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Aliases for SNRNP70 Gene

Aliases for SNRNP70 Gene

  • Small Nuclear Ribonucleoprotein 70kDa (U1) 2 3
  • RNPU1Z 3 4 6
  • SNRP70 3 4 6
  • RPU1 3 4 6
  • U1 SnRNP 70 KDa 3 4
  • U1-70K 3 4
  • U1RNP 3 6
  • Small Nuclear Ribonucleoprotein 70kDa (RNP Antigen) 2
  • U1 Small Nuclear Ribonucleoprotein 70 KDa 3
  • SnRNP70 4
  • U170K 3
  • U1AP1 4
  • Snp1 3
  • U1AP 3

External Ids for SNRNP70 Gene

Previous Symbols for SNRNP70 Gene

  • RNPU1Z
  • RPU1
  • SNRP70

Summaries for SNRNP70 Gene

GeneCards Summary for SNRNP70 Gene

SNRNP70 (Small Nuclear Ribonucleoprotein 70kDa (U1)) is a Protein Coding gene. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SNRNP35.

UniProtKB/Swiss-Prot for SNRNP70 Gene

  • Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5 splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA

Gene Wiki entry for SNRNP70 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRNP70 Gene

Genomics for SNRNP70 Gene

Genomic Location for SNRNP70 Gene

Start:
49,085,208 bp from pter
End:
49,108,613 bp from pter
Size:
23,406 bases
Orientation:
Plus strand

Genomic View for SNRNP70 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNRNP70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRNP70 Gene

Regulatory Elements for SNRNP70 Gene

Proteins for SNRNP70 Gene

  • Protein details for SNRNP70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08621-RU17_HUMAN
    Recommended name:
    U1 small nuclear ribonucleoprotein 70 kDa
    Protein Accession:
    P08621
    Secondary Accessions:
    • B3KUA3
    • P78493
    • P78494
    • Q15364
    • Q15686
    • Q15687
    • Q15689
    • Q99377
    • Q9UE45
    • Q9UE46
    • Q9UE47
    • Q9UE48
    • Q9UFQ6

    Protein attributes for SNRNP70 Gene

    Size:
    437 amino acids
    Molecular mass:
    51557 Da
    Quaternary structure:
    • U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SCNM1. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Interacts with dephosphorylated SFRS13A and SFPQ. Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2.
    Miscellaneous:
    • Major ribonucleoprotein antigen recognized by the sera from patients with autoimmune diseases, such as systemic lupus erythematosus
    SequenceCaution:
    • Sequence=CAA28352.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA29964.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA29966.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SNRNP70 Gene

    Alternative splice isoforms for SNRNP70 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNRNP70 Gene

Proteomics data for SNRNP70 Gene at MOPED

Post-translational modifications for SNRNP70 Gene

Other Protein References for SNRNP70 Gene

No data available for DME Specific Peptides for SNRNP70 Gene

Domains for SNRNP70 Gene

Gene Families for SNRNP70 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for SNRNP70 Gene

UniProtKB/Swiss-Prot:

RU17_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • P08621
genes like me logo Genes that share domains with SNRNP70: view

Function for SNRNP70 Gene

Molecular function for SNRNP70 Gene

UniProtKB/Swiss-Prot Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5 splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA

Gene Ontology (GO) - Molecular Function for SNRNP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IMP 2467746
GO:0005515 protein binding IPI 14561889
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SNRNP70: view
genes like me logo Genes that share phenotypes with SNRNP70: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNRNP70 Gene

Localization for SNRNP70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRNP70 Gene

Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRNP70 Gene COMPARTMENTS Subcellular localization image for SNRNP70 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SNRNP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9531537
GO:0005685 U1 snRNP IDA 21113136
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with SNRNP70: view

Pathways for SNRNP70 Gene

genes like me logo Genes that share pathways with SNRNP70: view

Pathways by source for SNRNP70 Gene

1 BioSystems pathway for SNRNP70 Gene
1 KEGG pathway for SNRNP70 Gene

Gene Ontology (GO) - Biological Process for SNRNP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing TAS 3028775
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
GO:0043484 regulation of RNA splicing IMP 2467746
genes like me logo Genes that share ontologies with SNRNP70: view

Compounds for SNRNP70 Gene

(1) Novoseek inferred chemical compound relationships for SNRNP70 Gene

Compound -log(P) Hits PubMed IDs
serine 32.5 4
genes like me logo Genes that share compounds with SNRNP70: view

