SNN Gene
protein-coding GIFtS: 48
GCID: GC16P011669
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stannin
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Aliases
for SNN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Export aliases for SNN gene to outside databasesPrevious GC identifers: GC16P011545 GC16P011914 GC16P011728 |
Summaries
for SNN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SNN_HUMAN, O75324Function: Plays a role in the toxic effects of organotins
Gene Wiki entry for SNN
|
Genomic Views
for SNN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SNN gene promoter:
N-Myc SREBP-1a p53 SREBP-1c Nkx2-5 NF-kappaB NF-kappaB1 SREBP-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for SNN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13 Ensembl cytogenetic band: 16p13.13 HGNC cytogenetic band: 16p13SNN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P011669: view genomic region
(about GC identifiers)
Start:
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11,762,270 bp from pter |
End:
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11,773,015 bp from pter |
Size:
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10,746 bases |
Orientation:
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plus strand |
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Proteins
for SNN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNN_HUMAN, O75324 (See
protein sequence)Recommended Name: Stannin Size: 88 amino acids; 9497 Da
Subunit: Monomer
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein
1 PDB 3D structure from  and Proteopedia  for SNN:1ZZA (3D)
Secondary accessions: D3DUG4 Q6FGI0Explore the universe of human proteins at neXtProt for SNN: NX_O75324
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75324
SNN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003489.1
ENSEMBL proteins: ENSP00000329287
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005741 | mitochondrial outer membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SNN for ontologies About GeneDecksing
SNN Antibody Products:
Assay Products for SNN: |
Protein
Domains /
Families
for SNN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SNN for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75324ProtoNet protein and cluster: O75324 UniProtKB/Swiss-Prot: SNN_HUMAN, O75324Similarity: Belongs to the stannin family |
Function
for SNN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNN_HUMAN, O75324Function: Plays a role in the toxic effects of organotins Genatlas biochemistry entry for SNN:stannin,involved in the toxic effect of organotins
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SNN (NM_003498) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNN |
1 GenomeRNAi human phenotype for SNN:
|
Pathways & Interactions
for SNN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNN
1 Interacting protein for SNN (O753243) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SNN for ontologies About GeneDecksing
|
Drugs & Compounds
for SNN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SNN for compounds About GeneDecksing
 Browse Tocris compounds for SNN
3 Novoseek chemical compound relationships for SNN gene About this table
Search CenterWatch for drugs/clinical trials and news about SNN
|
Transcripts
for SNN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SNN gene: NM_003498.5 Unigene Cluster for SNN: Stannin Hs.618526 [show with all ESTs]Unigene Representative Sequence: NM_0034981 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000329565(uc002dbf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SNN (NM_003498) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SNN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNN |
Additional cDNA sequence: AF030196.1 AK025795.1 AL161976.1 BC005837.2 BC036100.1 BC036443.1 CR542127.1 CR542138.1 12 DOTS entries: DT.447430 DT.40126694 DT.95135635 DT.120656172 DT.120656151 DT.95167065 DT.100752122 DT.120656143 DT.120656203 DT.120656222 DT.101980962 DT.120656220 24/197 AceView cDNA sequences (see all 197): AW292025 AA903293 BM841235 BU728519 BF115522 AI216840 AA907804 AA604431 CB305719 R52256 BX444792 AI216843 NM_003498 BG055852 AA911492 F04590 AK025795 AA910913 F04556 AF030196 BM985224 BE387731 AW058083 BC036100
GeneLoc Exon Structure
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Expression
for SNN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SNN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAATGAAT
About this image
See SNN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNN
SOURCE GeneReport for Unigene cluster: Hs.618526
SABiosciences Expression via Pathway-Focused PCR Array including SNN:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNN |
Orthologs
for SNN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SNN gene from 5/11 species (see all 11) About this table
ENSEMBL Gene Tree for SNN (if available)
TreeFam Gene Tree for SNN (if available) |
Paralogs
for SNN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SNN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SNN (11762270 - 11773015 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SNN
1 CNV: 72459 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNN |
|
Disorders
/ Diseases
for SNN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SNN for disorders About GeneDecksing
OMIM gene information: 603032
OMIM disorders: --
3  diseases for SNN: About MalaCardscavernous hemangioma hemangioma neuronitis
1 disease from the University of Copenhagen DISEASES database for SNN:Cavernous hemangioma 3 Novoseek disease relationships for SNN gene About this table
Export disorders for SNN gene to outside databases
|
Publications
for SNN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SNN gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with SNN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Chromosomal localization and characterization of the stannin (Snn) gene. (PubMed id 9657854)1, 2, 3, 9 Dejneka N.S....Billingsley M.L. (1998)
- Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PubMed id 10233894)1, 2, 9 Horrevoets A.J.G.... Pannekoek H. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Localization and characterization of stannin: relationship to cellular sensitivity to organotin compounds. (PubMed id 9413842)1, 9 Dejneka N.S....Billingsley M.L. (1997)
- Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride. (PubMed id 16246365)2, 9 Buck-Koehntop B.A....Veglia G. (2005)
- Molecular neurotoxicology of trimethyltin: identification of stannin, a novel protein expressed in trimethyltin-sensitive cells. (PubMed id 1635553)1, 9 Toggas S.M....Billingsley M.L. (1992)
- Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408)1 Newton-Cheh C....Stricker B.H. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Phosphoproteomic analysis of the developing mouse brain. (PubMed id 15345747)1 Ballif B.A.... Gygi S.P. (2004)
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External Searches for SNN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SNN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SNN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SNN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SNN | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/snn/ |
|
| | |
About This Section
| Patent Information for SNN gene:
Search GeneIP for patents involving SNN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SNN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SNN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNN | | | OriGene Protein Over-expression Lysate for SNN | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SNN | | OriGene 3'-UTR Clone for SNN | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SNN | | OriGene Custom Protein Services for SNN | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNN | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNN |
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 |  |  |  | |
| | | | Search Tocris compounds for SNN |
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 | | | SNN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNN |
|  |  |  | | | | Search ThermoFisher Antibodies for SNN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNN |
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