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Aliases for SNRNP35 Gene

Aliases for SNRNP35 Gene

  • Small Nuclear Ribonucleoprotein U11/U12 Subunit 35 2 3 5
  • Small Nuclear Ribonucleoprotein 35kDa (U11/U12) 2 3
  • U1 SnRNP-Binding Protein Homolog 3 4
  • U11/U12 SnRNP 35 KDa Protein 3 4
  • Protein HM-1 3 4
  • U11/U12-35K 3 4
  • U1SNRNPBP 3 4
  • U11/U12 Small Nuclear Ribonucleoprotein 35 KDa Protein 3
  • Small Nuclear Ribonucleoprotein, U11/U12 35kDa Subunit 3
  • Small Nuclear Ribonucleoprotein U11/U12 35kDa Subunit 2
  • U1 SnRNP Binding Protein Homolog 2
  • U11/U12 SnRNP 35K 3
  • HM-1 3
  • HM1 4

External Ids for SNRNP35 Gene

Previous GeneCards Identifiers for SNRNP35 Gene

  • GC12P122509
  • GC12P123891
  • GC12P120904
  • GC12P123942

Summaries for SNRNP35 Gene

Entrez Gene Summary for SNRNP35 Gene

  • The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants encoding two distinct isoforms and representing a non-protein coding variant. [provided by RefSeq, Aug 2013]

GeneCards Summary for SNRNP35 Gene

SNRNP35 (Small Nuclear Ribonucleoprotein U11/U12 Subunit 35) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and mRNA Splicing - Minor Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SNRNP70.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRNP35 Gene

Genomics for SNRNP35 Gene

Regulatory Elements for SNRNP35 Gene

Enhancers for SNRNP35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F123443 1.6 FANTOM5 Ensembl ENCODE 5.8 -10.5 -10541 6.6 ZFP64 DMAP1 ZNF121 SP5 PPARG KAT8 MIER3 ETV4 HMBOX1 KDM1A RILPL2 RILPL1 C12orf65 LOC101927415 CDK2AP1 DNAH10 ENSG00000256092 SNRNP35 ENSG00000270445
GH12F123457 1.1 ENCODE 7.4 +1.3 1290 2.8 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 EIF2B1 RILPL2 GTF2H3 ENSG00000235423 RILPL1 DENR ZCCHC8 LOC101927415 SNRNP35 PIR40920
GH12F123477 1.2 FANTOM5 Ensembl ENCODE 5.9 +21.3 21267 2.5 JUN MAX ZIC2 ZNF121 POLR2A GLIS1 IRF1 MYC ZBTB17 RILPL1 DDX55 LOC101927415 SNRNP35 PITPNM2 PIR40920 ENSG00000274427
GH12F123093 1.7 FANTOM5 Ensembl ENCODE 4.1 -360.9 -360927 6.3 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF2 EIF2B1 ZCCHC8 PITPNM2 ATP6V0A2 KMT5A ENSG00000235423 GTF2H3 DENR LOC101927415 ENSG00000256092
GH12F123119 1.3 FANTOM5 Ensembl ENCODE 4.2 -336.0 -335951 4.3 PKNOX1 USF1 ZIC2 RFX5 SCRT2 CREM SRF SMAD5 MTA2 GFI1B PITPNM2 MPHOSPH9 SNRNP35 C12orf65 HIP1R GC12P123128 ENSG00000280381
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNRNP35 on UCSC Golden Path with GeneCards custom track

Promoters for SNRNP35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000438687 860 1800 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for SNRNP35 Gene

123,457,641 bp from pter
123,473,154 bp from pter
15,514 bases
Plus strand

Genomic View for SNRNP35 Gene

Genes around SNRNP35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRNP35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRNP35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRNP35 Gene

Proteins for SNRNP35 Gene

  • Protein details for SNRNP35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U11/U12 small nuclear ribonucleoprotein 35 kDa protein
    Protein Accession:
    Secondary Accessions:
    • A8K262
    • Q5XKN9

    Protein attributes for SNRNP35 Gene

    246 amino acids
    Molecular mass:
    29450 Da
    Quaternary structure:
    • Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.

