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Aliases for SND1 Gene

Aliases for SND1 Gene

  • Staphylococcal Nuclease And Tudor Domain Containing 1 2 3 5
  • Tudor Domain-Containing Protein 11 3 4
  • P100 EBNA2 Co-Activator 2 3
  • EBNA2 Coactivator P100 3 4
  • 100 KDa Coactivator 3 4
  • P100 Co-Activator 3 4
  • Tudor-SN 2 3
  • TDRD11 3 4
  • Staphylococcal Nuclease Domain Containing 1 3
  • Testis Tissue Sperm-Binding Protein Li 82P 3
  • EBNA-2 Co-Activator (100kD) 3
  • SND1-BRAF Fusion 3
  • P100 3

External Ids for SND1 Gene

Previous GeneCards Identifiers for SND1 Gene

  • GC07P126846
  • GC07P126886
  • GC07P127079
  • GC07P127292
  • GC07P121653

Summaries for SND1 Gene

GeneCards Summary for SND1 Gene

SND1 (Staphylococcal Nuclease And Tudor Domain Containing 1) is a Protein Coding gene. Diseases associated with SND1 include pituitary-dependent cushing's disease. Among its related pathways are Viral carcinogenesis and C-MYB transcription factor network. GO annotations related to this gene include nucleic acid binding and transcription cofactor activity.

UniProtKB/Swiss-Prot for SND1 Gene

  • Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).

Gene Wiki entry for SND1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SND1 Gene

Genomics for SND1 Gene

Regulatory Elements for SND1 Gene

Promoters for SND1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SND1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SND1 Gene

Chromosome:
7
Start:
127,652,119 bp from pter
End:
128,092,609 bp from pter
Size:
440,491 bases
Orientation:
Plus strand

Genomic View for SND1 Gene

Genes around SND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SND1 Gene

Proteins for SND1 Gene

  • Protein details for SND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7KZF4-SND1_HUMAN
    Recommended name:
    Staphylococcal nuclease domain-containing protein 1
    Protein Accession:
    Q7KZF4
    Secondary Accessions:
    • Q13122
    • Q96AG0

    Protein attributes for SND1 Gene

    Size:
    910 amino acids
    Molecular mass:
    101997 Da
    Quaternary structure:
    • Binds to acidic transactivation domain of EBNA2. Interacts with EAV NSP1. Interacts with GTF2E1 and GTF2E2. Forms a ternary complex with STAT6 and POLR2A. Interacts with STAT5 (By similarity).
    SequenceCaution:
    • Sequence=AAA80488.1; Type=Frameshift; Positions=5; Note=The frameshift leads to wrong initiation.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SND1 Gene

neXtProt entry for SND1 Gene

Proteomics data for SND1 Gene at MOPED

Post-translational modifications for SND1 Gene

  • Phosphorylated by PIM1 in vitro.
  • Ubiquitination at Lys 177, Lys 193, Lys 249, Lys 366, Lys 515, Lys 641, and Lys 886
  • Modification sites at PhosphoSitePlus

Other Protein References for SND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SND1 Gene

Domains & Families for SND1 Gene

Gene Families for SND1 Gene

Suggested Antigen Peptide Sequences for SND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7KZF4

UniProtKB/Swiss-Prot:

SND1_HUMAN :
  • Contains 4 TNase-like domains.
Domain:
  • Contains 4 TNase-like domains.
  • Contains 1 Tudor domain.
genes like me logo Genes that share domains with SND1: view

Function for SND1 Gene

Molecular function for SND1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).

Gene Ontology (GO) - Molecular Function for SND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
genes like me logo Genes that share ontologies with SND1: view
genes like me logo Genes that share phenotypes with SND1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SND1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SND1 Gene

Localization for SND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SND1 Gene

Cytoplasm. Nucleus. Melanosome. Note=In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SND1 Gene COMPARTMENTS Subcellular localization image for SND1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
mitochondrion 3
plasma membrane 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0016442 RISC complex IEA --
GO:0042470 melanosome IEA --
GO:0070062 extracellular exosome IDA 20458337
GO:0097433 dense body IEA --
genes like me logo Genes that share ontologies with SND1: view

Pathways & Interactions for SND1 Gene

genes like me logo Genes that share pathways with SND1: view

Pathways by source for SND1 Gene

1 BioSystems pathway for SND1 Gene
2 KEGG pathways for SND1 Gene

Gene Ontology (GO) - Biological Process for SND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0031047 gene silencing by RNA IEA --
genes like me logo Genes that share ontologies with SND1: view

No data available for SIGNOR curated interactions for SND1 Gene

Drugs & Compounds for SND1 Gene

No Compound Related Data Available

Transcripts for SND1 Gene

mRNA/cDNA for SND1 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SND1 Gene

Staphylococcal nuclease and tudor domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SND1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: - -
SP2:
SP3:
SP4: - - - - - - - - - - - - - - -
SP5:

ExUns: 23a · 23b ^ 24 ^ 25a · 25b
SP1: -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for SND1 Gene

