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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNN Gene

protein-coding   GIFtS: 48
GCID: GC16P011669

Stannin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
stannin1 2
AG8_12 3

External Ids:    HGNC: 111491   Entrez Gene: 83032   Ensembl: ENSG000001846027   OMIM: 6030325   UniProtKB: O753243   

Export aliases for SNN gene to outside databases

Previous GC identifers: GC16P011545 GC16P011914 GC16P011728


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SNN Gene: 
SNN (stannin) is a protein-coding gene. Diseases associated with SNN include cavernous hemangioma, and hemangioma.

UniProtKB/Swiss-Prot: SNN_HUMAN, O75324
Function: Plays a role in the toxic effects of organotins

Gene Wiki entry for SNN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNN gene promoter:
         N-Myc   SREBP-1a   p53   SREBP-1c   Nkx2-5   NF-kappaB   NF-kappaB1   SREBP-1b   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SNN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13   Ensembl cytogenetic band:  16p13.13   HGNC cytogenetic band: 16p13

SNN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNN gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P011669:  view genomic region     (about GC identifiers)

Start:
11,762,270 bp from pter      End:
11,773,015 bp from pter
Size:
10,746 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SNN_HUMAN, O75324 (See protein sequence)
Recommended Name: Stannin  
Size: 88 amino acids; 9497 Da
Subunit: Monomer
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein
1 PDB 3D structure from and Proteopedia for SNN:
1ZZA (3D)    
Secondary accessions: D3DUG4 Q6FGI0

Explore the universe of human proteins at neXtProt for SNN: NX_O75324

Explore proteomics data for SNN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75324

  • SNN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNN Protein Expression
    REFSEQ proteins: NP_003489.1  
    ENSEMBL proteins: 
     ENSP00000329287  

    Human Recombinant Protein Products for SNN: 
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    Cloud-Clone Corp. Proteins for SNN 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741mitochondrial outer membrane IEA--
    GO:0016021integral to membrane IEA--

    SNN for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for SNN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR015137 SNN_cytoplasm
     IPR015136 SNN_linker
     IPR027435 Stannin
     IPR015135 SNN_transmemb

    Graphical View of Domain Structure for InterPro Entry O75324

    ProtoNet protein and cluster: O75324

    UniProtKB/Swiss-Prot: SNN_HUMAN, O75324
    Similarity: Belongs to the stannin family


    SNN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNN_HUMAN, O75324
    Function: Plays a role in the toxic effects of organotins

         Genatlas biochemistry entry for SNN:
    stannin,involved in the toxic effect of organotins

    Phenotypes:
         1 GenomeRNAi human phenotype for SNN:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SNN 
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    hsa-miR-194* hsa-miR-3194-5p hsa-miR-188-5p hsa-miR-199a-3p hsa-miR-298 hsa-miR-149 hsa-miR-489 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSNN 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNN

    1 Interacting protein for SNN (O753243) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631043I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006950response to stress TAS9657854
    GO:0009628response to abiotic stimulus TAS9657854

    SNN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SNN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNN

    3 Novoseek inferred chemical compound relationships for SNN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trimethyltin 94.1 35 15798003 (5), 8786553 (4), 1635553 (3), 16246365 (3) (see all 8)
    dimethyltin 91.5 3 15521759 (1), 15923056 (1)
    lipid 0 4 16246365 (3), 16453279 (1)

    Search CenterWatch for drugs/clinical trials and news about SNN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNN gene: 
    NM_003498.5  

    Unigene Cluster for SNN:

    Stannin
    Hs.618526  [show with all ESTs]
    Unigene Representative Sequence: NM_003498
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329565(uc002dbf.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNN
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate SNN (see all 74):
    hsa-miR-194* hsa-miR-3194-5p hsa-miR-188-5p hsa-miR-199a-3p hsa-miR-298 hsa-miR-149 hsa-miR-489 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSNN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SNN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNN
    Clone
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    OriGene clones in human, mouse for SNN (see all 5)
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    GenScript: all cDNA clones in your preferred vector: SNN (NM_003498)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNN
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNN

    Additional mRNA sequence: 

    AF030196.1 AK025795.1 AL161976.1 BC005837.2 BC036100.1 BC036443.1 CR542127.1 CR542138.1 

    12 DOTS entries:

    DT.447430  DT.40126694  DT.95135635  DT.120656172  DT.120656151  DT.95167065  DT.100752122  DT.120656143 
    DT.120656203  DT.120656222  DT.101980962  DT.120656220 

