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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNRK Gene

protein-coding   GIFtS: 60
GCID: GC03P043303

SNF related kinase
 Explore 3 diseases affiliated with
SNRK via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNRK    

Aliases
for SNRK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SNF Related Kinase1 2     FLJ202241
KIAA00961 3 5     SNF-1 Related Kinase2
HSNFRK1 2     SNF-Related Serine/Threonine-Protein Kinase2
SNF1-Related Kinase2 3     SNFRK3
EC 2.7.11.13 8     EC 2.7.118

External Ids:    HGNC: 305981   Entrez Gene: 548612   Ensembl: ENSG000001637887   OMIM: 6127605   UniProtKB: Q9NRH23   

Export aliases for SNRK gene to outside databases

Previous GC identifers: GC03P042632 GC03P042508 GC03P043147 GC03P043288


Summaries
for SNRK gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SNRK:
SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al.,
2002 (PubMed 12234663)).(supplied by OMIM, Apr 2009)

UniProtKB/Swiss-Prot: SNRK_HUMAN, Q9NRH2
Function: May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal
apoptosis

Gene Wiki entry for SNRK


Genomic Views
for SNRK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNRK gene promoter:
         p300   c-Myb   MRF-2   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SNRK promoter sequence
   Search SABiosciences Chromatin IP Primers for SNRK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNRK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p22.1

SNRK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNRK gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P043303:  view genomic region     (about GC identifiers)

Start:
 43,328,004 bp from pter      End:
 43,466,256 bp from pter
Size:
 138,253 bases      Orientation:
 plus strand

Proteins
for SNRK gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SNRK_HUMAN, Q9NRH2 (See protein sequence)
Recommended Name: SNF-related serine/threonine-protein kinase  
Size: 765 amino acids; 84276 Da
Cofactor: Magnesium
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA07744.2; Type=Erroneous initiation; Sequence=CAH18415.1; Type=Erroneous initiation;
Secondary accessions: B2RAV6 Q14706 Q68D15 Q6IQ46 Q9NXI7
Alternative splicing: 2 isoforms:  Q9NRH2-1   Q9NRH2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SNRK: NX_Q9NRH2

Post-translational modifications:

  • Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA)
    • pseudo kinase and CAB391
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NRH2

    • 4/8 DME Specific Peptides for SNRK (Q9NRH2) (see all 8)
     DLITRML  VVHRDLK  FAVVKLA  AVKVIDK 

    SNRK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001094064.1  NP_060189.3  

    ENSEMBL proteins: 
     ENSP00000401246   ENSP00000411375   ENSP00000296088   ENSP00000409516  

    Human Recombinant Protein Products: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): SNRK
    OriGene Custom Protein Services for SNRK 
    GenScript Custom Purified and Recombinant Proteins Services for SNRK
    Novus Biologicals SNRK Proteins
    Novus Biologicals SNRK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SNRK

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--


    SNRK for ontologies           About GeneDecksing



    SNRK Antibody Products: 
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    ThermoFisher Antibody for SNRK

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    Uscn ELISAs and CLIAs for SNRK

    Protein Domains /
    Families
    for SNRK gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNRK for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR015940 UBA/transl_elong_EF1B_N_euk

    Graphical View of Domain Structure for InterPro Entry Q9NRH2

    ProtoNet protein and cluster: Q9NRH2

    1 Blocks protein family: IPB000449 Ubiquitin-associated domain

    UniProtKB/Swiss-Prot: SNRK_HUMAN, Q9NRH2
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    Function
    for SNRK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SNRK_HUMAN, Q9NRH2
    Function: May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal
    apoptosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-173

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRK
    8/127 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRK (see all 127):
    hsa-miR-26a-2* hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-218-1* hsa-miR-200a hsa-miR-938
    SwitchGear 3'UTR luciferase reporter plasmid: SNRK 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRK (see all 7)
    OriGene shRNA RFP: SNRK
    OriGene siRNA: SNRK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRK

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SNRK

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNRK (see all 5)
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    GenScript: all cDNA clones in your preferred vector (see all 2): SNRK (NM_017719)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRK 

