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Aliases for SNED1 Gene

Aliases for SNED1 Gene

  • Sushi, Nidogen And EGF-Like Domains 1 2 3
  • Insulin-Responsive Sequence DNA-Binding Protein 1 3 4
  • IRE-BP1 3 4
  • Sushi, Nidogen And EGF-Like Domain-Containing Protein 1 3
  • Insulin Responsive Sequence DNA Binding Protein-1 3
  • 6720455I24Rik Homolog 3
  • SST3 3
  • Snep 3

External Ids for SNED1 Gene

Previous GeneCards Identifiers for SNED1 Gene

  • GC02P241658
  • GC02P241586
  • GC02P241938
  • GC02P233694

Summaries for SNED1 Gene

GeneCards Summary for SNED1 Gene

SNED1 (Sushi, Nidogen And EGF-Like Domains 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NOTCH2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNED1 Gene

Genomics for SNED1 Gene

Regulatory Elements for SNED1 Gene

Transcription factor binding sites by QIAGEN in the SNED1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNED1 Gene

240,998,793 bp from pter
241,095,568 bp from pter
96,776 bases
Plus strand

Genomic View for SNED1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNED1 Gene

Proteins for SNED1 Gene

  • Protein details for SNED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sushi, nidogen and EGF-like domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B5MDC3
    • B7WNK6
    • B7WPM0
    • Q336F4
    • Q336F5
    • Q8N369
    • Q8TEP7

    Protein attributes for SNED1 Gene

    1413 amino acids
    Molecular mass:
    152204 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH27939.1; Type=Miscellaneous discrepancy; Note=Intron retention. The N-terminal region arises from intron retention.; Evidence={ECO:0000305}; Sequence=AAQ04558.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SNED1 Gene


neXtProt entry for SNED1 Gene

Proteomics data for SNED1 Gene at MOPED

Post-translational modifications for SNED1 Gene

  • Glycosylation at Asn145, Asn408, Asn977, and Ser1247
  • Modification sites at PhosphoSitePlus

Other Protein References for SNED1 Gene

No data available for DME Specific Peptides for SNED1 Gene

Domains for SNED1 Gene

Gene Families for SNED1 Gene

Suggested Antigen Peptide Sequences for SNED1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 15 EGF-like domains.
  • Contains 15 EGF-like domains.
  • Contains 3 fibronectin type-III domains.
  • Contains 2 follistatin-like domains.
  • Contains 1 NIDO domain.
  • Contains 1 Sushi (CCP/SCR) domain.
genes like me logo Genes that share domains with SNED1: view

Function for SNED1 Gene

Gene Ontology (GO) - Molecular Function for SNED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SNED1: view

Phenotypes for SNED1 Gene

GenomeRNAi human phenotypes for SNED1:
genes like me logo Genes that share phenotypes with SNED1: view

Animal Model Products

miRNA for SNED1 Gene

miRTarBase miRNAs that target SNED1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SNED1 Gene

Localization for SNED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNED1 Gene


Subcellular locations from

Jensen Localization Image for SNED1 Gene COMPARTMENTS Subcellular localization image for SNED1 gene
Compartment Confidence
extracellular 3
plasma membrane 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SNED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SNED1: view

Pathways for SNED1 Gene

SuperPathways for SNED1 Gene

No Data Available

Interacting Proteins for SNED1 Gene

Gene Ontology (GO) - Biological Process for SNED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion IEA --
genes like me logo Genes that share ontologies with SNED1: view

No data available for Pathways by source for SNED1 Gene

Drugs for SNED1 Gene

(1) Novoseek inferred chemical compound relationships for SNED1 Gene

Compound -log(P) Hits PubMed IDs
octreotide 69.1 2
genes like me logo Genes that share compounds with SNED1: view

Transcripts for SNED1 Gene

Unigene Clusters for SNED1 Gene

Sushi, nidogen and EGF-like domains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNED1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20
SP1: - -
SP3: -

Relevant External Links for SNED1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNED1 Gene

mRNA expression in normal human tissues for SNED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SNED1 Gene

This gene is overexpressed in Serum (63.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SNED1 Gene

