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Aliases for SNRNP35 Gene

Aliases for SNRNP35 Gene

  • Small Nuclear Ribonucleoprotein 35kDa (U11/U12) 2 3
  • U1 SnRNP Binding Protein Homolog 2 3
  • U1 SnRNP-Binding Protein Homolog 3 4
  • U11/U12 SnRNP 35 KDa Protein 3 4
  • Protein HM-1 3 4
  • U11/U12-35K 3 4
  • U1SNRNPBP 3 4
  • U11/U12 Small Nuclear Ribonucleoprotein 35 KDa Protein 3
  • U1-SnRNP Binding Protein Homolog 3
  • U11/U12 SnRNP 35K 3
  • HM-1 3
  • HM1 4

External Ids for SNRNP35 Gene

Previous GeneCards Identifiers for SNRNP35 Gene

  • GC12P122509
  • GC12P123891
  • GC12P120904
  • GC12P123942

Summaries for SNRNP35 Gene

Entrez Gene Summary for SNRNP35 Gene

  • The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants encoding two distinct isoforms and representing a non-protein coding variant. [provided by RefSeq, Aug 2013]

GeneCards Summary for SNRNP35 Gene

SNRNP35 (Small Nuclear Ribonucleoprotein 35kDa (U11/U12)) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SNRNP70.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRNP35 Gene

Genomics for SNRNP35 Gene

Regulatory Elements for SNRNP35 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNRNP35 Gene

Start:
123,457,641 bp from pter
End:
123,473,154 bp from pter
Size:
15,514 bases
Orientation:
Plus strand

Genomic View for SNRNP35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNRNP35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRNP35 Gene

Proteins for SNRNP35 Gene

  • Protein details for SNRNP35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16560-U1SBP_HUMAN
    Recommended name:
    U11/U12 small nuclear ribonucleoprotein 35 kDa protein
    Protein Accession:
    Q16560
    Secondary Accessions:
    • A8K262
    • Q5XKN9

    Protein attributes for SNRNP35 Gene

    Size:
    246 amino acids
    Molecular mass:
    29450 Da
    Quaternary structure:
    • Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.

    Alternative splice isoforms for SNRNP35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNRNP35 Gene

Proteomics data for SNRNP35 Gene at MOPED

Post-translational modifications for SNRNP35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNRNP35 Gene

No data available for DME Specific Peptides for SNRNP35 Gene

Domains for SNRNP35 Gene

Gene Families for SNRNP35 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for SNRNP35 Gene

Suggested Antigen Peptide Sequences for SNRNP35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16560

UniProtKB/Swiss-Prot:

U1SBP_HUMAN :
  • Q16560
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with SNRNP35: view

Function for SNRNP35 Gene

Gene Ontology (GO) - Molecular Function for SNRNP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with SNRNP35: view

Animal Model Products

CRISPR Products

miRNA for SNRNP35 Gene

miRTarBase miRNAs that target SNRNP35

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNRNP35

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNRNP35 Gene

Localization for SNRNP35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRNP35 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRNP35 Gene COMPARTMENTS Subcellular localization image for SNRNP35 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SNRNP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18559850
GO:0005689 U12-type spliceosomal complex IDA 15146077
genes like me logo Genes that share ontologies with SNRNP35: view

Pathways for SNRNP35 Gene

SuperPathways for SNRNP35 Gene

No Data Available

Interacting Proteins for SNRNP35 Gene

Gene Ontology (GO) - Biological Process for SNRNP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IC 15146077
genes like me logo Genes that share ontologies with SNRNP35: view

No data available for Pathways by source for SNRNP35 Gene

Transcripts for SNRNP35 Gene

Unigene Clusters for SNRNP35 Gene

Small nuclear ribonucleoprotein 35kDa (U11/U12):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNRNP35

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRNP35 Gene

No ASD Table

Relevant External Links for SNRNP35 Gene

GeneLoc Exon Structure for
SNRNP35
ECgene alternative splicing isoforms for
SNRNP35

Expression for SNRNP35 Gene

mRNA expression in normal human tissues for SNRNP35 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNRNP35 Gene

SOURCE GeneReport for Unigene cluster for SNRNP35 Gene Hs.632738

mRNA Expression by UniProt/SwissProt for SNRNP35 Gene

Q16560-U1SBP_HUMAN
Tissue specificity: Expressed in heart, liver, skeletal muscle and pancreas.
genes like me logo Genes that share expressions with SNRNP35: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SNRNP35 Gene

Orthologs for SNRNP35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRNP35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRNP35 35
  • 99.46 (n)
  • 99.6 (a)
SNRNP35 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNRNP35 35
  • 86.94 (n)
  • 92.24 (a)
SNRNP35 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRNP35 35
  • 87.4 (n)
  • 92.28 (a)
SNRNP35 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700128F08Rik 36
  • 49 (a)
OneToMany
Snrnp35 35
  • 82.92 (n)
  • 89.75 (a)
Snrnp35 16
Snrnp35 36
  • 90 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SNRNP35 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNRNP35 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snrnp35 35
  • 82.1 (n)
  • 89.34 (a)
chicken
(Gallus gallus)
Aves SNRNP35 35
  • 76.61 (n)
  • 79.83 (a)
SNRNP35 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNRNP35 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25076 35
tropical clawed frog
(Silurana tropicalis)
Amphibia snrnp35 35
  • 68.99 (n)
  • 74.42 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14465 35
snrnp35 35
  • 69.25 (n)
  • 75.6 (a)
snrnp35 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012250 35
  • 51.87 (n)
  • 51.25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNP1 36
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G43370 35
  • 51.4 (n)
  • 55.87 (a)
rice
(Oryza sativa)
Liliopsida Os.5580 35
Os09g0513700 35
  • 55.75 (n)
  • 54.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToOne
Species with no ortholog for SNRNP35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNRNP35 Gene

ENSEMBL:
Gene Tree for SNRNP35 (if available)
TreeFam:
Gene Tree for SNRNP35 (if available)

Paralogs for SNRNP35 Gene

Paralogs for SNRNP35 Gene

genes like me logo Genes that share paralogs with SNRNP35: view

Variants for SNRNP35 Gene

Sequence variations from dbSNP and Humsavar for SNRNP35 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs6606748 -- 123,468,192(+) catcc(C/T)tacta intron-variant
rs7297035 -- 123,462,519(+) ttttt(G/T)cttct intron-variant
rs7306670 -- 123,463,203(+) ctaca(C/G)gcgtg intron-variant, upstream-variant-2KB
rs7315742 -- 123,460,982(+) ttttt(A/T)aaaaa intron-variant
rs7315901 -- 123,461,135(+) ttttg(A/G)gacgg intron-variant

Relevant External Links for SNRNP35 Gene

HapMap Linkage Disequilibrium report
SNRNP35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SNRNP35 Gene

Disorders for SNRNP35 Gene

No disorders were found for SNRNP35 Gene.

No data available for UniProtKB/Swiss-Prot for SNRNP35 Gene

Publications for SNRNP35 Gene

  1. Cloning and characterization of a family of cDNAs from human histiocyte macrophage cells encoding an arginine-rich basic protein related to the 70 kD U1-snRNP splicing factor. (PMID: 10520751) Adams D.S. … Czop J.K. (DNA Seq. 1998) 2 3 4 23
  2. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 2 3
  3. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will C.L. … Luehrmann R. (RNA 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Minor spliceosome components are predominantly localized in the nucleus. (PMID: 18559850) Pessa H.K. … Frilander M.J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3

Products for SNRNP35 Gene

Sources for SNRNP35 Gene

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