Subcategory (RNA class) for SNORA45B Gene
Quality Score for this RNA gene is
Aliases for SNORA45B Gene
External Ids for SNORA45B Gene
ORGUL Members for SNORA45B Gene
Previous HGNC Symbols for SNORA45B Gene
Small nucleolar RNAs (snoRNAs) are small noncoding RNAs involved in RNA processing. Box H/ACA snoRNAs, such as SNORA45, direct the conversion of uridine to pseudouridine at specific residues of ribosomal RNAs or small nuclear RNAs (snRNAs) (Gu et al., 2005).[supplied by OMIM, Mar 2008]
GeneCards Summary for SNORA45B Gene
SNORA45B (Small Nucleolar RNA, H/ACA Box 45B) is an RNA Gene, and is affiliated with the snoRNA class.
fRNAdb sequence ontologies for SNORA45B Gene - the ORGUL cluster for this gene includes several descriptions:
H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
Small nucleolar RNA SNORA3/SNORA45 family: The members of this family belong to the H/ACA class of snoRNAs which are thought to guide the sites of modification of uridines to pseudouridines . This family includes mouse snoMBI-28 and human homologues ACA3 (SNORA3) and ACA3-2 (SNORA45). Both ACA3 and ACA3-2 share the same host gene . MBI-28, ACA3 and ACA3-2 are all predicted to guide the pseudouridylation of residues in 28S rRNA [1,2,3].