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Aliases for SNORA68 Gene

Subcategory (RNA class) for SNORA68 Gene

snoRNA

Quality Score for this RNA gene is

12.2

Aliases for SNORA68 Gene

  • Small Nucleolar RNA, H/ACA Box 68 2 3 5
  • RNA, U68 Small Nucleolar 2 3
  • U68 Small Nucleolar RNA 3
  • U68 SnoRNA 3
  • SNORA68A 3
  • RNU68 3
  • U68 3

External Ids for SNORA68 Gene

Previous HGNC Symbols for SNORA68 Gene

  • RNU68

Previous GeneCards Identifiers for SNORA68 Gene

  • GC19P017837
  • GC19P017973
  • GC19P017538
  • GC19P017971
  • GC19P018176
  • GC19P018294
  • GC19P018328
  • GC19P018701
  • GC19P019011
  • GC19P019329

Summaries for SNORA68 Gene

GeneCards Summary for SNORA68 Gene

SNORA68 (Small Nucleolar RNA, H/ACA Box 68) is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for SNORA68 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.

  • Small nucleolar RNA SNORA68: U68 is a member of the H/ACA class of small nucleolar RNAs (snoRNAs) which act as guides in the the modification of uridines to pseudouridines [2].

Additional gene information for SNORA68 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORA68 Gene

Genomics for SNORA68 Gene

GeneHancer (GH) Regulatory Elements for SNORA68 Gene

Promoters and enhancers for SNORA68 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I017859 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.2 234 7.3 HDGF HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 RPL18A GC19P019761 GC19P019917 GC19P020083 GC19P020207 GC19P020222 PIR54406 PIR61491 SNORA68 ENSG00000268030
GH19I017775 Enhancer 1.1 Ensembl ENCODE 11.7 -86.2 -86234 1.8 HDGF HDAC1 PKNOX1 RB1 YBX1 BATF KLF5 IRF4 THRB RAD21 FCHO1 UNC13A RPL18A INSL3 SNORA68 GC19M017755 B3GNT3
GH19I017915 Enhancer 0.8 ENCODE 12.6 +53.7 53720 1.2 PKNOX1 KLF17 RFX5 GTF3C2 SCRT2 RCOR1 FOS EGR2 GATAD2B TSHZ1 SNORA68 RPL18A CCDC124 ENSG00000279617
GH19I018636 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 4.5 +774.8 774763 2.7 HDGF PKNOX1 ATF1 GLI4 ZNF2 ZBTB7B YY1 TCF12 POLR2B GLIS2 KLHL26 NR2C2AP ENSG00000268030 TMEM161A MAU2 RPL18A CRTC1 SNORA68
GH19I017703 Enhancer 0.7 ENCODE 11.6 -158.6 -158581 0.2 CTCF ZNF654 SP2 TRIM22 REST RAD21 SP1 CC2D1A KLF16 ARID2 PIR50741 INSL3 RPL18A SNORA68 MAP1S
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNORA68 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNORA68 gene promoter:

Genomic Locations for SNORA68 Gene

Genomic Locations for SNORA68 Gene
chr19:17,862,588-17,862,720
(GRCh38/hg38)
Size:
133 bases
Orientation:
Plus strand
chr19:17,973,397-17,973,529
(GRCh37/hg19)

Genomic View for SNORA68 Gene

Genes around SNORA68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORA68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORA68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORA68 Gene

ORGUL Member Location for SNORA68 Gene

ORGUL Member Location for SNORA68 gene

Proteins for SNORA68 Gene

Post-translational modifications for SNORA68 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORA68 Gene

Domains & Families for SNORA68 Gene

Gene Families for SNORA68 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORA68: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORA68 Gene

Function for SNORA68 Gene

Phenotypes From GWAS Catalog for SNORA68 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORA68 Gene

Localization for SNORA68 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNORA68 Gene

Pathways & Interactions for SNORA68 Gene

SuperPathways for SNORA68 Gene

No Data Available

Interacting Proteins for SNORA68 Gene

Gene Ontology (GO) - Biological Process for SNORA68 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORA68 Gene

Drugs & Compounds for SNORA68 Gene

No Compound Related Data Available

Transcripts for SNORA68 Gene

mRNA/cDNA for SNORA68 Gene

(2) Additional mRNA sequences :
(2297) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNORA68 Gene

Small nucleolar RNA, H/ACA box 68:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNORA68 Gene

No ASD Table

Relevant External Links for SNORA68 Gene

GeneLoc Exon Structure for
SNORA68
ECgene alternative splicing isoforms for
SNORA68

Expression for SNORA68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNORA68 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNORA68 Gene:

SNORA68

SOURCE GeneReport for Unigene cluster for SNORA68 Gene:

Hs.684118
genes like me logo Genes that share expression patterns with SNORA68: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORA68 Gene

Orthologs for SNORA68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORA68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORA68 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNORA68 34
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm22661 34
  • 74 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia SNORA68 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNORA68 34 34 34
  • 66 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SNORA68 34 34
  • 64 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SNORA68 34
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SNORA68 34
  • 63 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii SNORA68 34 34
  • 61 (a)
ManyToMany
Species where no ortholog for SNORA68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNORA68 Gene

ENSEMBL:
Gene Tree for SNORA68 (if available)
TreeFam:
Gene Tree for SNORA68 (if available)

Paralogs for SNORA68 Gene

No data available for Paralogs for SNORA68 Gene

Variants for SNORA68 Gene

Sequence variations from dbSNP and Humsavar for SNORA68 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000338719 -- 17,861,301(+) G/C upstream_transcript_variant
rs1001422649 -- 17,862,035(+) T/C upstream_transcript_variant
rs1001875539 -- 17,862,334(+) G/A upstream_transcript_variant
rs1001941410 -- 17,860,832(+) G/A upstream_transcript_variant
rs1003499292 -- 17,861,101(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNORA68 Gene

Variant ID Type Subtype PubMed ID
nsv833772 CNV gain+loss 17160897

Additional Variant Information for SNORA68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORA68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORA68 Gene

Disorders for SNORA68 Gene

Additional Disease Information for SNORA68

No disorders were found for SNORA68 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORA68 Gene

Publications for SNORA68 Gene

  1. The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation. (PMID: 9106664) Ganot P … Kiss T (Genes & development 1997) 1 2 3 58
  2. Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs. (PMID: 9182768) Ganot P … Kiss T (Cell 1997) 1 2 3 58
  3. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G … Montanini B (Genomics 2009) 3 58
  4. The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. (PMID: 18089548) Genome Information Integration Project And H-Invitational 2 … Gojobori T (Nucleic acids research 2008) 1
  5. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. (PMID: 16381836) Lestrade L … Weber MJ (Nucleic acids research 2006) 1

Products for SNORA68 Gene

Sources for SNORA68 Gene

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