    Alternative splice isoforms for SNRNP35 Gene


neXtProt entry for SNRNP35 Gene

Post-translational modifications for SNRNP35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNRNP35 Gene

No data available for DME Specific Peptides for SNRNP35 Gene

Domains & Families for SNRNP35 Gene

Gene Families for SNRNP35 Gene

Protein Domains for SNRNP35 Gene

Suggested Antigen Peptide Sequences for SNRNP35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with SNRNP35: view

Function for SNRNP35 Gene

Gene Ontology (GO) - Molecular Function for SNRNP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IBA --
GO:0017069 snRNA binding IBA --
genes like me logo Genes that share ontologies with SNRNP35: view
genes like me logo Genes that share phenotypes with SNRNP35: view

Animal Model Products

miRNA for SNRNP35 Gene

miRTarBase miRNAs that target SNRNP35

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRNP35 Gene

Localization for SNRNP35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRNP35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNRNP35 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SNRNP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000243 commitment complex IBA --
GO:0005634 nucleus IDA 18559850
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005689 U12-type spliceosomal complex IDA 15146077
genes like me logo Genes that share ontologies with SNRNP35: view

Pathways & Interactions for SNRNP35 Gene

genes like me logo Genes that share pathways with SNRNP35: view

Pathways by source for SNRNP35 Gene

Gene Ontology (GO) - Biological Process for SNRNP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IC 15146077
genes like me logo Genes that share ontologies with SNRNP35: view

No data available for SIGNOR curated interactions for SNRNP35 Gene

Transcripts for SNRNP35 Gene

Unigene Clusters for SNRNP35 Gene

Small nuclear ribonucleoprotein 35kDa (U11/U12):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRNP35 Gene

No ASD Table

Relevant External Links for SNRNP35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNRNP35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNRNP35 Gene

Protein differential expression in normal tissues from HIPED for SNRNP35 Gene

This gene is overexpressed in CD4 Tcells (54.1) and Pancreas (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNRNP35 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNRNP35 Gene:


SOURCE GeneReport for Unigene cluster for SNRNP35 Gene:


mRNA Expression by UniProt/SwissProt for SNRNP35 Gene:

Tissue specificity: Expressed in heart, liver, skeletal muscle and pancreas.
genes like me logo Genes that share expression patterns with SNRNP35: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for SNRNP35 Gene

Orthologs for SNRNP35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRNP35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNRNP35 34 35
  • 99.46 (n)
(Monodelphis domestica)
Mammalia SNRNP35 35
  • 88 (a)
(Canis familiaris)
Mammalia SNRNP35 34 35
  • 87.4 (n)
(Bos Taurus)
Mammalia SNRNP35 34 35
  • 86.94 (n)
(Mus musculus)
Mammalia Snrnp35 34 16 35
  • 82.92 (n)
1700128F08Rik 35
  • 49 (a)
(Rattus norvegicus)
Mammalia Snrnp35 34
  • 82.1 (n)
(Ornithorhynchus anatinus)
Mammalia SNRNP35 35
  • 81 (a)
(Gallus gallus)
Aves SNRNP35 34 35
  • 76.61 (n)
(Anolis carolinensis)
Reptilia SNRNP35 35
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snrnp35 34
  • 68.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25076 34
(Danio rerio)
Actinopterygii snrnp35 34 35
  • 69.25 (n)
Dr.14465 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012250 34
  • 51.87 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNP1 35
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G43370 34
  • 51.4 (n)
(Oryza sativa)
Liliopsida Os09g0513700 34
  • 55.75 (n)
Os.5580 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 56 (a)
Species where no ortholog for SNRNP35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNRNP35 Gene

Gene Tree for SNRNP35 (if available)
Gene Tree for SNRNP35 (if available)

Paralogs for SNRNP35 Gene

Paralogs for SNRNP35 Gene

genes like me logo Genes that share paralogs with SNRNP35: view

Variants for SNRNP35 Gene

Sequence variations from dbSNP and Humsavar for SNRNP35 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs111237193 -- 123,470,630(+) AATAC(-/A)AAAAT intron-variant, downstream-variant-500B
rs111382577 -- 123,457,656(+) GAGGC(C/G)GAGGC upstream-variant-2KB, utr-variant-5-prime
rs111439154 -- 123,472,448(+) CGAGA(A/G)GCTTG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111593238 -- 123,463,025(+) AATGA(C/G/T)AACTA intron-variant, upstream-variant-2KB
rs111702987 -- 123,465,768(+) GGTGA(C/T)ATCCG intron-variant, nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SNRNP35 Gene

Variant ID Type Subtype PubMed ID
nsv1037260 CNV gain 25217958

Variation tolerance for SNRNP35 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNRNP35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRNP35 Gene

Disorders for SNRNP35 Gene

Relevant External Links for SNRNP35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SNRNP35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRNP35 Gene

Publications for SNRNP35 Gene

  1. Cloning and characterization of a family of cDNAs from human histiocyte macrophage cells encoding an arginine-rich basic protein related to the 70 kD U1-snRNP splicing factor. (PMID: 10520751) Adams D.S. … Czop J.K. (DNA Seq. 1998) 2 3 4 22 64
  2. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will C.L. … Luehrmann R. (RNA 2004) 3 4 64
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64

Products for SNRNP35 Gene

Sources for SNRNP35 Gene

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