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Aliases for SNRNP25 Gene

Aliases for SNRNP25 Gene

  • Small Nuclear Ribonucleoprotein U11/U12 Subunit 25 2 3
  • Small Nuclear Ribonucleoprotein, U11/U12 25kDa Subunit 2 3 5
  • Small Nuclear Ribonucleoprotein 25kDa (U11/U12) 2 3
  • U11/U12 SnRNP 25 KDa Protein 3 4
  • U11/U12 SnRNP 25K 2 3
  • Minus-99 Protein 3 4
  • C16orf33 3 4
  • Chromosome 16 Open Reading Frame 33 2
  • U11/U12-25K 4

External Ids for SNRNP25 Gene

Previous HGNC Symbols for SNRNP25 Gene

  • C16orf33

Previous GeneCards Identifiers for SNRNP25 Gene

  • GC16P000044
  • GC16P000103
  • GC16P000022

Summaries for SNRNP25 Gene

Entrez Gene Summary for SNRNP25 Gene

  • Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010]

GeneCards Summary for SNRNP25 Gene

SNRNP25 (Small Nuclear Ribonucleoprotein U11/U12 Subunit 25) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRNP25 Gene

Genomics for SNRNP25 Gene

Regulatory Elements for SNRNP25 Gene

Promoters for SNRNP25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNRNP25 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNRNP25 Gene

Chromosome:
16
Start:
53,010 bp from pter
End:
57,669 bp from pter
Size:
4,660 bases
Orientation:
Plus strand

Genomic View for SNRNP25 Gene

Genes around SNRNP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRNP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRNP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRNP25 Gene

Proteins for SNRNP25 Gene

  • Protein details for SNRNP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV90-SNR25_HUMAN
    Recommended name:
    U11/U12 small nuclear ribonucleoprotein 25 kDa protein
    Protein Accession:
    Q9BV90
    Secondary Accessions:
    • Q1W6H3
    • Q6IEF8
    • Q9H5W4

    Protein attributes for SNRNP25 Gene

    Size:
    132 amino acids
    Molecular mass:
    15270 Da
    Quaternary structure:
    • Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.

neXtProt entry for SNRNP25 Gene

Proteomics data for SNRNP25 Gene at MOPED

Post-translational modifications for SNRNP25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNRNP25 Gene

No data available for DME Specific Peptides for SNRNP25 Gene

Domains & Families for SNRNP25 Gene

Protein Domains for SNRNP25 Gene

Suggested Antigen Peptide Sequences for SNRNP25 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BV90

UniProtKB/Swiss-Prot:

SNR25_HUMAN :
  • Contains 1 ubiquitin-like domain.
Domain:
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with SNRNP25: view

No data available for Gene Families for SNRNP25 Gene

Function for SNRNP25 Gene

Phenotypes for SNRNP25 Gene

genes like me logo Genes that share phenotypes with SNRNP25: view

Animal Model Products

miRNA for SNRNP25 Gene

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRNP25 Gene

Localization for SNRNP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRNP25 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRNP25 Gene COMPARTMENTS Subcellular localization image for SNRNP25 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SNRNP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005689 U12-type spliceosomal complex IDA 15146077
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SNRNP25: view

Pathways & Interactions for SNRNP25 Gene

genes like me logo Genes that share pathways with SNRNP25: view

Pathways by source for SNRNP25 Gene

Gene Ontology (GO) - Biological Process for SNRNP25 Gene

None

No data available for SIGNOR curated interactions for SNRNP25 Gene

Drugs & Compounds for SNRNP25 Gene

No Compound Related Data Available

Transcripts for SNRNP25 Gene

Unigene Clusters for SNRNP25 Gene

Small nuclear ribonucleoprotein 25kDa (U11/U12):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNRNP25 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -

Relevant External Links for SNRNP25 Gene

GeneLoc Exon Structure for
SNRNP25
ECgene alternative splicing isoforms for
SNRNP25

Expression for SNRNP25 Gene

mRNA expression in normal human tissues for SNRNP25 Gene

Protein differential expression in normal tissues from HIPED for SNRNP25 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNRNP25 Gene



SOURCE GeneReport for Unigene cluster for SNRNP25 Gene Hs.15277

genes like me logo Genes that share expression patterns with SNRNP25: view

Protein tissue co-expression partners for SNRNP25 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNRNP25 Gene

Orthologs for SNRNP25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRNP25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRNP25 36
  • 100 (a)
OneToOne
SNRNP25 35
  • 99.24 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia SNRNP25 36
  • 98 (a)
OneToOne
SNRNP25 35
  • 88.35 (n)
  • 98.37 (a)
dog
(Canis familiaris)
Mammalia SNRNP25 35
  • 89.9 (n)
  • 96.21 (a)
SNRNP25 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snrnp25 36
  • 98 (a)
OneToOne
Snrnp25 16
Snrnp25 35
  • 88.35 (n)
  • 98.37 (a)
oppossum
(Monodelphis domestica)
Mammalia SNRNP25 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNRNP25 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snrnp25 35
  • 88.35 (n)
  • 98.37 (a)
chicken
(Gallus gallus)
Aves C16ORF33 35
  • 73.54 (n)
  • 76.34 (a)
SNRNP25 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNRNP25 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68520 35
tropical clawed frog
(Silurana tropicalis)
Amphibia snrnp25 35
  • 71.21 (n)
  • 81.06 (a)
Str.20169 35
zebrafish
(Danio rerio)
Actinopterygii snrnp25 36
  • 60 (a)
OneToOne
snrnp25 35
  • 70.45 (n)
  • 78.79 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G07860 35
  • 46.5 (n)
  • 40.34 (a)
Species with no ortholog for SNRNP25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNRNP25 Gene

ENSEMBL:
Gene Tree for SNRNP25 (if available)
TreeFam:
Gene Tree for SNRNP25 (if available)

Paralogs for SNRNP25 Gene

(1) SIMAP similar genes for SNRNP25 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNRNP25: view

No data available for Paralogs for SNRNP25 Gene

Variants for SNRNP25 Gene

Sequence variations from dbSNP and Humsavar for SNRNP25 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1045001 -- 57,275(+) AACAG(G/T)AACTG utr-variant-3-prime
rs11547280 -- 57,154(+) CAGAC(A/G)GGACA utr-variant-3-prime
rs17355701 -- 55,875(+) AGCAC(A/G)TCAGC reference, missense
rs34400346 -- 55,740(+) TTCTC(A/C)CCATG intron-variant
rs57112603 -- 56,706(+) CTCTC(C/T)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNRNP25 Gene

Variant ID Type Subtype PubMed ID
nsv904623 CNV Gain+Loss 21882294
dgv2455n71 CNV Loss 21882294
esv2422427 CNV Duplication 17116639
dgv789e1 CNV Complex 17122850
nsv522688 CNV Loss 19592680
nsv518291 CNV Loss 19592680
dgv2456n71 CNV Loss 21882294
nsv904628 CNV Loss 21882294
esv988339 CNV Deletion 20482838

Variation tolerance for SNRNP25 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNRNP25 Gene

HapMap Linkage Disequilibrium report
SNRNP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRNP25 Gene

Disorders for SNRNP25 Gene

Relevant External Links for SNRNP25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNRNP25

No disorders were found for SNRNP25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRNP25 Gene

Publications for SNRNP25 Gene

  1. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will C.L. … Luehrmann R. (RNA 2004) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Minor spliceosome components are predominantly localized in the nucleus. (PMID: 18559850) Pessa H.K. … Frilander M.J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3

Products for SNRNP25 Gene

Sources for SNRNP25 Gene

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