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SNORA12 Gene(RNA Gene)

Small Nucleolar RNA, H/ACA Box 12

GCID:
GC10M100240
GIFtS:
16
Genes Participants
UDN Logo

Aliases for SNORA12 Gene

Subcategory (RNA class) for SNORA12 Gene

snoRNA

Quality Score for this RNA gene is

12

Aliases for SNORA12 Gene

  • Small Nucleolar RNA, H/ACA Box 12 2 3 5
  • U108 SnoRNA 3
  • U108 3

External Ids for SNORA12 Gene

ORGUL Members for SNORA12 Gene

Previous GeneCards Identifiers for SNORA12 Gene

  • GC10M101986
  • GC10M095625
  • GC10M101998
  • GC10M102002
  • GC10M100238

Summaries for SNORA12 Gene

Entrez Gene Summary for SNORA12 Gene

  • Small nucleolar RNAs (snoRNAs) are small noncoding RNAs involved in RNA processing. Box H/ACA snoRNAs, such as SNORA12, direct the conversion of uridine to pseudouridine at specific residues of ribosomal RNAs or small nuclear RNAs (snRNAs) (Gu et al., 2005).[supplied by OMIM, Mar 2008]

GeneCards Summary for SNORA12 Gene

SNORA12 (Small Nucleolar RNA, H/ACA Box 12) is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for SNORA12 Gene - the ORGUL cluster for this gene includes several descriptions:

  • H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.

  • Small nucleolar RNA SNORA12: U108 belongs to the H/ACA family of snoRNAs. The sequence is predicted to guide the pseudouridylation of the U372 residue in the 28S rRNA subunit. However it has not been reported as a pseudouridylation site.

Additional gene information for SNORA12 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORA12 Gene

Genomics for SNORA12 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for SNORA12 Gene

Promoters and enhancers for SNORA12 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10I100246 Promoter 0.5 EPDnew 0.4 -9.6 -9603 0.1 CWF19L1 PHBP9 BLOC1S2 ENSG00000236308 ERLIN1 GC10M100239 SNORA12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNORA12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNORA12 gene promoter:

Genomic Locations for SNORA12 Gene

Genomic Locations for SNORA12 Gene
chr10:100,237,156-100,237,302
(GRCh38/hg38)
Size:
147 bases
Orientation:
Minus strand
chr10:101,996,913-101,997,059
(GRCh37/hg19)

Genomic View for SNORA12 Gene

Genes around SNORA12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORA12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORA12 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SNORA12 Gene

ORGUL Member Location for SNORA12 Gene

ORGUL Member Location for SNORA12 gene

Proteins for SNORA12 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for SNORA12 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORA12 Gene

Domains & Families for SNORA12 Gene

Gene Families for SNORA12 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORA12: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORA12 Gene

Function for SNORA12 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORA12 Gene

Localization for SNORA12 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNORA12 Gene

Pathways & Interactions for SNORA12 Gene

SuperPathways for SNORA12 Gene

PathCards logo More details on SuperPathways for SNORA12
No Data Available

Interacting Proteins for SNORA12 Gene

Gene Ontology (GO) - Biological Process for SNORA12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORA12 Gene

Drugs & Compounds for SNORA12 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SNORA12 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SNORA12 Gene

(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNORA12 Gene

Small nucleolar RNA, H/ACA box 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNORA12 Gene

No ASD Table

Relevant External Links for SNORA12 Gene

GeneLoc Exon Structure for
SNORA12
ECgene alternative splicing isoforms for
SNORA12

Expression for SNORA12 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNORA12 Gene

mRNA expression in normal human tissues for SNORA12 Gene
mRNA expression by GTEx for SNORA12 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNORA12 Gene:

SNORA12

SOURCE GeneReport for Unigene cluster for SNORA12 Gene:

Hs.662165
genes like me logo Genes that share expression patterns with SNORA12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORA12 Gene

Orthologs for SNORA12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORA12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SNORA12 34
  • 99 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SNORA12 34
  • 89 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia SNORA12 34
  • 87 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Gm24336 34
  • 77 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia SNORA12 34
  • 67 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia SNORA12 34
  • 59 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves SNORA12 34
  • 53 (a)
 OneToMany
Species where no ortholog for SNORA12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SNORA12 Gene

ENSEMBL:
Gene Tree for SNORA12 (if available)
TreeFam:
Gene Tree for SNORA12 (if available)

Paralogs for SNORA12 Gene

No data available for Paralogs for SNORA12 Gene

Variants for SNORA12 Gene

Sequence variations from dbSNP and Humsavar for SNORA12 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000866778 -- 100,238,812(-) G/A upstream_transcript_variant
rs1001096657 -- 100,239,142(-) C/G upstream_transcript_variant
rs1001152180 -- 100,237,200(-) T/C/G non_coding_transcript_variant
rs1006815150 -- 100,237,422(-) A/G upstream_transcript_variant
rs1007728227 -- 100,238,396(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNORA12 Gene

Variant ID Type Subtype PubMed ID
nsv516860 CNV loss 19592680

Additional Variant Information for SNORA12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORA12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORA12 Gene

Disorders for SNORA12 Gene

Additional Disease Information for SNORA12

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SNORA12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORA12 Gene

Publications for SNORA12 Gene

  1. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. (PMID: 16381836) Lestrade L … Weber MJ (Nucleic acids research 2006) 1 2 3 58
  2. A novel experimental approach for systematic identification of box H/ACA snoRNAs from eukaryotes. (PMID: 16361266) Gu AD … Qu LH (Nucleic acids research 2005) 1 2 3 58
  3. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A … Müller CR (Thrombosis and haemostasis 2011) 3 58
  4. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G … Montanini B (Genomics 2009) 3 58
  5. The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. (PMID: 18089548) Genome Information Integration Project And H-Invitational 2 … Gojobori T (Nucleic acids research 2008) 1

Products for SNORA12 Gene

Sources for SNORA12 Gene

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