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Aliases for SNORA68 Gene

Subcategory (RNA class) for SNORA68 Gene

snoRNA

Quality Score for this RNA gene is

12.2

Aliases for SNORA68 Gene

  • Small Nucleolar RNA, H/ACA Box 68 2 3 5
  • RNA, U68 Small Nucleolar 2 3
  • U68 Small Nucleolar RNA 3
  • U68 SnoRNA 3
  • SNORA68A 3
  • RNU68 3
  • U68 3

External Ids for SNORA68 Gene

Previous HGNC Symbols for SNORA68 Gene

  • RNU68

Previous GeneCards Identifiers for SNORA68 Gene

  • GC19P017837
  • GC19P017973
  • GC19P017538
  • GC19P017971
  • GC19P018176
  • GC19P018294
  • GC19P018328

Summaries for SNORA68 Gene

GeneCards Summary for SNORA68 Gene

SNORA68 (Small Nucleolar RNA, H/ACA Box 68) is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for SNORA68 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.

  • Small nucleolar RNA SNORA68: U68 is a member of the H/ACA class of small nucleolar RNAs (snoRNAs) which act as guides in the the modification of uridines to pseudouridines [2].

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORA68 Gene

Genomics for SNORA68 Gene

Regulatory Elements for SNORA68 Gene

Enhancers for SNORA68 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F017915 0.7 ENCODE 12.5 +53.7 53720 1.2 PKNOX1 KLF17 RFX5 GTF3C2 SCRT2 RCOR1 FOS EGR2 TSHZ1 SREBF1 UPF1 ENSG00000268030 SNORA68 RPL18A MVB12A ENSG00000268938 CCDC124 ENSG00000279617
GH19F017775 0.6 Ensembl ENCODE 11.7 -86.2 -86234 1.8 HDGF HDAC1 PKNOX1 TBL1XR1 YBX1 THRB RAD21 GATA2 EGR1 ZNF143 FCHO1 UNC13A RPL18A SNORA68 INSL3 GC19M017755 B3GNT3
GH19F017703 0.2 ENCODE 11.6 -158.6 -158582 0.2 CTCF ZNF654 SP2 TRIM22 REST ZBTB7A RAD21 KLF16 NFYB ZNF143 INSL3 RPL18A SNORA68 PIR50741 MAP1S
GH19F018663 1.1 Ensembl ENCODE 5.7 +801.2 801214 1.6 SRF TEAD4 KLHL26 SNORA68 CRTC1
GH19F018671 0.7 Ensembl ENCODE 5.3 +810.0 810000 1.5 CTCF POLR2A REST RAD21 C19orf60 CRTC1 SNORA68 TMEM59L KLHL26
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SNORA68 on UCSC Golden Path with GeneCards custom track

Genomic Location for SNORA68 Gene

Chromosome:
19
Start:
17,862,588 bp from pter
End:
17,862,720 bp from pter
Size:
133 bases
Orientation:
Plus strand

Genomic View for SNORA68 Gene

Genes around SNORA68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORA68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORA68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORA68 Gene

ORGUL Member Location for SNORA68 Gene

ORGUL Member Location for SNORA68 gene

Proteins for SNORA68 Gene

Post-translational modifications for SNORA68 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORA68 Gene

Domains & Families for SNORA68 Gene

Gene Families for SNORA68 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORA68: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORA68 Gene

Function for SNORA68 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORA68 Gene

Localization for SNORA68 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SNORA68 Gene

Pathways & Interactions for SNORA68 Gene

SuperPathways for SNORA68 Gene

No Data Available

Interacting Proteins for SNORA68 Gene

Gene Ontology (GO) - Biological Process for SNORA68 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORA68 Gene

Transcripts for SNORA68 Gene

mRNA/cDNA for SNORA68 Gene

(2) Additional mRNA sequences :
(2297) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNORA68 Gene

Small nucleolar RNA, H/ACA box 68:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNORA68 Gene

No ASD Table

Relevant External Links for SNORA68 Gene

GeneLoc Exon Structure for
SNORA68
ECgene alternative splicing isoforms for
SNORA68

Expression for SNORA68 Gene

mRNA expression in normal human tissues for SNORA68 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNORA68 Gene:

SNORA68

SOURCE GeneReport for Unigene cluster for SNORA68 Gene:

Hs.684118
genes like me logo Genes that share expression patterns with SNORA68: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SNORA68 Gene

Orthologs for SNORA68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORA68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORA68 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNORA68 35
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm22661 35
  • 74 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia SNORA68 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNORA68 35 35 35
  • 66 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SNORA68 35 35
  • 64 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SNORA68 35
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SNORA68 35
  • 63 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii SNORA68 35 35
  • 61 (a)
ManyToMany
Species where no ortholog for SNORA68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNORA68 Gene

ENSEMBL:
Gene Tree for SNORA68 (if available)
TreeFam:
Gene Tree for SNORA68 (if available)

Paralogs for SNORA68 Gene

No data available for Paralogs for SNORA68 Gene

Variants for SNORA68 Gene

Sequence variations from dbSNP and Humsavar for SNORA68 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10422405 -- 17,862,080(+) TGTGG(C/T)CTCTC intron-variant, upstream-variant-2KB
rs10423882 -- 17,862,349(+) AAGAC(A/G)AAAGG intron-variant, upstream-variant-2KB
rs1059228 -- 17,862,139(+) TCTGG(C/G)TGCGC upstream-variant-2KB, reference, missense
rs111339452 -- 17,861,492(+) GGGCT(A/C/G)CGTGG intron-variant, upstream-variant-2KB
rs111956581 -- 17,861,290(+) CCTTT(A/C)AGCTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNORA68 Gene

Variant ID Type Subtype PubMed ID
nsv833772 CNV gain+loss 17160897

Relevant External Links for SNORA68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORA68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORA68 Gene

Disorders for SNORA68 Gene

Relevant External Links for SNORA68

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNORA68

No disorders were found for SNORA68 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORA68 Gene

Publications for SNORA68 Gene

  1. The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation. (PMID: 9106664) Ganot P. … Kiss T. (Genes Dev. 1997) 1 2 3 64
  2. Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs. (PMID: 9182768) Ganot P. … Kiss T. (Cell 1997) 1 2 3 64
  3. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G. … Montanini B. (Genomics 2009) 3 64
  4. The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. (PMID: 18089548) . … Gojobori T. (Nucleic Acids Res. 2008) 1
  5. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. (PMID: 16381836) Lestrade L. … Weber M.J. (Nucleic Acids Res. 2006) 1

Products for SNORA68 Gene

Sources for SNORA68 Gene

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