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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNORA70 Gene

RNA gene   GIFtS: 19
GCID: GC0XP153628

small nucleolar RNA, H/ACA box 70

(Previous names: RNA, U70 small nucleolar )
(Previous symbol: RNU70)
  Search for SNORA70
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for SNORA70    

Aliases
for SNORA70 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Subcategory (RNA class): snoRNA

Quality score for this RNA gene is 6.2

Aliases
Small Nucleolar RNA, H/ACA Box 701 2
DXS648E1 2
RNU701 2
U701 2
RNA, U70 Small Nucleolar1

External Ids:    HGNC: 102311   Entrez Gene: 267782   Ensembl: ENSG000002071657   
ORGUL members:    fRNAdb10:FR345638 FR173133 FR173133 FR345638 FR219674      
H-InvDB:HIT000383120    
NCBI:L44140 M81806 AF218023 Y11164 BX936347 see all 7    
NONCODE:u4007    
Rfam:RF00156    
RNAdb:RNZ36874 SNO1567    

Export aliases for SNORA70 gene to outside databases

Previous GC identifer: GC0XP153281


Summaries
for SNORA70 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
fRNAdb sequence ontologies for SNORA70 - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
H_ACA_box_snoRNA - Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.

View fRNAdb secondary structures for SNORA70

Genomic Views
for SNORA70 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNORA70 gene promoter:
         p53   AP-1   AML1a   Nkx2-5   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNORA70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

SNORA70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNORA70 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153628:  view genomic region     (about GC identifiers)

Start:
 153,628,622 bp from pter      End:
 153,628,756 bp from pter
Size:
 135 bases      Orientation:
 plus strand
ORGUL member locations:
Legend (see complete legend)

  • FR0219674
  • FR0345638
  • FR0173133
153628621 153628689 153628756 chrX

Proteins
for SNORA70 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --

Protein Domains /
Families
for SNORA70 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for SNORA70 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Inhib. RNA
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In Situ Assay
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Pathways & Interactions
for SNORA70 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNORA70

Drugs & Compounds
for SNORA70 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SNORA70
Search CenterWatch for drugs/clinical trials and news about SNORA70 

Transcripts
for SNORA70 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
 3 fRNAdb Secondary structures:


Unigene Cluster for SNORA70:

Small nucleolar RNA, H/ACA box 70
Hs.744703
Unigene Representative Sequence: NR_000011
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000384436(snoRNA)

miRNA
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Inhib. RNA
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Primer
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Additional cDNA sequence: 

NR_000011.1 Y11164.1 

24/2625 AceView cDNA sequences (see all 2625):

BM474456 BM888415 BM784897 CD247645 BM782819 BU931826 BM850114 CB130578 
BG167728 BU176793 Y11164 AA989618 BM423740 BQ220389 CD247985 BU180653 
BQ213012 BM850676 BQ939656 F37254 BE140510 F26084 AW339475 BQ233681 

GeneLoc Exon Structure


Expression
for SNORA70 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for SNORA70:H-invDB

SNORA70 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
SOURCE GeneReport for Unigene cluster: Hs.744703
    SABiosciences Custom PCR Arrays for SNORA70
Primer
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In Situ
Assay Products: 
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Orthologs
for SNORA70 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of human and mouse.

Orthologs for SNORA70 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Snora705 small nucleolar RNA, H/ACA box 70   --   X (37.94 cM) 74272492 


ENSEMBL Gene Tree for SNORA70 (if available)
TreeFam Gene Tree for SNORA70 (if available) 

Paralogs
for SNORA70 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SNORA70 gene
ENSG000002066612  ENSG000002525052  ENSG000002518932  ENSG000002521332  ENSG000002520142  ENSG000002526172  ENSG000002069092  ENSG000002023892  
ENSG000002526572  ENSG000002517962  ENSG000002519252  ENSG000002530422  ENSG000002002372  ENSG000002069582  ENSG000002019452  ENSG000002521992  
ENSG000002072442  ENSG000002529692  ENSG000002068862  ENSG000002525262  ENSG000002527242  ENSG000002530272  ENSG000002066372  ENSG000002072742  
ENSG000002528782  ENSG000002023792  ENSG000002522582  ENSG000002013762  ENSG000002521272  ENSG000002070982  

SNORA70 for paralogs           About GeneDecksing



Genomic Variants
for SNORA70 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SNORA70
     2 Inversions: 0674 37365
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNORA70
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Disorders / Diseases
for SNORA70 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
SNORA70 for disorders           About MalaCards

SNORA70 for disorders           About GeneDecksing

OMIM gene information: 312173 300066 300209 300211 300221 300273 300310 300406 300421 300424 300428 301220 302801 304050 305435 426000 310465 313000    

Export disorders for SNORA70 gene to outside databases

Publications
for SNORA70 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SNORA70 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with SNORA70)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Human box H/ACA pseudouridylation guide RNA machinery. (PubMed id 15199136)1, 3 Kiss A.M....Kiss T. (2004)
  2. The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation. (PubMed id 9106664)1, 3 Ganot P....Kiss T. (1997)
  3. Eukaryotic snoRNAs: a paradigm for gene expression fl exibility. (PubMed id 19446021)1 Dieci G....Montanini B. (2009)
  4. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)1 Chen E.Y....D'Urso M. (1996)
  5. (PubMed id 16273071)10 
  6. (PubMed id 15608161)10 
  7. (PubMed id 10902565)10 
  8. (PubMed id 12007400)10 
  9. (PubMed id 8797828)10 
  10. (PubMed id 10736225)10 

External Searches for SNORA70 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing SNORA70 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 26778 HGNC: 10231 AceView: RPL10 Ensembl:ENSG00000207165 euGenes: HUgn26778
ECgene: SNORA70 H-InvDB: SNORA70

Other Databases showing SNORA70 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing SNORA70 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SNORA70 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for SNORA70 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SNORA70 gene:
Search GeneIP for patents involving SNORA70

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for SNORA70 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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