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Aliases for SNORA73B Gene

Subcategory (RNA class) for SNORA73B Gene

snoRNA

Quality Score for this RNA gene is

7

Aliases for SNORA73B Gene

  • Small Nucleolar RNA, H/ACA Box 73B 2 3 5
  • RNA, U105A Small Nucleolar 2 3
  • RNA, U17b Small Nucleolar 2 3
  • RNA, U17b Small Nuclear 3
  • RNU105A 3
  • RNU17B 3
  • 105A 3
  • U17B 3
  • E1c 3

External Ids for SNORA73B Gene

Previous HGNC Symbols for SNORA73B Gene

  • RNU17B
  • RNU105A

Previous GeneCards Identifiers for SNORA73B Gene

  • GC01U901294
  • GC01P028711
  • GC01P028838
  • GC01P028839
  • GC01P028845
  • GC01P028854
  • GC01P028862

Summaries for SNORA73B Gene

GeneCards Summary for SNORA73B Gene

SNORA73B (Small Nucleolar RNA, H/ACA Box 73B) is an RNA Gene, and is affiliated with the snoRNA class. Diseases associated with SNORA73B include St. Louis Encephalitis and Murray Valley Encephalitis.

fRNAdb sequence ontologies for SNORA73B Gene - the ORGUL cluster for this gene includes several descriptions:

  • H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.

  • Small nucleolar RNA SNORA73 family: U17 (SNORA73A and SNORA73B) also known as E1 belongs to the H/ACA class of small nucleolar RNAs (snoRNAs). Vertebrate U17 is intron-encoded and ranges in length from 200-230 nucleotides, longer than most snoRNAs. It is one of the most abundant snoRNAs in human cells and is essential for the cleavage of pre-rRNA within the 5' external transcribed spacer (ETS) [1]. This cleavage leads to the formation of 18S rRNA. Regions of the U17 RNA are complementary to rRNA and act as guides for RNA/RNA interactions, although these regions do not seem to be well conserved between organisms [2].

View fRNAdb secondary structures for SNORA73B

Additional gene information for SNORA73B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORA73B Gene

Genomics for SNORA73B Gene

Regulatory Elements for SNORA73B Gene

Enhancers for SNORA73B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H028881 2 FANTOM5 Ensembl ENCODE dbSUPER 27 +376.7 376685 6.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 SRSF4 TRNAU1AP GMEB1 SNHG12 YTHDF2 TMEM200B PHACTR4 RCC1 EYA3 ENSG00000237934
GH01H028171 2 FANTOM5 Ensembl ENCODE dbSUPER 19.6 -334.2 -334158 6.4 HDGF PKNOX1 FOXA2 ARNT FEZF1 YBX1 ZNF766 ZNF143 ZNF207 MCM3 PTAFR GMEB1 SNHG12 TRNAU1AP WASF2 YTHDF2 PHACTR4 NPM1P39 ACTG1P20 RCC1
GH01H028579 1.2 ENCODE 30.5 +72.6 72643 4.5 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN GMEB1 SRSF4 TRNAU1AP FAM76A SNHG12 YTHDF2 PHACTR4 SNORA73B RCC1 ENSG00000231344
GH01H028647 1.2 ENCODE 30.4 +139.9 139888 2.7 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ZFP41 GMEB1 SRSF4 YTHDF2 TRNAU1AP FAM76A SNHG12 PHACTR4 EYA3 RCC1 PPP1R8
GH01H028504 1.4 ENCODE dbSUPER 21.7 -0.4 -350 6.6 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A YBX1 DMAP1 GMEB1 TRNAU1AP SRSF4 PHACTR4 YTHDF2 SNHG12 FAM76A RCC1 SNORA73B SNHG3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNORA73B on UCSC Golden Path with GeneCards custom track

Promoters for SNORA73B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003877 -1858 3401 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2

Genomic Locations for SNORA73B Gene

Genomic Locations for SNORA73B Gene
chr1:28,508,558-28,508,762
(GRCh38/hg38)
Size:
205 bases
Orientation:
Plus strand
chr1:28,835,071-28,835,274
(GRCh37/hg19)

Genomic View for SNORA73B Gene

Genes around SNORA73B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORA73B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORA73B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORA73B Gene

ORGUL Member Location for SNORA73B Gene

ORGUL Member Location for SNORA73B gene

Proteins for SNORA73B Gene

Post-translational modifications for SNORA73B Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORA73B Gene

