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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNCG Gene

protein-coding   GIFtS: 63
GCID: GC10P088708

Synuclein, Gamma (Breast Cancer-Specific Protein 1)

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synuclein, Gamma (Breast Cancer-Specific Protein 1)1 2     persyn2
BCSG12 3 5     PERSYN3
synoretin1 2     PRSN3
Breast Cancer-Specific Gene 1 Protein2 3     Persyn3
SR2 3     Synoretin3
gamma-synuclein2     

External Ids:    HGNC: 111411   Entrez Gene: 66232   Ensembl: ENSG000001732677   OMIM: 6029985   UniProtKB: O760703   

Export aliases for SNCG gene to outside databases

Previous GC identifers: GC10P087599 GC10P087941 GC10P088849 GC10P088382 GC10P082572


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNCG Gene:
This gene encodes a member of the synuclein family of proteins which are believed to be involved in the
pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor
development. (provided by RefSeq, Jan 2010)

GeneCards Summary for SNCG Gene: 
SNCG (synuclein, gamma (breast cancer-specific protein 1)) is a protein-coding gene. Diseases associated with SNCG include ovarian endometriosis, and follicular dendritic cell sarcoma. GO annotations related to this gene include alpha-tubulin binding and beta-tubulin binding. An important paralog of this gene is SNCB.

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070
Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture
during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to
calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin.
Activates the MAPK and Elk-1 signal transduction pathway (By similarity)

Gene Wiki entry for SNCG (Gamma-synuclein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNCG gene promoter:
         HOXA9B   HOXA9   AML1a   C/EBPalpha   PPAR-gamma1   HSF2   Meis-1a   PPAR-gamma2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNCG promoter sequence
   Search SABiosciences Chromatin IP Primers for SNCG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNCG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.2-q23.3   Ensembl cytogenetic band:  10q23.2   HGNC cytogenetic band: 10q23.2-q23.3

SNCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNCG gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P088708:  view genomic region     (about GC identifiers)

Start:
88,718,288 bp from pter      End:
88,723,017 bp from pter
Size:
4,730 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070 (See protein sequence)
Recommended Name: Gamma-synuclein  
Size: 127 amino acids; 13331 Da
Subunit: May be a centrosome-associated protein
Subcellular location: Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center,
centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In
mitotic cells, localized to the poles of the spindle
Secondary accessions: O15104 Q96P61

Explore the universe of human proteins at neXtProt for SNCG: NX_O76070

Explore proteomics data for SNCG at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by
    other kinases
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O76070

  • SNCG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNCG Protein Expression
    REFSEQ proteins: NP_003078.2  
    ENSEMBL proteins: 
     ENSP00000344658   ENSP00000361087  

    Human Recombinant Protein Products for SNCG: 
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    Enzo Life Sciences proteins for SNCG
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SNCG
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SNCG
    GenScript Custom Purified and Recombinant Proteins Services for SNCG
    Novus Biologicals SNCG Proteins
    Novus Biologicals SNCG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SNCG
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005815microtubule organizing center IEA--
    GO:0005819spindle IEA--
    GO:0005886plasma membrane IEA--
    GO:0030424axon ----

    SNCG for ontologies           About GeneDecksing



    SNCG Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SNCG
    R&D Systems Antibodies for SNCG (Synuclein-gamma)
    OriGene Antibodies for SNCG
    OriGene Custom Antibody Services for SNCG
    GenScript Custom Superior Antibodies Services for SNCG
    Novus Biologicals SNCG Antibodies
    Abcam antibodies for SNCG
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for SNCG
    LSBio Antibodies in human, mouse, rat for SNCG 

    Assay Products for SNCG: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNCG
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR002462 Synuclein_gamma
     IPR001058 Synuclein

    Graphical View of Domain Structure for InterPro Entry O76070

    ProtoNet protein and cluster: O76070

    1 Blocks protein domain: IPB001058 Synuclein signature

    UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070
    Similarity: Belongs to the synuclein family


