Subcategory (RNA class) for SNORD115-37 Gene
Quality Score for this RNA gene is
ORGUL Members for SNORD115-37 Gene
Previous GeneCards Identifiers for SNORD115-37 Gene
GeneCards Summary for SNORD115-37 Gene
SNORD115-37 (Small Nucleolar RNA, C/D Box 115-37) is an RNA Gene, and is affiliated with the snoRNA class. Diseases associated with SNORD115-37 include prader-willi syndrome.
fRNAdb sequence ontologies for SNORD115-37 Gene - the ORGUL cluster for this gene includes several descriptions:
C_D_box_snoRNA: Most box C/D snoRNAs also contain long (>10 nt) sequences complementary to rRNA. Boxes C and D, as well as boxes C' and D', are usually located in close proximity, and form a structure known as the box C/D motif. This motif is important for snoRNA stability, processing, nucleolar targeting and function. A small number of box C/D snoRNAs are involved in rRNA processing; most, however, are known or predicted to serve as guide RNAs in ribose methylation of rRNA. Targeting involves direct base pairing of the snoRNA at the rRNA site to be modified and selection of a rRNA nucleotide a fixed distance from box D or D'.
Small nucleolar RNA SNORD115: HBII-52 is a member of the C/D class of snoRNAs, which contain the C (UGAUGA) and D (CUGA) box motifs. HBII-52 is encoded in a tandemly repeated array with another C/D snoRNA, HBII-85, in the Prader-Willi syndrome (PWS) region of chromosome 15. HBII-52 is exclusively expressed in the brain but is absent in PWS patients. HBII-52 lacks any significant complementarity with ribosomal RNAs, but does have an 18-nt region of conserved complementarity to serotonin 2C receptor mRNA.