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SNRK Gene

protein-coding   GIFtS: 62
GCID: GC03P043303

SNF Related Kinase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
SNF Related Kinase1 2     SNF-1 Related Kinase2
SNF1-Related Kinase2 3     SNF-Related Serine/Threonine-Protein Kinase2
EC 2.7.11.13 8     SNFRK3
KIAA00963 5     EC 2.7.118
HSNFRK2     

External Ids:    HGNC: 305981   Entrez Gene: 548612   Ensembl: ENSG000001637887   OMIM: 6127605   UniProtKB: Q9NRH23   
ORGUL members:         

Export aliases for SNRK gene to outside databases

Previous GC identifers: GC03P042632 GC03P042508 GC03P043147 GC03P043288


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNRK Gene:
SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et
al., 2002 (PubMed 12234663)).(supplied by OMIM, Apr 2009)

GeneCards Summary for SNRK Gene:
SNRK (SNF related kinase) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is BRSK1.

UniProtKB/Swiss-Prot: SNRK_HUMAN, Q9NRH2
Function: May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal
apoptosis

Gene Wiki entry for SNRK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNRK gene promoter:
         p300   c-Myb   MRF-2   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SNRK promoter sequence
   Search Chromatin IP Primers for SNRK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNRK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p22.1

SNRK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRK gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P043303:  view genomic region     (about GC identifiers)

Start:
43,328,004 bp from pter      End:
43,466,256 bp from pter
Size:
138,253 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SNRK_HUMAN, Q9NRH2 (See protein sequence)
Recommended Name: SNF-related serine/threonine-protein kinase  
Size: 765 amino acids; 84276 Da
Cofactor: Magnesium
Sequence caution: Sequence=BAA07744.2; Type=Erroneous initiation; Sequence=CAH18415.1; Type=Erroneous initiation;
Secondary accessions: B2RAV6 Q14706 Q68D15 Q6IQ46 Q9NXI7
Alternative splicing: 2 isoforms:  Q9NRH2-1   Q9NRH2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SNRK: NX_Q9NRH2

Explore proteomics data for SNRK at MOPED

Post-translational modifications: 

  • Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA)
    pseudo kinase and CAB391
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SNRK (Q9NRH2) (see all 8)
     AVKVIDK  DLITRML  DSESRRR  VHRDLKP 


    See SNRK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001094064.1  NP_060189.3  

    ENSEMBL proteins: 
     ENSP00000401246   ENSP00000411375   ENSP00000296088   ENSP00000409516  

    SNRK Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant SNRK Protein
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    OriGene Protein Over-expression Lysate for SNRK
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SNRK
    GenScript Custom Purified and Recombinant Proteins Services for SNRK
    Novus Biologicals SNRK Proteins
    Novus Biologicals SNRK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SNRK

     
    Search eBioscience for Proteins for SNRK 

     
    antibodies-online proteins for SNRK (6 products) 

     
    antibodies-online peptides for SNRK

    SNRK Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SNRK
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    Abcam antibodies for SNRK
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    antibodies-online antibodies for SNRK (25 products) 

    SNRK Assay Products:

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    Cloud-Clone Corp. ELISAs for SNRK
    Cloud-Clone Corp. CLIAs for SNRK
    Search eBioscience for ELISAs for SNRK 
    antibodies-online kits for SNRK (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: SNF related kinase
    SNRK subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR015940 UBA/transl_elong_EF1B_N_euk
     IPR000719 Prot_kinase_dom
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NRH2

    ProtoNet protein and cluster: Q9NRH2

    1 Blocks protein domain: IPB000449 Ubiquitin-associated domain

    UniProtKB/Swiss-Prot: SNRK_HUMAN, Q9NRH2
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    Find genes that share domains with SNRK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNRK_HUMAN, Q9NRH2
    Function: May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal
    apoptosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-173

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA12234663
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA12234663
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IDA12234663
         
    Find genes that share ontologies with SNRK           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SNRK:
     Decreased substrate adherent c  Increased cell death HMECs cel  Upregulation of Wnt/beta-caten 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SNRK

