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Aliases for SNRK Gene

Aliases for SNRK Gene

  • SNF Related Kinase 2 3
  • SNF1-Related Kinase 3 4
  • EC 2.7.11.1 4 63
  • SNF-1 Related Kinase 3
  • EC 2.7.11 63
  • KIAA0096 4
  • HSNFRK 3
  • SNFRK 4

External Ids for SNRK Gene

Previous GeneCards Identifiers for SNRK Gene

  • GC03P042632
  • GC03P042508
  • GC03P043147
  • GC03P043288

Summaries for SNRK Gene

Entrez Gene Summary for SNRK Gene

  • SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009]

GeneCards Summary for SNRK Gene

SNRK (SNF Related Kinase) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MARK4.

UniProtKB/Swiss-Prot for SNRK Gene

  • May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.

Gene Wiki entry for SNRK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRK Gene

Genomics for SNRK Gene

Regulatory Elements for SNRK Gene

Genomic Location for SNRK Gene

Chromosome:
3
Start:
43,286,512 bp from pter
End:
43,424,764 bp from pter
Size:
138,253 bases
Orientation:
Plus strand

Genomic View for SNRK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRK Gene

Proteins for SNRK Gene

  • Protein details for SNRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRH2-SNRK_HUMAN
    Recommended name:
    SNF-related serine/threonine-protein kinase
    Protein Accession:
    Q9NRH2
    Secondary Accessions:
    • B2RAV6
    • Q14706
    • Q68D15
    • Q6IQ46
    • Q9NXI7

    Protein attributes for SNRK Gene

    Size:
    765 amino acids
    Molecular mass:
    84276 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA07744.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18415.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SNRK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNRK Gene

Proteomics data for SNRK Gene at MOPED

Selected DME Specific Peptides for SNRK Gene

Post-translational modifications for SNRK Gene

  • Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNRK Gene

Domains & Families for SNRK Gene

Gene Families for SNRK Gene

Suggested Antigen Peptide Sequences for SNRK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRH2

UniProtKB/Swiss-Prot:

SNRK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SNRK: view

Function for SNRK Gene

Molecular function for SNRK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-173.
UniProtKB/Swiss-Prot Function:
May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.

Enzyme Numbers (IUBMB) for SNRK Gene

Gene Ontology (GO) - Molecular Function for SNRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 12234663
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 12234663
GO:0005524 ATP binding IDA 12234663
genes like me logo Genes that share ontologies with SNRK: view
genes like me logo Genes that share phenotypes with SNRK: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNRK

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SNRK Gene

Localization for SNRK Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNRK Gene COMPARTMENTS Subcellular localization image for SNRK gene
Compartment Confidence
nucleus 4
plasma membrane 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for SNRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SNRK: view

Pathways & Interactions for SNRK Gene

SuperPathways for SNRK Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 12234663
GO:0030099 myeloid cell differentiation TAS 12234663
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with SNRK: view

No data available for Pathways by source and SIGNOR curated interactions for SNRK Gene

Drugs & Compounds for SNRK Gene

(2) Drugs for SNRK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for SNRK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with SNRK: view

Transcripts for SNRK Gene

Unigene Clusters for SNRK Gene

SNF related kinase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNRK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRK Gene

No ASD Table

Relevant External Links for SNRK Gene

GeneLoc Exon Structure for
SNRK
ECgene alternative splicing isoforms for
SNRK

Expression for SNRK Gene

mRNA expression in normal human tissues for SNRK Gene

Protein differential expression in normal tissues from HIPED for SNRK Gene

This gene is overexpressed in Liver, secretome (22.8), CD8 Tcells (11.0), Frontal cortex (10.0), and CD4 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SNRK Gene



SOURCE GeneReport for Unigene cluster for SNRK Gene Hs.476052

mRNA Expression by UniProt/SwissProt for SNRK Gene

Q9NRH2-SNRK_HUMAN
Tissue specificity: Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.
genes like me logo Genes that share expression patterns with SNRK: view

Protein tissue co-expression partners for SNRK Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SNRK Gene

Orthologs for SNRK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNRK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNRK 35
  • 86.44 (n)
  • 95.26 (a)
SNRK 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRK 35
  • 88.62 (n)
  • 94.31 (a)
SNRK 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snrk 35
  • 84.25 (n)
  • 91.92 (a)
Snrk 16
Snrk 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNRK 35
  • 99.56 (n)
  • 99.61 (a)
SNRK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snrk 35
  • 83.98 (n)
  • 91.66 (a)
oppossum
(Monodelphis domestica)
Mammalia SNRK 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNRK 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNRK 35
  • 80.7 (n)
  • 92.29 (a)
SNRK 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNRK 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snrk 35
  • 76.57 (n)
  • 87.17 (a)
zebrafish
(Danio rerio)
Actinopterygii snrka 35
  • 70 (n)
  • 78.32 (a)
zgc73231 35
snrka 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8485 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK524.4 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIN4 36
  • 16 (a)
ManyToMany
HSL1 36
  • 12 (a)
ManyToMany
KCC4 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToOne
Species with no ortholog for SNRK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNRK Gene

ENSEMBL:
Gene Tree for SNRK (if available)
TreeFam:
Gene Tree for SNRK (if available)

Paralogs for SNRK Gene

Paralogs for SNRK Gene

genes like me logo Genes that share paralogs with SNRK: view

Variants for SNRK Gene

Sequence variations from dbSNP and Humsavar for SNRK Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1034513 -- 43,324,113(+) CCAGT(A/G)TACAT intron-variant
rs1034514 -- 43,302,105(-) CCCAG(A/C)ATAAC intron-variant
rs1395373 -- 43,291,398(-) TGGAT(A/G)CTAGG intron-variant
rs1472807 -- 43,288,421(-) CCCAA(C/T)CTATA intron-variant
rs1506618 -- 43,287,454(-) ATGAA(A/G)CTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNRK Gene

Variant ID Type Subtype PubMed ID
esv2752008 CNV Gain 17911159
nsv876732 CNV Loss 21882294
esv22433 CNV Loss 19812545

Variation tolerance for SNRK Gene

Residual Variation Intolerance Score: 5.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNRK Gene

HapMap Linkage Disequilibrium report
SNRK
Human Gene Mutation Database (HGMD)
SNRK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRK Gene

Disorders for SNRK Gene

Relevant External Links for SNRK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNRK
genes like me logo Genes that share disorders with SNRK: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRK Gene

Publications for SNRK Gene

  1. The central regulation of plant physiology by adenylates. (PMID: 20005151) Geigenberger P. … Fernie A.R. (Trends Plant Sci. 2010) 23 67
  2. The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. (PMID: 19717424) Wertheim G.B. … Chodosh L.A. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67
  3. N-myristoylation regulates the SnRK1 pathway in Arabidopsis. (PMID: 17827350) Pierre M. … Meinnel T. (Plant Cell 2007) 23 67
  4. snf1lk encodes a protein kinase that may function in cell cycle regulation. (PMID: 15177563) Stephenson A. … Ruiz J.C. (Genomics 2004) 23 67
  5. Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung. (PMID: 12842817) Favre C.J. … McDonald D.M. (Am. J. Physiol. Heart Circ. Physiol. 2003) 23 67

Products for SNRK Gene

Sources for SNRK Gene

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