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Aliases for SNORA2B Gene

Subcategory (RNA class) for SNORA2B Gene

snoRNA

Quality Score for this RNA gene is

11.2

Aliases for SNORA2B Gene

  • Small Nucleolar RNA, H/ACA Box 2B 2 3
  • ACA2b SnoRNA 3
  • ACA2b 3

External Ids for SNORA2B Gene

Previous GeneCards Identifiers for SNORA2B Gene

  • GC12M047349
  • GC12M049061
  • GC12M046095

Summaries for SNORA2B Gene

GeneCards Summary for SNORA2B Gene

SNORA2B (Small Nucleolar RNA, H/ACA Box 2B) is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for SNORA2B Gene - the ORGUL cluster for this gene includes several descriptions:

  • H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • Small nucleolar RNA SNORA2/SNORA34 family: The members of this family belong to the H/ACA class of snoRNAs which are predicted to guide the sites of modification of uridines to pseudouridines [1]. This family includes human snoRNAs ACA2a (SNORA2A), ACA2b (SNORA2B) and ACA34 (SNORA34). ACA2a and ACA2a are predicted to guide pseudouridylation of U4263 and U4282 in 28S rRNA and ACA34 is predicted to guide the pseudouridylation of residue U4269 and U4282 of 28S rRNA [2]. In humans all three of these snoRNAs share the same host gene [2].

View fRNAdb secondary structures for SNORA2B

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORA2B Gene

Genomics for SNORA2B Gene

Regulatory Elements for SNORA2B Gene

Genomic Location for SNORA2B Gene

Start:
48,667,457 bp from pter
End:
48,667,593 bp from pter
Size:
137 bases
Orientation:
Minus strand

Genomic View for SNORA2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNORA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORA2B Gene

ORGUL Member Location for SNORA2B Gene

ORGUL Member Location for SNORA2B gene

Proteins for SNORA2B Gene

Post-translational modifications for SNORA2B Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORA2B Gene

Domains for SNORA2B Gene

Gene Families for SNORA2B Gene

HGNC:
  • SNORA :ncRNAs / Small nucleolar RNAs : H/ACA box containing

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORA2B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORA2B Gene

Function for SNORA2B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SNORA2B Gene

Localization for SNORA2B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SNORA2B Gene

Pathways for SNORA2B Gene

SuperPathways for SNORA2B Gene

No Data Available

Interacting Proteins for SNORA2B Gene

Gene Ontology (GO) - Biological Process for SNORA2B Gene

None

No data available for Pathways by source for SNORA2B Gene

Transcripts for SNORA2B Gene

fRNAdb Secondary structures for SNORA2B Gene

  • RF00410;SNORA2;DAAB015074512.1/326-243

mRNA/cDNA for SNORA2B Gene

(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNORA2B Gene

Small nucleolar RNA, H/ACA box 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNORA2B Gene

No ASD Table

Relevant External Links for SNORA2B Gene

GeneLoc Exon Structure for
SNORA2B
ECgene alternative splicing isoforms for
SNORA2B

Expression for SNORA2B Gene

mRNA expression in normal human tissues for SNORA2B Gene

SOURCE GeneReport for Unigene cluster for SNORA2B Gene Hs.683444

genes like me logo Genes that share expressions with SNORA2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for SNORA2B Gene

Orthologs for SNORA2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORA2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORA2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNORA2 36
  • 88 (a)
ManyToMany
SNORA2 36
  • 94 (a)
ManyToMany
SNORA2 36
  • 93 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia SNORA2 36
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Snora2b 16
Snora2b 36
  • 93 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia SNORA2 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SNORA2 36
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves SNORA2 36
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SNORA2 36
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii SNORA2 36
  • 67 (a)
OneToMany
Species with no ortholog for SNORA2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNORA2B Gene

ENSEMBL:
Gene Tree for SNORA2B (if available)
TreeFam:
Gene Tree for SNORA2B (if available)

Paralogs for SNORA2B Gene

No data available for Paralogs for SNORA2B Gene

Variants for SNORA2B Gene

Structural Variations from Database of Genomic Variants (DGV) for SNORA2B Gene

Variant ID Type Subtype PubMed ID
nsv438209 CNV Loss 16468122

Relevant External Links for SNORA2B Gene

HapMap Linkage Disequilibrium report
SNORA2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SNORA2B Gene

Disorders for SNORA2B Gene

No disorders were found for SNORA2B Gene.

No data available for UniProtKB/Swiss-Prot for SNORA2B Gene

Publications for SNORA2B Gene

  1. Human box H/ACA pseudouridylation guide RNA machinery. (PMID: 15199136) Kiss A.M. … Kiss T. (Mol. Cell. Biol. 2004) 2 3
  2. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. (PMID: 16381836) Lestrade L. … Weber M.J. (Nucleic Acids Res. 2006) 2 3
  3. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G. … Montanini B. (Genomics 2009) 3

Products for SNORA2B Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate SNORA2B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SNORA2B
    • Block miRNA regulation of SNORA2B using miScript Target Protectors

    Sources for SNORA2B Gene

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