Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SNRNP70 Gene

protein-coding   GIFtS: 60
GCID: GC19P049588

Small Nuclear Ribonucleoprotein 70kDa (U1)

(Previous name: small nuclear ribonucleoprotein 70kDa (RNP antigen))
(Previous symbols: RNPU1Z, RPU1, SNRP70)
  Search for SNRNP70
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Small Nuclear Ribonucleoprotein 70kDa (U1)1 2     Small Nuclear Ribonucleoprotein 70kDa (RNP Antigen)1
RNPU1Z1 2 3 5     Snp12
RPU11 2 3 5     U170K2
SNRP701 2 3 5     U1AP2
U1-70K2 3     U1 Small Nuclear Ribonucleoprotein 70 KDa2
U1 SnRNP 70 KDa2 3     U1AP13
U1RNP2 5     snRNP703

External Ids:    HGNC: 111501   Entrez Gene: 66252   Ensembl: ENSG000001048527   OMIM: 1807405   UniProtKB: P086213   

Export aliases for SNRNP70 gene to outside databases

Previous GC identifers: GC19P054285 GC19P054287 GC19P045964


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SNRNP70 Gene:
SNRNP70 (small nuclear ribonucleoprotein 70kDa (U1)) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SNRNP35.

UniProtKB/Swiss-Prot: RU17_HUMAN, P08621
Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5'
splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The
truncated isoforms cannot bind U1-snRNA

Gene Wiki entry for SNRNP70 (SnRNP70) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNRNP70 gene promoter:
         NF-YA   SREBP-1c   SREBP-1b   NF-YB   CBF-B   CBF-A   SREBP-1a   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRNP70 promoter sequence
   Search Chromatin IP Primers for SNRNP70

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNRNP70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

SNRNP70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRNP70 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049588:  view genomic region     (about GC identifiers)

Start:
49,588,465 bp from pter      End:
49,611,870 bp from pter
Size:
23,406 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RU17_HUMAN, P08621 (See protein sequence)
Recommended Name: U1 small nuclear ribonucleoprotein 70 kDa  
Size: 437 amino acids; 51557 Da
Subunit: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that
assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at
least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SCNM1. Found in
a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic
splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Interacts with dephosphorylated
SFRS13A and SFPQ. Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2
Miscellaneous: Major ribonucleoprotein antigen recognized by the sera from patients with autoimmune diseases, such
as systemic lupus erythematosus
Sequence caution: Sequence=CAA28352.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAA29964.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA29966.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for SNRNP70:
2L5I (3D)        2L5J (3D)        3CW1 (3D)        3PGW (3D)    
Secondary accessions: B3KUA3 P78493 P78494 Q15364 Q15686 Q15687 Q15689 Q99377 Q9UE45 Q9UE46
Q9UE47 Q9UE48 Q9UFQ6
Alternative splicing: 4 isoforms:  P08621-1   P08621-2   P08621-3   P08621-4   

Explore the universe of human proteins at neXtProt for SNRNP70: NX_P08621

Explore proteomics data for SNRNP70 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Extensively phosphorylated on serine residues in the C-terminal region1
  • Ubiquitination2 at Lys27, Lys87, Lys103, Lys130
  • Modification sites at PhosphoSitePlus

  • See SNRNP70 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003080.2  
    ENSEMBL proteins: 
     ENSP00000468952   ENSP00000470023   ENSP00000472998   ENSP00000221448   ENSP00000385077  
     ENSP00000471006   ENSP00000468828  
    Reactome Protein details: P08621

    SNRNP70 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SNRNP70
    OriGene Protein Over-expression Lysate for SNRNP70
    OriGene MassSpec for SNRNP70
    OriGene Custom Protein Services for SNRNP70
    GenScript Custom Purified and Recombinant Proteins Services for SNRNP70
    Novus Biologicals SNRNP70 Protein
    Novus Biologicals SNRNP70 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SNRNP70
    Cloud-Clone Corp. Proteins for SNRNP70

     
    Search eBioscience for Proteins for SNRNP70 

    SNRNP70 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SNRNP70
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SNRNP70
    Novus Biologicals SNRNP70 Antibodies
    Search for Antibodies for SNRNP70 at Abcam
    Cloud-Clone Corp. Antibodies for SNRNP70
    Search ThermoFisher Antibodies for SNRNP70
    LSBio Antibodies in human, mouse, rat for SNRNP70

    SNRNP70 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of SNRNP70
    OriGene Custom Assay Services for SNRNP70
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNRNP70
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SNRNP70
    Cloud-Clone Corp. CLIAs for SNRNP70
    Search eBioscience for ELISAs for SNRNP70 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR022023 U1snRNP70_N
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry P08621

