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Aliases for SNRNP27 Gene

Aliases for SNRNP27 Gene

  • Small Nuclear Ribonucleoprotein U4/U6.U5 Subunit 27 2 3 5
  • U4/U6.U5 Small Nuclear Ribonucleoprotein 27 KDa Protein 2 3
  • Small Nuclear Ribonucleoprotein, U4/U6.U5 27kDa Subunit 2 3
  • Small Nuclear Ribonucleoprotein 27kDa (U4/U6.U5) 2 3
  • U4/U6.U5 Tri-SnRNP-Associated 27 KDa Protein 3 4
  • U4/U6.U5 Tri-SnRNP-Associated Protein 3 3 4
  • U4/U6.U5-27K 3 4
  • 27K 3 4
  • Putative Nucleic Acid Binding Protein RY-1 3
  • Nucleic Acid Binding Protein RY 1 2
  • Nucleic Acid-Binding Protein RY-1 4
  • U4/U6.U5 SnRNP 27 KDa Protein 4
  • RY1 3

External Ids for SNRNP27 Gene

Previous GeneCards Identifiers for SNRNP27 Gene

  • GC02P069975
  • GC02P070120

Summaries for SNRNP27 Gene

Entrez Gene Summary for SNRNP27 Gene

  • This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the long arm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for SNRNP27 Gene

SNRNP27 (Small Nuclear Ribonucleoprotein U4/U6.U5 Subunit 27) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SNRNP27 Gene

  • May play a role in mRNA splicing.

Additional gene information for SNRNP27 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRNP27 Gene

Genomics for SNRNP27 Gene

Regulatory Elements for SNRNP27 Gene

Enhancers for SNRNP27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H069761 2 FANTOM5 Ensembl ENCODE dbSUPER 39 -121.1 -121132 21.9 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 SNRNP27 ANXA4 MXD1 GMCL1 PCBP1 GC02P069822 ENSG00000231024
GH02H069931 1.9 FANTOM5 Ensembl ENCODE dbSUPER 34.9 +40.4 40376 4.7 PKNOX1 FOXA2 ATF1 MLX ARNT ARID4B DMAP1 FOS ATF7 RUNX3 MXD1 SNRNP27 ASPRV1 PCBP1 PCBP1-AS1 GMCL1 C2orf42 PIR33848
GH02H069794 1.5 Ensembl ENCODE dbSUPER 42.1 -95.2 -95185 7 PKNOX1 ATF1 ARNT FEZF1 ZNF2 TCF12 ZNF766 GATA2 ELK1 ATF7 SNRNP27 GMCL1 ANXA4 MXD1 PCBP1-AS1 GC02P069822 ENSG00000231024
GH02H069817 1.2 Ensembl ENCODE 50.8 -76.4 -76360 0.4 FOXA2 ATF1 ARID4B YY1 SLC30A9 ZNF143 FOS RUNX3 REST KAT8 SNRNP27 ANXA4 MXD1 GC02P069822 ENSG00000231024
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNRNP27 on UCSC Golden Path with GeneCards custom track

Promoters for SNRNP27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for SNRNP27 Gene

Genomic Locations for SNRNP27 Gene
12,016 bases
Plus strand

Genomic View for SNRNP27 Gene

Genes around SNRNP27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRNP27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRNP27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRNP27 Gene

Proteins for SNRNP27 Gene

  • Protein details for SNRNP27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
    Protein Accession:
    Secondary Accessions:
    • Q15410

    Protein attributes for SNRNP27 Gene

    155 amino acids
    Molecular mass:
    18860 Da
    Quaternary structure:
    • Part of a tri-snRNP complex.
    • Sequence=CAA53949.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SNRNP27 Gene

Post-translational modifications for SNRNP27 Gene

  • Phosphorylated in vitro by snRNP-associated protein kinase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNRNP27 Gene

No data available for DME Specific Peptides for SNRNP27 Gene

Domains & Families for SNRNP27 Gene

Gene Families for SNRNP27 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNRNP27 Gene

Suggested Antigen Peptide Sequences for SNRNP27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SNUT3 family.
  • Belongs to the SNUT3 family.
genes like me logo Genes that share domains with SNRNP27: view

Function for SNRNP27 Gene

Molecular function for SNRNP27 Gene

UniProtKB/Swiss-Prot Function:
May play a role in mRNA splicing.