    Cell Line
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    Search LifeMap BioReagents cell lines for SNRK

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRK

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA12234663
    GO:0004674protein serine/threonine kinase activity IDA12234663
    GO:0005524ATP binding IDA12234663


    SNRK for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for SNRK:
     Decreased substrate adherent c  Increased cell death HMECs cel  Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for SNRK gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selected targets of CREB1
    		Selected targets of CREB11.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SNRK
        Selected targets of CREB1




    SNRK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNRK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for SNRK (Q9NRH22, 3 ENSP000002960884) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK11Q158312, 3, ENSP000003248564MINT-56664 I2D: score=2 STRING: ENSP00000324856
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    STK16O757163, ENSP000003799644I2D: score=2 STRING: ENSP00000379964
    HSPA1BP081073I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA12234663
    GO:0030099myeloid cell differentiation TAS12234663


    SNRK for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNRK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNRK

    3 HMDB Compounds for SNRK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about SNRK 

    Transcripts
    for SNRK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNRK gene (2 alternative transcripts): 
    NM_001100594.1  NM_017719.4  

    Unigene Cluster for SNRK:

    SNF related kinase
    Hs.476052  [show with all ESTs]
    Unigene Representative Sequence: NM_017719
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454177 ENST00000429705(uc003cmt.4 uc011azr.2) ENST00000296088(uc003cms.4 uc010hik.3)
    ENST00000437827 ENST00000462810(uc003cmu.3) ENST00000484791 ENST00000481892
    ENST00000468628

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): SNRK
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNRK
    8/127 QIAGEN miScript miRNA Assays for microRNAs that regulate SNRK (see all 127):
    hsa-miR-26a-2* hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-15a hsa-miR-218-1* hsa-miR-200a hsa-miR-938
    SwitchGear 3'UTR luciferase reporter plasmid: SNRK 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNRK (see all 7)
    OriGene shRNA RFP: SNRK
    OriGene siRNA: SNRK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNRK
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNRK (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SNRK (NM_017719)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNRK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNRK 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNRK
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNRK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNRK

    Additional cDNA sequence: 

    AK025449.1 AK026013.1 AK098414.1 AK291360.1 AK295187.1 AK314376.1 BC071567.1 CR749621.1 
    D43636.2 U57452.1 

    15 DOTS entries:

    DT.92357231  DT.100731824  DT.92422222  DT.117837  DT.120874939  DT.120874915  DT.100782085  DT.99927928 
    DT.100782087  DT.91712849  DT.92060879  DT.100782092  DT.40195722  DT.91689438  DT.91704775 

    24/204 AceView cDNA sequences (see all 204):

    CB164017 CB853755 CB156795 D43636 BQ720689 AA771728 AA447664 CB130788 
    AI138601 CA777359 AW102997 AW026904 BM459667 BP379351 AI090896 AW299608 
    AW058535 AA027903 BG621894 BX501150 AI492214 BM721421 CA449657 BF437353 

    GeneLoc Exon Structure


    Expression
    for SNRK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNRK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTGTATGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SNRK expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SNRK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNRK

    SOURCE GeneReport for Unigene cluster: Hs.476052

    UniProtKB/Swiss-Prot: SNRK_HUMAN, Q9NRH2
    Tissue specificity: Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis

        SABiosciences Custom PCR Arrays for SNRK
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNRK

    Orthologs
    for SNRK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SNRK gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SNRK1 SNF related kinase 80.7(n)
    92.29(a)    		   420675  NM_001199702.1  NP_001186631.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SNRK6
    		 --
    		 91(a)
    		 1 ↔ 1
    		 1(192750199-192774007)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BX853762.12   -- 76.32(n)    BX853762.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc732312 hypothetical protein MGC73231 72.64(n)   393806  BC060922.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG84851 CG8485 54.56(n)
    56.08(a)    		   36579  NM_166043.1  NP_725372.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ZK524.46
    		 --
    		 24(a)
    		 1 ↔ 1
    		 I(7460850-7466420)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 CAMK_KIN1/SNF1/Nim1_like_AMPKh.1 - CAMK includes c...
    		 23(a)
    		 possible ortholog
    		 7(5101510-5106299)