    SNCG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYUG_HUMAN, O76070
    Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture
    during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to
    calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin.
    Activates the MAPK and Elk-1 signal transduction pathway (By similarity)

         Genatlas biochemistry entry for SNCG:
    gamma synuclein,expressed during pre and postnatal development in the cell bodies and axons of primary sensory
    neurons,sympathetic neurons and motoneurons of peripheral and central nervous system,predominantly expressed in
    substantia nigra,maybe involved in exocytosis of synaptic vesicles,putatively involved in the pathogenesis of
    neurodegenerative diseases (but not found in amyotrophic lateral sclerosis or familial Parkinson) and
    overexpressed in breast tumors

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0043014alpha-tubulin binding IEA--
    GO:0048487beta-tubulin binding IEA--
         
    SNCG for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sncg):
     behavior/neurological  cellular  homeostasis/metabolism  nervous system 

    SNCG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sncgtm1Vlb for SNCG

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SNCG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SNCG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNCG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNCG 

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SNCG (see all 10):
    hsa-miR-3673 hsa-miR-15a hsa-miR-497 hsa-miR-103a hsa-miR-424 hsa-miR-15b* hsa-miR-195 hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidSNCG 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SNCG

    Clone
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    GenScript: all cDNA clones in your preferred vector: SNCG (NM_003087)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNCG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCG
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                         Customized lentivirus expression plasmids for stable overexpression of SNCG 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNCG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNCG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/25 Interacting proteins for SNCG (O760703 ENSP000003610874) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284823, ENSP000002158324I2D: score=4 STRING: ENSP00000215832
    MAPK3P273613, ENSP000002630254I2D: score=4 STRING: ENSP00000263025
    MAPK8P459833, ENSP000003534834I2D: score=4 STRING: ENSP00000353483
    DYNLL1P631673, ENSP000002425774I2D: score=2 STRING: ENSP00000242577
    FUBP1Q96AE43, ENSP000003598044I2D: score=2 STRING: ENSP00000359804
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002118aggressive behavior IEA--
    GO:0007268synaptic transmission IEA--
    GO:0008344adult locomotory behavior IEA--
    GO:0014059regulation of dopamine secretion IEA--
    GO:0042220response to cocaine IEA--

    SNCG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SNCG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNCG (SYUG)

    2 HMDB Compounds for SNCG    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--

    6 Novoseek inferred chemical compound relationships for SNCG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 40.7 3 11526506 (1), 12566312 (1)
    paclitaxel 27.1 7 16773211 (3), 12121974 (2), 12959183 (1)
    estrogen 11.5 5 12873981 (3), 15231664 (1)
    agar 5.5 2 11016747 (1), 12970872 (1)
    iron 0 1 10934140 (1)
    tyrosine 0 2 12716427 (1), 16392036 (1)

    Search CenterWatch for drugs/clinical trials and news about SNCG / SYUG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNCG gene: 
    NM_003087.2  

    Unigene Cluster for SNCG:

    Synuclein, gamma (breast cancer-specific protein 1)
    Hs.349470  [show with all ESTs]
    Unigene Representative Sequence: BU595229
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465679 ENST00000348795 ENST00000372017(uc001keb.2) ENST00000483064


    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SNCG (see all 10):
    hsa-miR-3673 hsa-miR-15a hsa-miR-497 hsa-miR-103a hsa-miR-424 hsa-miR-15b* hsa-miR-195 hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidSNCG 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNCG
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCG
    Sirion Biotech Customized lentivirus for stable overexpression of SNCG 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNCG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNCG

    Additional mRNA sequence: 

    AF010126.1 AF017256.1 AF411524.1 AK223367.1 AK311652.1 AK312141.1 BC014098.2 CR541788.1 
    CR541790.1 EU019993.1 

    9 DOTS entries:

    DT.444070  DT.121238404  DT.95243972  DT.97843198  DT.121238422  DT.91744356  DT.95169337  DT.121238439 
    DT.99965408 

    24/267 AceView cDNA sequences (see all 267):

