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SND1 Gene

protein-coding   GIFtS: 58
GCID: GC07P127292

Staphylococcal Nuclease And Tudor Domain Containing 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Staphylococcal Nuclease And Tudor Domain Containing 11 2     P100 Co-Activator2 3
Tudor-SN1 2     EBNA-2 Co-Activator (100kD)2
P100 EBNA2 Co-Activator1 2     p1002
Tudor Domain-Containing Protein 112 3     SND1-BRAF Fusion2
100 KDa Coactivator2 3     Staphylococcal Nuclease Domain Containing 12
TDRD112 3     Staphylococcal Nuclease Domain-Containing Protein 12
EBNA2 Coactivator P1002 3     P1005

External Ids:    HGNC: 306461   Entrez Gene: 270442   Ensembl: ENSG000001971577   OMIM: 6021815   UniProtKB: Q7KZF43   

Export aliases for SND1 gene to outside databases

Previous GC identifers: GC07P126846 GC07P126886 GC07P127079 GC07P121653


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SND1 Gene:
SND1 (staphylococcal nuclease and tudor domain containing 1) is a protein-coding gene. Diseases associated with SND1 include autism spectrum disorder, and kaposi's sarcoma. GO annotations related to this gene include nuclease activity and nucleic acid binding.

UniProtKB/Swiss-Prot: SND1_HUMAN, Q7KZF4
Function: Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1
regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen
2 (EBNA2)

Gene Wiki entry for SND1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SND1 gene promoter:
         TBP   HFH-3   AML1a   CUTL1   Evi-1   FOXI1   TFIID   c-Myb   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 14): SND1 promoter sequence
   Search Chromatin IP Primers for SND1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SND1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q31.3

SND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SND1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P127292:  view genomic region     (about GC identifiers)

Start:
127,292,202 bp from pter      End:
127,732,661 bp from pter
Size:
440,460 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 126,675,657-127,115,790     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SND1_HUMAN, Q7KZF4 (See protein sequence)
Recommended Name: Staphylococcal nuclease domain-containing protein 1  
Size: 910 amino acids; 101997 Da
Subunit: Binds to acidic transactivation domain of EBNA2. Interacts with EAV NSP1. Interacts with GTF2E1 and
GTF2E2. Forms a ternary complex with STAT6 and POLR2A. Interacts with STAT5 (By similarity)
Sequence caution: Sequence=AAA80488.1; Type=Frameshift; Positions=5; Note=The frameshift leads to wrong
initiation;
Selected PDB 3D structures from and Proteopedia for SND1 (see all 7):
2E6N (3D)        2HQE (3D)        2HQX (3D)        2O4X (3D)        3BDL (3D)        3OMC (3D)    
Secondary accessions: Q13122 Q96AG0

Explore the universe of human proteins at neXtProt for SND1: NX_Q7KZF4

Explore proteomics data for SND1 at MOPED

Post-translational modifications: 

  • Phosphorylated by PIM1 in vitro1
  • Ubiquitination2 at Lys177, Lys193, Lys249, Lys366, Lys515, Lys641, Lys886
  • Modification sites at PhosphoSitePlus

  • See SND1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055205.2  
    ENSEMBL proteins: 
     ENSP00000346762   ENSP00000419327  

    SND1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for SND1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TDRD: Tudor domain containing

    4 InterPro protein domains:
     IPR016685 Silence_cplx_Nase-comp_TudorSN
     IPR016071 Staphylococal_nuclease_OB-fold
     IPR002071 Thermonucl_AS
     IPR002999 Tudor

    Graphical View of Domain Structure for InterPro Entry Q7KZF4

    ProtoNet protein and cluster: Q7KZF4

    1 Blocks protein domain: IPB008191 Maternal tudor protein

    UniProtKB/Swiss-Prot: SND1_HUMAN, Q7KZF4
    Similarity: Contains 4 TNase-like domains
    Similarity: Contains 1 Tudor domain


    SND1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SND1_HUMAN, Q7KZF4
    Function: Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1
    regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen
    2 (EBNA2)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003712transcription cofactor activity TAS7651391
    GO:0004518nuclease activity IEA--
    GO:0005515protein binding IPI--
    GO:0016788hydrolase activity, acting on ester bonds ----
         
    SND1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SND1:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SND1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SND1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SND1

    miRNA
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    miRTarBase miRNAs that target SND1:
    hsa-mir-93-5p (MIRT048839), hsa-mir-877-3p (MIRT036835), hsa-mir-16-5p (MIRT051278), hsa-mir-26b-5p (MIRT029612)

