SNRNP25 Gene
protein-coding GIFtS: 44
GCID: GC16P000103
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small nuclear ribonucleoprotein 25kDa (U11/U12)(Previous name: chromosome 16 open reading frame 33 )
(Previous symbol: C16orf33)
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Aliases
for SNRNP25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Small Nuclear Ribonucleoprotein 25kDa (U11/U12)1 2 | | Chromosome 16 Open Reading Frame 331 | | C16orf331 2 3 | | U11/U12 Small Nuclear Ribonucleoprotein 25 KDa Protein2 | | Minus-99 Protein2 3 | | U11/U12 SnRNP 25K2 | | U11/U12 SnRNP 25 KDa Protein2 3 | | U11/U12-25K3 |
Export aliases for SNRNP25 gene to outside databasesPrevious GC identifers: GC16P000044 GC16P000022 |
Summaries
for SNRNP25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SNRNP25:
Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes andremoves U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found insome eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-typespliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is acomponent of the U12-type spliceosome. (provided by RefSeq, Apr 2010)
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Genomic Views
for SNRNP25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNRNP25 gene promoter:
E2F-4 E2F-3a STAT1 E2F-5 p53 STAT1beta E2F-2 STAT1alpha E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNRNP25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRNP25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3SNRNP25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P000103: view genomic region
(about GC identifiers)
Start:
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103,010 bp from pter |
End:
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107,669 bp from pter |
Size:
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4,660 bases |
Orientation:
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plus strand |
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Proteins
for SNRNP25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNR25_HUMAN, Q9BV90 (See
protein sequence)Recommended Name: U11/U12 small nuclear ribonucleoprotein 25 kDa protein Size: 132 amino acids; 15270 Da
Subunit: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome
Subcellular location: Nucleus
Caution: It is uncertain whether Met-1 or Met-10 is the initiator
Secondary accessions: Q1W6H3 Q6IEF8 Q9H5W4Explore the universe of human proteins at neXtProt for SNRNP25: NX_Q9BV90
SNRNP25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078847.1
ENSEMBL proteins: ENSP00000293861 ENSP00000380974 ENSP00000391289 ENSP00000372482
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SNRNP25 for ontologies About GeneDecksing
SNRNP25 Antibody Products:
Assay Products for SNRNP25: |
Protein
Domains /
Families
for SNRNP25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNRNP25 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BV90ProtoNet protein and cluster: Q9BV90 1 Blocks protein family: IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: SNR25_HUMAN, Q9BV90Similarity: Contains 1 ubiquitin-like domain |
Function
for SNRNP25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRNP25 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRNP25 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SNRNP25 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRNP25 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRNP25 |
1 GenomeRNAi human phenotype for SNRNP25:
|
Pathways & Interactions
for SNRNP25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNRNP25
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SNRNP25 for ontologies About GeneDecksing
|
Drugs & Compounds
for SNRNP25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SNRNP25
Search CenterWatch for drugs/clinical trials and news about SNRNP25 / SNR25
|
Transcripts
for SNRNP25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNRNP25 gene: NM_024571.3 Unigene Cluster for SNRNP25: Small nuclear ribonucleoprotein 25kDa (U11/U12) Hs.15277 [show with all ESTs]Unigene Representative Sequence: BC0013817 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000293861(uc002cfj.4) ENST00000397876 ENST00000493672 ENST00000417493
ENST00000466183 ENST00000481947 ENST00000383018
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRNP25 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRNP25 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SNRNP25 (NM_024571) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNRNP25 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRNP25 |
Additional cDNA sequence: AK026593.1 BC001381.1 BC009179.1 Z84714.1 7 DOTS entries: DT.213827 DT.213826 DT.95275307 DT.100861693 DT.120670922 DT.99935488 DT.40108600 24/182 AceView cDNA sequences (see all 182): AA335786 AI820975 BU846188 BM794653 BU521371 CR620069 CR609842 BM006127 CR613103 BQ222254 BQ686053 BM691420 BM712091 CR594984 CR590942 BI252475 AA888591 AA873067 Z84714 CB126572 BU608952 AJ708079 BG024156 CA749008
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for SNRNP25 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
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| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for SNRNP25
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Expression
for SNRNP25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNRNP25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGACCCAC
About this image
See SNRNP25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNRNP25
SOURCE GeneReport for Unigene cluster: Hs.15277
SABiosciences Custom PCR Arrays for SNRNP25
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNRNP25
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNRNP25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRNP25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRNP25 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRNP25 |
Orthologs
for SNRNP25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for SNRNP25 gene from 8/19 species (see all 19) About this table
ENSEMBL Gene Tree for SNRNP25 (if available)
TreeFam Gene Tree for SNRNP25 (if available) |
Paralogs
for SNRNP25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SNRNP25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNRNP25 (103010 - 107669 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SNRNP25
2 CNVs: 3986 5329 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNRNP25 |
|
Disorders
/ Diseases
for SNRNP25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNRNP25 for disorders About GeneDecksing
1  disease for SNRNP25: About MalaCardsgenetic disease
Export disorders for SNRNP25 gene to outside databases
|
Publications
for SNRNP25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNRNP25 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SNRNP25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2, 3 Will C.L.... Luehrmann R. (2004)
- A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. (PubMed id 16728641)1, 2 De Gobbi M.... Higgs D.R. (2006)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Minor spliceosome components are predominantly localized in the nucleus. (PubMed id 18559850)1 Pessa H.K....Frilander M.J. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SNRNP25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SNRNP25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNRNP25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNRNP25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNRNP25 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SNRNP25 gene:
Search GeneIP for patents involving SNRNP25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNRNP25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNRNP25 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNRNP25 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRNP25 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRNP25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRNP25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRNP25 |
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 | | | SNRNP25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRNP25 |
|  |  |  | | | | Search ThermoFisher Antibodies for SNRNP25 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRNP25 |
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