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Aliases for SND1 Gene

Aliases for SND1 Gene

  • Staphylococcal Nuclease And Tudor Domain Containing 1 2 3
  • Tudor Domain-Containing Protein 11 3 4
  • P100 EBNA2 Co-Activator 2 3
  • EBNA2 Coactivator P100 3 4
  • 100 KDa Coactivator 3 4
  • P100 Co-Activator 3 4
  • Tudor-SN 2 3
  • TDRD11 3 4
  • Staphylococcal Nuclease Domain-Containing Protein 1 3
  • Staphylococcal Nuclease Domain Containing 1 3
  • EBNA-2 Co-Activator (100kD) 3
  • SND1-BRAF Fusion 3
  • P100, 6
  • P100 3

External Ids for SND1 Gene

Previous GeneCards Identifiers for SND1 Gene

  • GC07P126846
  • GC07P126886
  • GC07P127079
  • GC07P127292
  • GC07P121653

Summaries for SND1 Gene

GeneCards Summary for SND1 Gene

SND1 (Staphylococcal Nuclease And Tudor Domain Containing 1) is a Protein Coding gene. Among its related pathways are Epstein-Barr virus infection and Viral carcinogenesis. GO annotations related to this gene include nucleic acid binding and nuclease activity.

UniProtKB/Swiss-Prot for SND1 Gene

  • Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).

Gene Wiki entry for SND1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SND1 Gene

Genomics for SND1 Gene

Regulatory Elements for SND1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SND1 Gene

127,652,148 bp from pter
128,092,609 bp from pter
440,462 bases
Plus strand

Genomic View for SND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SND1 Gene

Proteins for SND1 Gene

  • Protein details for SND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Staphylococcal nuclease domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q13122
    • Q96AG0

    Protein attributes for SND1 Gene

    910 amino acids
    Molecular mass:
    101997 Da
    Quaternary structure:
    • Binds to acidic transactivation domain of EBNA2. Interacts with EAV NSP1. Interacts with GTF2E1 and GTF2E2. Forms a ternary complex with STAT6 and POLR2A. Interacts with STAT5 (By similarity).
    • Sequence=AAA80488.1; Type=Frameshift; Positions=5; Note=The frameshift leads to wrong initiation.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SND1 Gene

neXtProt entry for SND1 Gene

Proteomics data for SND1 Gene at MOPED

Post-translational modifications for SND1 Gene

  • Phosphorylated by PIM1 in vitro.
  • Ubiquitination at Lys177, Lys193, Lys249, Lys366, Lys515, Lys641, and Lys886
  • Modification sites at PhosphoSitePlus

Other Protein References for SND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SND1 Gene

Domains for SND1 Gene

Gene Families for SND1 Gene

Suggested Antigen Peptide Sequences for SND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 TNase-like domains.
  • Contains 4 TNase-like domains.
  • Contains 1 Tudor domain.
genes like me logo Genes that share domains with SND1: view

Function for SND1 Gene

Molecular function for SND1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).

Gene Ontology (GO) - Molecular Function for SND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003712 transcription cofactor activity IEA --
GO:0004518 nuclease activity IEA --
GO:0005515 protein binding IPI 20643132
GO:0016788 hydrolase activity, acting on ester bonds --
genes like me logo Genes that share ontologies with SND1: view

Phenotypes for SND1 Gene

GenomeRNAi human phenotypes for SND1:
genes like me logo Genes that share phenotypes with SND1: view

Animal Model Products

miRNA for SND1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SND1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SND1 Gene

Localization for SND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SND1 Gene

Cytoplasm. Nucleus. Melanosome. Note=In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Jensen Localization Image for SND1 Gene COMPARTMENTS Subcellular localization image for SND1 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0016020 membrane IDA 16210410
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with SND1: view

Pathways for SND1 Gene

genes like me logo Genes that share pathways with SND1: view

Pathways by source for SND1 Gene

1 BioSystems pathway for SND1 Gene
2 KEGG pathways for SND1 Gene

Gene Ontology (GO) - Biological Process for SND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008152 metabolic process --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with SND1: view

Transcripts for SND1 Gene

mRNA/cDNA for SND1 Gene

(10) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SND1 Gene

Staphylococcal nuclease and tudor domain containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SND1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SND1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: - -
SP4: - - - - - - - - - - - - - - -

ExUns: 23a · 23b ^ 24 ^ 25a · 25b
SP1: -
SP2: -

Relevant External Links for SND1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SND1 Gene

mRNA expression in normal human tissues for SND1 Gene

Protein differential expression in normal tissues for SND1 Gene

This gene is overexpressed in Bone marrow stromal cell (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SND1 Gene

