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SNORD63 Gene(RNA Gene)

Small Nucleolar RNA, C/D Box 63

GCID:
GC05M138561
GIFtS:
24
Genes Participants
UDN Logo

Aliases for SNORD63 Gene

Subcategory (RNA class) for SNORD63 Gene

snoRNA

Quality Score for this RNA gene is

3

Aliases for SNORD63 Gene

  • Small Nucleolar RNA, C/D Box 63 2 3 5
  • RNA, U63 Small Nucleolar 2 3
  • SNORD63A 3
  • RNU63 3
  • U63 3

External Ids for SNORD63 Gene

ORGUL Members for SNORD63 Gene

Previous HGNC Symbols for SNORD63 Gene

  • RNU63

Previous GeneCards Identifiers for SNORD63 Gene

  • GC05M137926
  • GC05M133087
  • GC05M137897
  • GC05M137901

Summaries for SNORD63 Gene

GeneCards Summary for SNORD63 Gene

SNORD63 (Small Nucleolar RNA, C/D Box 63) is an RNA Gene, and is affiliated with the snoRNA class. Diseases associated with SNORD63 include Ablepharon-Macrostomia Syndrome.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNORD63 Gene

Genomics for SNORD63 Gene

Products:

  1. Regulatory Element

Regulatory Elements for SNORD63 Gene

Enhancers for SNORD63 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G138458 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +101.7 101651 2.0 ELF3 PKNOX1 ATF1 MLX ARID4B DNMT3B ZSCAN9 RARA SLC30A9 IKZF2 REEP2 ENSG00000222937 SNORD63 HSPA9 LRRTM2 CDC25C FAM53C FAM13B ETF1 EGR1
GH05G138695 1.6 Ensembl ENCODE dbSUPER 10.2 -135.3 -135335 1.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 FOS LOC105379194 HNRNPA0 CDC23 KDM3B CTNNA1 HSPA9 SNORD63 ENSG00000222937 ENSG00000238745
GH05G138438 1.2 ENCODE dbSUPER 10.9 +121.8 121769 1.9 RB1 AGO1 ZFP64 ZEB1 ZNF23 GLIS2 EGR1 ZNF366 ZNF391 EGR2 ENSG00000222937 SNORD63 HSPA9 REEP2 GC05P138442
GH05G138461 1.1 FANTOM5 Ensembl dbSUPER 11.6 +99.7 99673 0.5 RAD51 USF2 MAX NFYC PRDM10 PRDM1 REEP2 ENSG00000222937 SNORD63 HSPA9 FAM53C ETF1 GC05M138244 EGR1
GH05G139310 1.3 Ensembl ENCODE dbSUPER 9.7 -749.8 -749801 0.8 KLF1 ZNF2 RAD21 ZFHX2 ZNF366 SMC3 FOS ZNF600 PRDM10 EGR2 MATR3 PAIP2 SNORA74A SLC23A1 HSPA9 ENSG00000222937 SNORD63 PIR61462 RN7SKP64
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNORD63 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SNORD63 gene promoter:

Genomic Location for SNORD63 Gene

Chromosome:
5
Start:
138,561,043 bp from pter
End:
138,561,110 bp from pter
Size:
68 bases
Orientation:
Minus strand

Genomic View for SNORD63 Gene

Genes around SNORD63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORD63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORD63 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SNORD63 Gene

Proteins for SNORD63 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for SNORD63 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORD63 Gene

Domains & Families for SNORD63 Gene

Gene Families for SNORD63 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORD63: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORD63 Gene

Function for SNORD63 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORD63 Gene

Localization for SNORD63 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNORD63 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SNORD63 Gene

Pathways & Interactions for SNORD63 Gene

SuperPathways for SNORD63 Gene

PathCards logo More details on SuperPathways for SNORD63
No Data Available

Interacting Proteins for SNORD63 Gene

Gene Ontology (GO) - Biological Process for SNORD63 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORD63 Gene

Drugs & Compounds for SNORD63 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SNORD63 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SNORD63 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNORD63 Gene

No ASD Table

Relevant External Links for SNORD63 Gene

GeneLoc Exon Structure for
SNORD63
ECgene alternative splicing isoforms for
SNORD63

Expression for SNORD63 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNORD63 Gene

mRNA expression in normal human tissues for SNORD63 Gene
mRNA expression by GTEx for SNORD63 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNORD63 Gene:

SNORD63
genes like me logo Genes that share expression patterns with SNORD63: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORD63 Gene

Orthologs for SNORD63 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORD63 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SNORD63 35
  • 100 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Gm26109 35
  • 83 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SNORD63 35
  • 80 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia SNORD63 35
  • 78 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia SNORD63 35
  • 75 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia SNORD63 35
  • 65 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves SNORD63 35
  • 74 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia SNORD63 35
  • 72 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii SNORD63 35
  • 66 (a)
 OneToMany
Species where no ortholog for SNORD63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNORD63 Gene

ENSEMBL:
Gene Tree for SNORD63 (if available)
TreeFam:
Gene Tree for SNORD63 (if available)

Paralogs for SNORD63 Gene

No data available for Paralogs for SNORD63 Gene

Variants for SNORD63 Gene

Sequence variations from dbSNP and Humsavar for SNORD63 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1002495043 -- 138,561,446(+) GAATT(A/C)TTTAG intron-variant, upstream-variant-2KB
rs1002530522 -- 138,562,615(+) ATAAA(A/G)TTTAT intron-variant, upstream-variant-2KB
rs1002587916 -- 138,562,278(+) GGTGC(A/G)GTGGC intron-variant, upstream-variant-2KB
rs1004400214 -- 138,560,843(+) GTACC(C/T)GGCCT intron-variant, downstream-variant-500B
rs1005758071 -- 138,560,784(+) ACCTC(A/G)TGATC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SNORD63 Gene

Variant ID Type Subtype PubMed ID
nsv599818 CNV loss 21841781

Relevant External Links for SNORD63 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORD63

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORD63 Gene

Disorders for SNORD63 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNORD63 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ablepharon-macrostomia syndrome
  • ablepharon macrostomia syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SNORD63

Genetic Association Database (GAD)
SNORD63
Human Genome Epidemiology (HuGE) Navigator
SNORD63
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNORD63
genes like me logo Genes that share disorders with SNORD63: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNORD63 Gene

Publications for SNORD63 Gene

  1. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PMID: 19240791) Graubert T.A. … Walter M.J. (PLoS ONE 2009) 3 46 64
  2. A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus. (PMID: 8962077) Tycowski K.T. … Steitz J.A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 64
  3. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G. … Montanini B. (Genomics 2009) 3 64

Products for SNORD63 Gene

Sources for SNORD63 Gene

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