    BM838642 CB107161 CA434240 BM748818 AI637713 BM693306 H49348 BE299889 
    BG413520 BI836596 CR541790 CR541788 AB075855 CB045310 NM_006829 BQ694475 
    BQ430954 AW006481 CD722742 BE566379 AI434794 BM668990 BM704419 AJ346418 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SNCG (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d
    SP1:                          -           -     -     -           -           -                           
    SP2:                          -           -     -                 -           -                           
    SP3:                          -           -                       -           -                           
    SP4:                          -           -     -     -           -                                       
    SP5:                                      -     -     -           -           -                           


    ECgene alternative splicing isoforms for SNCG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNCG expression in normal human tissues (normalized intensities)      SNCG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCTGCCCA
    SNCG Expression
    About this image


    SNCG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 26 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Thalamus
             Septum   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             Immature Schwann Cells Peripheral Nerve Domain
             colon ; peripheral nerve/ganglion   
             spinal/ganglion/dorsal root ganglion   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Spinal Ventral Columns
             brain/midbrain/lateral wall   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Retina
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Sertoli cells Seminiferous Tubules
             epididymis ; glandular cells   

    See SNCG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNCG

    SOURCE GeneReport for Unigene cluster: Hs.349470

    UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070
    Tissue specificity: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus
    callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNCG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SNCG gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sncg1 , 5 synuclein, gamma1, 5 85.64(n)1
    89.43(a)1
      14 (20.81 cM)5
    206181  NM_011430.31  NP_035560.11 
     343702745 
    chicken
    (Gallus gallus)
    Aves SNCG1 synuclein, gamma (breast cancer-specific protein 1) 75.89(n)
    82.14(a)
      395392  NM_204672.1  NP_990003.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BG306962.12   -- 74.25(n)    BG306962.1 


    ENSEMBL Gene Tree for SNCG (if available)
    TreeFam Gene Tree for SNCG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNCG gene
    SNCB2  SNCA2  
    3 SIMAP similar genes for SNCG using alignment to 4 protein entries:     SYUG_HUMAN (see all proteins):
    NACP    SNCA    SNCB

    SNCG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/122 SNPs in SNCG are shown (see all 122)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs42449731,2
    C,F,A--88717140(+) CGTCCA/TACGGG 1 -- us2k113Minor allele frequency- T:0.03NA WA CSA EU 5833
    rs1132555961,2
    C--88719432(+) CTCAGG/TTGAGA 1 -- spd10--------
    rs1125304441,2
    C--88719433(+) TCAGGG/TGAGAA 1 -- spd10--------
    rs7601121,2
    C,F,H--88719569(+) ACCATA/GAGGCT 1 -- int124Minor allele frequency- T:0.00EA NA NS WA 2614
    rs1429577511,2
    C,F--88719758(+) CATAGT/CGGCCG 2 /A /V mis11Minor allele frequency- C:0.00NA 3856
    rs1998519041,2
    --88719788(+) CAACGC/TCGTGA 2 A V mis10--------
    rs7601131,2
    C,F,A--88719789(+) AACGCC/GGTGAG 2 A syn112Minor allele frequency- G:0.25MN NA WA CSA EA EU 5552
    rs1448195431,2
    C--88719814(+) GCAGCG/ATCAAC 2 /I /V mis11Minor allele frequency- A:0.00NA 4460
    rs1492343891,2
    C,F--88719859(+) ACATCG/ACGGTC 2 /T /A mis11Minor allele frequency- A:0.00NA 4494
    rs1118001781,2
    C,F--88719873(+) TCCGGG/AGTGGT 2 /G syn11Minor allele frequency- A:0.01NA 4474

