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Aliases for SNRK Gene

Aliases for SNRK Gene

  • SNF Related Kinase 2 3 5
  • SNF1-Related Kinase 3 4
  • EC 2.7.11.1 4 61
  • SNF-Related Serine/Threonine-Protein Kinase 3
  • SNF-1 Related Kinase 3
  • EC 2.7.11 61
  • KIAA0096 4
  • HSNFRK 3
  • SNFRK 4

External Ids for SNRK Gene

Previous GeneCards Identifiers for SNRK Gene

  • GC03P042632
  • GC03P042508
  • GC03P043147
  • GC03P043288

Summaries for SNRK Gene

Entrez Gene Summary for SNRK Gene

  • SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009]

GeneCards Summary for SNRK Gene

SNRK (SNF Related Kinase) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MELK.

UniProtKB/Swiss-Prot for SNRK Gene

  • May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.

Gene Wiki entry for SNRK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRK Gene

Genomics for SNRK Gene

Regulatory Elements for SNRK Gene

Enhancers for SNRK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G043387 1.8 FANTOM5 Ensembl ENCODE dbSUPER 36.9 +103.4 103447 4.4 HDAC1 FOXA2 ZBTB40 RAD21 YY1 GATA2 FOS ETV6 ZBTB11 CEBPB SNRK ABHD5 SNRK-AS1 ENSG00000271941 ANO10 ENSG00000251811
GH03G043392 1.4 FANTOM5 Ensembl ENCODE dbSUPER 28.1 +107.5 107524 2.5 JUN ETV1 ZNF175 MAX RAD21 NR2F2 GATA2 FOS MYC SNRK SNRK-AS1 ABHD5 ANO10 ENSG00000251811
GH03G043255 1.1 FANTOM5 Ensembl 30.7 -29.9 -29875 1.7 ZNF175 MAX CEBPG RAD21 RARA YY1 HNF4G TRIM24 FOXA3 HLF SNRK ABHD5 SNRK-AS1 CCDC13 LOC105377052 GC03P043190
GH03G043316 1.4 Ensembl ENCODE dbSUPER 11.6 +31.3 31325 2.3 ELF3 ATF1 FOXA2 DNMT3B RAD21 RARA YY1 GATA4 CREM MIXL1 SNRK-AS1 SNRK ABHD5 RN7SL517P ENSG00000271941
GH03G043869 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +585.3 585285 5.0 JUN SIN3A RAD21 ZNF316 GATA2 POLR2A NFE2 PRDM10 FOS ZNF548 ENSG00000261786 ZNF502 RNU6-367P SNRK MIR138-1 TOPAZ1 ANO10 GC03P043926 ENSG00000235886
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNRK on UCSC Golden Path with GeneCards custom track

Promoters for SNRK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151464 988 3001 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF143 ZNF207

Genomic Location for SNRK Gene

Chromosome:
3
Start:
43,286,512 bp from pter
End:
43,424,764 bp from pter
Size:
138,253 bases
Orientation:
Plus strand

Genomic View for SNRK Gene

Genes around SNRK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRK Gene

Proteins for SNRK Gene

  • Protein details for SNRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRH2-SNRK_HUMAN
    Recommended name:
    SNF-related serine/threonine-protein kinase
    Protein Accession:
    Q9NRH2
    Secondary Accessions:
    • B2RAV6
    • Q14706
    • Q68D15
    • Q6IQ46
    • Q9NXI7

    Protein attributes for SNRK Gene

    Size:
    765 amino acids
    Molecular mass:
    84276 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA07744.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18415.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SNRK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNRK Gene

Selected DME Specific Peptides for SNRK Gene

Q9NRH2:
  • DLITRML
  • LAYSAPEI
  • DSESRRR
  • AVKVIDK
  • VVHRDLK
  • RDLKPEN
  • FAVVKLA
  • VHRDLKP

Post-translational modifications for SNRK Gene

  • Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SNRK

Domains & Families for SNRK Gene

Gene Families for SNRK Gene

Suggested Antigen Peptide Sequences for SNRK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRH2

UniProtKB/Swiss-Prot:

SNRK_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SNRK: view

Function for SNRK Gene

Molecular function for SNRK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-173.
UniProtKB/Swiss-Prot Function:
May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.

