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Aliases for SNRNP27 Gene

Aliases for SNRNP27 Gene

  • Small Nuclear Ribonucleoprotein 27kDa (U4/U6.U5) 2 3
  • U4/U6.U5 Tri-SnRNP-Associated 27 KDa Protein 3 4
  • U4/U6.U5 Tri-SnRNP-Associated Protein 3 3 4
  • U4/U6.U5-27K 3 4
  • 27K 3 4
  • U4/U6.U5 Small Nuclear Ribonucleoprotein 27 KDa Protein 3
  • Putative Nucleic Acid Binding Protein RY-1 3
  • Nucleic Acid Binding Protein RY 1 2
  • Nucleic Acid-Binding Protein RY-1 4
  • U4/U6.U5 SnRNP 27 KDa Protein 4
  • RY1 3

External Ids for SNRNP27 Gene

Previous GeneCards Identifiers for SNRNP27 Gene

  • GC02P069975
  • GC02P070120

Summaries for SNRNP27 Gene

Entrez Gene Summary for SNRNP27 Gene

  • This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the long arm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for SNRNP27 Gene

SNRNP27 (Small Nuclear Ribonucleoprotein 27kDa (U4/U6.U5)) is a Protein Coding gene. Among its related pathways are Spliceosome. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SNRNP27 Gene

  • May play a role in mRNA splicing

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRNP27 Gene

Genomics for SNRNP27 Gene

Regulatory Elements for SNRNP27 Gene

Genomic Location for SNRNP27 Gene

69,893,560 bp from pter
69,905,575 bp from pter
12,016 bases
Plus strand

Genomic View for SNRNP27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNRNP27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRNP27 Gene

Proteins for SNRNP27 Gene

  • Protein details for SNRNP27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
    Protein Accession:
    Secondary Accessions:
    • Q15410

    Protein attributes for SNRNP27 Gene

    155 amino acids
    Molecular mass:
    18860 Da
    Quaternary structure:
    • Part of a tri-snRNP complex
    • Sequence=CAA53949.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SNRNP27 Gene

Proteomics data for SNRNP27 Gene at MOPED

Post-translational modifications for SNRNP27 Gene

  • Phosphorylated in vitro by snRNP-associated protein kinase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNRNP27 Gene

No data available for DME Specific Peptides for SNRNP27 Gene

Domains for SNRNP27 Gene

Protein Domains for SNRNP27 Gene


Suggested Antigen Peptide Sequences for SNRNP27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8WVK2
  • Belongs to the SNUT3 family.
genes like me logo Genes that share domains with SNRNP27: view

No data available for Gene Families for SNRNP27 Gene

Function for SNRNP27 Gene

Molecular function for SNRNP27 Gene

UniProtKB/Swiss-Prot Function: May play a role in mRNA splicing

Gene Ontology (GO) - Molecular Function for SNRNP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding NAS 7931148
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with SNRNP27: view

Phenotypes for SNRNP27 Gene

GenomeRNAi human phenotypes for SNRNP27:
genes like me logo Genes that share phenotypes with SNRNP27: view

Animal Model Products

CRISPR Products

miRNA for SNRNP27 Gene

miRTarBase miRNAs that target SNRNP27

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SNRNP27 Gene

Localization for SNRNP27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRNP27 Gene

Subcellular locations from

Jensen Localization Image for SNRNP27 Gene COMPARTMENTS Subcellular localization image for SNRNP27 gene
Compartment Confidence
nucleus 3
cytosol 2
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for SNRNP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus --
GO:0071011 precatalytic spliceosome IBA --
genes like me logo Genes that share ontologies with SNRNP27: view

Pathways for SNRNP27 Gene

SuperPathways for SNRNP27 Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with SNRNP27: view

Pathways by source for SNRNP27 Gene

1 KEGG pathway for SNRNP27 Gene

Gene Ontology (GO) - Biological Process for SNRNP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008150 biological_process ND --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SNRNP27: view

Transcripts for SNRNP27 Gene

Unigene Clusters for SNRNP27 Gene

Small nuclear ribonucleoprotein 27kDa (U4/U6.U5):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNRNP27

