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Aliases for SNORA66 Gene

Subcategory (RNA class) for SNORA66 Gene

snoRNA

Quality Score for this RNA gene is

3

Aliases for SNORA66 Gene

  • Small Nucleolar RNA, H/ACA Box 66 2 3 5
  • RNA, U66 Small Nucleolar 2 3
  • RNU66 3
  • U66 3

External Ids for SNORA66 Gene

ORGUL Members for SNORA66 Gene

Previous HGNC Symbols for SNORA66 Gene

  • RNU66

Previous GeneCards Identifiers for SNORA66 Gene

  • GC01P093078
  • GC01P093306
  • GC01P091427

Summaries for SNORA66 Gene

Entrez Gene Summary for SNORA66 Gene

  • This gene encodes a non-coding RNA that functions in the biogenesis of other small nuclear RNAs. This RNA is found in the nucleolus, where it may be involved in the pseudouridylation of 18S ribosomal RNA. This RNA is found associated with the GAR1 protein. [provided by RefSeq, Apr 2009]

GeneCards Summary for SNORA66 Gene

SNORA66 (Small Nucleolar RNA, H/ACA Box 66) is an RNA Gene, and is affiliated with the snoRNA class.

Additional gene information for SNORA66 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNORA66 Gene

Genomics for SNORA66 Gene

GeneHancer (GH) Regulatory Elements for SNORA66 Gene

Promoters and enhancers for SNORA66 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I092831 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 94.1 -7.3 -7290 4.2 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 RPL5 GC01P092832 SNORA66 SNORD21 CCDC18-AS1 MTF2 MIG7 DR1 GLMN RPAP2
GH01I093177 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 67.2 +339.3 339256 4.8 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 ZNF263 SP3 CCDC18 GC01M093180 TMED5 CCDC18-AS1 SNORA66 SNORD21 RPL5 MIG7 DNTTIP2 RPAP2
GH01I093078 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 54.7 +239.7 239716 4.5 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 MTF2 CCDC18-AS1 SNORA66 SNORD21 TRR-TCT1-1 GLMN RPAP2 RPL5 DR1 DNTTIP2
GH01I091882 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.5 -955.7 -955680 4.4 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF213 TGFBR3 HFM1 RPAP2 SNORA66 SNORD21 RPL5 GLMN ENSG00000189195 ZNF644 GC01M091855
GH01I093344 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.3 +506.8 506824 5.9 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 CCDC18-AS1 DR1 SNORD21 SNORA66 MTF2 DNTTIP2 CCDC18 EVI5 FNBP1L GC01M093359
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNORA66 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNORA66 gene promoter:

Genomic Locations for SNORA66 Gene

Genomic Locations for SNORA66 Gene
chr1:92,840,719-92,840,851
(GRCh38/hg38)
Size:
133 bases
Orientation:
Plus strand
chr1:93,306,276-93,306,408
(GRCh37/hg19)

Genomic View for SNORA66 Gene

Genes around SNORA66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORA66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORA66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORA66 Gene

Proteins for SNORA66 Gene

Post-translational modifications for SNORA66 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORA66 Gene

Domains & Families for SNORA66 Gene

Gene Families for SNORA66 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORA66: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORA66 Gene

Function for SNORA66 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORA66 Gene

Localization for SNORA66 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNORA66 Gene

Pathways & Interactions for SNORA66 Gene

SuperPathways for SNORA66 Gene

No Data Available

Interacting Proteins for SNORA66 Gene

Gene Ontology (GO) - Biological Process for SNORA66 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORA66 Gene

Drugs & Compounds for SNORA66 Gene

No Compound Related Data Available

Transcripts for SNORA66 Gene

mRNA/cDNA for SNORA66 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNORA66 Gene

No ASD Table

Relevant External Links for SNORA66 Gene

GeneLoc Exon Structure for
SNORA66
ECgene alternative splicing isoforms for
SNORA66

Expression for SNORA66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNORA66 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNORA66 Gene:

SNORA66
genes like me logo Genes that share expression patterns with SNORA66: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORA66 Gene

Orthologs for SNORA66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORA66 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORA66 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNORA66 34
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNORA66 34
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm26387 34
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNORA66 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNORA66 34
  • 70 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SNORA66 34
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SNORA66 34
  • 72 (a)
OneToMany
Species where no ortholog for SNORA66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SNORA66 Gene

ENSEMBL:
Gene Tree for SNORA66 (if available)
TreeFam:
Gene Tree for SNORA66 (if available)

Paralogs for SNORA66 Gene

No data available for Paralogs for SNORA66 Gene

Variants for SNORA66 Gene

Sequence variations from dbSNP and Humsavar for SNORA66 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs10874744 benign, Diamond-Blackfan anemia 92,840,760(+) G/A non_coding_transcript_variant
rs773839391 conflicting-interpretations-of-pathogenicity, Diamond-Blackfan anemia 92,840,626(+) G/C upstream_transcript_variant
rs1000305053 -- 92,841,100(+) T/C downstream_transcript_variant
rs1002840787 -- 92,840,203(+) G/T upstream_transcript_variant
rs1003533956 -- 92,838,774(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNORA66 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV deletion 23290073
nsv1008602 CNV gain 25217958
nsv508393 CNV deletion 20534489

Additional Variant Information for SNORA66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORA66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORA66 Gene

Disorders for SNORA66 Gene

Additional Disease Information for SNORA66

No disorders were found for SNORA66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORA66 Gene

Publications for SNORA66 Gene

  1. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. (PMID: 16381836) Lestrade L … Weber MJ (Nucleic acids research 2006) 2 3 58
  2. Human box H/ACA pseudouridylation guide RNA machinery. (PMID: 15199136) Kiss AM … Kiss T (Molecular and cellular biology 2004) 2 3 58
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
  4. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G … Montanini B (Genomics 2009) 3 58

Products for SNORA66 Gene

Sources for SNORA66 Gene

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