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNRK:
    hsa-mir-21-5p (MIRT031002), hsa-mir-128-3p (MIRT022051), hsa-mir-193b-3p (MIRT041578)

    Block miRNA regulation of human, mouse, rat SNRK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNRK (see all 127):
    hsa-miR-26a-2* hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-218-1* hsa-miR-200a hsa-miR-938
    SwitchGear 3'UTR luciferase reporter plasmidSNRK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNRK
    Predesigned siRNA for gene silencing in human, mouse, rat SNRK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNRK

    Clone
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    OriGene clones in human, mouse for SNRK (see all 14)
    OriGene ORF clones in mouse, rat for SNRK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SNRK (NM_017719)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRK
    Addgene plasmids for SNRK 

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SNRK 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNRK_HUMAN, Q9NRH2: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    chloroplast2
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    Find genes that share ontologies with SNRK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNRK About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of CREB1
    Selected targets of CREB1



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNRK
    Interactions:

        GeneGlobe Interaction Network for SNRK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SNRK (Q9NRH22, 3 ENSP000002960884) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA12234663
    GO:0030099myeloid cell differentiation TAS12234663

    Find genes that share ontologies with SNRK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNRK

    3 HMDB Compounds for SNRK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SNRK gene (2 alternative transcripts): 
    NM_001100594.1  NM_017719.4  

    Unigene Cluster for SNRK:

    SNF related kinase
    Hs.476052  [show with all ESTs]
    Unigene Representative Sequence: NM_017719
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454177 ENST00000429705(uc003cmt.4 uc011azr.2) ENST00000296088(uc003cms.4 uc010hik.3)
    ENST00000437827 ENST00000462810(uc003cmu.3) ENST00000484791 ENST00000481892
    ENST00000468628
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SNRK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNRK (see all 127):
    hsa-miR-26a-2* hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-218-1* hsa-miR-200a hsa-miR-938
    SwitchGear 3'UTR luciferase reporter plasmidSNRK 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SNRK
    Predesigned siRNA for gene silencing in human, mouse, rat SNRK
    Clone
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    OriGene clones in human, mouse for SNRK (see all 14)
    OriGene ORF clones in mouse, rat for SNRK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SNRK (NM_017719)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRK
    Addgene plasmids for SNRK 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNRK
    OriGene qSTAR qPCR primer pairs in human, mouse for SNRK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNRK
      QuantiTect SYBR Green Assays in human, mouse, rat SNRK
      QuantiFast Probe-based Assays in human, mouse, rat SNRK

    Additional mRNA sequence: 

    AK025449.1 AK026013.1 AK098414.1 AK291360.1 AK295187.1 AK314376.1 BC071567.1 CR749621.1 
    D43636.2 U57452.1 

    15 DOTS entries:

    DT.92357231  DT.100731824  DT.92422222  DT.117837  DT.120874939  DT.120874915  DT.100782085  DT.99927928 
    DT.100782087  DT.91712849  DT.92060879  DT.100782092  DT.40195722  DT.91689438  DT.91704775 

    Selected AceView cDNA sequences (see all 204):

    CB164017 BE550696 BE504203 BP379617 AK026013 BF590999 AI635754 AI251440 
    AU130582 AI653233 AI138601 BE046388 AA771728 BM904451 BP380294 AI090896 
    AA399335 NM_017719 AW299608 BQ012493 BG621894 AA027903 BP379351 CB130788 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNRK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGTATGT
    SNRK Expression
    About this image

    SNRK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNRK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.476052

    UniProtKB/Swiss-Prot: SNRK_HUMAN, Q9NRH2
    Tissue specificity: Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the
    testis

