Subcategory (RNA class) for SNORA73A Gene
Quality Score for this RNA gene is
Aliases for SNORA73A Gene
ORGUL Members for SNORA73A Gene
Previous HGNC Symbols for SNORA73A Gene
Previous GeneCards Identifiers for SNORA73A Gene
GeneCards Summary for SNORA73A Gene
SNORA73A (Small Nucleolar RNA, H/ACA Box 73A) is an RNA Gene, and is affiliated with the snoRNA class. Diseases associated with SNORA73A include maple syrup urine disease, type ii.
fRNAdb sequence ontologies for SNORA73A Gene - the ORGUL cluster for this gene includes several descriptions:
H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.
Small nucleolar RNA SNORA73 family: U17 (SNORA73A and SNORA73B) also known as E1 belongs to the H/ACA class of small nucleolar RNAs (snoRNAs). Vertebrate U17 is intron-encoded and ranges in length from 200-230 nucleotides, longer than most snoRNAs. It is one of the most abundant snoRNAs in human cells and is essential for the cleavage of pre-rRNA within the 5' external transcribed spacer (ETS) . This cleavage leads to the formation of 18S rRNA. Regions of the U17 RNA are complementary to rRNA and act as guides for RNA/RNA interactions, although these regions do not seem to be well conserved between organisms .