Transcripts for SNRNP70 Gene

Unigene Clusters for SNRNP70 Gene

Small nuclear ribonucleoprotein 70kDa (U1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNRNP70 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: -
SP8: - -
SP9: - -
SP10: -
SP11: - -
SP12: -
SP13:

ExUns: 12d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SNRNP70 Gene

GeneLoc Exon Structure for
SNRNP70
ECgene alternative splicing isoforms for
SNRNP70

Expression for SNRNP70 Gene

mRNA expression in normal human tissues for SNRNP70 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNRNP70 Gene

SOURCE GeneReport for Unigene cluster for SNRNP70 Gene Hs.467097

genes like me logo Genes that share expressions with SNRNP70: view

Orthologs for SNRNP70 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRNP70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRNP70 36
  • 99.62 (n)
  • 100 (a)
SNRNP70 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNRNP70 36
  • 91.34 (n)
  • 98.62 (a)
SNRNP70 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRNP70 36
  • 88.66 (n)
  • 94.71 (a)
SNRNP70 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snrnp70 36
  • 85.52 (n)
  • 95.63 (a)
Snrnp70 16
Snrnp70 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNRNP70 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNRNP70 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snrnp70 36
  • 88.01 (n)
  • 97.56 (a)
lizard
(Anolis carolinensis)
Reptilia SNRNP70 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397946 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8913 36
zebrafish
(Danio rerio)
Actinopterygii snrnp70 37
  • 57 (a)
OneToOne
wufc20b04 36
fruit fly
(Drosophila melanogaster)
Insecta snRNP-U1-70K 37
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rnp-7 37
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNP1 37
  • 27 (a)
OneToMany
SNP1 39
rice
(Oryza sativa)
Liliopsida Os.4669 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.649 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10607 37
  • 41 (a)
OneToOne
Species with no ortholog for SNRNP70:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNRNP70 Gene

ENSEMBL:
Gene Tree for SNRNP70 (if available)
TreeFam:
Gene Tree for SNRNP70 (if available)

Paralogs for SNRNP70 Gene

Paralogs for SNRNP70 Gene

Selected SIMAP similar genes for SNRNP70 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SNRNP70: view

Variants for SNRNP70 Gene

Sequence variations from dbSNP and Humsavar for SNRNP70 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs734570 -- 49,103,192(+) GGTTT(C/T)TGAGG intron-variant
rs753576 -- 49,087,524(-) TAAGC(C/T)CTCCA intron-variant
rs1058882 -- 49,108,062(+) CGTGG(C/T)GGCGG reference, synonymous-codon, utr-variant-5-prime
rs1058973 -- 49,108,345(+) AGGGT(C/T)TGGGC reference, synonymous-codon
rs1059034 -- 49,108,445(+) GTGAA(A/G)AGGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SNRNP70 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833857 CNV Loss 17160897
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912252 CNV Loss 21882294
nsv912254 CNV Loss 21882294
nsv912255 CNV Loss 21882294
nsv912256 CNV Loss 21882294
nsv912258 CNV Loss 21882294
dgv3971n71 CNV Loss 21882294

Relevant External Links for SNRNP70 Gene

HapMap Linkage Disequilibrium report
SNRNP70

Disorders for SNRNP70 Gene

(5) Novoseek inferred disease relationships for SNRNP70 Gene

Disease -log(P) Hits PubMed IDs
mixed connective tissue disease 60.4 3
lupus erythematosus systemic 52.3 4
autoimmune response 46.4 1
autoimmune diseases 12.3 1
tumors 0 1
genes like me logo Genes that share disorders with SNRNP70: view

No data available for UniProtKB/Swiss-Prot for SNRNP70 Gene

Publications for SNRNP70 Gene

  1. Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3. (PMID: 2147422) Spritz R.A. … Mohrenweiser H.W. (Genomics 1990) 3 4 23
  2. Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors. (PMID: 8332490) Woppmann A. … Luehrmann R. (Nucleic Acids Res. 1993) 3 4 23
  3. Association of polyadenylation cleavage factor I with U1 snRNP. (PMID: 14561889) Awasthi S. … Alwine J.C. (RNA 2003) 3 4 23
  4. Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions. (PMID: 11514619) Shav-Tal Y. … Zipori D. (Mol. Biol. Cell 2001) 3 4 23
  5. Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution. (PMID: 19325628) Pomeranz Krummel D.A. … Nagai K. (Nature 2009) 4 23

Products for SNRNP70 Gene

Sources for SNRNP70 Gene

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