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Aliases for SNRNP27 Gene

Aliases for SNRNP27 Gene

  • Small Nuclear Ribonucleoprotein U4/U6.U5 Subunit 27 2 3
  • Small Nuclear Ribonucleoprotein, U4/U6.U5 27kDa Subunit 2 3 5
  • Small Nuclear Ribonucleoprotein 27kDa (U4/U6.U5) 2 3
  • U4/U6.U5 Tri-SnRNP-Associated 27 KDa Protein 3 4
  • U4/U6.U5 Tri-SnRNP-Associated Protein 3 3 4
  • U4/U6.U5-27K 3 4
  • 27K 3 4
  • U4/U6.U5 Small Nuclear Ribonucleoprotein 27 KDa Protein 2
  • Putative Nucleic Acid Binding Protein RY-1 3
  • Nucleic Acid Binding Protein RY 1 2
  • Nucleic Acid-Binding Protein RY-1 4
  • U4/U6.U5 SnRNP 27 KDa Protein 4
  • RY1 3

External Ids for SNRNP27 Gene

Previous GeneCards Identifiers for SNRNP27 Gene

  • GC02P069975
  • GC02P070120

Summaries for SNRNP27 Gene

Entrez Gene Summary for SNRNP27 Gene

  • This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the long arm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for SNRNP27 Gene

SNRNP27 (Small Nuclear Ribonucleoprotein U4/U6.U5 Subunit 27) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SNRNP27 Gene

  • May play a role in mRNA splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRNP27 Gene

Genomics for SNRNP27 Gene

Regulatory Elements for SNRNP27 Gene

Enhancers for SNRNP27 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNRNP27 on UCSC Golden Path with GeneCards custom track

Promoters for SNRNP27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNRNP27 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNRNP27 Gene

Chromosome:
2
Start:
69,893,560 bp from pter
End:
69,905,575 bp from pter
Size:
12,016 bases
Orientation:
Plus strand

Genomic View for SNRNP27 Gene

Genes around SNRNP27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRNP27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRNP27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRNP27 Gene

Proteins for SNRNP27 Gene

  • Protein details for SNRNP27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVK2-SNR27_HUMAN
    Recommended name:
    U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
    Protein Accession:
    Q8WVK2
    Secondary Accessions:
    • Q15410

    Protein attributes for SNRNP27 Gene

    Size:
    155 amino acids
    Molecular mass:
    18860 Da
    Quaternary structure:
    • Part of a tri-snRNP complex.
    SequenceCaution:
    • Sequence=CAA53949.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SNRNP27 Gene

Proteomics data for SNRNP27 Gene at MOPED

Post-translational modifications for SNRNP27 Gene

  • Phosphorylated in vitro by snRNP-associated protein kinase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNRNP27 Gene

No data available for DME Specific Peptides for SNRNP27 Gene

Domains & Families for SNRNP27 Gene

Protein Domains for SNRNP27 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SNRNP27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVK2

UniProtKB/Swiss-Prot:

SNR27_HUMAN :
  • Belongs to the SNUT3 family.
Family:
  • Belongs to the SNUT3 family.
genes like me logo Genes that share domains with SNRNP27: view

No data available for Gene Families for SNRNP27 Gene

Function for SNRNP27 Gene

Molecular function for SNRNP27 Gene

UniProtKB/Swiss-Prot Function:
May play a role in mRNA splicing.

Gene Ontology (GO) - Molecular Function for SNRNP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding NAS 7931148
genes like me logo Genes that share ontologies with SNRNP27: view
genes like me logo Genes that share phenotypes with SNRNP27: view

Animal Models for SNRNP27 Gene

MGI Knock Outs for SNRNP27:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNRNP27 Gene

Localization for SNRNP27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRNP27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRNP27 Gene COMPARTMENTS Subcellular localization image for SNRNP27 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for SNRNP27 Gene

Pathways & Interactions for SNRNP27 Gene

genes like me logo Genes that share pathways with SNRNP27: view

Pathways by source for SNRNP27 Gene

Gene Ontology (GO) - Biological Process for SNRNP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SNRNP27: view

No data available for SIGNOR curated interactions for SNRNP27 Gene

Drugs & Compounds for SNRNP27 Gene

No Compound Related Data Available

Transcripts for SNRNP27 Gene

Unigene Clusters for SNRNP27 Gene

Small nuclear ribonucleoprotein 27kDa (U4/U6.U5):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNRNP27 Gene

