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Aliases for SND1 Gene

Aliases for SND1 Gene

  • Staphylococcal Nuclease And Tudor Domain Containing 1 2 3 5
  • Tudor Domain-Containing Protein 11 3 4
  • EBNA2 Coactivator P100 3 4
  • Tudor-SN 2 3
  • TDRD11 3 4
  • Staphylococcal Nuclease Domain-Containing Protein 1 3
  • Testis Tissue Sperm-Binding Protein Li 82P 3
  • P100 EBNA2 Co-Activator 2
  • 100 KDa Coactivator 4
  • P100 Co-Activator 4
  • P100 3

External Ids for SND1 Gene

Previous GeneCards Identifiers for SND1 Gene

  • GC07P126846
  • GC07P126886
  • GC07P127079
  • GC07P127292
  • GC07P121653

Summaries for SND1 Gene

Entrez Gene Summary for SND1 Gene

  • This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]

GeneCards Summary for SND1 Gene

SND1 (Staphylococcal Nuclease And Tudor Domain Containing 1) is a Protein Coding gene. Diseases associated with SND1 include Pituitary-Dependent Cushing's Disease. Among its related pathways are HIV Life Cycle and Epstein-Barr virus infection. GO annotations related to this gene include nucleic acid binding and transcription cofactor activity.

UniProtKB/Swiss-Prot for SND1 Gene

  • Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).

Gene Wiki entry for SND1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SND1 Gene

Genomics for SND1 Gene

Regulatory Elements for SND1 Gene

Enhancers for SND1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F127707 0.9 ENCODE 43.8 +55.6 55590 1.3 PKNOX1 SIN3A NFXL1 ZNF2 RAD21 GLIS2 CBX5 ZNF366 ZNF143 FOS SND1 ZNF800 ENSG00000242588 ENSG00000224138 ENSG00000243302 ENSG00000230715 ENSG00000243679 GCC1 RBM28 ENSG00000229413
GH07F128010 1.1 ENCODE 31.3 +359.2 359248 1.2 HDGF PKNOX1 CREB3L1 SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 SP3 SND1 ENSG00000242588 ZNF800 LRRC4 ENSG00000243302 ENSG00000224138 ENSG00000230715 RN7SL81P ENSG00000243679 GC07P128011
GH07F128002 1.1 Ensembl ENCODE 30.6 +352.5 352533 3.7 ELF3 SOX13 TFAP4 PKNOX1 TAL1 RAD21 RARA TEAD3 YY1 NCOR1 SND1 LRRC4 ENSG00000242588 LOC105375492 SND1-IT1
GH07F127819 1.2 Ensembl ENCODE 24.4 +168.4 168444 2.0 HDGF PKNOX1 FEZF1 GLI4 ZNF2 GLIS2 FOS NCOA1 MXD4 JUNB SND1 ENSG00000240790 LRRC4 LOC100196944 PIR48128
GH07F127534 2 VISTA Ensembl 14.6 -116.2 -116207 3.2 GLIS1 FOXP2 ZIC2 EZH2 SND1 ENSG00000240790 LOC101928333 GCC1 GC07P127521 GC07P127561
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SND1 on UCSC Golden Path with GeneCards custom track

Promoters for SND1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000683272 381 3001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143

Genomic Location for SND1 Gene

127,652,119 bp from pter
128,092,609 bp from pter
440,491 bases
Plus strand

Genomic View for SND1 Gene

Genes around SND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SND1 Gene

Proteins for SND1 Gene

  • Protein details for SND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Staphylococcal nuclease domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q13122
    • Q96AG0

    Protein attributes for SND1 Gene

    910 amino acids
    Molecular mass:
    101997 Da
    Quaternary structure:
    • Binds to acidic transactivation domain of EBNA2. Interacts with EAV NSP1. Interacts with GTF2E1 and GTF2E2. Forms a ternary complex with STAT6 and POLR2A. Interacts with STAT5 (By similarity).
    • Sequence=AAA80488.1; Type=Frameshift; Positions=5; Note=The frameshift leads to wrong initiation.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SND1 Gene

neXtProt entry for SND1 Gene

Post-translational modifications for SND1 Gene

  • Phosphorylated by PIM1 in vitro.
  • Ubiquitination at Lys 177, Lys 193, Lys 249, Lys 366, Lys 515, Lys 641, and Lys 886
  • Modification sites at PhosphoSitePlus

Other Protein References for SND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SND1 Gene

Domains & Families for SND1 Gene

Gene Families for SND1 Gene

Suggested Antigen Peptide Sequences for SND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 TNase-like domains.
  • Contains 4 TNase-like domains.
  • Contains 1 Tudor domain.
genes like me logo Genes that share domains with SND1: view

Function for SND1 Gene

Molecular function for SND1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).

Gene Ontology (GO) - Molecular Function for SND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003712 transcription cofactor activity TAS 7651391
GO:0004518 nuclease activity IBA --
GO:0005515 protein binding IPI 20643132
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SND1: view
genes like me logo Genes that share phenotypes with SND1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SND1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SND1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SND1 Gene

Localization for SND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SND1 Gene

Cytoplasm. Nucleus. Melanosome. Note=In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SND1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
mitochondrion 3
plasma membrane 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0016020 membrane IDA 16210410
genes like me logo Genes that share ontologies with SND1: view

Pathways & Interactions for SND1 Gene

genes like me logo Genes that share pathways with SND1: view

Pathways by source for SND1 Gene

1 BioSystems pathway for SND1 Gene
2 Reactome pathways for SND1 Gene
2 KEGG pathways for SND1 Gene

Gene Ontology (GO) - Biological Process for SND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006401 RNA catabolic process IBA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with SND1: view

