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Aliases for SNRNP25 Gene

Aliases for SNRNP25 Gene

  • Small Nuclear Ribonucleoprotein U11/U12 Subunit 25 2 3 5
  • Small Nuclear Ribonucleoprotein, U11/U12 25kDa Subunit 2 3
  • Small Nuclear Ribonucleoprotein 25kDa (U11/U12) 2 3
  • U11/U12 SnRNP 25 KDa Protein 3 4
  • U11/U12 SnRNP 25K 2 3
  • Minus-99 Protein 3 4
  • C16orf33 3 4
  • U11/U12 Small Nuclear Ribonucleoprotein 25 KDa Protein 3
  • Chromosome 16 Open Reading Frame 33 2
  • U11/U12-25K 4

External Ids for SNRNP25 Gene

Previous HGNC Symbols for SNRNP25 Gene

  • C16orf33

Previous GeneCards Identifiers for SNRNP25 Gene

  • GC16P000044
  • GC16P000103
  • GC16P000022

Summaries for SNRNP25 Gene

Entrez Gene Summary for SNRNP25 Gene

  • Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010]

GeneCards Summary for SNRNP25 Gene

SNRNP25 (Small Nuclear Ribonucleoprotein U11/U12 Subunit 25) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression.

Additional gene information for SNRNP25 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRNP25 Gene

Genomics for SNRNP25 Gene

Regulatory Elements for SNRNP25 Gene

Enhancers for SNRNP25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H000033 1.4 FANTOM5 Ensembl ENCODE 20.7 -18.0 -17993 2 HDGF ZSCAN4 SIN3A ZNF2 SCRT2 FOS ATF7 ZNF114 CEBPB ELF1 IL9RP3 LUC7L SNRNP25 ENSG00000228779 LMF1 ENSG00000262528 WDR90 LOC105371184 METTL26 RAB11FIP3
GH16H000052 1.1 ENCODE 23 +0.7 692 1 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF143 WDR90 SNRNP25 WDR24 CHTF18 ENSG00000268836 WASH4P ENSG00000269482 LUC7L RHOT2 POLR3K
GH16H000066 1.8 FANTOM5 ENCODE dbSUPER 11 +20.5 20492 13 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF143 WASH4P WDR90 RHOT2 ENSG00000268836 LUC7L CHTF18 NPRL3 WDR24 RHBDF1 CAPN15
GH16H000037 1.1 Ensembl ENCODE 14.2 -14.5 -14488 2 SIN3A KLF17 ATF7 ETV6 RUNX3 CREM IKZF2 EGR2 SMARCA5 CBFB IL9RP3 SNRNP25 GC16P000050
GH16H000083 1.3 Ensembl ENCODE dbSUPER 9.1 +32.1 32141 2 HDGF PKNOX1 KLF17 BMI1 BATF RAD21 EGR1 ZNF143 FOS ATF7 SNRNP25 GC16M000080 PIR62648
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNRNP25 on UCSC Golden Path with GeneCards custom track

Promoters for SNRNP25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082115 490 1801 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF143

Genomic Location for SNRNP25 Gene

Chromosome:
16
Start:
53,010 bp from pter
End:
57,669 bp from pter
Size:
4,660 bases
Orientation:
Plus strand

Genomic View for SNRNP25 Gene

Genes around SNRNP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRNP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRNP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRNP25 Gene

Proteins for SNRNP25 Gene

  • Protein details for SNRNP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV90-SNR25_HUMAN
    Recommended name:
    U11/U12 small nuclear ribonucleoprotein 25 kDa protein
    Protein Accession:
    Q9BV90
    Secondary Accessions:
    • Q1W6H3
    • Q6IEF8
    • Q9H5W4

    Protein attributes for SNRNP25 Gene

    Size:
    132 amino acids
    Molecular mass:
    15270 Da
    Quaternary structure:
    • Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.

neXtProt entry for SNRNP25 Gene

Post-translational modifications for SNRNP25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNRNP25 Gene

No data available for DME Specific Peptides for SNRNP25 Gene

Domains & Families for SNRNP25 Gene

Gene Families for SNRNP25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNRNP25 Gene

Suggested Antigen Peptide Sequences for SNRNP25 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNRNP25: view

No data available for UniProtKB/Swiss-Prot for SNRNP25 Gene

Function for SNRNP25 Gene

Phenotypes From GWAS Catalog for SNRNP25 Gene

Gene Ontology (GO) - Molecular Function for SNRNP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SNRNP25: view
genes like me logo Genes that share phenotypes with SNRNP25: view

