SNRNP27 Gene
protein-coding GIFtS: 48
GCID: GC02P070120
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small nuclear ribonucleoprotein 27kDa (U4/U6.U5)
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Aliases
for SNRNP27 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Small Nuclear Ribonucleoprotein 27kDa (U4/U6.U5)1 2 | | U4/U6.U5 Tri-SnRNP-Associated Protein 32 3 | | RY11 2 | | Putative Nucleic Acid Binding Protein RY-12 | | 27K2 3 | | U4/U6.U5 Small Nuclear Ribonucleoprotein 27 KDa Protein2 | | U4/U6.U5-27K2 3 | | Nucleic Acid-Binding Protein RY-13 | | U4/U6.U5 Tri-SnRNP-Associated 27 KDa Protein2 3 | | U4/U6.U5 SnRNP 27 KDa Protein3 |
Export aliases for SNRNP27 gene to outside databasesPrevious GC identifers: GC02P069975 GC02P069857 |
Summaries
for SNRNP27 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SNRNP27:
This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing byfacilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infectedwith the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the longarm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene. (provided by RefSeq,Feb 2011)
UniProtKB/Swiss-Prot: SNR27_HUMAN, Q8WVK2Function: May play a role in mRNA splicing
|
Genomic Views
for SNRNP27 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNRNP27 gene promoter:
MyoD CBF-C CREB CBF-B CBF-A deltaCREB CP1C CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNRNP27
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRNP27 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p13.3 Ensembl cytogenetic band: 2p13.3 HGNC cytogenetic band: 2p14SNRNP27 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P070120: view genomic region
(about GC identifiers)
Start:
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70,120,692 bp from pter |
End:
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70,132,707 bp from pter |
Size:
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12,016 bases |
Orientation:
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plus strand |
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Proteins
for SNRNP27 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNR27_HUMAN, Q8WVK2 (See
protein sequence)Recommended Name: U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein Size: 155 amino acids; 18860 Da
Subunit: Part of a tri-snRNP complex
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=CAA53949.1; Type=Erroneous initiation;
Secondary accessions: Q15410Explore the universe of human proteins at neXtProt for SNRNP27: NX_Q8WVK2
Post-translational modifications:
Phosphorylated in vitro by snRNP-associated protein kinase1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WVK2
SNRNP27 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006848.1
ENSEMBL proteins: ENSP00000244227 ENSP00000386608 ENSP00000395144 ENSP00000430449
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SNRNP27 for ontologies About GeneDecksing
SNRNP27 Antibody Products:
Assay Products for SNRNP27: |
Protein
Domains /
Families
for SNRNP27 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNRNP27 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WVK2ProtoNet protein and cluster: Q8WVK2 1 Blocks protein family: IPB013957 Protein of unknown function DUF1777
UniProtKB/Swiss-Prot: SNR27_HUMAN, Q8WVK2Similarity: Belongs to the SNUT3 family |
Function
for SNRNP27 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNR27_HUMAN, Q8WVK2Function: May play a role in mRNA splicing
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRNP27 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRNP27
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRNP27 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
SNRNP27 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SNRNP27:
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Pathways & Interactions
for SNRNP27 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for SNRNP27):
SNRNP27 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNRNP27
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/12 Interacting proteins for SNRNP27 (Q8WVK22, 3 ENSP000002442274) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SNRNP27 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNRNP27 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNRNP27
Search CenterWatch for drugs/clinical trials and news about SNRNP27 / SNR27
|
Transcripts
for SNRNP27 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNRNP27 gene: NM_006857.2 Unigene Cluster for SNRNP27: Small nuclear ribonucleoprotein 27kDa (U4/U6.U5) Hs.54649 [show with all ESTs]Unigene Representative Sequence: NM_0068575 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000244227(uc002sfv.3 uc002sfw.3) ENST00000409116 ENST00000450162
ENST00000488986 ENST00000487029
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRNP27 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRNP27
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SNRNP27 (NM_006857) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNRNP27 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRNP27 |
Additional cDNA sequence: AK291128.1 AK312041.1 BC017890.1 NR_037862.1 X76302.1 11 DOTS entries: DT.92446523 DT.447187 DT.95265809 DT.100765469 DT.100788522 DT.92446519 DT.120808164 DT.120943351 DT.91703895 DT.91833207 DT.100670791 24/305 AceView cDNA sequences (see all 305): AW515036 CR536495 CR609338 BM745205 AW452063 AI822059 BU175562 BE858684 AI358518 BM840232 BE857484 AI356638 BX089768 CR600623 AI203363 CR623125 CR591484 BI715440 BQ214057 AI652379 BU164850 BQ271787 CR617839 BQ012297
GeneLoc Exon Structure
|
Expression
for SNRNP27 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNRNP27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTGCCATT
About this image
See SNRNP27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNRNP27
SOURCE GeneReport for Unigene cluster: Hs.54649
SABiosciences Custom PCR Arrays for SNRNP27
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNRNP27
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNRNP27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRNP27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRNP27 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRNP27 |
Orthologs
for SNRNP27 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SNRNP27 gene from 9/26 species (see all 26) About this table
ENSEMBL Gene Tree for SNRNP27 (if available)
TreeFam Gene Tree for SNRNP27 (if available) |
Paralogs
for SNRNP27 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SNRNP27 gene
- PRPF38A2
SNRNP27 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SNRNP27
PGOHUM00000235396
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Genomic Variants
for SNRNP27 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNRNP27 (70120692 - 70132707 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for SNRNP27
1 CNV: 97878
7 Indels: 46033 78586 43081 61776 67945 89713 40335 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNRNP27 |
|
Disorders
/ Diseases
for SNRNP27 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SNRNP27 for disorders About MalaCards
SNRNP27 for disorders About GeneDecksing
1 disease from the University of Copenhagen DISEASES database for SNRNP27:Malignant hyperthermia Export disorders for SNRNP27 gene to outside databases
|
Publications
for SNRNP27 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNRNP27 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with SNRNP27) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Altered expression of the novel cellular gene as a consequence of integration of human T cell lymphotropic virus type 1. (PubMed id 7931148)1, 2, 3 Nakamura Y.... Katamine S. (1994)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase. (PubMed id 9085842)1, 2 Fetzer S.... Luehrmann R. (1997)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
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External Searches for SNRNP27 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNRNP27 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNRNP27 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNRNP27 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNRNP27 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SNRNP27 gene:
Search GeneIP for patents involving SNRNP27
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNRNP27 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNRNP27 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNRNP27 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRNP27 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRNP27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRNP27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRNP27 |
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 | | | SNRNP27 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRNP27 |
|  |  |  | | | | Search ThermoFisher Antibodies for SNRNP27 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRNP27 |
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