SOURCE GeneReport for Unigene cluster for SND1 Gene Hs.122523

mRNA Expression by UniProt/SwissProt for SND1 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with SND1: view

Expression partners for SND1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SND1 Gene

Orthologs for SND1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SND1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SND1 35
  • 91.94 (n)
  • 98.68 (a)
SND1 36
  • 99 (a)
(Canis familiaris)
Mammalia SND1 35
  • 93.19 (n)
  • 99.01 (a)
SND1 36
  • 99 (a)
(Mus musculus)
Mammalia Snd1 35
  • 90.71 (n)
  • 97.44 (a)
Snd1 16
Snd1 36
  • 97 (a)
(Pan troglodytes)
Mammalia SND1 35
  • 99.74 (n)
  • 99.89 (a)
SND1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Snd1 35
  • 90.19 (n)
  • 97.44 (a)
(Monodelphis domestica)
Mammalia SND1 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia SND1 36
  • 93 (a)
(Anolis carolinensis)
Reptilia SND1 36
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76153 35
snd1 35
  • 77 (n)
  • 88.07 (a)
African clawed frog
(Xenopus laevis)
Amphibia 2e999-prov 35
(Danio rerio)
Actinopterygii snd1 35
  • 75.19 (n)
  • 85.38 (a)
snd1 36
  • 84 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005672 35
  • 56.03 (n)
  • 49.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tudor-SN 35
  • 54.76 (n)
  • 53.31 (a)
Tudor-SN 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea tsn-1 35
  • 54.19 (n)
  • 49.37 (a)
tsn-1 36
  • 45 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons Tudor2 35
  • 48.75 (n)
  • 39.5 (a)
(Oryza sativa)
Liliopsida Os02g0523500 35
  • 49.74 (n)
  • 40 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02134 35
  • 47.8 (n)
  • 37.89 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes snd1 35
  • 44.53 (n)
  • 35.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
CSA.5484 36
  • 57 (a)
Species with no ortholog for SND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SND1 Gene

Gene Tree for SND1 (if available)
Gene Tree for SND1 (if available)

Paralogs for SND1 Gene

No data available for Paralogs for SND1 Gene

Variants for SND1 Gene

Sequence variations from dbSNP and Humsavar for SND1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs124756 -- 128,083,261(+) AGGAG(A/G)CAAAG intron-variant
rs141450 -- 127,812,366(-) CATCT(C/G)AAAGA intron-variant
rs178734 -- 128,074,366(+) GTTCT(A/G)GGGGT intron-variant
rs184431 -- 128,091,266(+) agtac(A/C)atggc intron-variant
rs225241 -- 128,074,439(+) CCCAC(A/G)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SND1 Gene

Variant ID Type Subtype PubMed ID
nsv831122 CNV Gain 17160897
nsv5942 CNV Insertion 18451855
nsv831123 CNV Gain 17160897
esv2663660 CNV Deletion 23128226
nsv510115 CNV Loss 20534489
nsv526535 CNV Gain 19592680
esv2656712 CNV Deletion 23128226
esv2612143 CNV Insertion 19546169
esv267464 CNV Insertion 20981092
esv2735126 CNV Deletion 23290073
nsv526032 CNV Loss 19592680
esv2558418 CNV Deletion 19546169
esv2401641 CNV Deletion 18987734
esv2735127 CNV Deletion 23290073
esv997448 CNV Deletion 20482838
nsv365757 CNV Loss 16902084
esv6141 CNV Loss 19470904
nsv5944 CNV Insertion 18451855
esv268126 CNV Insertion 20981092

Relevant External Links for SND1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SND1 Gene

Disorders for SND1 Gene

Relevant External Links for SND1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SND1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SND1 Gene

Publications for SND1 Gene

  1. The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. (PMID: 7651391) Tong X. … Kieff E. (Mol. Cell. Biol. 1995) 2 3 4
  2. Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. (PMID: 12234934) Yang J. … Silvennoinen O. (EMBO J. 2002) 3 4 23
  3. The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development. (PMID: 9003410) Callebaut I. … Mornon J.P. (Biochem. J. 1997) 2 3 23
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Coactivator P100 protein enhances STAT6-dependent transcriptional activation but has no effect on STAT1-mediated gene transcription. (PMID: 20225206) Wang X. … Yang J. (Anat Rec (Hoboken) 2010) 3 23

Products for SND1 Gene

  • Addgene plasmids for SND1

Sources for SND1 Gene

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