No ASD Table

Relevant External Links for SNRNP27 Gene

GeneLoc Exon Structure for
SNRNP27
ECgene alternative splicing isoforms for
SNRNP27

Expression for SNRNP27 Gene

mRNA expression in normal human tissues for SNRNP27 Gene

Protein differential expression in normal tissues from HIPED for SNRNP27 Gene

This gene is overexpressed in Adrenal (16.0), Lung (12.4), CD8 Tcells (7.0), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNRNP27 Gene



SOURCE GeneReport for Unigene cluster for SNRNP27 Gene Hs.54649

genes like me logo Genes that share expression patterns with SNRNP27: view

Protein tissue co-expression partners for SNRNP27 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNRNP27 Gene

Orthologs for SNRNP27 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNRNP27 Gene

Organism Taxonomy Gene Similarity Type Details
rat
(Rattus norvegicus)
Mammalia Snrnp27 35
  • 89.46 (n)
  • 98.06 (a)
mouse
(Mus musculus)
Mammalia Snrnp27 16
Snrnp27 36
  • 97 (a)
OneToOne
Snrnp27 35
  • 91.18 (n)
  • 98.06 (a)
cow
(Bos Taurus)
Mammalia SNRNP27 36
  • 100 (a)
OneToOne
SNRNP27 35
  • 93.98 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia SNRNP27 36
  • 97 (a)
OneToOne
SNRNP27 35
  • 92.47 (n)
  • 98.06 (a)
oppossum
(Monodelphis domestica)
Mammalia SNRNP27 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNRNP27 36
  • 100 (a)
OneToOne
SNRNP27 35
  • 99.57 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves SNRNP27 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNRNP27 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5847 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1696 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13288 35
snrnp27 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8410 35
fruit fly
(Drosophila melanogaster)
Insecta ytr 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea snrp-27 36
  • 48 (a)
OneToOne
Species with no ortholog for SNRNP27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNRNP27 Gene

ENSEMBL:
Gene Tree for SNRNP27 (if available)
TreeFam:
Gene Tree for SNRNP27 (if available)

Paralogs for SNRNP27 Gene

Pseudogenes.org Pseudogenes for SNRNP27 Gene

genes like me logo Genes that share paralogs with SNRNP27: view

No data available for Paralogs for SNRNP27 Gene

Variants for SNRNP27 Gene

Sequence variations from dbSNP and Humsavar for SNRNP27 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs4853137 -- 69,894,967(+) GCCAC(C/T)GCTCC intron-variant
rs3078818 -- 69,895,975(+) GTTTG(-/T)TTTTT intron-variant
rs1048130 -- 69,904,452(+) TATAT(A/G)CAGTT intron-variant, utr-variant-3-prime
rs1048165 -- 69,904,832(+) CCCCC(A/C)AAAAA nc-transcript-variant, utr-variant-3-prime
rs1048266 -- 69,905,544(+) TTTGT(A/G)ACATG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SNRNP27 Gene

Variant ID Type Subtype PubMed ID
nsv834254 CNV Gain 17160897
esv2676897 CNV Deletion 23128226
nsv511168 CNV Loss 21212237
esv2632499 CNV Deletion 19546169
esv26099 CNV Gain+Loss 19812545
nsv821606 CNV Deletion 20802225
esv2152444 CNV Deletion 18987734
esv4119 CNV Deletion 18987735
nsv511788 CNV Loss 21212237
esv2720175 CNV Deletion 23290073
esv2657588 CNV Deletion 23128226
esv9663 CNV Loss 19470904
nsv829455 CNV Loss 20364138

Variation tolerance for SNRNP27 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNRNP27 Gene

HapMap Linkage Disequilibrium report
SNRNP27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRNP27 Gene

Disorders for SNRNP27 Gene

Relevant External Links for SNRNP27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNRNP27

No disorders were found for SNRNP27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRNP27 Gene

Publications for SNRNP27 Gene

  1. The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase. (PMID: 9085842) Fetzer S. … Luehrmann R. (RNA 1997) 2 3 4 67
  2. Altered expression of the novel cellular gene as a consequence of integration of human T cell lymphotropic virus type 1. (PMID: 7931148) Nakamura Y. … Katamine S. (J. Gen. Virol. 1994) 2 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for SNRNP27 Gene

Sources for SNRNP27 Gene

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