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Aliases for SNORD46 Gene

Subcategory (RNA class) for SNORD46 Gene

snoRNA

Quality Score for this RNA gene is

11.2

Aliases for SNORD46 Gene

  • Small Nucleolar RNA, C/D Box 46 2 3
  • RNA, U46 Small Nuclear 2 3
  • RNA, U40 Small Nuclear 2 3
  • RNA, U40 Small Nucleolar 3
  • U40 Small Nucleolar RNA 3
  • U40 SnoRNA 3
  • RNU40 3
  • RNU46 3
  • U40 3
  • U46 3

External Ids for SNORD46 Gene

Previous Symbols for SNORD46 Gene

  • RNU46
  • RNU40

Summaries for SNORD46 Gene

GeneCards Summary for SNORD46 Gene

SNORD46 (Small Nucleolar RNA, C/D Box 46) is a RNA Gene, and belongs to snoRNA RNA class.

fRNAdb sequence ontologies for SNORD46 Gene - the ORGUL cluster for this gene includes several descriptions:

  • C_D_box_snoRNA: Most box C/D snoRNAs also contain long (>10 nt) sequences complementary to rRNA. Boxes C and D, as well as boxes C' and D', are usually located in close proximity, and form a structure known as the box C/D motif. This motif is important for snoRNA stability, processing, nucleolar targeting and function. A small number of box C/D snoRNAs are involved in rRNA processing; most, however, are known or predicted to serve as guide RNAs in ribose methylation of rRNA. Targeting involves direct base pairing of the snoRNA at the rRNA site to be modified and selection of a rRNA nucleotide a fixed distance from box D or D'.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • Small nucleolar RNA SNORD46: U40 is a C/D box small nucleolar RNA, also known as snoZ153 in plants. The human sequence has also been annotated in the sequence databases as U46. U40 is encoded in intron 2 of the ribosomal protein S8 gene in human, and is hypothesised to guide methylation of 2'-O-ribose residues on 28S ribosomal RNA [1].

View fRNAdb secondary structures for SNORD46

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORD46 Gene

Genomics for SNORD46 Gene

Genomic Location for SNORD46 Gene

Start:
44,776,490 bp from pter
End:
44,776,593 bp from pter
Size:
104 bases
Orientation:
Plus strand

Genomic View for SNORD46 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNORD46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORD46 Gene

Regulatory Elements for SNORD46 Gene

ORGUL Member Location for SNORD46 Gene

ORGUL Member Location for SNORD46 gene

Proteins for SNORD46 Gene

Post-translational modifications for SNORD46 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORD46 Gene

Domains for SNORD46 Gene

Gene Families for SNORD46 Gene

HGNC:
  • SNORD :ncRNAs / Small nucleolar RNAs : C/D box containing
genes like me logo Genes that share domains with SNORD46: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for SNORD46 Gene

Function for SNORD46 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SNORD46 Gene

Localization for SNORD46 Gene

No data available for Gene Ontology (GO) - Cellular Components for SNORD46 Gene

Pathways for SNORD46 Gene

SuperPathways for SNORD46 Gene

No Data Available

Interacting Proteins for SNORD46 Gene

Gene Ontology (GO) - Biological Process for SNORD46 Gene

None

No data available for Pathways by source for SNORD46 Gene

Transcripts for SNORD46 Gene

fRNAdb Secondary structures for SNORD46 Gene

  • RF00218;SNORD46;DAAB014579303.1/318-383

mRNA/cDNA for SNORD46 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SNORD46 Gene

No ASD Table

Relevant External Links for SNORD46 Gene

GeneLoc Exon Structure for
SNORD46
ECgene alternative splicing isoforms for
SNORD46

Expression for SNORD46 Gene

mRNA expression in normal human tissues for SNORD46 Gene

genes like me logo Genes that share expressions with SNORD46: view

Orthologs for SNORD46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORD46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORD46 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNORD46 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNORD46 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm26330 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNORD46 37
  • 66 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii SNORD46 37
  • 69 (a)
OneToMany
Species with no ortholog for SNORD46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNORD46 Gene

ENSEMBL:
Gene Tree for SNORD46 (if available)
TreeFam:
Gene Tree for SNORD46 (if available)

Paralogs for SNORD46 Gene

No data available for Paralogs for SNORD46 Gene

Variants for SNORD46 Gene

Structural Variations from Database of Genomic Variants (DGV) for SNORD46 Gene

Variant ID Type Subtype PubMed ID
nsv461406 CNV Loss 19166990
nsv870815 CNV Loss 21882294

Relevant External Links for SNORD46 Gene

HapMap Linkage Disequilibrium report
SNORD46

No data available for Sequence variations from dbSNP and Humsavar for SNORD46 Gene

Disorders for SNORD46 Gene

No disorders were found for SNORD46 Gene.

No data available for UniProtKB/Swiss-Prot for SNORD46 Gene

Publications for SNORD46 Gene

  1. Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. (PMID: 8674114) Kiss-LA!szlA^ Z. … Kiss T. (Cell 1996) 2 3
  2. Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs. (PMID: 8764399) Nicoloso M. … Bachellerie J.P. (J. Mol. Biol. 1996) 2 3
  3. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G. … Montanini B. (Genomics 2009) 3
  4. A study of the transfer of insulin-requiring diabetic patients from U-40 to U-100 Lente insulin. (PMID: 1606943) Abdulkadir J. … Bekele G. (Ethiop. Med. J. 1992) 23

Products for SNORD46 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate SNORD46
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SNORD46
    • Block miRNA regulation of SNORD46 using miScript Target Protectors

    Sources for SNORD46 Gene

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