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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNRPA Gene

protein-coding   GIFtS: 61
GCID: GC19P041256

Small Nuclear Ribonucleoprotein Polypeptide A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Small Nuclear Ribonucleoprotein Polypeptide A1 2     Mud12
U1-A2 3     U1 Small Nuclear Ribonucleoprotein A2
U1A2 3     U1 Small Nuclear RNP-Specific A2
U1 SnRNP A2 3     U1 SnRNP-Specific Protein A2

External Ids:    HGNC: 111511   Entrez Gene: 66262   Ensembl: ENSG000000773127   OMIM: 1822855   UniProtKB: P090123   

Export aliases for SNRPA gene to outside databases

Previous GC identifers: GC19P041896 GC19P041648 GC19P045932 GC19P045948 GC19P037690


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNRPA Gene:
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which
binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates
itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling
of splicing and polyadenylation. (provided by RefSeq, Oct 2010)

GeneCards Summary for SNRPA Gene: 
SNRPA (small nuclear ribonucleoprotein polypeptide A) is a protein-coding gene. Diseases associated with SNRPA include mixed connective tissue disease, and yellow fever, and among its related super-pathways are mRNA Processing and Generic Transcription Pathway. GO annotations related to this gene include RNA binding and snRNA binding. An important paralog of this gene is SNRPB2.

UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012
Function: Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is
required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be
involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif
in vitro

Gene Wiki entry for SNRPA (Small nuclear ribonucleoprotein polypeptide A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNRPA gene promoter:
         SRF   STAT1   SRF (504 AA)   ATF-2   STAT1beta   STAT1alpha   Max   c-Jun   Ik-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRPA promoter sequence
   Search SABiosciences Chromatin IP Primers for SNRPA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

SNRPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRPA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041256:  view genomic region     (about GC identifiers)

Start:
41,256,542 bp from pter      End:
41,271,297 bp from pter
Size:
14,756 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012 (See protein sequence)
Recommended Name: U1 small nuclear ribonucleoprotein A  
Size: 282 amino acids; 31280 Da
Subunit: Belongs to the spliceosome where it is associated with snRNP U1. Interacts with SFPQ. Also component of a
snRNP-free complex with SFPQ
Subcellular location: Nucleus
6/59 PDB 3D structures from and Proteopedia for SNRPA (see all 59):
1AUD (3D)        1CX0 (3D)        1DRZ (3D)        1DZ5 (3D)        1FHT (3D)        1M5K (3D)    

Explore the universe of human proteins at neXtProt for SNRPA: NX_P09012

Explore proteomics data for SNRPA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09012

  • SNRPA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNRPA Protein Expression
    REFSEQ proteins: NP_004587.1  
    ENSEMBL proteins: 
     ENSP00000470534   ENSP00000243563   ENSP00000469224   ENSP00000472449   ENSP00000472258  
     ENSP00000472355   ENSP00000471230  
    Reactome Protein details: P09012
    Human Recombinant Protein Products for SNRPA: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
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    OriGene Purified Protein for SNRPA
    OriGene Protein Over-expression Lysate for SNRPA
    OriGene MassSpec for SNRPA 
    OriGene Custom Protein Services for SNRPA
    GenScript Custom Purified and Recombinant Proteins Services for SNRPA
    Novus Biologicals SNRPA Protein
    Novus Biologicals SNRPA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNRPA 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9731529

    SNRPA for ontologies           About GeneDecksing



    SNRPA Antibody Products: 
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    Novus Biologicals SNRPA Antibodies
    Abcam antibodies for SNRPA
    Cloud-Clone Corp. Antibodies for SNRPA 
    ThermoFisher Antibody for SNRPA
    LSBio Antibodies in human, mouse, rat for SNRPA 

    Assay Products for SNRPA: 
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    GenScript Custom Assay Services for SNRPA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SNRPA 
    Cloud-Clone Corp. CLIAs for SNRPA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR024888 U1_snRNP_A/U2_snRNP_B''
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry P09012

    ProtoNet protein and cluster: P09012

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SNRPA_HUMAN, P09012
    Similarity: Belongs to the RRM U1 A/B'' family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    SNRPA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNRPA_HUMAN, P09012
    Function: Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is
    required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be
    involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif
    in vitro

