start:
|
41,256,759 bp from pter |
End:
|
41,271,297 bp from pter |
Size:
|
14,539 bases |
Orientation:
|
plus strand |
|
Proteins
for SNRPA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012 (See
protein sequence)Recommended Name: U1 small nuclear ribonucleoprotein A Size: 282 amino acids; 31280 Da
Subunit: Belongs to the spliceosome where it is associated with snRNP U1. Interacts with SFPQ. Also component of asnRNP-free complex with SFPQ
Subcellular location: Nucleus
6/59 PDB 3D structures from  and Proteopedia  for SNRPA (see all 59):1AUD (3D)
1CX0 (3D)
1DRZ (3D)
1DZ5 (3D)
1FHT (3D)
1M5K (3D)
Explore the universe of human proteins at neXtProt for SNRPA: NX_P09012
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P09012
SNRPA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004587.1
ENSEMBL proteins: ENSP00000243563 Reactome Protein details: P09012
Human Recombinant Protein Products for SNRPA:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SNRPA for ontologies About GeneDecksing
SNRPA Antibody Products:
Assay Products for SNRPA: |
Protein
Domains /
Families
for SNRPA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNRPA for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P09012ProtoNet protein and cluster: P09012 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012Similarity: Belongs to the RRM U1 A/B'' familySimilarity: Contains 2 RRM (RNA recognition motif) domains |
Function
for SNRPA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SNRPA_HUMAN, P09012Function: Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is requiredfor the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved incoupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro Genatlas biochemistry entry for SNRPA:samll ribonucleoprotein U1,A polypeptide
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SNRPA for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SNRPA (NM_004596) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNRPA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA |
|
Pathways & Interactions
for SNRPA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | | | 2 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for SNRPA
5 
Reactome Pathways for SNRPA
1 
Kegg Pathway (Kegg details for SNRPA):
SNRPA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNRPA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/617 Interacting proteins for SNRPA (P090121, 2, 3 ENSP000002435634) via UniProtKB, MINT, STRING, and/or I2D (see all 617)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SNRPA for ontologies About GeneDecksing
|
Drugs & Compounds
for SNRPA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SNRPA for compounds About GeneDecksing
 Browse Tocris compounds for SNRPA
1 DrugBank Compound for SNRPA About this table
7 Novoseek chemical compound relationships for SNRPA gene About this table
Search CenterWatch for drugs/clinical trials and news about SNRPA
|
Transcripts
for SNRPA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNRPA gene: NM_004596.4 Unigene Cluster for SNRPA: Small nuclear ribonucleoprotein polypeptide A Hs.466775 [show with all ESTs]Unigene Representative Sequence: NM_0045961 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000243563(uc002ooz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SNRPA (NM_004596) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNRPA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA |
Additional cDNA sequence: AK293140.1 AK313182.1 BC000405.2 BC008290.1 X06347.1 17 DOTS entries: DT.97854609 DT.100827444 DT.80102050 DT.100827448 DT.121436155 DT.100647055 DT.100827455 DT.305096 DT.100750095 DT.121436170 DT.100827445 DT.100827454 DT.121436208 DT.100719490 DT.100827446 DT.100827447 DT.95206669 488 AceView cDNA sequences (see top 24): CA306578 BC008290 CA420448 CR612581 CR613649 BE501622 CR606390 CR620634 CR607723 CR595370 BP871078 BI768440 CR591403 AI188213 CR611065 BM682690 BX417996 CR597793 CR593045 BM740167 BM718224 CR614107 CR597345 CR622302 CR620163 AI949381 BQ068261 NM_004596 BQ182227 BX402880 CR606659 CA313815 BX402083 BU728996 CR614230 BU630723 CR611939 BU949457 CR609533 AW848338 BI907674 BQ447022 CF128304 BM478204 AI870262 BQ671697 BQ689851 BM701785 AW245480 AW168541 AI452558 BQ650463 CR604415 CR617901 AI359889 CR624653 BG577318 BQ670032 BU633509 BC000405 CR602490 CR597355 CA418847 BM827602 BE879259 BU541141 BE269541 BG913339 BX376254 BX325024 BM761211 BX354237 CN483212 BM707719 BI827275 BQ064240 BE732526 