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Aliases for SNRNP35 Gene

Aliases for SNRNP35 Gene

  • Small Nuclear Ribonucleoprotein U11/U12 Subunit 35 2 3
  • Small Nuclear Ribonucleoprotein, U11/U12 35kDa Subunit 3 5
  • Small Nuclear Ribonucleoprotein 35kDa (U11/U12) 2 3
  • U1 SnRNP Binding Protein Homolog 2 3
  • U1 SnRNP-Binding Protein Homolog 3 4
  • U11/U12 SnRNP 35 KDa Protein 3 4
  • Protein HM-1 3 4
  • U11/U12-35K 3 4
  • U1SNRNPBP 3 4
  • Small Nuclear Ribonucleoprotein U11/U12 35kDa Subunit 2
  • U1-SnRNP Binding Protein Homolog 3
  • U11/U12 SnRNP 35K 3
  • HM-1 3
  • HM1 4

External Ids for SNRNP35 Gene

Previous GeneCards Identifiers for SNRNP35 Gene

  • GC12P122509
  • GC12P123891
  • GC12P120904
  • GC12P123942

Summaries for SNRNP35 Gene

Entrez Gene Summary for SNRNP35 Gene

  • The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants encoding two distinct isoforms and representing a non-protein coding variant. [provided by RefSeq, Aug 2013]

GeneCards Summary for SNRNP35 Gene

SNRNP35 (Small Nuclear Ribonucleoprotein U11/U12 Subunit 35) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SNRNP70.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRNP35 Gene

Genomics for SNRNP35 Gene

Regulatory Elements for SNRNP35 Gene

Enhancers for SNRNP35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNRNP35 on UCSC Golden Path with GeneCards custom track

Promoters for SNRNP35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNRNP35 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNRNP35 Gene

123,457,641 bp from pter
123,473,154 bp from pter
15,514 bases
Plus strand

Genomic View for SNRNP35 Gene

Genes around SNRNP35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRNP35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRNP35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRNP35 Gene

Proteins for SNRNP35 Gene

  • Protein details for SNRNP35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U11/U12 small nuclear ribonucleoprotein 35 kDa protein
    Protein Accession:
    Secondary Accessions:
    • A8K262
    • Q5XKN9

    Protein attributes for SNRNP35 Gene

    246 amino acids
    Molecular mass:
    29450 Da
    Quaternary structure:
    • Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.

    Alternative splice isoforms for SNRNP35 Gene


neXtProt entry for SNRNP35 Gene

Proteomics data for SNRNP35 Gene at MOPED

Post-translational modifications for SNRNP35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNRNP35 Gene

No data available for DME Specific Peptides for SNRNP35 Gene

Domains & Families for SNRNP35 Gene

Gene Families for SNRNP35 Gene

Protein Domains for SNRNP35 Gene

Suggested Antigen Peptide Sequences for SNRNP35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with SNRNP35: view

Function for SNRNP35 Gene

Gene Ontology (GO) - Molecular Function for SNRNP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003729 mRNA binding IBA --
genes like me logo Genes that share ontologies with SNRNP35: view
genes like me logo Genes that share phenotypes with SNRNP35: view

Animal Model Products

miRNA for SNRNP35 Gene

miRTarBase miRNAs that target SNRNP35

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRNP35 Gene

Localization for SNRNP35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRNP35 Gene

Subcellular locations from

Jensen Localization Image for SNRNP35 Gene COMPARTMENTS Subcellular localization image for SNRNP35 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SNRNP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005689 U12-type spliceosomal complex IDA 15146077
genes like me logo Genes that share ontologies with SNRNP35: view

Pathways & Interactions for SNRNP35 Gene

genes like me logo Genes that share pathways with SNRNP35: view

Pathways by source for SNRNP35 Gene

Interacting Proteins for SNRNP35 Gene

Gene Ontology (GO) - Biological Process for SNRNP35 Gene


No data available for SIGNOR curated interactions for SNRNP35 Gene

Drugs & Compounds for SNRNP35 Gene

No Compound Related Data Available

Transcripts for SNRNP35 Gene

Unigene Clusters for SNRNP35 Gene

Small nuclear ribonucleoprotein 35kDa (U11/U12):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNRNP35 Gene

