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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNRNP35 Gene

protein-coding   GIFtS: 45
GCID: GC12P123891

Small Nuclear Ribonucleoprotein 35kDa (U11/U12)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Small Nuclear Ribonucleoprotein 35kDa (U11/U12)1 2     U11/U12 SnRNP 35 KDa Protein2 3
U1 SnRNP Binding Protein Homolog1 2     HM-12
Protein HM-12 3     U1-SnRNP Binding Protein Homolog2
U11/U12-35K2 3     U11/U12 Small Nuclear Ribonucleoprotein 35 KDa Protein2
U1SNRNPBP2 3     U11/U12 SnRNP 35K2
U1 SnRNP-Binding Protein Homolog2 3     HM13

External Ids:    HGNC: 308521   Entrez Gene: 110662   Ensembl: ENSG000001842097   UniProtKB: Q165603   

Export aliases for SNRNP35 gene to outside databases

Previous GC identifers: GC12P122509 GC12P120904


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNRNP35 Gene:
The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA
recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of
a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins
(snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants
encoding two distinct isoforms and representing a non-protein coding variant. (provided by RefSeq, Aug 2013)

GeneCards Summary for SNRNP35 Gene: 
SNRNP35 (small nuclear ribonucleoprotein 35kDa (U11/U12)) is a protein-coding gene. Diseases associated with SNRNP35 include pulmonary fibrosis. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SNRNP70.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNRNP35 gene promoter:
         HOXA9B   HOXA9   GR   GR-beta   YY1   Meis-1b   AREB6   GR-alpha   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNRNP35 promoter sequence
   Search SABiosciences Chromatin IP Primers for SNRNP35

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRNP35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

SNRNP35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRNP35 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P123891:  view genomic region     (about GC identifiers)

Start:
123,942,188 bp from pter      End:
123,957,701 bp from pter
Size:
15,514 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: U1SBP_HUMAN, Q16560 (See protein sequence)
Recommended Name: U11/U12 small nuclear ribonucleoprotein 35 kDa protein  
Size: 246 amino acids; 29450 Da
Subunit: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome
Subcellular location: Nucleus
Secondary accessions: A8K262 Q5XKN9
Alternative splicing: 2 isoforms:  Q16560-1   Q16560-2   

Explore the universe of human proteins at neXtProt for SNRNP35: NX_Q16560

Explore proteomics data for SNRNP35 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16560

  • SNRNP35 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNRNP35 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_073208.1  NP_851030.1  

    ENSEMBL proteins: 
     ENSP00000432595   ENSP00000403310   ENSP00000340774  

    Human Recombinant Protein Products for SNRNP35: 
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    Novus Biologicals SNRNP35 Protein
    Novus Biologicals SNRNP35 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNRNP35 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18559850
    GO:0005689U12-type spliceosomal complex IDA15146077

    SNRNP35 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for SNRNP35


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q16560

    ProtoNet protein and cluster: Q16560

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: U1SBP_HUMAN, Q16560
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    SNRNP35 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
         
    SNRNP35 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SNRNP35 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNRNP35

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/9 Interacting proteins for SNRNP35 (Q165602, 3 ENSP000004033104) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILKQ134182, 3MINT-8258657 I2D: score=2 
    MAP4K2Q128512, 3MINT-8260471 I2D: score=2 
    TAB1Q157502, 3MINT-8260361 I2D: score=2 
    TNFSF11O147882, 3MINT-8274764 I2D: score=2 
    CDC23ENSP000003783504STRING: ENSP00000378350
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IC15146077

    SNRNP35 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNRNP35 (U1SBP)

    Search CenterWatch for drugs/clinical trials and news about SNRNP35 / U1SBP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNRNP35 gene (4 alternative transcripts): 
    NM_022717.3  NM_180699.3  NM_007020.2  NM_180703.2  

    Unigene Cluster for SNRNP35:

    Small nuclear ribonucleoprotein 35kDa (U11/U12)
    Hs.632738  [show with all ESTs]
    Unigene Representative Sequence: AK290127
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526639(uc001ufb.1 uc021rfv.1) ENST00000529904(uc021rfu.1)
    ENST00000527158(uc001ufc.1) ENST00000529201 ENST00000412157 ENST00000350887

    miRNA
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    Inhib. RNA
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRNP35
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                         Customized lentivirus expression plasmids for stable overexpression of SNRNP35 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRNP35
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRNP35

    Additional mRNA sequence: 

    AK290127.1 BC009622.1 BC028485.1 BC047678.1 BC054034.1 BC093671.1 BC111955.1 U44798.1 
    U44799.1 

    10 DOTS entries:

    DT.101983337  DT.75128211  DT.100754367  DT.100754369  DT.121175262  DT.92422193  DT.95088062  DT.97845484 
    DT.87046251  DT.92421480 

    24/105 AceView cDNA sequences (see all 105):