    HapMap Linkage Disequilibrium report for SNCG (88718288 - 88723017 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SNCG:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv428236CNV Loss18775914
    nsv895859CNV Loss21882294
    nsv895858CNV Loss21882294
    esv33376CNV Loss17666407
    nsv470969CNV Loss18288195
    nsv517487CNV Gain+Loss19592680
    dgv312e1CNV Complex17122850
    dgv310e1CNV Complex17122850
    dgv311e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602998    OMIM disorders: --

    20/41 diseases for SNCG (see all 41):    About MalaCards
    ovarian endometriosis    follicular dendritic cell sarcoma    dendritic cell sarcoma    lewy body dementia
    breast cancer    pancreatic ductal adenocarcinoma    ovarian epithelial cancer    endometrial adenocarcinoma
    multiple system atrophy    gaucher's disease    endometriosis    amyloidosis
    parkinson's disease    dementia    retinoblastoma    albinism
    esophageal squamous cell carcinoma    gallbladder cancer    alzheimer's disease    glaucoma

    3 diseases from the University of Copenhagen DISEASES database for SNCG:
    Parkinson's disease     Lewy body dementia     Multiple system atrophy

    SNCG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/30 Novoseek inferred disease relationships for SNCG gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegenerative diseases 73 17 11091093 (1), 11369507 (1), 17681534 (1), 12559990 (1) (see all 14)
    parkinson disease 71.9 14 10557341 (2), 17681534 (1), 19711118 (1), 10852916 (1) (see all 13)
    multiple system atrophy 70.7 1 9749615 (1)
    lewy body disease 66.9 4 18577885 (2), 10557341 (1)
    breast carcinoma 57.7 28 12072430 (2), 11526506 (2), 16773211 (2), 17234772 (1) (see all 14)
    neurodegeneration 53.3 4 19246516 (1), 10934140 (1), 9700196 (1)
    alzheimers disease 52.7 11 11433431 (2), 9044857 (1), 10777786 (1), 18461469 (1) (see all 9)
    dementia 49.8 4 18577885 (2), 17681539 (1), 10557341 (1)
    breast cancer 46.8 97 14504205 (6), 16142440 (6), 16821081 (5), 17534899 (5) (see all 22)
    fibrillation 42.5 5 17088319 (3), 11812782 (1)

    Genetic Association Database (GAD): SNCG
    Human Genome Epidemiology (HuGE) Navigator: SNCG (6 documents)
    Tumor Gene Database (TGDB): SNCG

    Export disorders for SNCG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNCG gene, integrated from 9 sources (see all 148):
    (articles sorted by number of sources associating them with SNCG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization, expression and polymorphism of the human persyn gene. (PubMed id 9700196)1, 2, 3, 9 Ninkina N.N.... Buchman V.L. (1998)
    2. Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. (PubMed id 9044857)1, 2, 3, 9 Ji H.... Shi Y.E. (1997)
    3. Gamma synuclein: subcellular localization in neuronal and non- neuronal cells and effect on signal transduction. (PubMed id 11746666)1, 2, 9 Surguchov A.... Surgucheva I. (2001)
    4. Identification, localization and characterization of the human gamma- synuclein gene. (PubMed id 9737786)1, 2, 9 Lavedan C.... Polymeropoulos M.H. (1998)
    5. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. (PubMed id 10852916)1, 2, 9 Pronin A.N.... Benovic J.L. (2000)
    6. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PubMed id 17373700)1, 4 Morgan A.R....Williams J. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. [Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease] (PubMed id 14556204)1, 4 Su J.J....Ren D.M. (2003)
    9. Evaluation of the gamma-synuclein gene in German Parkinson's disease patients. (PubMed id 11585599)1, 4 Kruger R....Riess O. (2001)
    10. Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis. (PubMed id 16821081)1, 9 Wu K....Shi Y.E. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6623 HGNC: 11141 AceView: SNCGandC10orf116andKIAA1975 Ensembl:ENSG00000173267 euGenes: HUgn6623
    ECgene: SNCG H-InvDB: SNCG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNCG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SNCG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNCG gene:
    Search GeneIP for patents involving SNCG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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