    Block miRNA regulation of human, mouse, rat SND1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SND1 (see all 12):
    hsa-miR-320a hsa-miR-361-5p hsa-miR-3166 hsa-miR-1324 hsa-miR-320d hsa-miR-1224-5p hsa-miR-320b hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidSND1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SND1
    Predesigned siRNA for gene silencing in human, mouse, rat SND1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SND1 (see all 8)
    OriGene ORF clones in mouse, rat for SND1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SND1 (NM_014390)
    Sino Biological Human cDNA Clone for SND1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SND1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SND1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SND1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SND1_HUMAN, Q7KZF4: Cytoplasm. Nucleus. Melanosome. Note=In IL-4 stimulated cells colocalizes with STAT6 in the
    nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion2
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0016442RISC complex IEA--
    GO:0042470melanosome IEA--

    SND1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SND1 About    
    See pathways by source

    SuperPathContained pathways About
    1Viral carcinogenesis
    Viral carcinogenesis
    2Epstein-Barr virus infection
    Epstein-Barr virus infection
    3C-MYB transcription factor network
    C-MYB transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SND1
        C-MYB transcription factor network



    2 Kegg Pathways  (Kegg details for SND1):
        Epstein-Barr virus infection
    Viral carcinogenesis


    SND1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SND1
    Interactions:

        GeneGlobe Interaction Network for SND1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SND1 (Q7KZF41, 2, 3 ENSP000003467624) via UniProtKB, MINT, STRING, and/or I2D (see all 632)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBA5Q9GZZ92, 3, ENSP000003485654MINT-7945693 I2D: score=3 STRING: ENSP00000348565
    DHX9Q082112, 3, ENSP000003565204MINT-7945693 I2D: score=1 STRING: ENSP00000356520
    SNW1Q135732, 3, ENSP000002615314MINT-7945693 I2D: score=1 STRING: ENSP00000261531
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    G3BP1Q132831, 2, 3, ENSP000003485784EBI-1044112,EBI-1047359 MINT-7968779 MINT-7968768 MINT-7968789 I2D: score=1 STRING: ENSP00000348578
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0031047gene silencing by RNA IEA--

    SND1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SND1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SND1 gene: 
    NM_014390.2  

    Unigene Cluster for SND1:

    Staphylococcal nuclease and tudor domain containing 1
    Hs.122523  [show with all ESTs]
    Unigene Representative Sequence: NM_014390
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354725(uc003vmi.3 uc010lle.3) ENST00000463020 ENST00000461056
    ENST00000468621 ENST00000483503 ENST00000492772 ENST00000468166 ENST00000465900
    ENST00000486037 ENST00000484767 ENST00000492840 ENST00000470723 ENST00000467238
    ENST00000470463 ENST00000489417 ENST00000485871
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SND1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SND1 (see all 12):
    hsa-miR-320a hsa-miR-361-5p hsa-miR-3166 hsa-miR-1324 hsa-miR-320d hsa-miR-1224-5p hsa-miR-320b hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidSND1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SND1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SND1 (NM_014390)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SND1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SND1
    Primer
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    OriGene qPCR primer pairs and template standards for SND1
    OriGene qSTAR qPCR primer pairs in human, mouse for SND1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SND1
      QuantiTect SYBR Green Assays in human, mouse, rat SND1
      QuantiFast Probe-based Assays in human, mouse, rat SND1

    Additional mRNA sequence: 

    AB209510.1 AK096583.1 AK304181.1 AK309014.1 AK312313.1 AY273894.1 BC017180.2 BC020423.1 
    BT009785.1 U22055.1 

    Selected DOTS entries (see all 46):

    DT.450785  DT.91922113  DT.100845929  DT.100721250  DT.97855700  DT.95276353  DT.95240781  DT.95276368 
    DT.101974544  DT.95276373  DT.121105903  DT.92465216  DT.97855698  DT.121106003  DT.418871  DT.91754263 
    DT.95276347  DT.100845928  DT.100845933  DT.121105809  DT.121105815  DT.121105846  DT.121105927  DT.85105100 

    9 AceView cDNA sequences:

    BG468657 H52008 H52124 AW604661 BE697320 T19943 BG824165 AW604654 
    AW732848 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SND1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
    SP1:                                                                    -                                                                             -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:              -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                                         
    SP5:                                                                                                                                                            

    ExUns: 23a · 23b ^ 24 ^ 25a · 25b
    SP1:        -                     
    SP2:        -                     
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for SND1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SND1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGAGGTGC
    SND1 Expression
    About this image

    SND1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SND1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.122523