Animal Model Products

CRISPR Products

miRNA for SNRNP25 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SNRNP25
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRNP25 Gene

Localization for SNRNP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRNP25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNRNP25 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytokinetic bridge (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNRNP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18559850
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005689 U12-type spliceosomal complex IDA 15146077
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SNRNP25: view

Pathways & Interactions for SNRNP25 Gene

genes like me logo Genes that share pathways with SNRNP25: view

Pathways by source for SNRNP25 Gene

Gene Ontology (GO) - Biological Process for SNRNP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IC 15146077
genes like me logo Genes that share ontologies with SNRNP25: view

No data available for SIGNOR curated interactions for SNRNP25 Gene

Drugs & Compounds for SNRNP25 Gene

No Compound Related Data Available

Transcripts for SNRNP25 Gene

Unigene Clusters for SNRNP25 Gene

Small nuclear ribonucleoprotein 25kDa (U11/U12):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SNRNP25
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SNRNP25 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -

Relevant External Links for SNRNP25 Gene

GeneLoc Exon Structure for
SNRNP25
ECgene alternative splicing isoforms for
SNRNP25

Expression for SNRNP25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNRNP25 Gene

Protein differential expression in normal tissues from HIPED for SNRNP25 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNRNP25 Gene



Protein tissue co-expression partners for SNRNP25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNRNP25 Gene:

SNRNP25

SOURCE GeneReport for Unigene cluster for SNRNP25 Gene:

Hs.15277

Evidence on tissue expression from TISSUES for SNRNP25 Gene

  • Intestine(4.4)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with SNRNP25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNRNP25 Gene

Orthologs for SNRNP25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRNP25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRNP25 33 34
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia SNRNP25 33 34
  • 89.9 (n)
cow
(Bos Taurus)
Mammalia SNRNP25 33 34
  • 88.35 (n)
mouse
(Mus musculus)
Mammalia Snrnp25 33 16 34
  • 88.35 (n)
rat
(Rattus norvegicus)
Mammalia Snrnp25 33
  • 88.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SNRNP25 34
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNRNP25 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves C16ORF33 33
  • 73.54 (n)
SNRNP25 34
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNRNP25 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snrnp25 33
  • 71.21 (n)
Str.20169 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68520 33
zebrafish
(Danio rerio)
Actinopterygii snrnp25 33 34
  • 70.45 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G07860 33
  • 46.5 (n)
Species where no ortholog for SNRNP25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNRNP25 Gene

ENSEMBL:
Gene Tree for SNRNP25 (if available)
TreeFam:
Gene Tree for SNRNP25 (if available)

Paralogs for SNRNP25 Gene

(1) SIMAP similar genes for SNRNP25 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNRNP25: view

No data available for Paralogs for SNRNP25 Gene

Variants for SNRNP25 Gene

Sequence variations from dbSNP and Humsavar for SNRNP25 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000268642 -- 54,809(+) CCTCC(C/T)GGGTT intron-variant, upstream-variant-2KB
rs1001032004 -- 54,278(+) AAATG(A/G)CATTT intron-variant, upstream-variant-2KB
rs1001400177 -- 55,006(+) TGCTC(A/C)TCATG intron-variant, upstream-variant-2KB
rs1001463169 -- 54,071(+) CGGGC(G/T)GGGGC intron-variant, upstream-variant-2KB
rs1001860029 -- 51,879(+) GCCCG(A/G)CGTGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNRNP25 Gene

Variant ID Type Subtype PubMed ID
dgv2688n100 CNV gain 25217958
dgv2689n100 CNV gain 25217958
dgv2690n100 CNV gain 25217958
esv2422427 CNV duplication 17116639
esv2760065 CNV gain 17122850
esv988339 CNV deletion 20482838
nsv1037456 CNV gain+loss 25217958
nsv1044142 CNV gain 25217958
nsv1044732 CNV loss 25217958
nsv1045829 CNV gain 25217958
nsv518291 CNV loss 19592680
nsv522688 CNV loss 19592680

Variation tolerance for SNRNP25 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNRNP25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNRNP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRNP25 Gene

Disorders for SNRNP25 Gene

Relevant External Links for SNRNP25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNRNP25

No disorders were found for SNRNP25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRNP25 Gene

Publications for SNRNP25 Gene

  1. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will CL … Lührmann R (RNA (New York, N.Y.) 2004) 2 3 4 60
  2. A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. (PMID: 16728641) De Gobbi M … Higgs DR (Science (New York, N.Y.) 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 60

Products for SNRNP25 Gene

Sources for SNRNP25 Gene

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