         Genatlas biochemistry entry for SNRPA:
    samll ribonucleoprotein U1,A polypeptide

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IDA19561594
    GO:0005515protein binding IPI10688667
    GO:0017069snRNA binding IEA--
         
    SNRPA for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SNRPA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SNRPA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNRPA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNRPA 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPA
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPA:
    hsa-miR-644 hsa-miR-1231 hsa-miR-654-3p hsa-miR-106a* hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidSNRPA 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SNRPA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNRPA
    Sirion Biotech Customized adenovirus for overexpression of SNRPA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SNRPA (see all 8)
    OriGene ORF clones in mouse, rat for SNRPA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNRPA (NM_004596)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA
    Sirion Biotech Customized lentivirus for stable overexpression of SNRPA 
                         Customized lentivirus expression plasmids for stable overexpression of SNRPA 

    Cell Line
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    Search LifeMap BioReagents cell lines for SNRPA
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRPA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SNRPA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA processing0.46
    mRNA Splicing - Major Pathway0.82
    Spliceosome0.31
    2Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNRPA
        mRNA processing

    5        Reactome Pathways for SNRPA
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA


    1         Kegg Pathway  (Kegg details for SNRPA):
        Spliceosome


    SNRPA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNRPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/644 Interacting proteins for SNRPA (P090121, 2, 3 ENSP000002435634) via UniProtKB, MINT, STRING, and/or I2D (see all 644)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN2Q166372, 3, ENSP000003701194MINT-14308 MINT-7947479 I2D: score=1 STRING: ENSP00000370119
    PTBP1P265992, 3, ENSP000003494284MINT-8332987 MINT-7947479 I2D: score=3 STRING: ENSP00000349428
    SF3A2Q154282, 3, ENSP000002214944MINT-5205386 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    SMN1Q166372, 3MINT-14308 MINT-7947479 I2D: score=1 
    C19orf43Q9BQ612, 3, ENSP000002427844MINT-8332954 I2D: score=4 STRING: ENSP00000242784
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    SNRPA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SNRPA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNRPA

    1 DrugBank Compound for SNRPA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Malonic acidMalonate (see all 2)141-82-2target----

    7 Novoseek inferred chemical compound relationships for SNRPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 41.5 21 12670951 (4), 16943419 (2), 10742179 (2), 11839494 (1) (see all 8)
    hydrogen 27.4 8 11788718 (2), 12466552 (2), 16407334 (1), 16738410 (1) (see all 6)
    adenine 19.3 6 12466552 (3), 15491147 (1), 16278830 (1)
    guanidine hydrochloride 17.1 1 15476390 (1)
    cysteine 0.481 1 10852733 (1)
    atp 0 2 10648562 (1)
    iron 0 4 1584791 (1)

    Search CenterWatch for drugs/clinical trials and news about SNRPA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNRPA gene: 
    NM_004596.4  

    Unigene Cluster for SNRPA:

    Small nuclear ribonucleoprotein polypeptide A
    Hs.466775  [show with all ESTs]
    Unigene Representative Sequence: NM_004596
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601545 ENST00000243563(uc002ooz.3) ENST00000601253 ENST00000597353
    ENST00000599362 ENST00000599570 ENST00000601393 ENST00000598923 ENST00000600456
    ENST00000598452 ENST00000596860
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRPA
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRPA:
    hsa-miR-644 hsa-miR-1231 hsa-miR-654-3p hsa-miR-106a* hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidSNRPA 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SNRPA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRPA
    Clone
    Products:
         
    OriGene clones in human, mouse for SNRPA (see all 8)
    OriGene ORF clones in mouse, rat for SNRPA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNRPA (NM_004596)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRPA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRPA
    Sirion Biotech Customized lentivirus for stable overexpression of SNRPA 
                         Customized lentivirus expression plasmids for stable overexpression of SNRPA 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNRPA
    OriGene qSTAR qPCR primer pairs in human, mouse for SNRPA
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SNRPA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRPA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRPA

    Additional mRNA sequence: 