Domains & Families for SNORA73B Gene

Gene Families for SNORA73B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORA73B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORA73B Gene

Function for SNORA73B Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORA73B Gene

Localization for SNORA73B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNORA73B Gene

Pathways & Interactions for SNORA73B Gene

SuperPathways for SNORA73B Gene

No Data Available

Interacting Proteins for SNORA73B Gene

Gene Ontology (GO) - Biological Process for SNORA73B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORA73B Gene

Drugs & Compounds for SNORA73B Gene

No Compound Related Data Available

Transcripts for SNORA73B Gene

fRNAdb Secondary structures for SNORA73B Gene

  • RF00045;SNORA73;ADDF014166183.1/171-21

mRNA/cDNA for SNORA73B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNORA73B Gene

No ASD Table

Relevant External Links for SNORA73B Gene

GeneLoc Exon Structure for
SNORA73B
ECgene alternative splicing isoforms for
SNORA73B

Expression for SNORA73B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNORA73B Gene

NURSA nuclear receptor signaling pathways regulating expression of SNORA73B Gene:

SNORA73B

Evidence on tissue expression from TISSUES for SNORA73B Gene

  • Urine(2.2)
genes like me logo Genes that share expression patterns with SNORA73B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORA73B Gene

Orthologs for SNORA73B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORA73B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORA73 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNORA73 34 34 34
  • 83 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SNORA73 34 34 34
  • 77 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm25483 34
  • 66 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SNORA73 34
  • 77 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SNORA73 34 34
  • 75 (a)
ManyToMany
Species where no ortholog for SNORA73B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SNORA73B Gene

ENSEMBL:
Gene Tree for SNORA73B (if available)
TreeFam:
Gene Tree for SNORA73B (if available)

Paralogs for SNORA73B Gene

No data available for Paralogs for SNORA73B Gene

Variants for SNORA73B Gene

Sequence variations from dbSNP and Humsavar for SNORA73B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001089666 -- 28,506,792(+) CGCCT(A/G)CTGGG intron-variant, upstream-variant-2KB
rs1003191670 -- 28,507,815(+) TTGGT(C/T)AGGCT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1004000659 -- 28,508,483(+) AGATA(C/G)TAGCC intron-variant, upstream-variant-2KB
rs1004122457 -- 28,508,670(+) AGATG(A/G)AGCTG intron-variant, nc-transcript-variant
rs1004195021 -- 28,507,046(+) TTTTA(G/T)GATTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNORA73B Gene

Variant ID Type Subtype PubMed ID
nsv947421 CNV duplication 23825009
nsv947421 CNV duplication 23825009
nsv545919 CNV loss 21841781
nsv545919 CNV loss 21841781
nsv545916 CNV gain 21841781
nsv545916 CNV gain 21841781
esv3585587 CNV gain 21293372
esv3585587 CNV gain 21293372
esv3585585 CNV loss 21293372
esv3585585 CNV loss 21293372
esv3559994 CNV deletion 23714750
esv3559994 CNV deletion 23714750
esv2657760 CNV deletion 23128226
esv2657760 CNV deletion 23128226

Relevant External Links for SNORA73B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORA73B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORA73B Gene

Disorders for SNORA73B Gene

MalaCards: The human disease database

(2) MalaCards diseases for SNORA73B Gene - From: DISEASES

Disorder Aliases PubMed IDs
st. louis encephalitis
  • neuroinvasive st. louis encephalitis virus infection
murray valley encephalitis
  • australian encephalitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SNORA73B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNORA73B
genes like me logo Genes that share disorders with SNORA73B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNORA73B Gene

Publications for SNORA73B Gene

  1. Small nucleolar RNAs encoded by introns of the human cell cycle regulatory gene RCC1. (PMID: 8335005) Kiss T … Filipowicz W (The EMBO journal 1993) 1 2 3 60
  2. An updated human snoRNAome. (PMID: 27174936) Jorjani H … Gruber AR (Nucleic acids research 2016) 3 60
  3. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G … Montanini B (Genomics 2009) 3 60
  4. Intron-encoded small nucleolar RNAs: new RNA sequence variants and genomic loci. (PMID: 7530998) Selvamurugan N … Eliceiri GL (Biochimica et biophysica acta 1995) 3 60
  5. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. (PMID: 16381836) Lestrade L … Weber MJ (Nucleic acids research 2006) 1

Products for SNORA73B Gene

Sources for SNORA73B Gene

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