No data available for SIGNOR curated interactions for SND1 Gene

Transcripts for SND1 Gene

mRNA/cDNA for SND1 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SND1 Gene

Staphylococcal nuclease and tudor domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SND1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SND1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: - -
SP4: - - - - - - - - - - - - - - -

ExUns: 23a · 23b ^ 24 ^ 25a · 25b
SP1: -
SP2: -

Relevant External Links for SND1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SND1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SND1 Gene

Protein differential expression in normal tissues from HIPED for SND1 Gene

This gene is overexpressed in Bone marrow stromal cell (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SND1 Gene

Protein tissue co-expression partners for SND1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SND1 Gene:


SOURCE GeneReport for Unigene cluster for SND1 Gene:


mRNA Expression by UniProt/SwissProt for SND1 Gene:

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SND1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SND1 Gene

Orthologs for SND1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SND1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SND1 34 35
  • 99.74 (n)
(Monodelphis domestica)
Mammalia SND1 35
  • 96 (a)
(Canis familiaris)
Mammalia SND1 34 35
  • 93.19 (n)
(Ornithorhynchus anatinus)
Mammalia SND1 35
  • 93 (a)
(Bos Taurus)
Mammalia SND1 34 35
  • 91.94 (n)
(Mus musculus)
Mammalia Snd1 34 16 35
  • 90.71 (n)
(Rattus norvegicus)
Mammalia Snd1 34
  • 90.19 (n)
(Anolis carolinensis)
Reptilia SND1 35
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snd1 34
  • 77 (n)
MGC76153 34
African clawed frog
(Xenopus laevis)
Amphibia 2e999-prov 34
(Danio rerio)
Actinopterygii snd1 34 35
  • 75.19 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005672 34
  • 56.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tudor-SN 34 35
  • 54.76 (n)
(Caenorhabditis elegans)
Secernentea tsn-1 35 34
  • 54.19 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons Tudor2 34
  • 48.75 (n)
(Oryza sativa)
Liliopsida Os02g0523500 34
  • 49.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5484 35
  • 57 (a)
-- 35
  • 55 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02134 34
  • 47.8 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes snd1 34
  • 44.53 (n)
Species where no ortholog for SND1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SND1 Gene

Gene Tree for SND1 (if available)
Gene Tree for SND1 (if available)

Paralogs for SND1 Gene

No data available for Paralogs for SND1 Gene

Variants for SND1 Gene

Sequence variations from dbSNP and Humsavar for SND1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs796052170 Likely benign 128,074,593(+) GGTGG(A/C)GCACG reference, missense
rs1019578 -- 127,794,526(+) GACAT(A/T)CACAA intron-variant
rs10215276 -- 127,869,390(+) agcca(C/T)tacag intron-variant
rs10224771 -- 127,700,357(+) GTGAA(A/G)ACTTC intron-variant
rs10226394 -- 127,989,484(+) GCTTT(A/T)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SND1 Gene

Variant ID Type Subtype PubMed ID
nsv956008 CNV deletion 24416366
nsv949938 CNV duplication 24416366
nsv831123 CNV gain 17160897
nsv831122 CNV gain 17160897
nsv5944 CNV insertion 18451855
nsv5942 CNV insertion 18451855
nsv526535 CNV gain 19592680
nsv526032 CNV loss 19592680
nsv510115 OTHER sequence alteration 20534489
nsv478932 CNV novel sequence insertion 20440878
nsv478049 CNV novel sequence insertion 20440878
nsv477290 CNV novel sequence insertion 20440878
nsv365757 CNV deletion 16902084
nsv1144199 CNV deletion 24896259
nsv1137289 CNV deletion 24896259
nsv1122171 CNV deletion 24896259
nsv1075996 CNV deletion 25765185
nsv1075995 CNV deletion 25765185
nsv1031658 CNV gain 25217958
nsv1024743 CNV gain 25217958
esv997448 CNV deletion 20482838
esv6141 CNV loss 19470904
esv3614963 CNV loss 21293372
esv3614962 CNV gain 21293372
esv3614960 CNV loss 21293372
esv3614958 CNV loss 21293372
esv3572134 CNV loss 25503493
esv3542407 CNV deletion 23714750
esv3438774 CNV insertion 20981092
esv3342788 CNV insertion 20981092
esv3303847 CNV mobile element insertion 20981092
esv3303184 CNV mobile element insertion 20981092
esv2735127 CNV deletion 23290073
esv2735126 CNV deletion 23290073
esv2663660 CNV deletion 23128226
esv2656712 CNV deletion 23128226
esv2612143 CNV insertion 19546169
esv2558418 CNV deletion 19546169
esv2401641 CNV deletion 18987734
dgv3663n106 CNV deletion 24896259

Variation tolerance for SND1 Gene

Residual Variation Intolerance Score: 6.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SND1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SND1 Gene

Disorders for SND1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SND1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pituitary-dependent cushing's disease
  • overproduction of acth
- elite association - COSMIC cancer census association via MalaCards
Search SND1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SND1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SND1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SND1 Gene

Publications for SND1 Gene

  1. Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. (PMID: 12234934) Yang J. … Silvennoinen O. (EMBO J. 2002) 3 4 22 64
  2. The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development. (PMID: 9003410) Callebaut I. … Mornon J.P. (Biochem. J. 1997) 2 3 22 64
  3. The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. (PMID: 7651391) Tong X. … Kieff E. (Mol. Cell. Biol. 1995) 2 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Linkage and candidate gene studies of autism spectrum disorders in European populations. (PMID: 20442744) Holt R. … Monaco A.P. (Eur. J. Hum. Genet. 2010) 3 46 64

Products for SND1 Gene

Sources for SND1 Gene

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