    BM717649 BM694072 BM508077 BM704623 BM797196 BM714052 AA211268 AI453241 
    CA307572 BC020829 AA487864 BF437352 BC028485 AI734180 NM_180699 NM_180703 
    BM998075 BU856880 BU682752 CA441706 AA301542 BC054034 NM_007020 BE797187 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNRNP35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGGGGCCG
    SNRNP35 Expression
    About this image


    See SNRNP35 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNRNP35

    SOURCE GeneReport for Unigene cluster: Hs.632738

    UniProtKB/Swiss-Prot: U1SBP_HUMAN, Q16560
    Tissue specificity: Expressed in heart, liver, skeletal muscle and pancreas

        SABiosciences Custom PCR Arrays for SNRNP35
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRNP35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRNP35 gene from 9/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrnp351 , 5 small nuclear ribonucleoprotein 35 (U11/U12)1, 5 82.92(n)1
    89.75(a)1
      5 (63.61 cM)5
    761671  NM_029532.21  NP_083808.11 
     1244831345 
    chicken
    (Gallus gallus)
    Aves SNRNP351 small nuclear ribonucleoprotein 35kDa (U11/U12) 76.39(n)
    79.17(a)
      416823  XM_415114.3  XP_415114.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNRNP356
    Uncharacterized protein
    72(a)
    1 ↔ 1
    LGb(1799187-1799969)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.250762 Xenopus laevis transcribed sequence with moderate similarity more 76.73(n)    CB593293.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.144652 Transcribed sequence with weak similarity to protein more 72.69(n)    BI672983.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0122501 AGAP012250-PA 49.28(n)
    47.85(a)
      1280439  XM_320292.3  XP_320292.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNP16
    Component of U1 snRNP required for mRNA splicing v...
    19(a)
    1 → many
    IX(244657-245559)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G433701 U11/U12 small nuclear ribonucleoprotein 35 kDa protein 50.97(n)
    54.37(a)
      818938  NM_180064.2  NP_850395.1 
    rice
    (Oryza sativa)
    Liliopsida Os.55802 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.3(n)    AK071999.1 


    ENSEMBL Gene Tree for SNRNP35 (if available)
    TreeFam Gene Tree for SNRNP35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNRNP35 gene
    SNRNP702  

    SNRNP35 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/241 SNPs in SNRNP35 are shown (see all 241)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505872301,2
    --123940697(+) CTCGGC/TTCACT 1 -- us2k10--------
    rs1396661131,2
    --123940755(+) CAAGTA/GGCTGG 1 -- us2k10--------
    rs800725051,2
    C--123940866(-) CGGGCA/GGATCA 1 -- us2k12Minor allele frequency- G:0.25NA 4
    rs1429506961,2
    --123940885(+) TCCCAA/GTGTGC 1 -- us2k10--------
    rs79578391,2
    C,F,A--123941055(+) ccatcC/Ttccta 1 -- us2k112Minor allele frequency- T:0.11NA WA CSA EA 376
    rs1874951921,2
    --123941164(+) CTTATA/GCTTCT 1 -- us2k10--------
    rs1932344631,2
    --123941262(+) TTCCAC/TTGCAT 1 -- us2k10--------
    rs1394987601,2
    C--123941662(+) AAACA-/AACAACAA 1 -- us2k10--------
    rs1474600101,2
    --123941669(+) CAACAA/TCATAG 1 -- us2k10--------
    rs1399416581,2
    --123941730(+) TCAAGC/TCTCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SNRNP35 (123942188 - 123957701 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SNRNP35: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SNRNP35
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SNRNP35:    About MalaCards
    pulmonary fibrosis    


    SNRNP35 for disorders           About GeneDecksing


    Export disorders for SNRNP35 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNRNP35 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with SNRNP35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a family of cDNAs from human histiocyte macrophage cells encoding an arginine-rich basic protein related to the 70 kD U1-snRNP splicing factor. (PubMed id 10520751)1, 2, 3, 9 Adams D.S.... Czop J.K. (1998)
    2. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2 Will C.L.... Luehrmann R. (2004)
    3. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1, 3 Bonaldo M.F.... Soares M.B. (1996)
    4. Site-directed mutagenesis of the CC chemokine binding protein 35K-Fc reveals residues essential for activity and mutations that incr ease the potency of CC chemokine blockade. (PubMed id 21586597)1 White G.E....Greaves D.R. (2011)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Anti-U11/U12 RNP antibodies in systemic sclerosis: a new serologic marker associated with pulmonary fibrosis. (PubMed id 19565553)1 Fertig N....Feghali-Bostwick C.A. (2009)
    8. Minor spliceosome components are predominantly localized in the nucleus. (PubMed id 18559850)1 Pessa H.K....Frilander M.J. (2008)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11066 HGNC: 30852 AceView: U1SNRNPBP Ensembl:ENSG00000184209 euGenes: HUgn11066
    ECgene: SNRNP35 H-InvDB: SNRNP35

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNRNP35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNRNP35 gene:
    Search GeneIP for patents involving SNRNP35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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