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Aliases for SNN Gene

Aliases for SNN Gene

External Ids for SNN Gene

Previous GeneCards Identifiers for SNN Gene

  • GC16P011545
  • GC16P011914
  • GC16P011728

Summaries for SNN Gene

GeneCards Summary for SNN Gene

SNN (Stannin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SNN Gene

  • Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288).

Gene Wiki entry for SNN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNN Gene

Genomics for SNN Gene

Regulatory Elements for SNN Gene

Enhancers for SNN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F011639 1.8 FANTOM5 Ensembl ENCODE 13.8 -27.8 -27757 3.3 PKNOX1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 LITAF TNP2 LOC105371084 ENSG00000261560 ENSG00000199668 ENSG00000212228 PRM3 ENSG00000261293 LOC105371079 MTATP6P24
GH16F011667 1.4 FANTOM5 ENCODE 13.5 +2.0 1979 6.7 SIN3A ZNF48 GLIS2 ZNF143 FOS SP5 NFYC MXD4 REST TBX21 ZC3H7A TXNDC11 LITAF LOC105371084 ENSG00000261560 SNN HNRNPCP4 RSL1D1 COX6CP1 SNX29
GH16F011594 1.6 FANTOM5 Ensembl ENCODE 11 -71.2 -71214 5.2 PKNOX1 ZFP64 FEZF1 YBX1 YY1 ZNF121 ZNF143 FOS TBX21 ZNF623 LITAF SNN TXNDC11 SOCS1 ZC3H7A SNX29 LOC400499
GH16F011608 1.8 FANTOM5 Ensembl ENCODE 8.6 -56.1 -56093 8.6 PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 LITAF ENSG00000261560 TXNDC11 LOC105371084 SOCS1 HNRNPCP4 COX6CP1 ENSG00000261216 SNN ZC3H7A
GH16F011200 1.7 FANTOM5 Ensembl ENCODE 8.8 -466.4 -466365 2.9 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 FOS KLF13 MXD4 REST SOCS1 NUBP1 LOC105371084 HNRNPCP4 ENSG00000261560 RMI2 COX6CP1 ENSG00000261216 ENSG00000199668 TNP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNN on UCSC Golden Path with GeneCards custom track

Promoters for SNN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000148107 586 2401 TBP TBL1XR1 SIN3A ZNF48 GLIS2 EGR1 ZNF143 ETV6 FOS SP5

Genomic Location for SNN Gene

11,668,414 bp from pter
11,679,159 bp from pter
10,746 bases
Plus strand

Genomic View for SNN Gene

Genes around SNN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNN Gene

Proteins for SNN Gene

  • Protein details for SNN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DUG4
    • Q6FGI0

    Protein attributes for SNN Gene

    88 amino acids
    Molecular mass:
    9497 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for SNN Gene

neXtProt entry for SNN Gene

Post-translational modifications for SNN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNN Gene

Domains & Families for SNN Gene

Protein Domains for SNN Gene

Suggested Antigen Peptide Sequences for SNN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the stannin family.
  • Belongs to the stannin family.
genes like me logo Genes that share domains with SNN: view

No data available for Gene Families for SNN Gene

Function for SNN Gene

Molecular function for SNN Gene

GENATLAS Biochemistry:
stannin,involved in the toxic effect of organotins
UniProtKB/Swiss-Prot Function:
Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288).

Phenotypes for SNN Gene

genes like me logo Genes that share phenotypes with SNN: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNN Gene

Localization for SNN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNN Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNN gene
Compartment Confidence
extracellular 3
mitochondrion 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SNN: view

Pathways & Interactions for SNN Gene

No Data Available

Interacting Proteins for SNN Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000329287 O75324-SNN_HUMAN for SNN Gene via STRING IID

Gene Ontology (GO) - Biological Process for SNN Gene


No data available for Pathways by source and SIGNOR curated interactions for SNN Gene

Drugs & Compounds for SNN Gene

(3) Additional Compounds for SNN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNN: view

Transcripts for SNN Gene

mRNA/cDNA for SNN Gene

Unigene Clusters for SNN Gene

Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNN Gene

No ASD Table

Relevant External Links for SNN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNN Gene

This gene is overexpressed in Fetal Brain (59.3) and Frontal cortex (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNN Gene

Protein tissue co-expression partners for SNN Gene

NURSA nuclear receptor signaling pathways regulating expression of SNN Gene:


SOURCE GeneReport for Unigene cluster for SNN Gene:

genes like me logo Genes that share expression patterns with SNN: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SNN Gene

Orthologs for SNN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNN 34 35
  • 100 (n)
(Monodelphis domestica)
Mammalia SNN 35
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia SNN 35
  • 97 (a)
(Bos Taurus)
Mammalia SNN 34 35
  • 93.02 (n)
(Canis familiaris)
Mammalia SNN 34 35
  • 92.72 (n)
(Rattus norvegicus)
Mammalia Snn 34
  • 89.39 (n)
(Mus musculus)
Mammalia Snn 34 16 35
  • 89.02 (n)
(Gallus gallus)
Aves SNN 34 35
  • 81.01 (n)
(Anolis carolinensis)
Reptilia SNN 35
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snn 34
  • 80.23 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8490 34
(Danio rerio)
Actinopterygii snn 34 35
  • 79.46 (n)
wufj47f06 34
Species where no ortholog for SNN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNN Gene

Gene Tree for SNN (if available)
Gene Tree for SNN (if available)

Paralogs for SNN Gene

No data available for Paralogs for SNN Gene

Variants for SNN Gene

Sequence variations from dbSNP and Humsavar for SNN Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1050048 -- 11,677,615(+) GGCTC(C/T)CTGGT utr-variant-3-prime
rs1050049 -- 11,677,850(+) AAAGG(C/T)ACCTC utr-variant-3-prime
rs1050068 -- 11,676,092(+) ACGGG(C/T)GTGGT reference, synonymous-codon
rs1050069 -- 11,676,107(+) GTCAT(C/T)GTCAT reference, synonymous-codon
rs111549052 -- 11,670,454(+) CTTCT(C/G)GCCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNN Gene

Variant ID Type Subtype PubMed ID
nsv952922 CNV deletion 24416366
nsv571456 CNV gain 21841781
nsv524676 CNV loss 19592680
nsv457409 CNV gain 19166990
nsv1144756 CNV deletion 24896259
esv22331 CNV loss 19812545

Variation tolerance for SNN Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNN Gene

Disorders for SNN Gene

Relevant External Links for SNN

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SNN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNN Gene

Publications for SNN Gene

  1. Chromosomal localization and characterization of the stannin (Snn) gene. (PMID: 9657854) Dejneka N.S. … Billingsley M.L. (Mamm. Genome 1998) 2 3 4 22 64
  2. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PMID: 10233894) Horrevoets A.J.G. … Pannekoek H. (Blood 1999) 3 4 22 64
  3. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C. … Stricker B.H. (Nat. Genet. 2009) 3 46 64
  4. Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride. (PMID: 16246365) Buck-Koehntop B.A. … Veglia G. (J. Mol. Biol. 2005) 4 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SNN Gene

Sources for SNN Gene

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