BE616725 BI550139 BX453967 BQ650688 AW316553 BI769831 BU733243 BG394101 BM923215 BE797463 BI905814 AI928950 BG574857 BQ002918 BX442737 BM806788 AL520654 BM919643 BX422424 BM012923 BG824769 BG479185 BQ669289 AI990826 BG576032 CB152533 BQ943561 CB133035 BQ943748 BM769541 BQ573976 BE267649 BQ424608 BQ227253 AL530234 AL559056 AL524660 BF305994 X06347 BE313007 BE889079 BI837156 BG478688 BG024354 CB129486 BM920787 BG477784 BQ109525 AA512947 BE895907 N59036 BM855429 BQ930876 BI488528 BG746944 BE734932 CB305989 BQ691097 AL580757 BF971563 BQ446035 BI489989 BQ923703 BI597696 BQ917325 BM741663 AA295764 BG323629 CB127111 BM548236 BI521163 AI929204 AW138366 BM051616 BP430221 CB145609 BI908716 BE531105 AL522923 BM782694 BX417759 BM466034 AI682350 AU142110 BE408068 BE531350 BF811152 BE887302 BM803918 BG257028 BP346655 AI658741 BE559991 AI682344 BX402082 BG328370 BI913622 AL523990 BQ645278 BE258504 BE888636 CB108822 BX354251 AI347051 BE616063 BF980515 BP872619 W79655 CD049641 BU633156 AW518377 BQ653682 BM562047 BI261560 BQ445867 BM787929 AW245839 BE733579 BE561196 BI829168 BF916394 CA502836 BQ059771 BM800511 AL528815 BU542369 AW139570 AL525704 BU597402 BM769818 BU601858 BG035398 AI797562 BE787635 CB126456 BE732747 CF126649 BQ686239 BI258603 BX096095 BI916363 BU949216 AI125327 BQ226242 BX427443 BM789510 AW160891 BI760880 BG035894 BM555092 AU139052 BX354238 BX376255 BI770022 BI764236 BU783806 BQ001598 BI836822 BI916215 CB130704 BE734772 BQ689050 AW084578 N55164 BG683072 AA332151 BG251378 BM800862 BQ430334 BX335505 BE731039 AU121502 BE208210 CB216135 BX383865 AW340597 CD367967 AL520653 BQ218119 BM544546 BG829902 BI160233 AI874338 BE732963 BG287051 AI693964 BG703861 BX351247 BI838985 BX335504 AA010983 BU191623 BX402879 BM754530 BE559760 AI570173 BG765683 BX351054 BE560427 AA745946 AI523807 R45594 CF140587 BM803584 BM927853 BE261191 N53948 BQ060092 BF433761 BE880272 BG476797 AA076330 BI262176 BX383678 BX422423 BF338718 BF204668 AL522922 R68350 BE734938 BX362160 BU149133 BI824331 BG827174 BM917739 T28632 BE019956 BI465166 BE548036 AW662868 AA311059 H51205 BE737311 CD049106 BM992848 BG468870 BF310786 BX376072 CF140515 BE778134 BG386335 BP357809 BX374037 AA359464 BE559672 BM806624 BX383864 AA456176 AI989392 BG336143 AA157253 BE736817 BF308251 BE874495 BE206622 BQ952545 BG759146 BE622472 W32737 BE327975 BM973360 BG036310 BM923909 BG761017 AL518929 BM921429 BM452645 BF026772 AA335389 BQ884311 AL562374 AA514279 AI623556 BE733664 AL562585 BX351300 AW085901 BI909582 AA113145 BM923824 AA176264 CA488491 AW207879 AA693463 BX425184 AA411446 AA010651 AI951026 AU100381 BF349164 CB143818 R53855 BX393331 BI091580 BF805107 AW025887 T51855 BG105763 BE788219 BX325023 R36775 AI872701 CA489577 R68560 BE892193 BX376614 BQ440343 AA028115 BU180799 AL563678 AL523989 AW269411 BQ230261 BX454577 BG683722 AA134798 AL518928 CD366322 AA730999 AW044282 BM852353 BM888489 AI623598 BQ061678 BM793971 AA885389 AA112347 BG676684 BE937706 AA028118 CB960452 AA815024 BQ212231 AI619639 BM817994 H51240 AI000701 BE615656 AW468763 BU601753 BG575984 BE264562 AW403338 AA431562 AA074060 BF927787 BE208354 AA961962 AW084058 W31084 BE542734 BE547532 BE778213 R07842 AA076329 BU839621 BM459069 T51903 BI771176 AI024098 BI017859 AA827321 AA075759 CB128053 BF754891 AA953483 BX351013 AW571892 AI811540 BX342775 BF242341 BI490822 H47523 AL042711 BX355410 AI798015 W81356 W20492 AI018662 N55234 AI208134 BF305411 AA157349 CB993368 AI185263 AA448458 H47524 AA809911 AA205605 AI564883 AA813144 AA992489 R25535 BE207633 N98520 AI016414 AA609372 AW364551 AA205594 BI017847 AA860965 AA824359 BG335811 BF333751 BX342776 BE258321 BF806240 AW364536 BG719150 BG165497 T49870
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SNRPA (see all 10) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | - | | | | | | |
| SP2: | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | - | | | | | | - | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SNRPA
|
Expression
for SNRPA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNRPA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGCCCCTT
About this image
See SNRPA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNRPA
SOURCE GeneReport for Unigene cluster: Hs.466775
SABiosciences Custom PCR Arrays for SNRPA
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNRPA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SNRPA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA |
Orthologs
for SNRPA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SNRPA gene from 8/35 species (see all 35) About this table
