Subcategory (RNA class) for SNORA45A Gene
Quality Score for this RNA gene is
Aliases for SNORA45A Gene
ORGUL Members for SNORA45A Gene
Previous HGNC Symbols for SNORA45A Gene
GeneCards Summary for SNORA45A Gene
SNORA45A (Small Nucleolar RNA, H/ACA Box 45A) is an RNA Gene, and is affiliated with the snoRNA class. Among its related pathways are CFTR translational fidelity (class I mutations).
fRNAdb sequence ontologies for SNORA45A Gene - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.
Small nucleolar RNA SNORA3/SNORA45 family: The members of this family belong to the H/ACA class of snoRNAs which are thought to guide the sites of modification of uridines to pseudouridines . This family includes mouse snoMBI-28 and human homologues ACA3 (SNORA3) and ACA3-2 (SNORA45). Both ACA3 and ACA3-2 share the same host gene . MBI-28, ACA3 and ACA3-2 are all predicted to guide the pseudouridylation of residues in 28S rRNA [1,2,3].