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SNORD114-26 Gene(RNA Gene)

Small Nucleolar RNA, C/D Box 114-26

GCID:
GC14P102959
GIFtS:
11
Genes Participants
UDN Logo

Aliases for SNORD114-26 Gene

Subcategory (RNA class) for SNORD114-26 Gene

snoRNA

Quality Score for this RNA gene is

7

Aliases for SNORD114-26 Gene

  • Small Nucleolar RNA, C/D Box 114-26 2 3 5
  • 14q(II-26) 3

External Ids for SNORD114-26 Gene

ORGUL Members for SNORD114-26 Gene

Previous GeneCards Identifiers for SNORD114-26 Gene

  • GC14U900711
  • GC14P100550
  • GC14P100890
  • GC14P100975
  • GC14P101453
  • GC14P081637
  • GC14P101154
  • GC14P101332
  • GC14P102018
  • GC14P102268
  • GC14P102442
  • GC14P102616
  • GC14P102782

Summaries for SNORD114-26 Gene

GeneCards Summary for SNORD114-26 Gene

SNORD114-26 (Small Nucleolar RNA, C/D Box 114-26) is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for SNORD114-26 Gene - the ORGUL cluster for this gene includes several descriptions:

  • C_D_box_snoRNA: Most box C/D snoRNAs also contain long (>10 nt) sequences complementary to rRNA. Boxes C and D, as well as boxes C' and D', are usually located in close proximity, and form a structure known as the box C/D motif. This motif is important for snoRNA stability, processing, nucleolar targeting and function. A small number of box C/D snoRNAs are involved in rRNA processing; most, however, are known or predicted to serve as guide RNAs in ribose methylation of rRNA. Targeting involves direct base pairing of the snoRNA at the rRNA site to be modified and selection of a rRNA nucleotide a fixed distance from box D or D'.

  • Small nucleolar RNA SNORD113/SNORD114 family: The imprinted human domain at 14q32 contains two clusters of tandemly repeated small nucleolar RNAs named 14q(I) and 14q(II) snoRNAs. These two clusters are named SNORD113 and SNORD114 respectively in the HGNC approved gene symbol nomenclature. The snoRNAs found in both clusters are clearly related and are represented here by a single family. These snoRNAs are intron encoded and are processed from the tissue-specific non-coding human MEG8 RNA, which lies downstream of the imprinted genes DLK1 and GTL2. snoRNAs 14q(I) and 14q(II) differ from previously identified C/D box snoRNAs in their expression profiles and lack of complementarity to rRNA and snRNA. Homologues of these snoRNAs are found in the imprinted non-coding mouse transcript Rian, and in the rat non-coding Bsr (brain-specific repetitive) RNA.

View fRNAdb secondary structures for SNORD114-26

Additional gene information for SNORD114-26 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORD114-26 Gene

Genomics for SNORD114-26 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for SNORD114-26 Gene


Top Transcription factor binding sites by QIAGEN in the SNORD114-26 gene promoter:

Genomic Locations for SNORD114-26 Gene

Genomic Locations for SNORD114-26 Gene
chr14:100,987,046-100,987,117
(GRCh38/hg38)
Size:
72 bases
Orientation:
Plus strand
chr14:101,453,383-101,453,454
(GRCh37/hg19)

Genomic View for SNORD114-26 Gene

Genes around SNORD114-26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORD114-26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORD114-26 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SNORD114-26 Gene

ORGUL Member Location for SNORD114-26 Gene

ORGUL Member Location for SNORD114-26 gene

Proteins for SNORD114-26 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for SNORD114-26 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORD114-26 Gene

Domains & Families for SNORD114-26 Gene

Gene Families for SNORD114-26 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORD114-26: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORD114-26 Gene

Function for SNORD114-26 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORD114-26 Gene

Localization for SNORD114-26 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNORD114-26 Gene

Pathways & Interactions for SNORD114-26 Gene

SuperPathways for SNORD114-26 Gene

PathCards logo More details on SuperPathways for SNORD114-26
No Data Available

Interacting Proteins for SNORD114-26 Gene

Gene Ontology (GO) - Biological Process for SNORD114-26 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORD114-26 Gene

Drugs & Compounds for SNORD114-26 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SNORD114-26 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

fRNAdb Secondary structures for SNORD114-26 Gene

  • FR283024

mRNA/cDNA for SNORD114-26 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SNORD114-26 Gene

No ASD Table

Relevant External Links for SNORD114-26 Gene

GeneLoc Exon Structure for
SNORD114-26
ECgene alternative splicing isoforms for
SNORD114-26

Expression for SNORD114-26 Gene

Products:

  1. Primer
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORD114-26 Gene

Orthologs for SNORD114-26 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SNORD114-26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SNORD113 34
  • 100 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SNORD113 34
  • 83 (a)
 ManyToMany
Species where no ortholog for SNORD114-26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SNORD114-26 Gene

ENSEMBL:
Gene Tree for SNORD114-26 (if available)
TreeFam:
Gene Tree for SNORD114-26 (if available)

Paralogs for SNORD114-26 Gene

No data available for Paralogs for SNORD114-26 Gene

Variants for SNORD114-26 Gene

Sequence variations from dbSNP and Humsavar for SNORD114-26 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000682247 -- 100,986,391(+) TT/T upstream_transcript_variant
rs1001211985 -- 100,985,435(+) G/A upstream_transcript_variant
rs1001566361 -- 100,985,218(+) G/A upstream_transcript_variant
rs1002303017 -- 100,985,176(+) G/C upstream_transcript_variant
rs1002843673 -- 100,986,857(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNORD114-26 Gene

Variant ID Type Subtype PubMed ID
dgv1972n100 CNV loss 25217958
dgv1973n100 CNV gain+loss 25217958
dgv1974n100 CNV gain 25217958
dgv1975n100 CNV loss 25217958
dgv1976n100 CNV loss 25217958
nsv1052082 CNV loss 25217958
nsv1055067 CNV gain 25217958
nsv565859 CNV gain 21841781

Additional Variant Information for SNORD114-26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORD114-26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORD114-26 Gene

Disorders for SNORD114-26 Gene

Additional Disease Information for SNORD114-26

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SNORD114-26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORD114-26 Gene

Publications for SNORD114-26 Gene

  1. Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region. (PMID: 12045206) Cavaillé J … Bachellerie JP (Human molecular genetics 2002) 1 2 3 58
  2. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G … Montanini B (Genomics 2009) 3 58
  3. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. (PMID: 16381836) Lestrade L … Weber MJ (Nucleic acids research 2006) 1
  4. RNAdb--a comprehensive mammalian noncoding RNA database. (PMID: 15608161) Pang KC … Mattick JS (Nucleic acids research 2005) 1

Products for SNORD114-26 Gene

Sources for SNORD114-26 Gene

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