    UniProtKB/Swiss-Prot: SND1_HUMAN, Q7KZF4
    Tissue specificity: Ubiquitously expressed

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    QuantiFast Probe-based Assays in human, mouse, rat SND1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SND1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SND1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Snd11 , 5 staphylococcal nuclease and tudor domain containing more1, 5 90.71(n)1
    97.44(a)1
      6 (11.99 cM)5
    564631  NM_019776.21  NP_062750.21 
     284751395 
    lizard
    (Anolis carolinensis)
    Reptilia SND16
    staphylococcal nuclease and tudor domain containin...
    96(a)
    1 ↔ 1
    GL344065.1(65934-69473)
    African clawed frog
    (Xenopus laevis)
    Amphibia 2e999-prov2 staphylococcal nuclease domain containing 1 77.77(n)    BC043884.1 
    zebrafish
    (Danio rerio)
    Actinopterygii snd12 staphylococcal nuclease domain containing 1 77.64(n)   324404  AY272050.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tudor-SN1 Tudor-SN 54.76(n)
    53.31(a)
      38045  NM_138177.3  NP_612021.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tsn-11 tsn-1 54.19(n)
    49.37(a)
      173811  NM_062438.6  NP_494839.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons Tudor21 Tudor2 48.75(n)
    39.5(a)
      836300  NM_125572.2  NP_200986.1 
    rice
    (Oryza sativa)
    Liliopsida AK065061.12   -- 72.39(n)    AK065061.1 


    ENSEMBL Gene Tree for SND1 (if available)
    TreeFam Gene Tree for SND1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SND1 (see all 6745)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719824651,2
    C--121976363(+) CCCTC-/GTGT  
      GTGTGT
    GTGTG
    1 -- int10--------
    rs1460580551,2
    --127290271(+) TGACAC/TCTTGA 1 -- us2k10--------
    rs1400040741,2
    --127290391(+) TTTGGA/GGCAAA 1 -- us2k10--------
    rs1807280491,2
    --127290420(+) AAGATA/GTAAGA 1 -- us2k10--------
    rs624813611,2
    C,F--127290464(+) AGTTAT/CGATCA 1 -- us2k12Minor allele frequency- C:0.04NA 122
    rs1164684221,2
    F--127290553(+) GCAGAG/AGTCAA 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1856354991,2
    --127290562(+) AAGTTC/TACTGA 1 -- us2k10--------
    rs348357921,2
    C--127290770(+) GAGGT-/TT/TTT
            
    TTTTT
    2 -- us2k1 cds10--------
    rs1904356321,2
    --127290821(+) GGATCC/TAAGAA 1 -- us2k10--------
    rs1169330261,2
    F--127290876(+) ATAAAC/TTTACA 1 -- us2k11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for SND1 (127292202 - 127542202 bp, first 250kb of SND1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SND1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656712CNV Deletion23128226
    esv2735127CNV Deletion23290073
    esv2735126CNV Deletion23290073
    esv2401641CNV Deletion18987734
    esv2558418CNV Deletion19546169
    esv2663660CNV Deletion23128226
    esv997448CNV Deletion20482838
    esv267464CNV Insertion20981092
    esv2612143CNV Insertion19546169
    nsv5942CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SND1
    DNA2.0 Custom Variant and Variant Library Synthesis for SND1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602181    OMIM disorders: --

    8 diseases for SND1:    
    About MalaCards
    autism spectrum disorder    kaposi's sarcoma    sarcoma    hepatocellular carcinoma
    prostate cancer    prostatitis    hiv-1    malaria


    SND1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SND1
    Human Genome Epidemiology (HuGE) Navigator: SND1 (6 documents)

    Export disorders for SND1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SND1 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with SND1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. (PubMed id 7651391)1, 2, 3 Tong X.... Kieff E. (Mol. Cell. Biol. 1995)
    2. Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. (PubMed id 12234934)1, 2, 9 Yang J.... Silvennoinen O. (EMBO J. 2002)
    3. The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development. (PubMed id 9003410)1, 3, 9 Callebaut I. and Mornon J.P. (Biochem. J. 1997)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Linkage and candidate gene studies of autism spectrum disorders in European populations. (PubMed id 20442744)1, 4 Holt R....Monaco A.P. (Eur. J. Hum. Genet. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27044 HGNC: 30646 AceView: SND1 Ensembl:ENSG00000197157 euGenes: HUgn27044
    ECgene: SND1 Kegg: 27044 H-InvDB: SND1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SND1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SND1 gene:
    Search GeneIP for patents involving SND1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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