SNORD115-43 Gene

Aliases
for SNORD115-43 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC15U900709 GC15P023494 GC15P023570 GC15P023673 GC15P003618

Summaries
for SNORD115-43 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for SNORD115-43 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNORD115-43

SNORD115-43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P025494:  view genomic region     (about GC identifiers)

Proteins
for SNORD115-43 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Domains /
Families
for SNORD115-43 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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Function
for SNORD115-43 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Localization
for SNORD115-43 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Pathways & Interactions
for SNORD115-43 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for SNORD115-43 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for SNORD115-43 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for SNORD115-43 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for SNORD115-43:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

Primer Products:		Browse OriGene qPCR
		Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SNORD115-43
		Search QuantiTect SYBR Green Assays in human, mouse, rat SNORD115-43
		Search QuantiFast Probe-based Assays in human, mouse, rat SNORD115-43

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNORD115-43

Orthologs
for SNORD115-43 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for SNORD115-43 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for SNORD115-43 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SNORD115-43 (see all 25)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1923523651,2		--	25493187(+)	GGTCAC/TGCTGG	1	--	us2k1		0	--	--	--	--
rs1857211041,2	C	--	25493193(+)	GCTGGA/GGTTCT	1	--	us2k1		0	--	--	--	--
rs1395529931,2		--	25493246(+)	GCCCCA/GGAGAT	1	--	us2k1		0	--	--	--	--
rs1450543701,2		--	25493256(+)	TTCAGA/GACTGC	1	--	us2k1		0	--	--	--	--
rs118560041,2	C,F,H	--	25493288(+)	GGGACC/TGACCC	1	--	us2k1		5		NA WA CSA	9
rs1402591561,2		--	25493329(+)	TCCTTC/GAGCCT	1	--	us2k1		0	--	--	--	--
rs612432051,2	C	--	25493416(+)	CCCTGA/GGGGTT	1	--	us2k1		0	--	--	--	--
rs1512093481,2	C	--	25493496(+)	AAAGGA/G/TTGTCC	1	--	us2k1		0	--	--	--	--
rs1889813321,2		--	25493573(+)	AGCCAC/TGGGGT	1	--	us2k1		0	--	--	--	--
rs1927078191,2		--	25493709(+)	AAGTAC/TGTGGC	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for SNORD115-43 (25494345 - 25494426 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for SNORD115-43:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2749460	CNV	Deletion	23290073
dgv2286n71	CNV	Loss	21882294
nsv1467	CNV	Loss	18451855
nsv456731	CNV	Loss	19166990
esv33464	CNV	Gain	17666407
nsv903721	CNV	Gain	21882294
esv25915	CNV	Gain+Loss	19812545
nsv517360	CNV	Gain+Loss	19592680
nsv903722	CNV	Gain+Loss	21882294

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing SNORD115-43

DNA2.0 Custom Variant and Variant Library Synthesis for SNORD115-43

Disorders / Diseases
for SNORD115-43 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for SNORD115-43 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A. (PubMed id 11726556)^{1, 3} Runte M....Buiting K. (Hum. Mol. Genet. 2001)
2. Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization. (PubMed id 11106375)^{1, 3} CavaillAc J....HA1ttenhofer A. (Proc. Natl. Acad. Sci. U.S.A. 2000)
3. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PubMed id 19446021)¹ Dieci G....Montanini B. (Genomics 2009)
4. The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C. (PubMed id 16357227)¹ Kishore S. and Stamm S. (Science 2006)
5. Exclusion of the C/D box snoRNA gene cluster HBII-52 from a major role in Prader-Willi syndrome. (PubMed id 15565282)¹ Runte M....Buiting K. (Hum. Genet. 2005)
6. ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs. (PubMed id 15939761)¹ Vitali P....Huttenhofer A. (J. Cell Biol. 2005)
7. Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region. (PubMed id 12045206)¹ CavaillAc J....Bachellerie J.P. (Hum. Mol. Genet. 2002)

External Searches for SNORD115-43 gene

Genome Databases showing SNORD115-43 gene

Other Databases showing SNORD115-43 gene

Specialized Databases showing SNORD115-43 gene

Products
for SNORD115-43 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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