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SNIP1 Gene

protein-coding   GIFtS: 56
GCID: GC01M038002

Smad Nuclear Interacting Protein 1

  See SNIP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Smad Nuclear Interacting Protein 11 2
FHA Domain-Containing Protein SNIP12 3
PMRED2 5
Smad Nuclear-Interacting Protein 12

External Ids:    HGNC: 305871   Entrez Gene: 797532   Ensembl: ENSG000001638777   OMIM: 6082415   UniProtKB: Q8TAD83   

Export aliases for SNIP1 gene to outside databases

Previous GC identifers: GC01M037836 GC01M037057 GC01M037428 GC01M037429 GC01M037671 GC01M037774 GC01M036118


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SNIP1 Gene:
This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The
encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits
transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also
regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression.
Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED).
(provided by RefSeq, Mar 2012)

GeneCards Summary for SNIP1 Gene:
SNIP1 (Smad nuclear interacting protein 1) is a protein-coding gene. Diseases associated with SNIP1 include psychomotor retardation, epilepsy, and craniofacial dysmorphism, and tongue squamous cell carcinoma. An important paralog of this gene is PPP1R8.

UniProtKB/Swiss-Prot: SNIP1_HUMAN, Q8TAD8
Function: Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the
microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which
associates with both the 3'end of the CCND1 gene and its mRNA

Gene Wiki entry for SNIP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNIP1 gene promoter:
         GR   p53   AP-1   ATF-2   Nkx2-5   FOXO4   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNIP1 promoter sequence
   Search Chromatin IP Primers for SNIP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

SNIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNIP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M038002:  view genomic region     (about GC identifiers)

Start:
38,000,050 bp from pter      End:
38,019,903 bp from pter
Size:
19,854 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SNIP1_HUMAN, Q8TAD8 (See protein sequence)
Recommended Name: Smad nuclear-interacting protein 1  
Size: 396 amino acids; 45778 Da
Subunit: Binds SMAD4 and CREBBP/EP300. Binds the SMAD1/OAZ1/PSMB4 complex. Interacts with DROSHA and SMARCA4.
Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN
Secondary accessions: Q96SP9 Q9H9T7

Explore the universe of human proteins at neXtProt for SNIP1: NX_Q8TAD8

Explore proteomics data for SNIP1 at MOPED

Post-translational modifications: 

  • Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex1
  • Ubiquitination2 at Lys342
  • Modification sites at PhosphoSitePlus

  • See SNIP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078976.2  
    ENSEMBL proteins: 
     ENSP00000296215  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008984 SMAD_FHA_domain
     IPR000253 FHA_dom

    Graphical View of Domain Structure for InterPro Entry Q8TAD8

    ProtoNet protein and cluster: Q8TAD8

    UniProtKB/Swiss-Prot: SNIP1_HUMAN, Q8TAD8
    Similarity: Contains 1 FHA domain


    Find genes that share domains with SNIP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNIP1_HUMAN, Q8TAD8
    Function: Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the
    microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which
    associates with both the 3'end of the CCND1 gene and its mRNA

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17157259
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SNIP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SNIP1:
     Increased S DNA content 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Snip1):
     behavior/neurological  growth/size/body  homeostasis/metabolism  integument  mortality/aging 
     other  vision/eye 

    Find genes that share phenotypes with SNIP1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNIP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNIP1
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    Selected qRT-PCR Assays for microRNAs that regulate SNIP1 (see all 31):
    hsa-miR-3910 hsa-miR-607 hsa-miR-4311 hsa-miR-520d-5p hsa-miR-29a hsa-miR-29c hsa-miR-301a hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidSNIP1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNIP1_HUMAN, Q8TAD8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----

    Find genes that share ontologies with SNIP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SNIP1 About    
    See pathways by source

    SuperPathContained pathways About
    1TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    2Regulation of nuclear SMAD2/3 signaling
    Regulation of nuclear SMAD2/3 signaling


    2 BioSystems Pathways for SNIP1
        TGF-beta Receptor Signaling Pathway
    Regulation of nuclear SMAD2/3 signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNIP1
    Interactions:

        GeneGlobe Interaction Network for SNIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SNIP1 (Q8TAD81, 2, 3 ENSP000002962154) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3B1O755332, 3, ENSP000003353214MINT-8333504 MINT-62164 I2D: score=3 STRING: ENSP00000335321
    IKQ131231, 2, ENSP000003963014EBI-749336,EBI-713456 MINT-8337310 MINT-8332460 STRING: ENSP00000396301
    SNW1Q135731, 2, ENSP000002615314EBI-749336,EBI-632715 MINT-8337134 MINT-8332449 STRING: ENSP00000261531
    MYCP011061, 3, ENSP000003672074EBI-749336,EBI-447544 I2D: score=2 STRING: ENSP00000367207
    EIF3CQ996132, 3MINT-62165 I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007249I-kappaB kinase/NF-kappaB signaling IEA--
    GO:0035196production of miRNAs involved in gene silencing by miRNA IMP18632581

    Find genes that share ontologies with SNIP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNIP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SNIP1 gene: 
    NM_024700.3  

    Unigene Cluster for SNIP1:

    Smad nuclear interacting protein 1
    Hs.47232  [show with all ESTs]
    Unigene Representative Sequence: NM_024700
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296215(uc001cbi.3 uc010oid.2) ENST00000468040 ENST00000493916

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SNIP1 (see all 31):
    hsa-miR-3910 hsa-miR-607 hsa-miR-4311 hsa-miR-520d-5p hsa-miR-29a hsa-miR-29c hsa-miR-301a hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidSNIP1 3' UTR sequence
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    Primer
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    OriGene qPCR primer pairs and template standards for SNIP1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNIP1
      QuantiTect SYBR Green Assays in human, mouse, rat SNIP1
      QuantiFast Probe-based Assays in human, mouse, rat SNIP1