SOURCE GeneReport for Unigene cluster for SNED1 Gene Hs.471834

genes like me logo Genes that share expressions with SNED1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for SNED1 Gene

Orthologs for SNED1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNED1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SNED1 35
  • 85.07 (n)
  • 84.38 (a)
SNED1 36
  • 85 (a)
(Mus musculus)
Mammalia Sned1 35
  • 84.04 (n)
  • 84.54 (a)
Sned1 16
Sned1 36
  • 84 (a)
(Pan troglodytes)
Mammalia SNED1 35
  • 98.82 (n)
  • 98.44 (a)
SNED1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Sned1 35
  • 84.21 (n)
  • 84.69 (a)
(Bos Taurus)
Mammalia SNED1 36
  • 81 (a)
(Monodelphis domestica)
Mammalia SNED1 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia SNED1 36
  • 70 (a)
(Gallus gallus)
Aves SNED1 35
  • 74.19 (n)
  • 71.71 (a)
SNED1 36
  • 68 (a)
(Anolis carolinensis)
Reptilia SNED1 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sned1 35
  • 58.2 (n)
  • 53.13 (a)
(Danio rerio)
Actinopterygii sned1 35
  • 57.34 (n)
  • 53.43 (a)
sned1 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta C901 36
  • 23 (a)
uif 36
  • 9 (a)
(Caenorhabditis elegans)
Secernentea lin-12 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for SNED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNED1 Gene

Gene Tree for SNED1 (if available)
Gene Tree for SNED1 (if available)

Paralogs for SNED1 Gene

Paralogs for SNED1 Gene Pseudogenes for SNED1 Gene

genes like me logo Genes that share paralogs with SNED1: view

Variants for SNED1 Gene

Sequence variations from dbSNP and Humsavar for SNED1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs740392 -- 241,068,515(-) GCCCC(A/T)GGAAG intron-variant
rs758080 -- 241,071,251(+) GAGTC(C/T)GAGCC intron-variant
rs982326 -- 241,042,948(+) ATCCA(C/T)GTATT intron-variant
rs982327 -- 241,043,006(+) CCATG(C/T)ATGTG intron-variant
rs1123650 -- 241,042,489(-) CTGGG(C/T)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNED1 Gene

Variant ID Type Subtype PubMed ID
nsv876116 CNV Loss 21882294
nsv460167 CNV Gain 19166990
dgv4487n71 CNV Loss 21882294
nsv876204 CNV Loss 21882294
dgv4490n71 CNV Loss 21882294
nsv876219 CNV Loss 21882294
dgv4491n71 CNV Loss 21882294
esv2675882 CNV Deletion 23128226
esv2721965 CNV Deletion 23290073
esv2721966 CNV Deletion 23290073
esv2721967 CNV Deletion 23290073
esv1359552 CNV Insertion 17803354
esv2721968 CNV Deletion 23290073
esv2721969 CNV Deletion 23290073
esv1654437 CNV Insertion 17803354
esv2721970 CNV Deletion 23290073
esv2200022 CNV Deletion 18987734
dgv772e199 CNV Deletion 23128226
esv2721971 CNV Deletion 23290073
esv2077609 CNV Deletion 18987734
nsv213970 CNV Loss 16902084
esv2721972 CNV Deletion 23290073

Relevant External Links for SNED1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNED1 Gene

Disorders for SNED1 Gene

(1) Novoseek inferred disease relationships for SNED1 Gene

Disease -log(P) Hits PubMed IDs
tumors 4.65 1
genes like me logo Genes that share disorders with SNED1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for SNED1 Gene

Publications for SNED1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Cloning and expression analysis of the mouse stroma marker Snep encoding a novel nidogen domain protein. (PMID: 15162516) Leimeister C. … Gessler M. (Dev. Dyn. 2004) 3
  3. Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase. (PMID: 22266900) Roboti P. … High S. (J. Cell. Sci. 2012) 3
  4. Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women. (PMID: 22675492) Prescott J. … De Vivo I. (PLoS ONE 2012) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for SNED1 Gene

Sources for SNED1 Gene

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