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRNP27 Gene

No ASD Table

Relevant External Links for SNRNP27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNRNP27 Gene

mRNA expression in normal human tissues for SNRNP27 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNRNP27 Gene

SOURCE GeneReport for Unigene cluster for SNRNP27 Gene Hs.54649

genes like me logo Genes that share expressions with SNRNP27: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNRNP27 Gene

Orthologs for SNRNP27 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNRNP27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNRNP27 35
  • 99.57 (n)
  • 100 (a)
SNRNP27 36
  • 100 (a)
(Bos Taurus)
Mammalia SNRNP27 35
  • 93.98 (n)
  • 100 (a)
SNRNP27 36
  • 100 (a)
(Canis familiaris)
Mammalia SNRNP27 35
  • 92.47 (n)
  • 98.06 (a)
SNRNP27 36
  • 97 (a)
(Mus musculus)
Mammalia Snrnp27 35
  • 91.18 (n)
  • 98.06 (a)
Snrnp27 16
Snrnp27 36
  • 97 (a)
(Monodelphis domestica)
Mammalia SNRNP27 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Snrnp27 35
  • 89.46 (n)
  • 98.06 (a)
(Gallus gallus)
Aves SNRNP27 36
  • 88 (a)
(Anolis carolinensis)
Reptilia SNRNP27 36
  • 90 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5847 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1696 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8410 35
(Danio rerio)
Actinopterygii Dr.13288 35
snrnp27 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta ytr 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea snrp-27 36
  • 48 (a)
Species with no ortholog for SNRNP27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNRNP27 Gene

Gene Tree for SNRNP27 (if available)
Gene Tree for SNRNP27 (if available)

Paralogs for SNRNP27 Gene Pseudogenes for SNRNP27 Gene

genes like me logo Genes that share paralogs with SNRNP27: view

No data available for Paralogs for SNRNP27 Gene

Variants for SNRNP27 Gene

Sequence variations from dbSNP and Humsavar for SNRNP27 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1048130 -- 69,904,452(+) TATAT(A/G)CAGTT utr-variant-3-prime, intron-variant
rs1048139 -- 69,904,659(+) AGTAT(A/T)TCTAC utr-variant-3-prime, nc-transcript-variant
rs1048165 -- 69,904,832(+) CCCCC(A/C)AAAAA utr-variant-3-prime, nc-transcript-variant
rs1048195 -- 69,904,930(+) AAATC(A/C)CCTGT utr-variant-3-prime, nc-transcript-variant
rs1048266 -- 69,905,544(+) TTTGT(A/G)ACATG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SNRNP27 Gene

Variant ID Type Subtype PubMed ID
nsv834254 CNV Gain 17160897
esv2676897 CNV Deletion 23128226
nsv511168 CNV Loss 21212237
esv2632499 CNV Deletion 19546169
esv26099 CNV Gain+Loss 19812545
nsv821606 CNV Deletion 20802225
esv2152444 CNV Deletion 18987734
esv4119 CNV Deletion 18987735
nsv511788 CNV Loss 21212237
esv2720175 CNV Deletion 23290073
esv2657588 CNV Deletion 23128226
esv9663 CNV Loss 19470904
nsv829455 CNV Loss 20364138

Relevant External Links for SNRNP27 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRNP27 Gene

Disorders for SNRNP27 Gene

(1) University of Copenhagen DISEASES for SNRNP27 Gene

genes like me logo Genes that share disorders with SNRNP27: view

No data available for UniProtKB/Swiss-Prot for SNRNP27 Gene

Publications for SNRNP27 Gene

  1. Altered expression of the novel cellular gene as a consequence of integration of human T cell lymphotropic virus type 1. (PMID: 7931148) Nakamura Y. … Katamine S. (J. Gen. Virol. 1994) 2 3 4
  2. The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase. (PMID: 9085842) Fetzer S. … Luehrmann R. (RNA 1997) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. (PMID: 16723661) Liu S. … Luehrmann R. (RNA 2006) 3

Products for SNRNP27 Gene

Sources for SNRNP27 Gene

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