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Aliases for SNORD115-37 Gene

Subcategory (RNA class) for SNORD115-37 Gene

snoRNA

Quality Score for this RNA gene is

6

Aliases for SNORD115-37 Gene

  • Small Nucleolar RNA, C/D Box 115-37 2 3
  • HBII-52-37 3

External Ids for SNORD115-37 Gene

ORGUL Members for SNORD115-37 Gene

Summaries for SNORD115-37 Gene

GeneCards Summary for SNORD115-37 Gene

SNORD115-37 (Small Nucleolar RNA, C/D Box 115-37) is a RNA Gene, and belongs to snoRNA RNA class.

fRNAdb sequence ontologies for SNORD115-37 Gene - the ORGUL cluster for this gene includes several descriptions:

  • C_D_box_snoRNA: Most box C/D snoRNAs also contain long (>10 nt) sequences complementary to rRNA. Boxes C and D, as well as boxes C' and D', are usually located in close proximity, and form a structure known as the box C/D motif. This motif is important for snoRNA stability, processing, nucleolar targeting and function. A small number of box C/D snoRNAs are involved in rRNA processing; most, however, are known or predicted to serve as guide RNAs in ribose methylation of rRNA. Targeting involves direct base pairing of the snoRNA at the rRNA site to be modified and selection of a rRNA nucleotide a fixed distance from box D or D'.

  • Small nucleolar RNA SNORD115: HBII-52 is a member of the C/D class of snoRNAs, which contain the C (UGAUGA) and D (CUGA) box motifs. HBII-52 is encoded in a tandemly repeated array with another C/D snoRNA, HBII-85, in the Prader-Willi syndrome (PWS) region of chromosome 15. HBII-52 is exclusively expressed in the brain but is absent in PWS patients. HBII-52 lacks any significant complementarity with ribosomal RNAs, but does have an 18-nt region of conserved complementarity to serotonin 2C receptor mRNA.

View fRNAdb secondary structures for SNORD115-37

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORD115-37 Gene

Genomics for SNORD115-37 Gene

Genomic Location for SNORD115-37 Gene

Start:
25,237,986 bp from pter
End:
25,238,067 bp from pter
Size:
82 bases
Orientation:
Plus strand

Genomic View for SNORD115-37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNORD115-37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORD115-37 Gene

Regulatory Elements for SNORD115-37 Gene

ORGUL Member Location for SNORD115-37 Gene

ORGUL Member Location for SNORD115-37 gene

Proteins for SNORD115-37 Gene

Post-translational modifications for SNORD115-37 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORD115-37 Gene

Domains for SNORD115-37 Gene

Gene Families for SNORD115-37 Gene

HGNC:
  • SNORD :ncRNAs / Small nucleolar RNAs : C/D box containing
genes like me logo Genes that share domains with SNORD115-37: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for SNORD115-37 Gene

Function for SNORD115-37 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SNORD115-37 Gene

Localization for SNORD115-37 Gene

No data available for Gene Ontology (GO) - Cellular Components for SNORD115-37 Gene

Pathways for SNORD115-37 Gene

SuperPathways for SNORD115-37 Gene

No Data Available

Interacting Proteins for SNORD115-37 Gene

Gene Ontology (GO) - Biological Process for SNORD115-37 Gene

None

No data available for Pathways by source for SNORD115-37 Gene

Transcripts for SNORD115-37 Gene

fRNAdb Secondary structures for SNORD115-37 Gene

  • RF00105;SNORD115;AEKP01177458.1/5653-5572

mRNA/cDNA for SNORD115-37 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SNORD115-37 Gene

No ASD Table

Relevant External Links for SNORD115-37 Gene

GeneLoc Exon Structure for
SNORD115-37
ECgene alternative splicing isoforms for
SNORD115-37

Expression for SNORD115-37 Gene

mRNA expression in normal human tissues for SNORD115-37 Gene

genes like me logo Genes that share expressions with SNORD115-37: view

Orthologs for SNORD115-37 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SNORD115-37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORD115 37
  • 100 (a)
OneToOne
Species with no ortholog for SNORD115-37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SNORD115-37 Gene

ENSEMBL:
Gene Tree for SNORD115-37 (if available)
TreeFam:
Gene Tree for SNORD115-37 (if available)

Paralogs for SNORD115-37 Gene

No data available for Paralogs for SNORD115-37 Gene

Variants for SNORD115-37 Gene

Sequence variations from dbSNP and Humsavar for SNORD115-37 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2714761 -- 25,236,876(+) CCCAC(A/G)GCCCT upstream-variant-2KB
rs2719912 -- 25,237,623(+) CTGTT(A/C)CTCCA upstream-variant-2KB
rs2719913 -- 25,237,790(+) CCTCT(A/G)GTCCC upstream-variant-2KB
rs11857244 -- 25,237,641(+) GTGGC(A/G)GGGAG upstream-variant-2KB
rs11857390 -- 25,237,383(+) GCCCA(C/T)CATGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNORD115-37 Gene

Variant ID Type Subtype PubMed ID
nsv903722 CNV Gain+Loss 21882294
esv33464 CNV Gain 17666407
esv25915 CNV Gain+Loss 19812545
nsv517360 CNV Gain+Loss 19592680
dgv2286n71 CNV Loss 21882294
nsv1467 CNV Loss 18451855

Relevant External Links for SNORD115-37 Gene

HapMap Linkage Disequilibrium report
SNORD115-37

Disorders for SNORD115-37 Gene

No disorders were found for SNORD115-37 Gene.

No data available for UniProtKB/Swiss-Prot for SNORD115-37 Gene

Publications for SNORD115-37 Gene

  1. Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization. (PMID: 11106375) CavaillAc J. … HA1ttenhofer A. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3
  2. The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A. (PMID: 11726556) Runte M. … Buiting K. (Hum. Mol. Genet. 2001) 2 3
  3. Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region. (PMID: 12045206) CavaillAc J. … Bachellerie J.P. (Hum. Mol. Genet. 2002) 3
  4. Exclusion of the C/D box snoRNA gene cluster HBII-52 from a major role in Prader-Willi syndrome. (PMID: 15565282) Runte M. … Buiting K. (Hum. Genet. 2005) 3
  5. ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs. (PMID: 15939761) Vitali P. … Huttenhofer A. (J. Cell Biol. 2005) 3

Products for SNORD115-37 Gene

Sources for SNORD115-37 Gene

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