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Aliasesfor SNORA70B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section GeneCards Plus Subcategory (RNA class): snoRNAQuality score for this RNA gene is 5 Aliases Small Nucleolar RNA, H/ACA Box 70B 1 2 Small Nucleolar RNA, H/ACA Box 70B (Retrotransposed)1
External Ids: HGNC: 33618 1 Entrez Gene: 100124537 2 Ensembl: ENSG00000206937 7 Export aliases for SNORA70B gene to outside databases Previous GC identifers: GC02U901156 GC02M061501 GC02M061384
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Summariesfor SNORA70B gene (According to Entrez Gene ,
GeneCards ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section GeneCards Plus GeneCards Summary for SNORA70B Gene: SNORA70B (small nucleolar RNA, H/ACA box 70B) is an RNA gene, and is affiliated with the snoRNA class. fRNAdb sequence ontologies for SNORA70B - the ORGUL cluster for this gene includes several descriptions: Small nucleolar RNA SNORA70 - snoRNA U70 seems to be exclusive to mammals and is a member of the H/ACA class of snoRNA which contain H (ANANNA) and ACA box motifs. H/ACA box snoRNAs are involved in the conversion of uridines to pseudouridines (5-ribosyluracil) a constituent of structural RNAs (transfer, ribosomal, small nuclear, and small nucleolar) [1,2]. ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.H_ACA_box_snoRNA - Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.View fRNAdb secondary structures for SNORA70B
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Genomic Viewsfor SNORA70B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 75) ,
Regulatory elements and Epigenetics data according to
QIAGEN , and/or
SwitchGear Genomics )About This Section GeneCards Plus Regulatory elements: Regulatory transcription factor binding sites in the SNORA70B gene promoter:Nkx3-1 STAT5B FOXD3 Nkx3-1 v1 STAT5A CUTL1 Arnt IRF-7A Other transcription factors Search Chromatin IP Primers for SNORA70B Epigenetics: DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNORA70B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2p15 Ensembl cytogenetic band: 2p15 HGNC cytogenetic band: 2p15 SNORA70B Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M061645: view genomic region
(about GC identifiers )
Start: 61,644,379 bp from pter End:
61,644,513 bp from pter
Size: 135 bases Orientation:
minus strand
ORGUL member locations:Legend (see complete legend)
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Proteinsfor SNORA70B gene
(According to
1 UniProtKB ,
HORDE ,
2 neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Antibodies by
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section GeneCards Plus UniProtKB: --
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Domains /for SNORA70B gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section GeneCards Plus HGNC Gene Families: SNORA: ncRNAs / Small nucleolar RNAs : H/ACA box containing
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Functionfor SNORA70B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
QIAGEN
and/or HOMER ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
SwitchGear Genomics ,
Gene Editing from DNA2.0 ,
Clones from OriGene ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
ESI BIO ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene .)
About This Section GeneCards Plus Animal Models: Cell Line GenScript Custom overexpressing Cell Line Services for SNORA70B Browse ESI BIO Cell Lines and PureStem Progenitors for SNORA70B In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNORA70B
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Localizationfor SNORA70B gene
(According to UniProtKB , COMPARTMENTS Subcellular localization database ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene .)
About This Section GeneCards Plus
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Pathways & Interactionsfor SNORA70B gene
(SuperPaths according to PathCards ,
Pathways according to
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
QIAGEN ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene) .
About This Section GeneCards Plus Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNORA70B Interactions: Search GeneGlobe Interaction Network for SNORA70B
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Drugs & Compoundsfor SNORA70B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience ,
ApexBio ,
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB )
About This Section GeneCards Plus Browse compounds at ApexBio Browse Tocris compounds for SNORA70B
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Transcriptsfor SNORA70B gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
SwitchGear Genomics ,
OriGene ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene , and/or
QIAGEN
)About This Section GeneCards Plus 2 fRNAdb Secondary structures: 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000384210(snoRNA) GeneLoc Exon Structure
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Expression for SNORA70B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MaxQB ,
plus additional links to
SOURCE , and/or
BioGPS , and/or
UniProtKB ,QIAGEN ,
Primers from
OriGene , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section GeneCards Plus Expression evidence for SNORA70B:H-invDB See probesets specificity/sensitivity at GeneAnnot CGAP TAG: --
SNORA70B Protein expression data from MOPED1 2 3 : Custom PCR Arrays for SNORA70B Primer Browse OriGene qPCR Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat SNORA70B Search QuantiTect SYBR Green Assays in human, mouse, rat SNORA70B QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNORA70B
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Orthologsfor SNORA70B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section GeneCards Plus Orthologs for SNORA70B gene from Selected species (see all 5 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
zebrafish Actinopterygii SNORA706
Small nucleolar RNA SNORA70
65(a)
many ↔ many
23(20002510-20002643) ENSDARG00000081328
Species with no ortholog for SNORA70B ENSEMBL Gene Tree for SNORA70B (if available)TreeFam Gene Tree for SNORA70B (if available)
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Paralogsfor SNORA70B gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section GeneCards Plus
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Genomic Variantsfor SNORA70B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) , the Human Cytochrome P450 Allele
Nomenclature Database , and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN )
About This Section GeneCards Plus Structural Variations Database of Genomic Variants (DGV) 3 variations for SNORA70B : About this table Site Specific Mutation Identification with PCR Assays
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Disorders
/ Diseasesfor SNORA70B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section GeneCards Plus
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Publicationsfor SNORA70B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section GeneCards Plus PubMed articles for SNORA70B gene integrated from 10 sources :(articles sorted by number of sources associating them with SNORA70B) Utopia : connect your pdf to the dynamic
Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PubMed id 19446021) 1 (Genomics 2009) snoSeeker: an advanced computational package for screening of guide and orphan snoRNA genes in the human genome. (PubMed id 16990247) 1 (Nucleic Acids Res. 2006) (PubMed id 15103394) 10 (PubMed id 18089548) 10 (PubMed id 10902565) 10 (PubMed id 12007400) 10
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External Searches for SNORA70B gene (in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section GeneCards Plus
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Genome Databases showing SNORA70B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section GeneCards Plus
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Other Databases showing SNORA70B gene
(According to HUGE )
About This Section GeneCards Plus --
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Specialized Databases showing SNORA70B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , UniProtKB/TrEMBL , and/or others, e.g. Wikipedia and GeneReviews , via UniProtKB/Swiss-Prot )About This Section GeneCards Plus
Name Description PharmGKB entry for SNORA70B Pharmacogenomics, SNPs, Pathways
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About This Section GeneCards Plus Patent Information for SNORA70B gene: SNORA70B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SNORA70B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 . Clones from OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , and ESI BIO , PCR Arrays from QIAGEN , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , Enzo Life Sciences , and/or
ApexBio , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section GeneCards Plus
Block miRNA regulation of human, mouse, rat SNORA70B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SNORA70B DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNORA70B Predesigned siRNA for gene silencing in human mouse rat QuantiFast Probe-based Assays in human mouse rat Search QuantiTect SYBR Green Assays in human, mouse, rat SNORA70B Custom PCR Arrays for SNORA70B Search Chromatin IP Primers for SNORA70B Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SNORA70B Search GeneGlobe Interaction Network for SNORA70B Regulatory tfbs in SNORA70B promoter
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNORA70B
Search ThermoFisher Antibodies for SNORA70B
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SNORA70B
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