ENSEMBL Gene Tree for SNRPA (if available)
TreeFam Gene Tree for SNRPA (if available) |
Paralogs
for SNRPA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SNRPA gene
- SNRPB22
1 SIMAP similar gene for SNRPA using alignment to 7 protein entries: SNRPA_HUMAN (see all proteins):SNRPB2
SNRPA for paralogs About GeneDecksing
|
Genomic Variants
for SNRPA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNRPA (41256759 - 41271297 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SNRPA
1 CNV: 5100
1 Indel: 67545 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNRPA |
|
Disorders
/ Diseases
for SNRPA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNRPA for disorders About GeneDecksing
OMIM gene information: 182285
OMIM disorders: --
9  diseases for SNRPA: About MalaCardsmixed connective tissue disease connective tissue disease yellow fever lupus erythematosus
systemic lupus erythematosus myotonic dystrophy cervicitis hepatitis
malaria
2 diseases from the University of Copenhagen DISEASES database for SNRPA:Mixed connective tissue disease Systemic lupus erythematosus 3 Novoseek disease relationships for SNRPA gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mixed connective tissue disease |
47.7 |
1 |
7930595 (1) |
| lupus erythematosus systemic |
41 |
5 |
7930595 (1), 9342149 (1), 8605931 (1), 9328587 (1) (see all 5) |
| autoimmune diseases |
17.4 |
1 |
7687615 (1) |
Export disorders for SNRPA gene to outside databases
|
Publications
for SNRPA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNRPA gene, integrated from 9 sources (see all 147):
(articles sorted by number of sources associating them with SNRPA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. (PubMed id 9848648)1, 2, 9 Lutz C.S.... Alwine J.C. (1998)
- Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy. (PubMed id 9265619)1, 2, 9 Lu J. and Hall K.B. (1997)
- Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding. (PubMed id 8609632)1, 2, 9 Avis J.M....Neuhaus D. (1996)
- Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein. (PubMed id 1831431)1, 2, 9 Nelissen R.L.H.... van Venrooij W.J. (1991)
- Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. (PubMed id 2147232)1, 2, 9 Nagai K.... Evans P.R. (1990)
- Structural basis of the RNA-binding specificity of human U1A protein. (PubMed id 9312034)1, 2, 9 Allain F.H.-T.... Varani G. (1997)
- NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein. (PubMed id 8070414)1, 2, 9 Howe P.W.A.... Varani G. (1994)
- Crystal structure at 1.92-A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PubMed id 7984237)1, 2, 9 Oubridge C.... Nagai K. (1994)
- Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA. (PubMed id 1833186)1, 2, 9 Jessen T.-H.... Nagai K. (1991)
- Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. (PubMed id 19561594)1, 2 Ray D....Hughes T.R. (2009)
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External Searches for SNRPA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing SNRPA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SNRPA gene
(According to HUGE)
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Specialized Databases showing SNRPA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for SNRPA | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for SNRPA gene:
Search GeneIP for patents involving SNRPA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SNRPA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SNRPA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRPA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNRPA | | | OriGene Protein Over-expression Lysate for SNRPA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SNRPA | | OriGene 3'-UTR Clone for SNRPA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRPA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SNRPA | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SNRPA | | OriGene Custom Protein Services for SNRPA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNRPA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNRPA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPA |
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| | | | Search Tocris compounds for SNRPA |
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 | | | SNRPA Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SNRPA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA |
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