    AK293140.1 AK313182.1 BC000405.2 BC008290.1 X06347.1 

    17 DOTS entries:

    DT.97854609  DT.100827444  DT.80102050  DT.100827448  DT.121436155  DT.100647055  DT.100827455  DT.305096 
    DT.100750095  DT.121436170  DT.100827445  DT.100827454  DT.121436208  DT.100719490  DT.100827446  DT.100827447 
    DT.95206669 

    488 AceView cDNA sequences (see top 24):

    CR606390 BM740167 CR611065 CR614107 CR624653 CA306578 BM478204 BQ671697 
    BC000405 BM701785 AI452558 CR607723 CR617901 BM718224 BM682690 BQ670032 
    BG577318 BP871078 BU633509 CA313815 CR613649 BU630723 CR602490 CR622302 
    CR620163 CR591403 BQ650463 CR620634 AI949381 BQ182227 AI188213 BX402880 
    CR593045 CR597345 BQ068261 AW245480 BQ447022 CR604415 BU728996 CR609533 
    BX417996 CR614230 CR612581 BI768440 BU949457 CR595370 NM_004596 CR611939 
    BQ689851 CR597355 CA418847 AW168541 CF128304 AI870262 AW848338 BI907674 
    AI359889 CA420448 BC008290 CR606659 BE501622 BX402083 CR597793 BM548236 
    BM051616 BQ669289 AW518377 AI990826 BX325024 BX354251 BM855429 BQ002918 
    BX376255 BI769831 AI797562 AA512947 BI916215 BU733243 BM800862 AL524660 
    BM562047 BF971563 BE887302 BQ446035 CB129486 BM782694 BM803918 BX417759 
    BG024354 BE408068 BG824769 BP346655 BM466034 BQ109525 AW245839 BI913622 
    BQ001598 AL523990 BQ645278 BG035894 BQ917325 BF811152 BI908716 BQ064240 
    BE734932 AA295764 CB152533 BG574857 BP872619 CB130704 BE731039 BQ573976 
    BQ430334 BG478688 BM707719 BF980515 BM920787 BQ226242 BE531105 AW139570 
    CF126649 BU949216 BQ686239 AL520653 BU633156 BI916363 AU142110 BE616063 
    CD367967 BE561196 BQ923703 AW160891 AI347051 BG328370 BI521163 BQ059771 
    BX354237 BE733579 BI597696 BG746944 BQ227253 BM827602 BI488528 AW138366 
    CB127111 AI929204 BI550139 BM012923 AL520654 BQ650688 BG683072 BI760880 
    X06347 BM769541 BI261560 AW084578 BQ653682 AL559056 CA502836 AL580757 
    AA332151 N55164 BG477784 BI770022 BX376254 BM761211 BE208210 BF916394 
    BE258504 BE888636 BQ689050 BI489989 BI836822 BG479185 CB133035 BG257028 
    BX096095 BQ943561 BE797463 BM787929 BM741663 BX402082 CB216135 BU783806 
    AW316553 CD049641 AI658741 AL522923 BM789510 BX422424 AI928950 BI905814 
    BM806788 BX427443 BU541141 AW340597 BI258603 BE787635 CB145609 BM923215 
    CB305989 BI837156 BI827275 BG323629 BM919643 AI125327 AU121502 BE732747 
    BM800511 W79655 BG035398 BU601858 BU597402 BG251378 BE531350 BE734772 
    BX354238 AL528815 BQ930876 BM769818 AL525704 BI829168 BU542369 BI764236 
    BX335505 BG576032 CB108822 CB126456 BF305994 BE313007 AI682344 BX442737 
    BE732526 BE559991 BE879259 BG913339 BX453967 BE616725 BE269541 BX383865 
    BG394101 AU139052 BQ691097 AL530234 BQ424608 N59036 BE267649 BQ943748 
    CN483212 AI682350 BP430221 BM555092 BE889079 BQ445867 BE895907 R68350 
    AA745946 BE732963 BF026772 AL518929 R45594 BM921429 BX351054 AA010983 
    BX376072 BG287051 BG827174 BM927853 BI824331 AI693964 CD049106 AI523807 
    BE559760 BM992848 AA456176 BF310786 AL522922 BE559672 BM923909 BI262176 
    BE737311 BG765683 AA335389 BM452645 BQ952545 BE734938 AA157253 CF140587 
    BX351247 BG036310 BE880272 AW662868 BX335504 BE261191 T28632 N53948 
    AI570173 BF433761 BG476797 BF338718 BF204668 BG761017 BE778134 W32737 
    BM754530 BX383864 BE019956 BE206622 BE622472 BG829902 BG468870 BM917739 
    BI465166 BQ060092 BE736817 BE548036 BX362160 AI989392 BX422423 BP357809 
    BX402879 BU191623 BE560427 BG336143 H51205 BQ884311 BM806624 CF140515 
    AA359464 BG386335 BX374037 AA311059 BE327975 BF308251 BE874495 BI838985 
    BI160233 BG703861 BQ218119 AI874338 BM544546 BG759146 BU149133 AA076330 
    BM973360 BM803584 BX383678 BE892193 BQ440343 BI909582 BX325023 BE733664 
    R68560 BE788219 AL518928 R36775 BF805107 BX393331 BQ230261 BU180799 
    AA693463 AW207879 AA176264 AW269411 AU100381 BG105763 AA411446 BX351300 
    CA489577 AI951026 T51855 AL563678 BX376614 AW085901 AA010651 AL562585 
    AI872701 CB143818 R53855 BX454577 BG683722 CA488491 AL523989 AA113145 
    AW025887 AA028115 AA134798 BI091580 AA514279 AI623556 AL562374 BX425184 
    BF349164 BM923824 BE264562 BE208354 H51240 BM793971 AI619639 BG575984 
    AW084058 AA431562 BE615656 BM852353 BM817994 AW403338 AI000701 AA112347 
    AA885389 AI623598 BQ212231 AA815024 AW468763 AW044282 AA730999 AA028118 
    AA961962 BE937706 BM888489 CD366322 BG676684 CB960452 BU601753 BQ061678 
    W31084 BF927787 AA074060 BI771176 BE778213 BI017859 AA827321 BF754891 
    CB128053 R07842 BU839621 T51903 AA075759 AI024098 AA076329 BM459069 
    BE547532 BE542734 AA992489 N98520 AA205605 AA448458 AA157349 AI564883 
    R25535 AA809911 AI018662 AW571892 AA953483 AI185263 BX342775 BF305411 
    H47523 BX355410 AI208134 AI798015 BF242341 AL042711 AI811540 CB993368 
    BX351013 BE207633 AA813144 H47524 BI490822 W81356 W20492 N55234 
    AA824359 AA205594 BE258321 BF333751 BF806240 AW364536 AI016414 BI017847 
    BG335811 AW364551 AA860965 BX342776 AA609372 BG719150 T49870 BG165497 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SNRPA (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9
    SP1:                                                  -                       -                       -                 -               
    SP2:        -     -     -     -     -     -     -     -                       -                       -                 -               
    SP3:                          -     -     -           -                       -                       -                                 
    SP4:                          -     -     -           -                       -     -                                                   
    SP5:                    -     -     -     -           -                       -                                                         


