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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNORD114-2 Gene

RNA gene   GIFtS: 17
GCID: GC14P101418

small nucleolar RNA, C/D box 114-2
 Explore 1 disease affiliated with
SNORD114-2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNORD114-2    

Aliases
for SNORD114-2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Subcategory (RNA class): snoRNA

Quality score for this RNA gene is 4

Aliases
Small Nucleolar RNA, C/D Box 114-21 2
14q(II-2)1 2

External Ids:    HGNC: 329901   Entrez Gene: 7675782   Ensembl: ENSG000002008237   
ORGUL members:    fRNAdb10:FR038256 FR373523      
Rfam:RF00181    

Export aliases for SNORD114-2 gene to outside databases

Previous GC identifers: GC14U900707 GC14P100488 GC14P100862 GC14P100953 GC14P081599


Summaries
for SNORD114-2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
fRNAdb sequence ontology for SNORD114-2:
Small nucleolar RNA SNORD113/SNORD114 family - The imprinted human domain at 14q32 contains two clusters of tandemly repeated small nucleolar RNAs named 14q(I) and 14q(II) snoRNAs. These two clusters are named SNORD113 and SNORD114 respectively in the HGNC approved gene symbol nomenclature. The snoRNAs found in both clusters are clearly related and are represented here by a single family. These snoRNAs are intron encoded and are processed from the tissue-specific non-coding human MEG8 RNA, which lies downstream of the imprinted genes DLK1 and GTL2. snoRNAs 14q(I) and 14q(II) differ from previously identified C/D box snoRNAs in their expression profiles and lack of complementarity to rRNA and snRNA. Homologues of these snoRNAs are found in the imprinted non-coding mouse transcript Rian, and in the rat non-coding Bsr (brain-specific repetitive) RNA.

Genomic Views
for SNORD114-2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNORD114-2 gene promoter:
         HFH-3   FOXF2   Pax-2   Pax-2a   CUTL1   POU3F2   FOXL1   Pax-2b   FOXO1a   FOXO1   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNORD114-2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.31

SNORD114-2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNORD114-2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101418:  view genomic region     (about GC identifiers)

Start:
 101,418,193 bp from pter      End:
 101,418,270 bp from pter
Size:
 78 bases      Orientation:
 plus strand

Proteins
for SNORD114-2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --

Protein Domains /
Families
for SNORD114-2 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for SNORD114-2 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Animal Models:
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miRNA
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Pathways & Interactions
for SNORD114-2 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNORD114-2

Drugs & Compounds
for SNORD114-2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for SNORD114-2
Search CenterWatch for drugs/clinical trials and news about SNORD114-2 

Transcripts
for SNORD114-2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000363953(snoRNA)

miRNA
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Inhib. RNA
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GeneLoc Exon Structure


Expression
for SNORD114-2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for SNORD114-2:none

SNORD114-2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
SNORD114-2 Expression
About this image    SABiosciences Custom PCR Arrays for SNORD114-2

Primer
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In Situ
Assay Products: 
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Orthologs
for SNORD114-2 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

ENSEMBL Gene Tree for SNORD114-2 (if available)
TreeFam Gene Tree for SNORD114-2 (if available) 

Paralogs
for SNORD114-2 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for SNORD114-2 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/31 NCBI SNPs in SNORD114-2 are shown (see all 31)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 14 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs733509221,2
C,F--81598324(+) ATTTCT/CTGTTC 1 -- int15Minor allele frequency- C:0.08WA CSA NA EA 362
rs774539491,2
--81598600(+) ATCATC/TGTACA 1 -- int12Minor allele frequency- T:0.06CSA WA 120
rs1144810121,2
C,F--81598882(+) GAAACG/ACTCTT 1 -- int11Minor allele frequency- A:0.03WA 118
rs80076891,2
C,F--81598954(+) TGAAAA/GTTTTA 1 -- int11Minor allele frequency- G:0.03NA 120
rs757332221,2
C--81599195(+) AATTTT/GTAAAT 1 -- int12Minor allele frequency- G:0.12CSA WA 120
rs80123561,2
C--81599343(+) NNNNAA/CGTCAT 1 -- int13Minor allele frequency- C:0.04NA 124
rs2008581971,2
C--81599485(-) GGTCCA/CANNNN 1 -- int10--------
rs733509251,2
C,F--81599941(+) AAAAAG/TTTAAT 1 -- int14Minor allele frequency- T:0.09NA WA EA 362
rs767076671,2
F--81600025(+) AATCAA/GATGCT 1 -- int12Minor allele frequency- G:0.03NA EA 240
rs792693521,2
F--81600029(+) AAATGC/TTCTGC 1 -- int11Minor allele frequency- T:0.04EA 120

HapMap Linkage Disequilibrium report for SNORD114-2 (101418193 - 101418270 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for SNORD114-2: --

SABiosciences Cancer Mutation PCR Assays
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Disorders / Diseases
for SNORD114-2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
SNORD114-2 for disorders           About GeneDecksing

1 disease for SNORD114-2:    About MalaCards
angelman syndrome


Export disorders for SNORD114-2 gene to outside databases

Publications
for SNORD114-2 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SNORD114-2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SNORD114-2)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region. (PubMed id 12045206)1, 3 Cavaille J....Bachellerie J.P. (2002)
  2. Eukaryotic snoRNAs: a paradigm for gene expression fl exibility. (PubMed id 19446021)1 Dieci G....Montanini B. (2009)

External Searches for SNORD114-2 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing SNORD114-2 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 767578 HGNC: 32990 Ensembl:ENSG00000200823 euGenes: HUgn767578 ECgene: SNORD114-2
H-InvDB: SNORD114-2

Other Databases showing SNORD114-2 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing SNORD114-2 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SNORD114-2 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for SNORD114-2 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SNORD114-2 gene:
Search GeneIP for patents involving SNORD114-2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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