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Aliases for SNORA77 Gene

Subcategory (RNA class) for SNORA77 Gene

snoRNA

Quality Score for this RNA gene is

7.2

Aliases for SNORA77 Gene

  • Small Nucleolar RNA, H/ACA Box 77 2 3 5
  • SNORA77A 3
  • ACA63 3

External Ids for SNORA77 Gene

ORGUL Members for SNORA77 Gene

Previous GeneCards Identifiers for SNORA77 Gene

  • GC01P201965
  • GC01P203698
  • GC01P174864

Summaries for SNORA77 Gene

GeneCards Summary for SNORA77 Gene

SNORA77 (Small Nucleolar RNA, H/ACA Box 77) is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for SNORA77 Gene - the ORGUL cluster for this gene includes several descriptions:

  • ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

  • H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • Small nucleolar RNA SNORA77: ACA63 (SNORA77) is a member of the H/ACA class of snoRNAs that guide the sites of modification of uridines to pseudouridines [1]. This snoRNA was identified by computational screening and its expression in mouse experimentally verified by Northern blot and primer extension analysis [2]. ACA63 is proposed to guide the pseudouridylation of 18S rRNA U814 [2].

View fRNAdb secondary structures for SNORA77

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORA77 Gene

Genomics for SNORA77 Gene

Regulatory Elements for SNORA77 Gene

Enhancers for SNORA77 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G203647 2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -76.5 -76529 10.6 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 ZBTB7B YY1 ZNF766 MDM4 ATP2B4 SNRPE ZBED6 SNORA77 OPTC PPP1R15B LOC100131747 FMOD LOC730222
GH01G203669 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -56.0 -55991 8.0 FOXA2 PKNOX1 ARNT SIN3A ZNF2 ZNF766 FOS DEK JUNB REST ATP2B4 SNORA77 LAX1 BTG2 LOC100421749 PIR31474
GH01G203680 1.6 Ensembl ENCODE dbSUPER 10.8 -47.2 -47243 3.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF302 CBX5 ZNF143 FOS MDM4 SNRPE ZBED6 ATP2B4 OPTC SNORA77 LAX1 LOC100506672 RNU6-487P PPP1R15B
GH01G203665 1.2 Ensembl ENCODE dbSUPER 10.6 -62.1 -62119 3.3 NFIB TAL1 MAX RAD21 YY1 TCF12 POLR2A RFX1 NR2F2 FOXA1 ATP2B4 SNORA77 LOC100421749 PIR31474
GH01G203701 1.1 ENCODE dbSUPER 11.4 -27.3 -27339 0.5 HDGF PKNOX1 ARNT ZNF2 RAD21 GATA2 ZNF143 ZNF207 MIXL1 DEK OPTC ATP2B4 SNORA77 LAX1 PRELP FMOD LOC100131747 PIR31474 LOC100421749
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNORA77 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNORA77 Gene

Chromosome:
1
Start:
203,729,581 bp from pter
End:
203,729,705 bp from pter
Size:
125 bases
Orientation:
Plus strand

Genomic View for SNORA77 Gene

Genes around SNORA77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORA77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORA77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORA77 Gene

ORGUL Member Location for SNORA77 Gene

ORGUL Member Location for SNORA77 gene

Proteins for SNORA77 Gene

Post-translational modifications for SNORA77 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORA77 Gene

Domains & Families for SNORA77 Gene

Gene Families for SNORA77 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORA77: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORA77 Gene

Function for SNORA77 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORA77 Gene

Localization for SNORA77 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SNORA77 Gene

Pathways & Interactions for SNORA77 Gene

SuperPathways for SNORA77 Gene

No Data Available

Interacting Proteins for SNORA77 Gene

Gene Ontology (GO) - Biological Process for SNORA77 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORA77 Gene

Drugs & Compounds for SNORA77 Gene

No Compound Related Data Available

Transcripts for SNORA77 Gene

fRNAdb Secondary structures for SNORA77 Gene

  • FR322867

mRNA/cDNA for SNORA77 Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNORA77 Gene

Small nucleolar RNA, H/ACA box 77:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNORA77 Gene

No ASD Table

Relevant External Links for SNORA77 Gene

GeneLoc Exon Structure for
SNORA77
ECgene alternative splicing isoforms for
SNORA77

Expression for SNORA77 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNORA77 Gene

mRNA differential expression in normal tissues according to GTEx for SNORA77 Gene

This gene is overexpressed in Colon - Sigmoid (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of SNORA77 Gene:

SNORA77

SOURCE GeneReport for Unigene cluster for SNORA77 Gene:

Hs.676135
genes like me logo Genes that share expression patterns with SNORA77: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORA77 Gene

Orthologs for SNORA77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORA77 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORA77 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm25777 35
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SNORA77 35 35
  • 79 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia SNORA77 35
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SNORA77 35
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SNORA77 35
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves SNORA77 35
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SNORA77 35
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii SNORA77 35
  • 54 (a)
OneToMany
Species where no ortholog for SNORA77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNORA77 Gene

ENSEMBL:
Gene Tree for SNORA77 (if available)
TreeFam:
Gene Tree for SNORA77 (if available)

Paralogs for SNORA77 Gene

No data available for Paralogs for SNORA77 Gene

Variants for SNORA77 Gene

Sequence variations from dbSNP and Humsavar for SNORA77 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001954891 -- 203,727,711(+) CCTCA(A/G)CTTCA intron-variant, upstream-variant-2KB
rs1003082276 -- 203,728,545(+) ACTGG(C/G)CTTGC intron-variant, upstream-variant-2KB
rs1003308711 -- 203,730,119(+) ATTTC(C/T)TTTTC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003424709 -- 203,729,780(+) CCGGG(C/T)ACTGC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1004881235 -- 203,729,679(+) CCAGG(A/G)CGATG intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNORA77 Gene

Variant ID Type Subtype PubMed ID
nsv467994 CNV loss 19166990
nsv549007 CNV loss 21841781

Relevant External Links for SNORA77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORA77

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORA77 Gene

Disorders for SNORA77 Gene

Relevant External Links for SNORA77

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNORA77

No disorders were found for SNORA77 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORA77 Gene

Publications for SNORA77 Gene

  1. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. (PMID: 16381836) Lestrade L. … Weber M.J. (Nucleic Acids Res. 2006) 1 2 3 64
  2. Human box H/ACA pseudouridylation guide RNA machinery. (PMID: 15199136) Kiss A.M. … Kiss T. (Mol. Cell. Biol. 2004) 1 2 3 64
  3. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G. … Montanini B. (Genomics 2009) 3 64
  4. The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. (PMID: 18089548) . … Gojobori T. (Nucleic Acids Res. 2008) 1
  5. A computational screen for mammalian pseudouridylation guide H/ACA RNAs. (PMID: 16373490) Schattner P. … Lowe T.M. (RNA 2006) 1

Products for SNORA77 Gene

Sources for SNORA77 Gene

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