    ProtoNet protein and cluster: P08621

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RU17_HUMAN, P08621
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with SNRNP70           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RU17_HUMAN, P08621
    Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5'
    splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The
    truncated isoforms cannot bind U1-snRNA

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IMP2467746
    GO:0005515protein binding IPI14561889
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SNRNP70           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SNRNP70:
     Decreased Salmonella enterica   Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNRNP70
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNRNP70

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNRNP70
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNRNP70

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNRNP70:
    hsa-mir-92b-3p (MIRT040687), hsa-mir-92a-3p (MIRT049622), hsa-mir-615-3p (MIRT039874), hsa-mir-26b-5p (MIRT028809), hsa-mir-331-3p (MIRT043521), hsa-mir-193b-3p (MIRT041276)

    Block miRNA regulation of human, mouse, rat SNRNP70 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate SNRNP70:
    hsa-miR-605 hsa-miR-590-3p hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidSNRNP70 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNRNP70
    Predesigned siRNA for gene silencing in human, mouse, rat SNRNP70

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNRNP70

    Clone
    Products:
         
    OriGene clones in human, mouse for SNRNP70 (see all 6)
    OriGene ORF clones in mouse, rat for SNRNP70
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNRNP70 (NM_003089)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRNP70
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRNP70

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SNRNP70
    Browse ESI BIO Cell Lines and PureStem Progenitors for SNRNP70 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRNP70


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RU17_HUMAN, P08621: Nucleus. Nucleus speckle (By similarity). Nucleus, nucleoplasm (By similarity).
    Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IDA9531537
    GO:0005685U1 snRNP IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with SNRNP70           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SNRNP70 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome


    Find genes that share SuperPaths with SNRNP70           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SNRNP70
        mRNA processing

    1 Reactome Pathway for SNRNP70
        mRNA Splicing - Major Pathway


    1 Kegg Pathway  (Kegg details for SNRNP70):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNRNP70
    Interactions:

        Search GeneGlobe Interaction Network for SNRNP70

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNRNP70 (P086211, 2, 3 ENSP000002214484) via UniProtKB, MINT, STRING, and/or I2D (see all 935)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370119
    SMAD9O151982, 3, ENSP000003691544MINT-62151 MINT-61940 I2D: score=4 STRING: ENSP00000369154
    DDX17Q928412, 3, ENSP000003800334MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000380033
    CUL1Q136162, 3, ENSP000003268044MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000326804
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006397mRNA processing TAS3028775
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--
    GO:0043484regulation of RNA splicing IMP2467746

    Find genes that share ontologies with SNRNP70           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNRNP70 (RU17)

    1 Novoseek inferred chemical compound relationship for SNRNP70 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 32.5 4 9085842 (1), 18202700 (1), 18414657 (1), 8332490 (1)



    Find genes that share compounds with SNRNP70           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SNRNP70 gene (2 alternative transcripts): 
    NM_001009820.1  NM_003089.4  

    Unigene Cluster for SNRNP70:

    Small nuclear ribonucleoprotein 70kDa (U1)
    Hs.467097  [show with all ESTs]
    Unigene Representative Sequence: AL832819
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601065 ENST00000598984 ENST00000598441 ENST00000597936 ENST00000221448(uc002pmh.2 uc002pmk.3)
    ENST00000401730(uc002pmm.3 uc021uxh.1) ENST00000595231 ENST00000601411
    ENST00000599687 ENST00000544278
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SNRNP70 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate SNRNP70:
    hsa-miR-605 hsa-miR-590-3p hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidSNRNP70 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SNRNP70
    Predesigned siRNA for gene silencing in human, mouse, rat SNRNP70
    Clone
    Products:
         
    OriGene clones in human, mouse for SNRNP70 (see all 6)
    OriGene ORF clones in mouse, rat for SNRNP70
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNRNP70 (NM_003089)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRNP70
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRNP70
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNRNP70
    OriGene qSTAR qPCR primer pairs in human, mouse for SNRNP70
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNRNP70
      QuantiTect SYBR Green Assays in human, mouse, rat SNRNP70
      QuantiFast Probe-based Assays in human, mouse, rat SNRNP70

    Additional mRNA sequence: 

    AK027127.1 AK056808.1 AK096783.1 AK293120.1 AL117399.1 AL117507.1 AL832819.1 BC000342.2 
    BC001315.1 M22636.1 X06811.1 X06812.1 X06813.1 X06814.1 X06815.1 X06816.1 
    X06817.1 X06818.1 X06819.1 X07401.1 X07402.1 X07403.1 X84841.1 

    Selected DOTS entries (see all 34):

