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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SNORD22 Gene

RNA gene GIFtS: 27
GCID: GC11M062664

small nucleolar RNA, C/D box 22

(Previous names: RNA, U22 small nucleolar )
(Previous symbol: RNU22)

Explore 1 disease affiliated with
SNORD22 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Subcategory (RNA class): snoRNA

Quality score for this RNA gene is 5

Aliases
Small Nucleolar RNA, C/D Box 22¹ ²
RNU22¹ ²
U22¹ ²
RNA, U22 Small Nucleolar¹

External Ids:	HGNC: 10145¹	Entrez Gene: 9304²	Ensembl: ENSG00000207487⁷	OMIM: 603223⁵

ORGUL members:	fRNAdb¹⁰:FR090187 FR067111
	NCBI:L36588 U40580
	NONCODE:u3996
	Rfam:RF00099

Export aliases for SNORD22 gene to outside databases

Previous GC identifers: GC11M062393 GC11M062401 GC11M062411 GC11M062420 GC11M062621 GC11M058949

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

fRNAdb sequence ontology for SNORD22:
C_D_box_snoRNA - Most box C/D snoRNAs also contain long (>10 nt) sequences complementary to rRNA. Boxes C and D, as well as boxes C' and D', are usually located in close proximity, and form a structure known as the box C/D motif. This motif is important for snoRNA stability, processing, nucleolar targeting and function. A small number of box C/D snoRNAs are involved in rRNA processing; most, however, are known or predicted to serve as guide RNAs in ribose methylation of rRNA. Targeting involves direct base pairing of the snoRNA at the rRNA site to be modified and selection of a rRNA nucleotide a fixed distance from box D or D'.

View fRNAdb secondary structures for SNORD22

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SNORD22 gene promoter:
AP-1 SREBP-1c ATF-2 c-Jun SREBP-1b
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNORD22

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q13

SNORD22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNORD22 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M062664: view genomic region (about GC identifiers)

Start:	62,620,382 bp from pter	End:	62,620,507 bp from pter
Size:	126 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB: --

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SNORD22

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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About This Section

1 fRNAdb Secondary structure:

Unigene Cluster for SNORD22:

Small nucleolar RNA, C/D box 22

Hs.744737

Unigene Representative Sequence: NR_000008

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000384756(snoRNA)

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Additional cDNA sequence: NR_000008.2

24/522 AceView cDNA sequences (see all 522):

CR596891 CB996795 AA603777 BQ003499 BX091505 BM760031 CR603342 CD655154

CB128239 F24755 CB159240 BQ372739 BC011809 W05671 AI127678 CA426113

BI768134 BM772174 BM747357 CR621214 AA346840 BQ719301 AI440477 BM745770

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for SNORD22:none

SNORD22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTACTCTC

About this image
Genevestigator expression for SNORD22

SOURCE GeneReport for Unigene cluster: Hs.744737

SABiosciences Custom PCR Arrays for SNORD22

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for SNORD22 gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Snord22⁵	small nucleolar RNA, C/D box 22	--		19 (5.44 cM) 8725866

ENSEMBL Gene Tree for SNORD22 (if available)
TreeFam Gene Tree for SNORD22 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SNORD22 gene

ENSG00000252140² ENSG00000252365²

SNORD22 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148691220^1,2		--	62619886(+)	`CCTGGA/GTAACA`	2	--	nc-transcript-variantds500¹		0	--	--	--	--
rs182674853^1,2		--	62619908(+)	`TTGTAC/TCTAAA`	2	--	nc-transcript-variantds500¹		0	--	--	--	--
rs480730^1,2	H	--	62619990(+)	`ACACAG/CCAAAC`	2	--	nc-transcript-variantds500¹		4		NS EA	416
rs141304748^1,2		--	62619992(+)	`ACAGCA/TAACCC`	2	--	ds500¹ nc-transcript-variant		0	--	--	--	--
rs2071036^1,2	C,F,A,H,	--	62620037(-)	`GCAGAC/TACAGA`	2	--	ds500¹ nc-transcript-variant		29		EA NS NA WA	4120
rs35824901^1,2	C,	--	62620163(+)	`GAGGT-/AAAAAA`	2	--	int¹ ds500¹		1		NA	2
rs71056571^1,2	C	--	62620164(+)	`AAAAAA/-GTTCT`	2	--	ds500¹ int¹		1		NA	2
rs150775678^1,2		--	62620205(+)	`TGAACA/CCAATA`	2	--	ds500¹ int¹		0	--	--	--	--
rs139131039^1,2		--	62620246(+)	`TTGCTA/GTTATA`	2	--	int¹ ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SNORD22 (62620382 - 62620507 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SNORD22
1 CNV: 0150

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SNORD22 for disorders           About GeneDecksing

OMIM gene information: 603223 603222
1 disease for SNORD22:    About MalaCards

b-cell lymphomas

Export disorders for SNORD22 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SNORD22 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SNORD22)

Utopia: connect your pdf to the dynamic
world of online information

The U22 host gene (UHG): chromosomal localization of UHG and distribution of U22 small nucleolar RNA. (PubMed id 9387929)^{1, 3, 9} Frey M.R....Matera A.G. (1997)
A mammalian gene with introns instead of exons generating stable RNA products. (PubMed id 8559254)^{1, 3, 9} Tycowski K.T....Steitz J.A. (1996)
Requirement for intron-encoded U22 small nucleolar RNA in 18S ribosomal RNA maturation. (PubMed id 7985025)^{1, 9} Tycowski K.T....Steitz J.A. (1994)
Eukaryotic snoRNAs: a paradigm for gene expression fl exibility. (PubMed id 19446021)¹ Dieci G....Montanini B. (2009)
Intronic U50 small-nucleolar-RNA (snoRNA) host gene of no protein-coding potential is mapped at the chromosome breakpoint t(3;6)(q27;q15) of human B-cell lymphoma. (PubMed id 10792466)⁹ Tanaka R....Mori S. (2000)
Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes. (PubMed id 9819378)⁹ Smith C.M. and Steitz J.A. (1998)
(PubMed id 8797828)¹⁰
(PubMed id 10736225)¹⁰
(PubMed id 15608158)¹⁰

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9304	HGNC: 10145	AceView: RNU22	Ensembl:ENSG00000207487	euGenes: HUgn9304
ECgene: SNORD22	H-InvDB: SNORD22

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SNORD22	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SNORD22 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SNORD22 gene:
Search GeneIP for patents involving SNORD22

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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SNORD22 Gene

small nucleolar RNA, C/D box 22

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SNORD22 Gene

small nucleolar RNA, C/D box 22

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