    Additional mRNA sequence: 

    AK022615.1 AK027622.1 AK293229.1 AK297176.1 AK300796.1 AK315574.1 AY081909.1 BC027040.1 

    7 DOTS entries:

    DT.95163616  DT.121426053  DT.206933  DT.121426073  DT.95163619  DT.121426059  DT.95111137 

    Selected AceView cDNA sequences (see all 67):

    BQ007547 AI911973 BC027040 NM_024700 AK027622 CB216842 AA463716 BI754239 
    AY081909 BU620176 BM713898 CA420998 BQ016472 CD108121 AI299739 BU630597 
    CD368279 AK022615 BE218496 BE910636 BM726708 BP376058 BU754475 BI087586 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SNIP1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5
    SP1:                    -                     
    SP2:                                          


    ECgene alternative splicing isoforms for SNIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SNIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SNIP1 Expression
    About this image

    SNIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNIP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.47232

    UniProtKB/Swiss-Prot: SNIP1_HUMAN, Q8TAD8
    Tissue specificity: Ubiquitous, with highest expression in heart and skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SNIP1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snip11 , 5 Smad nuclear interacting protein 11, 5 84.07(n)1
    86.16(a)1
      4 (57.99 cM)5
    767931  NM_175246.41  NP_780455.21 
     1250666725 
    chicken
    (Gallus gallus)
    Aves SNIP11 Smad nuclear interacting protein 1 70.07(n)
    74.31(a)
      419616  XM_417763.4  XP_417763.3 
    lizard
    (Anolis carolinensis)
    Reptilia SNIP16
    Smad nuclear interacting protein 1
    73(a)
    1 ↔ 1
    GL343426.1(454849-459582)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480492202   -- 75.86(n)    48049220 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.173972 Transcribed sequence with weak similarity to protein more 73.18(n)    CK000022.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG171683 protein phosphatase inhibitor 60(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C32E8.53   -- 69(a)   I(3782139-3783182)   --


    ENSEMBL Gene Tree for SNIP1 (if available)
    TreeFam Gene Tree for SNIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SNIP1 gene
    PPP1R82  SLC4A1AP2  

    Find genes that share paralogs with SNIP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SNIP1 (see all 494)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0675424
    Psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED)4--see VAR_0675422 E G mis40--------
    rs1129991421,2
    C--38003945(+) TCTACT/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1119920281,2
    C,F--38004625(+) GCGCTC/ACTTAC 1 -- int12Minor allele frequency- A:0.07CSA WA 120
    rs710539781,2
    C--38007607(-) AAAACA/-AAAAA 1 -- int12Minor allele frequency- -:0.25NA 4
    rs676151661,2
    C--38009509(+) GCAAG-/GGGGGG 1 -- int10--------
    rs1116768571,2
    C,F--38009910(+) GGCGCG/TGTGGC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs340996171,2
    C--38011759(+) CCCCC-/C/CC  
            
    GCTCC
    1 -- int12NA 4
    rs1126618311,2
    C,F--38012153(+) GCCTAC/TAGTCC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs712787441,2
    C--38014699(-) TCTAGT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs563507521,2
    C--38016870(+) AAAAA-/AGGAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SNIP1 (38000050 - 38019903 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SNIP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834746CNV Loss17160897
    nsv483134CNV Loss15286789
    nsv524834CNV Gain19592680

    Human Gene Mutation Database (HGMD): SNIP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SNIP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608241   
    OMIM disorders: 614501  
    UniProtKB/Swiss-Prot: SNIP1_HUMAN, Q8TAD8
  • Psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED) [MIM:614501]: A disease
    characterized by severe psychomotor retardation, intractable seizures, dysmorphic features, and a lumpy skull
    surface. Patients are hypotonic and have poor feeding in the neonatal period. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 2 diseases for SNIP1:    
    About MalaCards
    psychomotor retardation, epilepsy, and craniofacial dysmorphism    tongue squamous cell carcinoma


    Find genes that share disorders with SNIP1           About GenesLikeMe


    Export disorders for SNIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SNIP1 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with SNIP1)
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    1. The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression. (PubMed id 15378006)1, 2, 3, 9 Roche K.C.... Perkins N.D. (Oncogene 2004)
    2. A novel Smad nuclear interacting protein, SNIP1, suppresses p300- dependent TGF-beta signal transduction. (PubMed id 10887155)1, 2, 3 Kim R.H.... Roberts A.B. (Genes Dev. 2000)
    3. Genetic mapping and exome sequencing identify variants associated with five novel diseases. (PubMed id 22279524)1, 2 Puffenberger E.G....Strauss K.A. (PLoS ONE 2012)
    4. Regulation of cyclin D1 RNA stability by SNIP1. (PubMed id 18794151)1, 2 Bracken C.P....Perkins N.D. (Cancer Res. 2008)
    5. The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis. (PubMed id 18632581)1, 2 Yu B.... Chen X. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs). (PubMed id 12097147)1, 2 Lin Y.... Wang T. (BMC Cell Biol. 2002)
    10. SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. (PubMed id 11567019)1, 2 Kim R.H.... Roberts A.B. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79753 HGNC: 30587 AceView: SNIP1 Ensembl:ENSG00000163877 euGenes: HUgn79753
    ECgene: SNIP1 H-InvDB: SNIP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SNIP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SNIP1 gene:
    Search GeneIP for patents involving SNIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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