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Aliases for SNORA77 Gene

Subcategory (RNA class) for SNORA77 Gene

snoRNA

Quality Score for this RNA gene is

7.2

Aliases for SNORA77 Gene

  • Small Nucleolar RNA, H/ACA Box 77 2 3 5
  • SNORA77A 3
  • ACA63 3

External Ids for SNORA77 Gene

Previous GeneCards Identifiers for SNORA77 Gene

  • GC01P201965
  • GC01P203698
  • GC01P174864

Summaries for SNORA77 Gene

GeneCards Summary for SNORA77 Gene

SNORA77 (Small Nucleolar RNA, H/ACA Box 77) is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for SNORA77 Gene - the ORGUL cluster for this gene includes several descriptions:

  • ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

  • H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • Small nucleolar RNA SNORA77: ACA63 (SNORA77) is a member of the H/ACA class of snoRNAs that guide the sites of modification of uridines to pseudouridines [1]. This snoRNA was identified by computational screening and its expression in mouse experimentally verified by Northern blot and primer extension analysis [2]. ACA63 is proposed to guide the pseudouridylation of 18S rRNA U814 [2].

View fRNAdb secondary structures for SNORA77

Additional gene information for SNORA77 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORA77 Gene

Genomics for SNORA77 Gene

GeneHancer (GH) Regulatory Elements for SNORA77 Gene

Promoters and enhancers for SNORA77 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I203647 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 -76.5 -76529 10.6 HDGF PKNOX1 SIN3A IRF4 CBX5 ZNF548 FOS JUNB REST SMARCA4 ATP2B4 ZC3H11A MDM4 SNRPE ZBED6 SNORA77 OPTC PPP1R15B LOC100131747 FMOD
GH01I203793 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.6 +66.5 66526 4.2 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZC3H11A ZBED6 MDM4 SNRPE LAX1 HNRNPA1P59 PPP1R15B SNORA77 GC01P203800 GC01M203753
GH01I203669 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -56.0 -55991 8 PKNOX1 ATF1 FOXA2 ARNT ZNF48 TCF12 ZNF766 ATF7 FOS DEK SNRPE ZC3H11A ATP2B4 ZBED6 SOX13 MDM4 SNORA77 LAX1 BTG2 LOC100421749
GH01I203680 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.9 -47.2 -47243 3.4 HDGF PKNOX1 FOXA2 ARNT ARID4B ZNF302 E2F8 KLF13 NFYC ZHX2 ATP2B4 ZC3H11A OPTC SNORA77 LAX1 RNU6-487P LOC100421749 PIR31474
GH01I203686 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.9 -43.1 -43135 0.9 FOXA2 ZNF792 ZNF449 RAD21 ZNF335 ZNF121 RCOR1 REST ZEB2 FOXA1 ATP2B4 OPTC SNORA77 LAX1 RNU6-487P LOC100421749 PIR31474
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNORA77 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNORA77 gene promoter:

Genomic Locations for SNORA77 Gene

Genomic Locations for SNORA77 Gene
chr1:203,729,581-203,729,705
(GRCh38/hg38)
Size:
125 bases
Orientation:
Plus strand
chr1:203,698,709-203,698,833
(GRCh37/hg19)

Genomic View for SNORA77 Gene

Genes around SNORA77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORA77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORA77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORA77 Gene

ORGUL Member Location for SNORA77 Gene

ORGUL Member Location for SNORA77 gene

Proteins for SNORA77 Gene

Post-translational modifications for SNORA77 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORA77 Gene

Domains & Families for SNORA77 Gene

Gene Families for SNORA77 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORA77: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORA77 Gene

Function for SNORA77 Gene

Phenotypes From GWAS Catalog for SNORA77 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORA77 Gene

Localization for SNORA77 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNORA77 Gene

Pathways & Interactions for SNORA77 Gene

SuperPathways for SNORA77 Gene

No Data Available

Interacting Proteins for SNORA77 Gene

Gene Ontology (GO) - Biological Process for SNORA77 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORA77 Gene

Drugs & Compounds for SNORA77 Gene

No Compound Related Data Available

Transcripts for SNORA77 Gene

fRNAdb Secondary structures for SNORA77 Gene

  • FR322867

mRNA/cDNA for SNORA77 Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNORA77 Gene

Small nucleolar RNA, H/ACA box 77:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNORA77 Gene

No ASD Table

Relevant External Links for SNORA77 Gene

GeneLoc Exon Structure for
SNORA77
ECgene alternative splicing isoforms for
SNORA77

Expression for SNORA77 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNORA77 Gene

mRNA differential expression in normal tissues according to GTEx for SNORA77 Gene

This gene is overexpressed in Colon - Sigmoid (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of SNORA77 Gene:

SNORA77

SOURCE GeneReport for Unigene cluster for SNORA77 Gene:

Hs.676135
genes like me logo Genes that share expression patterns with SNORA77: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORA77 Gene

Orthologs for SNORA77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORA77 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORA77 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm25777 34
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SNORA77 34 34
  • 79 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia SNORA77 34
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SNORA77 34
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SNORA77 34
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves SNORA77 34
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SNORA77 34
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii SNORA77 34
  • 54 (a)
OneToMany
Species where no ortholog for SNORA77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNORA77 Gene

ENSEMBL:
Gene Tree for SNORA77 (if available)
TreeFam:
Gene Tree for SNORA77 (if available)

Paralogs for SNORA77 Gene

No data available for Paralogs for SNORA77 Gene

Variants for SNORA77 Gene

Sequence variations from dbSNP and Humsavar for SNORA77 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001954891 -- 203,727,711(+) G/A upstream_transcript_variant
rs1003082276 -- 203,728,545(+) C/G upstream_transcript_variant
rs1003308711 -- 203,730,119(+) C/T downstream_transcript_variant
rs1003424709 -- 203,729,780(+) C/T downstream_transcript_variant
rs1004881235 -- 203,729,679(+) G/A non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNORA77 Gene

Variant ID Type Subtype PubMed ID
nsv467994 CNV loss 19166990
nsv549007 CNV loss 21841781

Additional Variant Information for SNORA77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORA77

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORA77 Gene

Disorders for SNORA77 Gene

Additional Disease Information for SNORA77

No disorders were found for SNORA77 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORA77 Gene

Publications for SNORA77 Gene

  1. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. (PMID: 16381836) Lestrade L … Weber MJ (Nucleic acids research 2006) 1 2 3 58
  2. Human box H/ACA pseudouridylation guide RNA machinery. (PMID: 15199136) Kiss AM … Kiss T (Molecular and cellular biology 2004) 1 2 3 58
  3. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G … Montanini B (Genomics 2009) 3 58
  4. The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. (PMID: 18089548) Genome Information Integration Project And H-Invitational 2 … Gojobori T (Nucleic acids research 2008) 1
  5. A computational screen for mammalian pseudouridylation guide H/ACA RNAs. (PMID: 16373490) Schattner P … Lowe TM (RNA (New York, N.Y.) 2006) 1

Products for SNORA77 Gene

Sources for SNORA77 Gene

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