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Aliases for SNORD118 Gene

Subcategory (RNA class) for SNORD118 Gene

snoRNA

Quality Score for this RNA gene is

3

Aliases for SNORD118 Gene

  • Small Nucleolar RNA, C/D Box 118 2 3 5
  • LCC 3
  • U8 3

External Ids for SNORD118 Gene

ORGUL Members for SNORD118 Gene

Previous GeneCards Identifiers for SNORD118 Gene

  • GC17U900626
  • GC17M008078
  • GC17M008079
  • GC17M008081
  • GC17M008083
  • GC17M008088
  • GC17M008114
  • GC17M008189
  • GC17M008238
  • GC17M008274
  • GC17M008300
  • GC17M008338
  • GC17M008367
  • GC17M008408

Summaries for SNORD118 Gene

GeneCards Summary for SNORD118 Gene

SNORD118 (Small Nucleolar RNA, C/D Box 118) is an RNA Gene, and is affiliated with the snoRNA class. Diseases associated with SNORD118 include Leukoencephalopathy, Brain Calcifications, And Cysts.

Additional gene information for SNORD118 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNORD118 Gene

Genomics for SNORD118 Gene

Regulatory Elements for SNORD118 Gene

Enhancers for SNORD118 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H008117 1.4 ENCODE dbSUPER 11.7 +52.3 52321 7 FEZF1 YY1 ZNF143 SP3 ZFP41 SSRP1 ZNF610 GLIS1 RCOR2 NBN NEURL4 SENP3 DVL2 NLGN2 PFAS ENSG00000265749 HES7 LOC100996842 ZBTB4 CTC1
GH17H008126 1.3 ENCODE dbSUPER 12.4 +47.0 46999 2 HDGF ARID4B SIN3A FEZF1 ZNF2 ZNF143 ZNF207 FOS DEK SP3 NEURL4 SENP3 DVL2 PFAS ENSG00000265749 LOC100996842 HES7 PER1 POLR2A SNORD10
GH17H008199 1.2 Ensembl ENCODE 11.6 -26.8 -26755 1 HDGF ZNF133 ZNF2 YY1 ZNF121 GLIS2 KLF7 ATF7 SP3 YY2 LINC00324 TMEM107 SNORD118 PFAS CTC1 ENSG00000271002 GC17P008239
GH17H008195 1.2 Ensembl ENCODE 11.6 -22.6 -22623 1 HDGF PKNOX1 TBL1XR1 RB1 SIN3A YBX1 BATF RAD21 THRB RARA LINC00324 SNORD118 VAMP2 ENSG00000271002 BORCS6
GH17H008109 1.1 Ensembl ENCODE 10.7 +63.7 63684 1 HDGF ATF1 RB1 NFIB ZNF2 RAD21 ZNF143 ATF7 RUNX3 SMARCA5 ALOXE3 ALOX12B LOC107985075 ALOX15B SNORD118 TMEM107 CNTROB TRAPPC1 KCNAB3 PFAS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNORD118 on UCSC Golden Path with GeneCards custom track

Promoters for SNORD118 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000282324 -112 1001 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC

Genomic Location for SNORD118 Gene

Chromosome:
17
Start:
8,173,453 bp from pter
End:
8,173,588 bp from pter
Size:
136 bases
Orientation:
Minus strand

Genomic View for SNORD118 Gene

Genes around SNORD118 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORD118 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORD118 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORD118 Gene

Proteins for SNORD118 Gene

Post-translational modifications for SNORD118 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORD118 Gene

Domains & Families for SNORD118 Gene

Gene Families for SNORD118 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORD118: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORD118 Gene

Function for SNORD118 Gene

Phenotypes From GWAS Catalog for SNORD118 Gene

Human Phenotype Ontology for SNORD118 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for SNORD118
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORD118 Gene

Localization for SNORD118 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNORD118 Gene

Pathways & Interactions for SNORD118 Gene

SuperPathways for SNORD118 Gene

No Data Available

Interacting Proteins for SNORD118 Gene

Gene Ontology (GO) - Biological Process for SNORD118 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORD118 Gene

Drugs & Compounds for SNORD118 Gene

No Compound Related Data Available

Transcripts for SNORD118 Gene

mRNA/cDNA for SNORD118 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for SNORD118
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SNORD118 Gene

No ASD Table

Relevant External Links for SNORD118 Gene

GeneLoc Exon Structure for
SNORD118
ECgene alternative splicing isoforms for
SNORD118

Expression for SNORD118 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNORD118 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNORD118 Gene:

SNORD118
genes like me logo Genes that share expression patterns with SNORD118: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORD118 Gene

Orthologs for SNORD118 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORD118 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U8 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia U8 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia U8 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm25369 34
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia U8 34
  • 63 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea U8 34
  • 52 (a)
OneToMany
Species where no ortholog for SNORD118 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SNORD118 Gene

ENSEMBL:
Gene Tree for SNORD118 (if available)
TreeFam:
Gene Tree for SNORD118 (if available)

Paralogs for SNORD118 Gene

No data available for Paralogs for SNORD118 Gene

Variants for SNORD118 Gene

Sequence variations from dbSNP and Humsavar for SNORD118 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs201787275 Pathogenic 8,173,444(+) TGATC(A/C/G)TCAGA downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs747057554 Pathogenic 8,173,566(+) CAGGT(-/A)AAGGA nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs75008470 Pathogenic 8,173,448(+) CGTCA(A/C/G/T)AAAGA downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs752171066 Pathogenic 8,174,573(+) AATAT(-/GAA)GAAGG upstream-variant-2KB, cds-indel
rs755495846 Pathogenic 8,173,531(+) AATCA(A/C/G/T)CATGT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SNORD118 Gene

Variant ID Type Subtype PubMed ID
nsv1964 CNV insertion 18451855
nsv527475 CNV loss 19592680
nsv827879 CNV gain 20364138
nsv833352 CNV loss 17160897
nsv833353 CNV loss 17160897

Relevant External Links for SNORD118 Gene

Human Gene Mutation Database (HGMD)
SNORD118
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORD118

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORD118 Gene

Disorders for SNORD118 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNORD118 Gene - From: OMIM and ClinVar

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SNORD118

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNORD118
genes like me logo Genes that share disorders with SNORD118: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNORD118 Gene

Publications for SNORD118 Gene

  1. U3, U8 and U13 comprise a new class of mammalian snRNPs localized in the cell nucleolus. (PMID: 2531075) Tyc K … Steitz JA (The EMBO journal 1989) 2 3 60
  2. Primary and secondary structure of U8 small nuclear RNA. (PMID: 2411727) Reddy R … Busch H (The Journal of biological chemistry 1985) 2 3 60
  3. Leukoencephalopathy with calcification and cysts: A cerebral microangiopathy caused by mutations in SNORD118. (PMID: 27793341) Livingston JH … Crow YJ (Journal of the neurological sciences 2017) 3 60
  4. Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts. (PMID: 27571260) Jenkinson EM … Crow YJ (Nature genetics 2016) 3 60
  5. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G … Montanini B (Genomics 2009) 3 60

Products for SNORD118 Gene

Sources for SNORD118 Gene

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