No ASD Table

Relevant External Links for SNRNP35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNRNP35 Gene

mRNA expression in normal human tissues for SNRNP35 Gene

Protein differential expression in normal tissues from HIPED for SNRNP35 Gene

This gene is overexpressed in CD4 Tcells (54.1) and Pancreas (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNRNP35 Gene

SOURCE GeneReport for Unigene cluster for SNRNP35 Gene Hs.632738

mRNA Expression by UniProt/SwissProt for SNRNP35 Gene

Tissue specificity: Expressed in heart, liver, skeletal muscle and pancreas.
genes like me logo Genes that share expression patterns with SNRNP35: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for SNRNP35 Gene

Orthologs for SNRNP35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRNP35 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SNRNP35 35
  • 86.94 (n)
  • 92.24 (a)
SNRNP35 36
  • 92 (a)
(Canis familiaris)
Mammalia SNRNP35 35
  • 87.4 (n)
  • 92.28 (a)
SNRNP35 36
  • 92 (a)
(Mus musculus)
Mammalia Snrnp35 35
  • 82.92 (n)
  • 89.75 (a)
Snrnp35 16
1700128F08Rik 36
  • 49 (a)
Snrnp35 36
  • 90 (a)
(Pan troglodytes)
Mammalia SNRNP35 35
  • 99.46 (n)
  • 99.6 (a)
SNRNP35 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Snrnp35 35
  • 82.1 (n)
  • 89.34 (a)
(Monodelphis domestica)
Mammalia SNRNP35 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia SNRNP35 36
  • 81 (a)
(Gallus gallus)
Aves SNRNP35 35
  • 76.61 (n)
  • 79.83 (a)
SNRNP35 36
  • 72 (a)
(Anolis carolinensis)
Reptilia SNRNP35 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snrnp35 35
  • 68.99 (n)
  • 74.42 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25076 35
(Danio rerio)
Actinopterygii Dr.14465 35
snrnp35 35
  • 69.25 (n)
  • 75.6 (a)
snrnp35 36
  • 67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012250 35
  • 51.87 (n)
  • 51.25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNP1 36
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G43370 35
  • 51.4 (n)
  • 55.87 (a)
(Oryza sativa)
Liliopsida Os.5580 35
Os09g0513700 35
  • 55.75 (n)
  • 54.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
Species with no ortholog for SNRNP35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNRNP35 Gene

Gene Tree for SNRNP35 (if available)
Gene Tree for SNRNP35 (if available)

Paralogs for SNRNP35 Gene

Paralogs for SNRNP35 Gene

genes like me logo Genes that share paralogs with SNRNP35: view

Variants for SNRNP35 Gene

Sequence variations from dbSNP and Humsavar for SNRNP35 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7297035 -- 123,462,519(+) ttttt(G/T)cttct intron-variant, upstream-variant-2KB
rs7300562 -- 123,466,876(+) aatga(G/T)ccacc intron-variant, downstream-variant-500B
rs7306670 -- 123,463,203(+) ctaca(C/G)gcgtg intron-variant, upstream-variant-2KB
rs13303311 -- 123,457,364(+) tctgc(C/T)tcccg upstream-variant-2KB
rs28413969 -- 123,461,952(+) GCTGA(C/T)CTCGT intron-variant

Variation tolerance for SNRNP35 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for SNRNP35 Gene

Disorders for SNRNP35 Gene

Relevant External Links for SNRNP35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SNRNP35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRNP35 Gene

Publications for SNRNP35 Gene

  1. Cloning and characterization of a family of cDNAs from human histiocyte macrophage cells encoding an arginine-rich basic protein related to the 70 kD U1-snRNP splicing factor. (PMID: 10520751) Adams D.S. … Czop J.K. (DNA Seq. 1998) 2 3 4 23 67
  2. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for SNRNP35 Gene

Sources for SNRNP35 Gene