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Aliases for SNN Gene

Aliases for SNN Gene

  • Stannin 2 3 5
  • AG8_1 3 4

External Ids for SNN Gene

Previous GeneCards Identifiers for SNN Gene

  • GC16P011545
  • GC16P011914
  • GC16P011728

Summaries for SNN Gene

GeneCards Summary for SNN Gene

SNN (Stannin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SNN Gene

  • Plays a role in the toxic effects of organotins.

Gene Wiki entry for SNN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNN Gene

Genomics for SNN Gene

Regulatory Elements for SNN Gene

Promoters for SNN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNN on UCSC Golden Path with GeneCards custom track

Genomic Location for SNN Gene

Chromosome:
16
Start:
11,668,414 bp from pter
End:
11,679,159 bp from pter
Size:
10,746 bases
Orientation:
Plus strand

Genomic View for SNN Gene

Genes around SNN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNN Gene

Proteins for SNN Gene

  • Protein details for SNN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75324-SNN_HUMAN
    Recommended name:
    Stannin
    Protein Accession:
    O75324
    Secondary Accessions:
    • D3DUG4
    • Q6FGI0

    Protein attributes for SNN Gene

    Size:
    88 amino acids
    Molecular mass:
    9497 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for SNN Gene

neXtProt entry for SNN Gene

Proteomics data for SNN Gene at MOPED

Post-translational modifications for SNN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNN Gene

Domains & Families for SNN Gene

Protein Domains for SNN Gene

Suggested Antigen Peptide Sequences for SNN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75324

UniProtKB/Swiss-Prot:

SNN_HUMAN :
  • Belongs to the stannin family.
Family:
  • Belongs to the stannin family.
genes like me logo Genes that share domains with SNN: view

No data available for Gene Families for SNN Gene

Function for SNN Gene

Molecular function for SNN Gene

GENATLAS Biochemistry:
stannin,involved in the toxic effect of organotins
UniProtKB/Swiss-Prot Function:
Plays a role in the toxic effects of organotins.

Phenotypes for SNN Gene

GenomeRNAi human phenotypes for SNN:
genes like me logo Genes that share phenotypes with SNN: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNN Gene

Localization for SNN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNN Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNN Gene COMPARTMENTS Subcellular localization image for SNN gene
Compartment Confidence
extracellular 3
mitochondrion 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with SNN: view

Pathways & Interactions for SNN Gene

SuperPathways for SNN Gene

No Data Available

Interacting Proteins for SNN Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000329287%0d%0a9606.ENSP00000358081%0d%0a9606.ENSP00000309503%0d%0a
Selected Interacting proteins: ENSP00000329287 O75324-SNN_HUMAN for SNN Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009628 response to abiotic stimulus TAS 9657854
genes like me logo Genes that share ontologies with SNN: view

No data available for Pathways by source and SIGNOR curated interactions for SNN Gene

Drugs & Compounds for SNN Gene

(3) Additional Compounds for SNN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNN: view

Transcripts for SNN Gene

mRNA/cDNA for SNN Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(197) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNN Gene

Stannin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNN Gene

No ASD Table

Relevant External Links for SNN Gene

GeneLoc Exon Structure for
SNN
ECgene alternative splicing isoforms for
SNN

Expression for SNN Gene

mRNA expression in normal human tissues for SNN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNN Gene

This gene is overexpressed in Fetal Brain (59.3) and Frontal cortex (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNN Gene



SOURCE GeneReport for Unigene cluster for SNN Gene Hs.618526

genes like me logo Genes that share expression patterns with SNN: view

Protein tissue co-expression partners for SNN Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNN Gene

Orthologs for SNN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNN 35
  • 93.02 (n)
  • 100 (a)
SNN 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNN 35
  • 92.72 (n)
  • 100 (a)
SNN 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snn 35
  • 89.02 (n)
  • 97.73 (a)
Snn 16
Snn 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNN 35
  • 100 (n)
  • 100 (a)
SNN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snn 35
  • 89.39 (n)
  • 97.73 (a)
oppossum
(Monodelphis domestica)
Mammalia SNN 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNN 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNN 35
  • 81.01 (n)
  • 95.35 (a)
SNN 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNN 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snn 35
  • 80.23 (n)
  • 90.7 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8490 35
zebrafish
(Danio rerio)
Actinopterygii snn 35
  • 79.46 (n)
  • 89.53 (a)
wufj47f06 35
snn 36
  • 89 (a)
OneToOne
Species with no ortholog for SNN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNN Gene

ENSEMBL:
Gene Tree for SNN (if available)
TreeFam:
Gene Tree for SNN (if available)

Paralogs for SNN Gene

No data available for Paralogs for SNN Gene

Variants for SNN Gene

Sequence variations from dbSNP and Humsavar for SNN Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs8191328 - 11,676,108(+) TCATC(A/G)TCATC reference, missense
rs8191329 - 11,676,321(+) TCCAC(A/G)GCTGA reference, missense
rs1802408 -- 11,678,357(+) TCACC(A/G)CAGCC utr-variant-3-prime
rs1802409 -- 11,678,374(+) TACAC(A/C)TAGGC utr-variant-3-prime
rs1050048 -- 11,677,615(+) GGCTC(C/T)CTGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SNN Gene

Variant ID Type Subtype PubMed ID
nsv457409 CNV Gain 19166990
nsv524676 CNV Loss 19592680
esv22331 CNV Loss 19812545

Variation tolerance for SNN Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNN Gene

HapMap Linkage Disequilibrium report
SNN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNN Gene

Disorders for SNN Gene

Relevant External Links for SNN

Genetic Association Database (GAD)
SNN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNN

No disorders were found for SNN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNN Gene

Publications for SNN Gene

  1. Chromosomal localization and characterization of the stannin (Snn) gene. (PMID: 9657854) Dejneka N.S. … Billingsley M.L. (Mamm. Genome 1998) 2 3 4 23 67
  2. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PMID: 10233894) Horrevoets A.J.G. … Pannekoek H. (Blood 1999) 3 23
  3. Localization and characterization of stannin: relationship to cellular sensitivity to organotin compounds. (PMID: 9413842) Dejneka N.S. … Billingsley M.L. (Neurochem. Int. 1997) 3 23
  4. Molecular neurotoxicology of trimethyltin: identification of stannin, a novel protein expressed in trimethyltin-sensitive cells. (PMID: 1635553) Toggas S.M. … Billingsley M.L. (Mol. Pharmacol. 1992) 3 23
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3

Products for SNN Gene

Sources for SNN Gene

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