    ECgene alternative splicing isoforms for SNRPA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNRPA expression in normal human tissues (normalized intensities)      SNRPA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCCCCTT
    SNRPA Expression
    About this image


    SNRPA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             cd34+ cells   

    See SNRPA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNRPA

    SOURCE GeneReport for Unigene cluster: Hs.466775
        SABiosciences Custom PCR Arrays for SNRPA
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRPA gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrpa1 , 5 small nuclear ribonucleoprotein polypeptide A1, 5 88.97(n)1
    96.44(a)1
      7 (15.84 cM)5
    536071  NM_001046637.11  NP_001040102.11 
     271870055 
    lizard
    (Anolis carolinensis)
    Reptilia SNRPA6
    Uncharacterized protein
    90(a)
    1 ↔ 1
    LGf(2806296-2810905)
    African clawed frog
    (Xenopus laevis)
    Amphibia snf-prov2 sans fille 77.7(n)    X57953.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC064308.12   -- 80.27(n)   324121  BC064308.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta snf1 sans fille 69.22(n)
    70.27(a)
      31442  NM_078490.3  NP_511045.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rnp-21 Protein RNP-2 60.03(n)
    56.22(a)
      177181  NM_068103.2  NP_500504.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSL1(YIR009W)4 U2B component of U2 snRNP, involved in splicing, binds more   --   9(374525-374860) 854826  NP_012274.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons U1A1 spliceosomal protein U1A 54.99(n)
    54.7(a)
      819371  NM_130326.2  NP_182280.1 
    rice
    (Oryza sativa)
    Liliopsida Os.97662 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.96(n)    AK102716.1 


