Subcategory (RNA class) for SNORA62 Gene
Quality Score for this RNA gene is
Aliases for SNORA62 Gene
ORGUL Members for SNORA62 Gene
Previous HGNC Symbols for SNORA62 Gene
Previous GeneCards Identifiers for SNORA62 Gene
GeneCards Summary for SNORA62 Gene
SNORA62 (Small Nucleolar RNA, H/ACA Box 62) is an RNA Gene, and is affiliated with the snoRNA class. Among its related pathways are Alpha6-Beta4 Integrin Signaling Pathway and CFTR translational fidelity (class I mutations).
fRNAdb sequence ontologies for SNORA62 Gene - the ORGUL cluster for this gene includes several descriptions:
H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.
Small nucleolar RNA SNORA62/SNORA6 family: The members of this family belong to the H/ACA class of snoRNAs which are predicted to guide the sites of modification of uridines to pseudouridines . This family includes human snoRNAs E2 (SNORA62), ACA6 (SNORA6) and M2 and mouse MBI-136. In humans both E2 and ACA6 are encoded in the introns on the same host gene (LAMR1)[1,3]. E2 is involved in the processing of eukaryotic pre-rRNA and has regions of complementarity to 28S rRNA . ACA6 is predicted to guide the pseudouridylation of residue U3616 of 28S rRNA .