    DT.97855508  DT.40245034  DT.97855505  DT.100888463  DT.100806143  DT.100888451  DT.102836261  DT.100888442 
    DT.95073530  DT.100888469  DT.100031168  DT.100888429  DT.92461032  DT.121435144  DT.100888461  DT.100888459 
    DT.100888452  DT.75116992  DT.121434960  DT.40273532  DT.100031171  DT.100644846  DT.121435118  DT.121435119 

    Selected AceView cDNA sequences (see all 48):

    CR612805 X06815 CR597473 CR608610 CR593135 X06819 X84841 CR600727 
    AL117507 CR626532 CR624970 X07403 CR611310 X06814 X06818 AK096783 
    CR616073 CR596341 X06812 CR608261 BC001315 X06811 NM_003089 CR624326 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SNRNP70 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
    SP1:                          -                             -                             -                 -                 -     -           -               
    SP2:                          -                             -                             -     -     -     -                 -     -                           
    SP3:                          -                             -                             -           -     -                 -     -                           
    SP4:                          -                             -                             -     -     -     -                 -     -           -               
    SP5:                          -     -     -                 -                                                                                                   

    ExUns: 12d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SNRNP70

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SNRNP70 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTCTGAGG
    SNRNP70 Expression
    About this image


    SNRNP70 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    SNRNP70 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNRNP70 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.467097
        Custom PCR Arrays for SNRNP70
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SNRNP70
    OriGene qSTAR qPCR primer pairs in human, mouse for SNRNP70
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNRNP70
    QuantiTect SYBR Green Assays in human, mouse, rat SNRNP70
    QuantiFast Probe-based Assays in human, mouse, rat SNRNP70
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRNP70

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRNP70 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrnp701 , 5 small nuclear ribonucleoprotein 70 (U1)1, 5 85.52(n)1
    95.63(a)1
      7 (29.28 cM)5
    206371  NM_009224.41  NP_033250.31 
     453764545 
    lizard
    (Anolis carolinensis)
    Reptilia SNRNP706
    small nuclear ribonucleoprotein 70kDa (U1)
    71(a)
    1 ↔ 1
    6(80015560-80034787)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979462 U1 70K 76.9(n)    X12430.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc20b042 wufc20b04 74.19(n)   324143  57060615 
    fruit fly
    (Drosophila melanogaster)
    Insecta snRNP-U1-70K6
    small ribonucleoprotein particle U1 subunit 70K
    42(a)
    1 ↔ 1
    2L(6968711-6971737)
    worm
    (Caenorhabditis elegans)
    Secernentea rnp-76
    Protein RNP-7 (rnp-7) mRNA, complete cds
    41(a)
    1 ↔ 1
    III(7158911-7161157) WBGene00004390
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNP1(YIL061C)4 Component of U1 snRNP required for mRNA splicing via more   --   9(245559-244657) 854749  NP_012203.1 
    rice
    (Oryza sativa)
    Liliopsida Os.46692 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.83(n)    AK059504.1 


    ENSEMBL Gene Tree for SNRNP70 (if available)
    TreeFam Gene Tree for SNRNP70 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SNRNP70 gene
    SNRNP352  
    8 SIMAP similar genes for SNRNP70 using alignment to 3 protein entries:     RU17_HUMAN (see all proteins):
    DKFZp434N041    CSTF2    EIF3G    DAZAP1    BOLL    RBMY1A1
    PUF60    FUSIP1

    Find genes that share paralogs with SNRNP70           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SNRNP70 (see all 588)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1874510231,2
    C--49586479(+) TGAGAA/TAGAGT 1 -- us2k10--------
    rs116670691,2
    C,F,A,H--49586556(+) tcaagC/Tgattc 1 -- us2k1 tfbs35Minor allele frequency- T:0.50NA WA 10
    rs1912826181,2
    --49586557(+) CAAGCA/GATTCT 1 -- us2k10--------
    rs116670721,2
    C,H--49586561(+) cgattA/Ctcctg 1 -- us2k12Minor allele frequency- C:0.25NA WA 4
    rs1831541671,2
    --49586651(+) GTTTCA/GCCATG 1 -- us2k10--------
    rs1462275311,2
    --49586748(+) ACACCC/TGGCCT 1 -- us2k10--------
    rs1878265631,2
    --49586812(+) CAGTCA/GTGCAA 1 -- us2k10--------
    rs1390867301,2
    C--49586884(+) GGTGCA/GTGCCA 1 -- us2k10--------
    rs1926490461,2
    --49586986(+) CCCACC/TTCGGC 1 -- us2k10--------
    rs129737701,2
    C,F--49587046(+) tctttC/Tttttt 1 -- us2k1 trp32Minor allele frequency- T:0.50NA 4