    ENSEMBL Gene Tree for SNRPA (if available)
    TreeFam Gene Tree for SNRPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNRPA gene
    SNRPB22  
    2 SIMAP similar genes for SNRPA using alignment to 7 protein entries:     SNRPA_HUMAN (see all proteins):
    SNRPB2    RBMX

    SNRPA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/301 SNPs in SNRPA are shown (see all 301)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1853428231,2
    --41257861(+) GGTCTA/GTGTGC 1 -- int10--------
    rs667432821,2
    C--41257952(+) AAGAAA/GCTGGG 1 -- int13Minor allele frequency- G:0.12WA NA 240
    rs1472987521,2
    --41258008(+) GAGGCC/TGAGGC 1 -- int10--------
    rs1399281031,2
    C--41258090(+) ATACAA/GAATTA 1 -- int10--------
    rs1897604541,2
    --41258215(+) ACAGCC/TTGGGC 1 -- int10--------
    rs1806876521,2
    --41258223(+) GGCAAC/GAAGAG 1 -- int10--------
    rs1859435221,2
    --41258238(+) ACTCCC/GTCTCA 1 -- int10--------
    rs104084521,2
    C,F,H--41258355(+) TAGGAA/GCCCAA 1 -- int111Minor allele frequency- G:0.05NS EA NA WA 1312
    rs1120469261,2
    F--41258381(+) GGTGGT/CTCAGG 1 -- int12Minor allele frequency- C:0.04CSA WA 120
    rs597057651,2
    C--41258485(+) AAAAA-/AAGGCTG 1 -- int11Minor allele frequency- AA:0.00NA 2

    HapMap Linkage Disequilibrium report for SNRPA (41256542 - 41271297 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SNRPA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833832CNV Loss17160897
    esv21537CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182285    OMIM disorders: --

    7 diseases for SNRPA:    About MalaCards
    mixed connective tissue disease    yellow fever    connective tissue disease    myotonic dystrophy
    lupus erythematosus    cervicitis    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for SNRPA:
    Mixed connective tissue disease     Lupus erythematosus

    SNRPA for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SNRPA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mixed connective tissue disease 47.7 1 7930595 (1)
    lupus erythematosus systemic 41 5 7930595 (1), 9342149 (1), 8605931 (1), 9328587 (1) (see all 5)
    autoimmune diseases 17.4 1 7687615 (1)


    Export disorders for SNRPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNRPA gene, integrated from 9 sources (see all 153):
    (articles sorted by number of sources associating them with SNRPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. (PubMed id 9848648)1, 2, 9 Lutz C.S.... Alwine J.C. (1998)
    2. Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy. (PubMed id 9265619)1, 2, 9 Lu J. and Hall K.B. (1997)
    3. Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding. (PubMed id 8609632)1, 2, 9 Avis J.M....Neuhaus D. (1996)
    4. Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein. (PubMed id 1831431)1, 2, 9 Nelissen R.L.H.... van Venrooij W.J. (1991)
    5. Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. (PubMed id 2147232)1, 2, 9 Nagai K.... Evans P.R. (1990)
    6. Structural basis of the RNA-binding specificity of human U1A protein. (PubMed id 9312034)1, 2, 9 Allain F.H.-T.... Varani G. (1997)
    7. NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein. (PubMed id 8070414)1, 2, 9 Howe P.W.A.... Varani G. (1994)
    8. Crystal structure at 1.92-A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PubMed id 7984237)1, 2, 9 Oubridge C.... Nagai K. (1994)
    9. Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA. (PubMed id 1833186)1, 2, 9 Jessen T.-H.... Nagai K. (1991)
    10. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. (PubMed id 19561594)1, 2 Ray D....Hughes T.R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6626 HGNC: 11151 AceView: SNRPA Ensembl:ENSG00000077312 euGenes: HUgn6626
    ECgene: SNRPA Kegg: 6626 H-InvDB: SNRPA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNRPA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNRPA gene:
    Search GeneIP for patents involving SNRPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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