Phenotypes From GWAS Catalog for SNRNP27 Gene

Gene Ontology (GO) - Molecular Function for SNRNP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding NAS 7931148
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with SNRNP27: view
genes like me logo Genes that share phenotypes with SNRNP27: view

Animal Models for SNRNP27 Gene

MGI Knock Outs for SNRNP27:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNRNP27 Gene

Localization for SNRNP27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRNP27 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNRNP27 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SNRNP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with SNRNP27: view

Pathways & Interactions for SNRNP27 Gene

genes like me logo Genes that share pathways with SNRNP27: view

Pathways by source for SNRNP27 Gene

Gene Ontology (GO) - Biological Process for SNRNP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008150 biological_process ND --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SNRNP27: view

No data available for SIGNOR curated interactions for SNRNP27 Gene

Drugs & Compounds for SNRNP27 Gene

No Compound Related Data Available

Transcripts for SNRNP27 Gene

Unigene Clusters for SNRNP27 Gene

Small nuclear ribonucleoprotein 27kDa (U4/U6.U5):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRNP27 Gene

No ASD Table

Relevant External Links for SNRNP27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNRNP27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNRNP27 Gene

Protein differential expression in normal tissues from HIPED for SNRNP27 Gene

This gene is overexpressed in Adrenal (16.0), Lung (12.4), CD8 Tcells (7.0), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNRNP27 Gene

Protein tissue co-expression partners for SNRNP27 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNRNP27 Gene:


SOURCE GeneReport for Unigene cluster for SNRNP27 Gene:


Evidence on tissue expression from TISSUES for SNRNP27 Gene

  • Blood(4.3)
  • Nervous system(3.8)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SNRNP27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNRNP27 Gene

Orthologs for SNRNP27 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNRNP27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNRNP27 33 34
  • 99.57 (n)
(Monodelphis domestica)
Mammalia SNRNP27 34
  • 97 (a)
(Bos Taurus)
Mammalia SNRNP27 33 34
  • 93.98 (n)
(Canis familiaris)
Mammalia SNRNP27 33 34
  • 92.47 (n)
(Mus musculus)
Mammalia Snrnp27 33 16 34
  • 91.18 (n)
(Rattus norvegicus)
Mammalia Snrnp27 33
  • 89.46 (n)
(Gallus gallus)
Aves SNRNP27 34
  • 88 (a)
(Anolis carolinensis)
Reptilia SNRNP27 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1696 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5847 33
(Danio rerio)
Actinopterygii snrnp27 34
  • 77 (a)
Dr.13288 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8410 33
fruit fly
(Drosophila melanogaster)
Insecta ytr 34
  • 41 (a)
(Caenorhabditis elegans)
Secernentea snrp-27 34
  • 48 (a)
Species where no ortholog for SNRNP27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNRNP27 Gene

Gene Tree for SNRNP27 (if available)
Gene Tree for SNRNP27 (if available)

Paralogs for SNRNP27 Gene Pseudogenes for SNRNP27 Gene

genes like me logo Genes that share paralogs with SNRNP27: view

No data available for Paralogs for SNRNP27 Gene

Variants for SNRNP27 Gene

Sequence variations from dbSNP and Humsavar for SNRNP27 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000133120 -- 69,903,229(+) TCTCT(C/G)AGAAG nc-transcript-variant, reference, missense
rs1000133988 -- 69,891,962(+) ACCGC(A/G)CCGGG upstream-variant-2KB
rs1000861754 -- 69,896,320(+) CCTCA(C/G)TTTGC intron-variant
rs1001291079 -- 69,895,980(+) TTTTT(G/T)TTTTT intron-variant
rs1002246113 -- 69,894,105(+) GCCGC(A/G)TAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNRNP27 Gene

Variant ID Type Subtype PubMed ID
dgv1930n106 CNV deletion 24896259
esv2152444 CNV deletion 18987734
esv26099 CNV gain+loss 19812545
esv2632499 CNV deletion 19546169
esv2657588 CNV deletion 23128226
esv2676897 CNV deletion 23128226
esv2720175 CNV deletion 23290073
esv2843792 CNV deletion 24192839
esv3558299 CNV deletion 23714750
nsv954191 CNV deletion 24416366
nsv834254 CNV gain 17160897
nsv829455 CNV loss 20364138
nsv821606 CNV deletion 20802225
nsv582177 CNV loss 21841781
nsv582176 CNV loss 21841781
nsv511788 CNV loss 21212237
nsv511168 CNV loss 21212237
esv9663 CNV loss 19470904
esv4119 CNV loss 18987735
esv3591195 CNV loss 21293372
esv3591194 CNV loss 21293372
esv3591193 CNV loss 21293372

Variation tolerance for SNRNP27 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNRNP27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRNP27 Gene

Disorders for SNRNP27 Gene

Relevant External Links for SNRNP27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SNRNP27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRNP27 Gene

Publications for SNRNP27 Gene

  1. The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase. (PMID: 9085842) Fetzer S … Lührmann R (RNA (New York, N.Y.) 1997) 2 3 4 60
  2. Altered expression of a novel cellular gene as a consequence of integration of human T cell lymphotropic virus type 1. (PMID: 7931148) Nakamura Y … Katamine S (The Journal of general virology 1994) 2 3 4 60
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SNRNP27 Gene

Sources for SNRNP27 Gene

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