    ENSEMBL Gene Tree for SNRK (if available)
    TreeFam Gene Tree for SNRK (if available) 

    Paralogs
    for SNRK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNRK gene
    BRSK12  NUAK12  MARK12  BRSK22  SIK32  SIK22  NUAK22  MARK22  
    NIM12  SIK12  MARK42  MARK32  
    18/46 SIMAP similar genes for SNRK using alignment to 2 protein entries:     SNRK_HUMAN (see all proteins) (see all similar genes):
    MARK4    RPS6KA2    PRKAA1    AURKA    CAMK2B    NUAK1
    KIN27    PNCK    PRKG1    RPS6KA3    TSSK1    TSSK1B
    TSSK2    PRKACB    CAMK1    SGK2    TSSK3    AURKB

    SNRK for paralogs           About GeneDecksing



    Genomic Variants
    for SNRK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/999 NCBI SNPs in SNRK are shown (see all 999)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1459198621,2
    		--43326026(+) AACATC/TAAAAA 2 -- us2k10--------
    rs730750241,2
    		C,--43326315(+) TATTGC/TAGCCA 2 -- us2k12Minor allele frequency- T:0.06NA 122
    rs50235441,2
    		C,F,H--43326421(+) AACAGC/AAGCAA 2 -- us2k14Minor allele frequency- A:0.00NS NA 402
    rs1466326021,2
    		--43326427(+) AGCAAC/TATAAA 2 -- us2k10--------
    rs1862397611,2
    		--43326490(+) ATATAA/TCTCAG 2 -- us2k10--------
    rs1889970471,2
    		--43326714(+) TACGAC/TTTCCA 2 -- us2k10--------
    rs558085881,2
    		--43326795(+) GAGGCA/C/TTAATC 2 -- us2k10--------
    rs117095171,2
    		C,F,H,--43326887(+) TGTTAT/CTACCC 2 -- us2k1 tfbs323Minor allele frequency- C:0.15NS EA NA WA 2706
    rs775079931,2
    		C,--43326912(+) TTTGCA/GCCTCC 2 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1408335391,2
    		--43327106(+) CTTGCC/TAGGGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SNRK (43328004 - 43466256 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SNRK
         1 CNV: 8421
         1 Indel: 68369
    Human Gene Mutation Database (HGMD): SNRK

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNRK
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    Disorders / Diseases
    for SNRK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNRK for disorders           About GeneDecksing

    OMIM gene information: 612760    OMIM disorders: --

    3 diseases for SNRK:    About MalaCards
    lymphedema    malaria    neuronitis


    Export disorders for SNRK gene to outside databases

    Publications
    for SNRK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNRK gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with SNRK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases. (PubMed id 8654423)1, 2, 3 Becker W.... Joost H.G. (1996)
    2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T....Kotani H. (1995)
    3. Cloning and characterization of human and mouse SNRK sucrose non- fermenting protein (SNF-1)-related kinases. (PubMed id 12234663)1, 2, 9 Kertesz N.... Labastie M.-C. (2002)
    4. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. (PubMed id 15733851)1, 2 Jaleel M....Alessi D.R. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    8. Snf1-related kinase inhibits colon cancer cell prolife ration through calcyclin-binding protein-dependent reduction of b-catenin. (PubMed id 22874833)1 Rines A.K....Ardehali H. (2012)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)

    External Searches for SNRK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SNRK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54861 HGNC: 30598 AceView: SNRK Ensembl:ENSG00000163788 euGenes: HUgn54861
    ECgene: SNRK H-InvDB: SNRK

    Other Databases showing SNRK gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0096

    Specialized Databases showing SNRK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNRK Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SNRK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SNRK gene:
    Search GeneIP for patents involving SNRK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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     Regulatory tfbs in SNRK promoter
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     SNRK Proteins, Antibodies, CLIAs, and ELISAs
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