Enzyme Numbers (IUBMB) for SNRK Gene

Gene Ontology (GO) - Molecular Function for SNRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 12234663
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA 12234663
GO:0005524 ATP binding IEA,IDA 12234663
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with SNRK: view
genes like me logo Genes that share phenotypes with SNRK: view

Animal Models for SNRK Gene

MGI Knock Outs for SNRK:

Animal Model Products

  • Taconic Biosciences Mouse Models for SNRK

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SNRK

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNRK Gene

Localization for SNRK Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNRK gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SNRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SNRK: view

Pathways & Interactions for SNRK Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA,IEA 12234663
GO:0016310 phosphorylation IEA --
GO:0030099 myeloid cell differentiation TAS 12234663
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with SNRK: view

No data available for Pathways by source and SIGNOR curated interactions for SNRK Gene

Drugs & Compounds for SNRK Gene

(2) Drugs for SNRK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for SNRK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with SNRK: view

Transcripts for SNRK Gene

Unigene Clusters for SNRK Gene

SNF related kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SNRK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRK Gene

No ASD Table

Relevant External Links for SNRK Gene

GeneLoc Exon Structure for
SNRK
ECgene alternative splicing isoforms for
SNRK

Expression for SNRK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNRK Gene

Protein differential expression in normal tissues from HIPED for SNRK Gene

This gene is overexpressed in Liver, secretome (22.8), CD8 Tcells (11.0), Frontal cortex (10.0), and CD4 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNRK Gene



Protein tissue co-expression partners for SNRK Gene

NURSA nuclear receptor signaling pathways regulating expression of SNRK Gene:

SNRK

SOURCE GeneReport for Unigene cluster for SNRK Gene:

Hs.476052

mRNA Expression by UniProt/SwissProt for SNRK Gene:

Q9NRH2-SNRK_HUMAN
Tissue specificity: Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.

Evidence on tissue expression from TISSUES for SNRK Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with SNRK: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNRK Gene

Orthologs for SNRK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNRK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRK 34 35
  • 99.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SNRK 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNRK 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRK 34 35
  • 88.62 (n)
cow
(Bos Taurus)
Mammalia SNRK 34 35
  • 86.44 (n)
mouse
(Mus musculus)
Mammalia Snrk 34 16 35
  • 84.25 (n)
rat
(Rattus norvegicus)
Mammalia Snrk 34
  • 83.98 (n)
chicken
(Gallus gallus)
Aves SNRK 34 35
  • 80.7 (n)
lizard
(Anolis carolinensis)
Reptilia SNRK 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snrk 34
  • 76.57 (n)
zebrafish
(Danio rerio)
Actinopterygii snrka 34 35
  • 70 (n)
zgc73231 34
fruit fly
(Drosophila melanogaster)
Insecta CG8485 35
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK524.4 35
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCC4 35
  • 17 (a)
ManyToMany
GIN4 35
  • 16 (a)
ManyToMany
HSL1 35
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 70 (a)
OneToOne
Species where no ortholog for SNRK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNRK Gene

ENSEMBL:
Gene Tree for SNRK (if available)
TreeFam:
Gene Tree for SNRK (if available)

Paralogs for SNRK Gene

Paralogs for SNRK Gene

genes like me logo Genes that share paralogs with SNRK: view

Variants for SNRK Gene

Sequence variations from dbSNP and Humsavar for SNRK Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs368877591 An ovarian mucinous carcinoma sample 43,348,090(+) CCAGC(A/G)GCTCG nc-transcript-variant, reference, missense
VAR_041099 An ovarian serous carcinoma sample
VAR_041100 A breast pleomorphic lobular carcinoma sample
rs1000008736 -- 43,288,983(+) TATTC(A/G)TGGAA intron-variant
rs1000024042 -- 43,294,764(+) TGACC(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNRK Gene

Variant ID Type Subtype PubMed ID
dgv8298n54 CNV loss 21841781
dgv8299n54 CNV gain 21841781
dgv8300n54 CNV gain 21841781
esv22433 CNV loss 19812545
esv2752008 CNV gain 17911159
esv3561802 CNV deletion 23714750
esv3596011 CNV gain 21293372
nsv1009102 CNV gain 25217958
nsv1072252 CNV deletion 25765185
nsv1144988 CNV deletion 24896259
nsv590156 CNV gain+loss 21841781
nsv590159 CNV gain+loss 21841781
nsv590160 CNV loss 21841781

Variation tolerance for SNRK Gene

Residual Variation Intolerance Score: 5.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNRK Gene

Human Gene Mutation Database (HGMD)
SNRK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNRK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRK Gene

Disorders for SNRK Gene

Relevant External Links for SNRK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNRK

No disorders were found for SNRK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRK Gene

Publications for SNRK Gene

  1. Cloning and characterization of human and mouse SNRK sucrose non- fermenting protein (SNF-1)-related kinases. (PMID: 12234663) Kertesz N. … Labastie M.-C. (Gene 2002) 3 4 22 64
  2. Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases. (PMID: 8654423) Becker W. … Joost H.G. (Eur. J. Biochem. 1996) 2 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4 64
  4. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. (PMID: 15733851) Jaleel M. … Alessi D.R. (FEBS Lett. 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SNRK Gene

Sources for SNRK Gene

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