Subcategory (RNA class) for SNORD42A Gene
Quality Score for this RNA gene is
Aliases for SNORD42A Gene
ORGUL Members for SNORD42A Gene
Previous HGNC Symbols for SNORD42A Gene
Previous GeneCards Identifiers for SNORD42A Gene
GeneCards Summary for SNORD42A Gene
SNORD42A (Small Nucleolar RNA, C/D Box 42A) is an RNA Gene, and is affiliated with the snoRNA class.
fRNAdb sequence ontologies for SNORD42A Gene - the ORGUL cluster for this gene includes several descriptions:
C_D_box_snoRNA: Most box C/D snoRNAs also contain long (>10 nt) sequences complementary to rRNA. Boxes C and D, as well as boxes C' and D', are usually located in close proximity, and form a structure known as the box C/D motif. This motif is important for snoRNA stability, processing, nucleolar targeting and function. A small number of box C/D snoRNAs are involved in rRNA processing; most, however, are known or predicted to serve as guide RNAs in ribose methylation of rRNA. Targeting involves direct base pairing of the snoRNA at the rRNA site to be modified and selection of a rRNA nucleotide a fixed distance from box D or D'.
Small nucleolar RNA SNORD42: snoRNA U42 is found in intron 3 of the ribosomal protein L23a (RPL23a) gene in humans and is also present in mice. U42 is a member of the C/D class of snoRNA which contain C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. Although the selection of the target nucleotide requires the antisense element and the conserved box D or D' of the snoRNA, the methyltransferase activity is supposed to reside in one of the protein components .