GeneLoc Exon Structure for
SND1
ECgene alternative splicing isoforms for
SND1

Expression for SND1 Gene

mRNA expression in normal human tissues for SND1 Gene

Protein differential expression in normal tissues from HIPED for SND1 Gene

This gene is overexpressed in Bone marrow stromal cell (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SND1 Gene



SOURCE GeneReport for Unigene cluster for SND1 Gene Hs.122523

mRNA Expression by UniProt/SwissProt for SND1 Gene

Q7KZF4-SND1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SND1: view

Protein tissue co-expression partners for SND1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SND1 Gene

Orthologs for SND1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SND1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SND1 35
  • 91.94 (n)
  • 98.68 (a)
SND1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SND1 35
  • 93.19 (n)
  • 99.01 (a)
SND1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snd1 35
  • 90.71 (n)
  • 97.44 (a)
Snd1 16
Snd1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SND1 35
  • 99.74 (n)
  • 99.89 (a)
SND1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snd1 35
  • 90.19 (n)
  • 97.44 (a)
oppossum
(Monodelphis domestica)
Mammalia SND1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SND1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SND1 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76153 35
snd1 35
  • 77 (n)
  • 88.07 (a)
African clawed frog
(Xenopus laevis)
Amphibia 2e999-prov 35
zebrafish
(Danio rerio)
Actinopterygii snd1 35
  • 75.19 (n)
  • 85.38 (a)
snd1 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005672 35
  • 56.03 (n)
  • 49.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tudor-SN 35
  • 54.76 (n)
  • 53.31 (a)
Tudor-SN 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tsn-1 35
  • 54.19 (n)
  • 49.37 (a)
tsn-1 36
  • 45 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons Tudor2 35
  • 48.75 (n)
  • 39.5 (a)
rice
(Oryza sativa)
Liliopsida Os02g0523500 35
  • 49.74 (n)
  • 40 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02134 35
  • 47.8 (n)
  • 37.89 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes snd1 35
  • 44.53 (n)
  • 35.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
CSA.5484 36
  • 57 (a)
OneToMany
Species with no ortholog for SND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SND1 Gene

ENSEMBL:
Gene Tree for SND1 (if available)
TreeFam:
Gene Tree for SND1 (if available)

Paralogs for SND1 Gene

No data available for Paralogs for SND1 Gene

Variants for SND1 Gene

Sequence variations from dbSNP and Humsavar for SND1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs225241 -- 128,074,439(+) CCCAC(A/G)GGCAC intron-variant
rs322820 -- 128,091,566(+) cttta(C/T)cacag intron-variant
rs322821 -- 128,089,835(+) GTTGG(C/T)GTTTT intron-variant
rs322822 -- 128,089,121(+) GCAAT(A/C)TTGGC intron-variant
rs322823 -- 128,087,348(+) GTGAG(A/G)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SND1 Gene

Variant ID Type Subtype PubMed ID
nsv831122 CNV Gain 17160897
nsv5942 CNV Insertion 18451855
nsv831123 CNV Gain 17160897
esv2663660 CNV Deletion 23128226
nsv510115 CNV Loss 20534489
nsv526535 CNV Gain 19592680
esv2656712 CNV Deletion 23128226
esv2612143 CNV Insertion 19546169
esv267464 CNV Insertion 20981092
esv2735126 CNV Deletion 23290073
nsv526032 CNV Loss 19592680
esv2558418 CNV Deletion 19546169
esv2401641 CNV Deletion 18987734
esv2735127 CNV Deletion 23290073
esv997448 CNV Deletion 20482838
nsv365757 CNV Loss 16902084
esv6141 CNV Loss 19470904
nsv5944 CNV Insertion 18451855
esv268126 CNV Insertion 20981092

Variation tolerance for SND1 Gene

Residual Variation Intolerance Score: 6.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SND1 Gene

HapMap Linkage Disequilibrium report
SND1
Human Gene Mutation Database (HGMD)
SND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SND1 Gene

Disorders for SND1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SND1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pituitary-dependent cushing's disease
  • overproduction of acth
- elite association - COSMIC cancer census association via MalaCards
Search SND1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SND1

Genetic Association Database (GAD)
SND1
Human Genome Epidemiology (HuGE) Navigator
SND1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SND1
genes like me logo Genes that share disorders with SND1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SND1 Gene

Publications for SND1 Gene

  1. The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. (PMID: 7651391) Tong X. … Kieff E. (Mol. Cell. Biol. 1995) 2 3 4 67
  2. The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development. (PMID: 9003410) Callebaut I. … Mornon J.P. (Biochem. J. 1997) 2 3 23
  3. Coactivator P100 protein enhances STAT6-dependent transcriptional activation but has no effect on STAT1-mediated gene transcription. (PMID: 20225206) Wang X. … Yang J. (Anat Rec (Hoboken) 2010) 3 23
  4. Staphylococcal nuclease domain-containing protein 1 as a potential tissue marker for prostate cancer. (PMID: 19435788) Kuruma H. … Egawa S. (Am. J. Pathol. 2009) 3 23
  5. Transcriptional co-activator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome. (PMID: 17576664) Yang J. … Silvennoinen O. (Nucleic Acids Res. 2007) 3 23

Products for SND1 Gene

Sources for SND1 Gene

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