    24/197 AceView cDNA sequences (see all 197):

    AF030196 F09637 BC036443 BF589510 BF115522 AK025795 F04556 BX094465 
    BG055852 F04590 F02682 R52256 AI216840 AA604431 BE387731 AA907804 
    AW292025 AL048830 AA910913 AA911492 AI937275 CB305719 F03757 F11990 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAATGAAT
    SNN Expression
    About this image


    See SNN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNN

    SOURCE GeneReport for Unigene cluster: Hs.618526
        SABiosciences Expression via Pathway-Focused PCR Array including SNN: 
              Drug Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SNN gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snn1 , 5 stannin1, 5 89.02(n)1
    97.73(a)1
      16 (6.32 cM)5
    206211  NM_009223.31  NP_033249.11 
     110662985 
    chicken
    (Gallus gallus)
    Aves SNN1 stannin 81.01(n)
    95.35(a)
      416429  XM_003642147.1  XP_003642195.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNN6
    Uncharacterized protein
    78(a)
    1 ↔ 1
    GL343691.1(286547-286813)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.84902 Xenopus laevis transcribed sequence with moderate similarity more 80(n)    BJ096958.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj47f062 Danio rerio cDNA clone MGC73221 IMAGE4144075, complete more 79.84(n)    BC060919.1 


    ENSEMBL Gene Tree for SNN (if available)
    TreeFam Gene Tree for SNN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/286 SNPs in SNN are shown (see all 286)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1508129481,2
    --11760390(+) CAGTCC/TGATCA 1 -- us2k10--------
    rs1394167291,2
    --11760419(+) ATGTAC/TTCAGC 1 -- us2k10--------
    rs615305281,2
    C,F--11760459(+) GACACA/GGCAGT 1 -- us2k13Minor allele frequency- G:0.19CSA WA 121
    rs1930625731,2
    --11760576(+) TAATCC/GCAGCA 1 -- us2k10--------
    rs1477319351,2
    --11760658(+) CTCTAC/TAAAAA 1 -- us2k10--------
    rs81912591,2
    C,F--11760695(+) catgcA/Gcctgt 1 -- us2k12Minor allele frequency- G:0.02NS CSA 154
    rs1855801401,2
    --11760814(+) TCTCTA/TAAAAA 1 -- us2k10--------
    rs1888423271,2
    --11761030(+) GGGAGA/GGCCCT 1 -- us2k10--------
    rs1443424031,2
    --11761058(+) TAAGCA/TGAGAT 1 -- us2k10--------
    rs1144588971,2
    C,F--11761110(+) ATAGGC/TAAAGG 1 -- us2k11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for SNN (11762270 - 11773015 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SNN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv524676CNV Loss19592680
    esv22331CNV Loss19812545
    nsv457409CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603032    OMIM disorders: --

    4 diseases for SNN:    About MalaCards
    cavernous hemangioma    hemangioma    endotheliitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SNN:
    Cavernous hemangioma

    SNN for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SNN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    intoxication 33.5 2 16246365 (1)
    necrosis 11.7 3 10233894 (1), 15798003 (1), 16572589 (1)
    tumors 0 3 10233894 (1), 15798003 (1), 16572589 (1)

    Genetic Association Database (GAD): SNN

    Export disorders for SNN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNN gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with SNN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization and characterization of the stannin (Snn) gene. (PubMed id 9657854)1, 2, 3, 9 Dejneka N.S....Billingsley M.L. (1998)
    2. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PubMed id 10233894)1, 2, 9 Horrevoets A.J.G.... Pannekoek H. (1999)
    3. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408)1, 4 Newton-Cheh C....Stricker B.H. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Localization and characterization of stannin: relationship to cellular sensitivity to organotin compounds. (PubMed id 9413842)1, 9 Dejneka N.S....Billingsley M.L. (1997)
    6. Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride. (PubMed id 16246365)2, 9 Buck-Koehntop B.A....Veglia G. (2005)
    7. Molecular neurotoxicology of trimethyltin: identification of stannin, a novel protein expressed in trimethyltin-sensitive cells. (PubMed id 1635553)1, 9 Toggas S.M....Billingsley M.L. (1992)
    8. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8303 HGNC: 11149 AceView: SNN Ensembl:ENSG00000184602 euGenes: HUgn8303
    ECgene: SNN H-InvDB: SNN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNN Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/snn/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNN gene:
    Search GeneIP for patents involving SNN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
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     Regulatory tfbs in SNN promoter
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     Proteins for SNN
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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