    HapMap Linkage Disequilibrium report for SNRNP70 (49588465 - 49611870 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SNRNP70:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3971n71CNV Loss21882294
    nsv912256CNV Loss21882294
    nsv912255CNV Loss21882294
    nsv912258CNV Loss21882294
    nsv833859CNV Loss17160897
    nsv833857CNV Loss17160897
    nsv912254CNV Loss21882294
    dgv3970n71CNV Loss21882294
    nsv912252CNV Loss21882294
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNRNP70
    DNA2.0 Custom Variant and Variant Library Synthesis for SNRNP70

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 180740    OMIM disorders: --

    4 diseases from the University of Copenhagen DISEASES database for SNRNP70:
    Mixed connective tissue disease     Lupus erythematosus     Systemic scleroderma     Myositis

    Find genes that share disorders with SNRNP70           About GenesLikeMe

    5 Novoseek inferred disease relationships for SNRNP70 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mixed connective tissue disease 60.4 3 15743477 (2), 11069087 (1)
    lupus erythematosus systemic 52.3 4 16263701 (1), 19035498 (1), 11069087 (1), 18202700 (1)
    autoimmune response 46.4 1 11069087 (1)
    autoimmune diseases 12.3 1 18202700 (1)
    tumors 0 1 10022522 (1)


    Export disorders for SNRNP70 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SNRNP70 gene, integrated from 10 sources (see all 158):
    (articles sorted by number of sources associating them with SNRNP70)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3. (PubMed id 2147422)1, 2, 9 Spritz R.A.... Mohrenweiser H.W. (Genomics 1990)
    2. Association of polyadenylation cleavage factor I with U1 snRNP. (PubMed id 14561889)1, 2, 9 Awasthi S. and Alwine J.C. (RNA 2003)
    3. Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors. (PubMed id 8332490)1, 2, 9 Woppmann A....Luehrmann R. (Nucleic Acids Res. 1993)
    4. Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions. (PubMed id 11514619)1, 2, 9 Shav-Tal Y.... Zipori D. (Mol. Biol. Cell 2001)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    9. Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. (PubMed id 14765198)1, 2 Shin C.... Manley J.L. (Nature 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6625 HGNC: 11150 AceView: SNRP70 Ensembl:ENSG00000104852 euGenes: HUgn6625
    ECgene: SNRNP70 Kegg: 6625 H-InvDB: SNRNP70

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SNRNP70 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SNRNP70 gene:
    Search GeneIP for patents involving SNRNP70

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of SNRNP70
     EMD Millipore Kits and Assays for the Analysis of SNRNP70
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SNRNP70  
     OriGene qPCR primer pairs and template standards for SNRNP70   OriGene Protein Over-expression Lysate for SNRNP70  
     OriGene MassSpec something-or-other for SNRNP70   OriGene clones in human, mouse for SNRNP70  
     OriGene qSTAR qPCR primer pairs in human, mouse for SNRNP70   OriGene Purified Protein for SNRNP70  
     OriGene ORF clones in mouse, rat for SNRNP70   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SNRNP70   OriGene Custom Protein Services for SNRNP70  

     
     
     Block miRNA regulation of human, mouse, rat SNRNP70 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SNRNP70
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNRNP70 Predesigned siRNA for gene silencing in human, mouse, rat SNRNP70
     QuantiFast Probe-based Assays in human, mouse, rat SNRNP70 QuantiTect SYBR Green Assays in human, mouse, rat SNRNP70
     Custom PCR Arrays for SNRNP70 Search Chromatin IP Primers for SNRNP70
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNRNP70  Search GeneGlobe Interaction Network for SNRNP70
     Regulatory tfbs in SNRNP70 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SNRNP70 GenScript cDNA clones with any tag delivered in your preferred vector for SNRNP70
     GenScript Custom Assay Services for SNRNP70 GenScript Custom overexpressing Cell Line Services for SNRNP70
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SNRNP70 (RU17)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SNRNP70 antibodies
     SNRNP70 proteins
     SNRNP70 lysates
     Search for Antibodies for SNRNP70 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SNRNP70
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SNRNP70
     Proteins for SNRNP70
     Antibodies for SNRNP70
     ELISAs for SNRNP70
     CLIAs for SNRNP70



     Browse ESI BIO Cell Lines and PureStem Progenitors for SNRNP70
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRNP70
     SwitchGear 3'UTR luciferase reporter plasmids for SNRNP70
     SwitchGear Promoter luciferase reporter plasmids for SNRNP70
     Search ThermoFisher Antibodies for SNRNP70
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRNP70
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNRNP70
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNRNP70
     LSBio Antibodies in human, mouse, rat for SNRNP70
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SNRNP70
      Search eBioscience for proteins for SNRNP70
      Search eBioscience for elisas for SNRNP70
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SNRNP70 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4