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    QuantiFast Probe-based Assays in human, mouse, rat SNRK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SNRK gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snrk1 , 5 SNF related kinase1, 5 84.25(n)1
    91.92(a)1
      9 (72.89 cM)5
    206231  NM_001164572.11  NP_001158044.11 
     1221172835 
    chicken
    (Gallus gallus)
    Aves SNRK1 SNF related kinase 80.7(n)
    92.29(a)
      420675  NM_001199702.1  NP_001186631.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNRK6
    SNF related kinase
    88(a)
    1 ↔ 1
    1(192747288-192774007)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX853762.12   -- 76.32(n)    BX853762.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc732312 hypothetical protein MGC73231 72.64(n)   393806  BC060922.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84856
    --
    40(a)
    1 ↔ 1
    2R(10123286-10127203)
    worm
    (Caenorhabditis elegans)
    Secernentea ZK524.46
    Protein ZK524.4 (ZK524.4) mRNA, complete cds
    32(a)
    1 ↔ 1
    I(7460854-7466424) WBGene00013994
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KCC46
    GIN46
    (see all 3)
    Protein kinase of the bud neck involved in the sep...
    Protein kinase involved in bud growth and assembly...
    (see all 3)
    17(a)
    16(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(79162-82275) YCL024W
    IV(1462358-1465786) YDR507C


    ENSEMBL Gene Tree for SNRK (if available)
    TreeFam Gene Tree for SNRK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNRK gene
    BRSK12  MARK12  BRSK22  SIK32  SIK22  MARK22  NIM1K2  SIK12  
    MARK42  MARK32  
    Selected SIMAP similar genes for SNRK using alignment to 2 protein entries:     SNRK_HUMAN (see all proteins) (see all similar genes):
    MARK4    RPS6KA2    PRKAA1    AURKA    CAMK2B    NUAK1
    KIN27    PNCK    RPS6KA3    TSSK1    TSSK1B    TSSK2
    PRKACB    CAMK1    SGK2    TSSK3    AURKB    CAMK1D

    Find genes that share paralogs with SNRK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNRK (see all 1089)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0410994
    An ovarian serous carcinoma sample4--see VAR_0410992 P L mis40--------
    VAR_0411004
    A breast pleomorphic lobular carcinoma sample4--see VAR_0411002 I M mis40--------
    VAR_0410984
    An ovarian mucinous carcinoma sample4--see VAR_0410982 G S mis40--------
    rs1459198621,2
    C--43326026(+) AACATC/TAAAAA 2 -- us2k10--------
    rs730750241,2
    C--43326315(+) TATTGC/TAGCCA 2 -- us2k12Minor allele frequency- T:0.06NA 122
    rs50235441,2
    C,F,H--43326421(+) AACAGC/AAGCAA 2 -- us2k14Minor allele frequency- A:0.00NS NA 402
    rs1466326021,2
    --43326427(+) AGCAAC/TATAAA 2 -- us2k10--------
    rs1467253631,2
    C--43326436(+) AATAC-/TTTA  
            
    TTTTT
    2 -- us2k10--------
    rs1862397611,2
    --43326490(+) ATATAA/TCTCAG 2 -- us2k10--------
    rs1889970471,2
    --43326714(+) TACGAC/TTTCCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SNRK (43328004 - 43466256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SNRK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv22433CNV Loss19812545
    nsv876732CNV Loss21882294
    esv2752008CNV Gain17911159

    Human Gene Mutation Database (HGMD): SNRK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNRK
    DNA2.0 Custom Variant and Variant Library Synthesis for SNRK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612760    OMIM disorders: --


    Find genes that share disorders with SNRK           About GenesLikeMe


    Export disorders for SNRK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNRK gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with SNRK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases. (PubMed id 8654423)1, 2, 3 Becker W.... Joost H.G. (Eur. J. Biochem. 1996)
    2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
    3. Cloning and characterization of human and mouse SNRK sucrose non- fermenting protein (SNF-1)-related kinases. (PubMed id 12234663)1, 2, 9 Kertesz N.... Labastie M.-C. (Gene 2002)
    4. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. (PubMed id 15733851)1, 2 Jaleel M....Alessi D.R. (FEBS Lett. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of I^-catenin. (PubMed id 22874833)1 Rines A.K....Ardehali H. (FASEB J. 2012)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54861 HGNC: 30598 AceView: SNRK Ensembl:ENSG00000163788 euGenes: HUgn54861
    ECgene: SNRK H-InvDB: SNRK

    (According to HUGE)
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    HUGE: KIAA0096

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNRK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNRK gene:
    Search GeneIP for patents involving SNRK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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