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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SNCG Gene

protein-coding GIFtS: 62
GCID: GC10P088708

synuclein, gamma (breast cancer-specific protein 1)

Explore 44 diseases affiliated with
SNCG via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Synuclein, Gamma (Breast Cancer-Specific Protein 1)¹ ²		Synoretin³
BCSG1¹ ² ³ ⁵		PERSYN³
SR¹ ² ³		PRSN³
Persyn³		Persyn³
Breast Cancer-Specific Gene 1 Protein² ³		Synoretin³
Gamma-Synuclein¹

External Ids:	HGNC: 11141¹	Entrez Gene: 6623²	Ensembl: ENSG00000173267⁷	OMIM: 602998⁵	UniProtKB: O76070³

Export aliases for SNCG gene to outside databases

Previous GC identifers: GC10P087599 GC10P087941 GC10P088849 GC10P088382 GC10P082572

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNCG:

This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of

neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. (provided

by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070

Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during

development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases

(By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal

transduction pathway (By similarity)

Gene Wiki entry for SNCG (Gamma-synuclein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SNCG gene promoter:
HOXA9B HOXA9 AML1a C/EBPalpha PPAR-gamma1 HSF2 Meis-1a PPAR-gamma2 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNCG promoter sequence

Search SABiosciences Chromatin IP Primers for SNCG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNCG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.2-q23.3 Ensembl cytogenetic band: 10q23.2 HGNC cytogenetic band: 10q23.2-q23.3

SNCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNCG gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P088708: view genomic region (about GC identifiers)

Start:	88,718,288 bp from pter	End:	88,723,017 bp from pter
Size:	4,730 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070 (See protein sequence)

Recommended Name: Gamma-synuclein

Size: 127 amino acids; 13331 Da

Subunit: May be a centrosome-associated protein

Subcellular location: Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton,

spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the

spindle

Secondary accessions: O15104 Q96P61

Explore the universe of human proteins at neXtProt for SNCG: NX_O76070

Post-translational modifications:

Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other

kinases¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O76070

SNCG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003078.2

ENSEMBL proteins:

ENSP00000344658 ENSP00000361087

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Enzo Life Sciences proteins for SNCG
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	Novus Biologicals SNCG Proteins Novus Biologicals SNCG Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for SNCG
	Browse Proteins at Uscn

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005815	microtubule organizing center	IEA	--
GO:0005819	spindle	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0030424	axon	--	--

SNCG for ontologies About GeneDecksing

SNCG Antibody Products:

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	Browse Antibodies at Uscn
	ThermoFisher Antibodies for SNCG

Assay Products for SNCG:

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	GenScript Custom Assay Services for SNCG
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SNCG for domains About GeneDecksing

2 InterPro domains/families:

IPR002462 Synuclein_gamma

IPR001058 Synuclein

Graphical View of Domain Structure for InterPro Entry O76070

ProtoNet protein and cluster: O76070

1 Blocks protein family: IPB001058 Synuclein signature

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070

Similarity: Belongs to the synuclein family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070

Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during

development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases

(By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal

transduction pathway (By similarity)

Genatlas biochemistry entry for SNCG:

gamma synuclein,expressed during pre and postnatal development in the cell bodies and axons of primary sensory

neurons,sympathetic neurons and motoneurons of peripheral and central nervous system,predominantly expressed in

substantia nigra,maybe involved in exocytosis of synaptic vesicles,putatively involved in the pathogenesis of

neurodegenerative diseases (but not found in amyotrophic lateral sclerosis or familial Parkinson) and overexpressed in

breast tumors

miRNA Products:		OriGene 3'-UTR Clone: SNCG Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNCG
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SNCG (see all 10):
		hsa-miR-3673 hsa-miR-15a hsa-miR-497 hsa-miR-103a hsa-miR-424 hsa-miR-15b* hsa-miR-195 hsa-miR-16

		SwitchGear 3'UTR luciferase reporter plasmid: SNCG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNCG (see all 7) OriGene shRNA RFP: SNCG OriGene siRNA: SNCG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNCG

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SNCG

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNCG (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNCG OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SNCG (NM_003087)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNCG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCG

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SNCG
		Search LifeMap BioReagents cell lines for SNCG

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SNCG

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0043014	alpha-tubulin binding	IEA	--
GO:0048487	beta-tubulin binding	IEA	--

SNCG for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Sncg^tm1Vlb for SNCG
     4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sncg):

behavior/neurological

cellular

homeostasis/metabolism

nervous system

SNCG for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SNCG

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/25 Interacting proteins for SNCG (O76070³ ENSP00000361087⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 25)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK1	P28482³, ENSP00000215832⁴	I2D: score=4 STRING: ENSP00000215832
MAPK3	P27361³, ENSP00000263025⁴	I2D: score=4 STRING: ENSP00000263025
MAPK8	P45983³, ENSP00000353483⁴	I2D: score=4 STRING: ENSP00000353483
DYNLL1	P63167³, ENSP00000242577⁴	I2D: score=2 STRING: ENSP00000242577
FUBP1	Q96AE4³, ENSP00000359804⁴	I2D: score=2 STRING: ENSP00000359804

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002118	aggressive behavior	IEA	--
GO:0007268	synaptic transmission	IEA	--
GO:0008344	adult locomotory behavior	IEA	--
GO:0014059	regulation of dopamine secretion	IEA	--
GO:0042220	response to cocaine	IEA	--

SNCG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SNCG for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SNCG

2 HMDB Compounds for SNCG About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Iron	Armco iron (see all 19)	7439-89-6	--

6 Novoseek chemical compound relationships for SNCG gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
5-aza-2'deoxycytidine	40.7	3	11526506 (1), 12566312 (1)
paclitaxel	27.1	7	16773211 (3), 12121974 (2), 12959183 (1)
estrogen	11.5	5	12873981 (3), 15231664 (1)
agar	5.5	2	11016747 (1), 12970872 (1)
iron	0	1	10934140 (1)
tyrosine	0	2	12716427 (1), 16392036 (1)

Search CenterWatch for drugs/clinical trials and news about SNCG / SYUG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SNCG gene:

NM_003087.2

Unigene Cluster for SNCG:

Synuclein, gamma (breast cancer-specific protein 1)

Hs.349470 [show with all ESTs]

Unigene Representative Sequence: BU595229

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000465679 ENST00000348795 ENST00000372017(uc001keb.2) ENST00000483064

miRNA Products:		OriGene 3'-UTR Clone: SNCG Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNCG
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SNCG (see all 10):
		hsa-miR-3673 hsa-miR-15a hsa-miR-497 hsa-miR-103a hsa-miR-424 hsa-miR-15b* hsa-miR-195 hsa-miR-16

		SwitchGear 3'UTR luciferase reporter plasmid: SNCG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNCG (see all 7) OriGene shRNA RFP: SNCG OriGene siRNA: SNCG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNCG

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNCG (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNCG OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SNCG (NM_003087)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNCG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCG

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNCG Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SNCG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNCG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNCG

Additional cDNA sequence:

AF010126.1 AF017256.1 AF411524.1 AK223367.1 AK311652.1 AK312141.1 BC014098.2 CR541788.1

CR541790.1 EU019993.1

9 DOTS entries:

DT.444070 DT.121238404 DT.95243972 DT.97843198 DT.121238422 DT.91744356 DT.95169337 DT.121238439

DT.99965408

24/267 AceView cDNA sequences (see all 267):

AA486472 BE566379 BU728272 BM838642 AA878084 CR541788 BM748818 AI434794

CA434240 NM_006829 BQ219402 H49348 CR541790 BG413520 BQ430954 BQ694475

BQ218148 CB107161 CB045310 AI637713 BM693306 AB075855 AW006481 AJ346418

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SNCG (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d
SP1:									-				-		-		-				-				-
SP2:									-				-		-						-				-
SP3:									-				-								-				-
SP4:									-				-		-		-				-
SP5:													-		-		-				-				-

ECgene alternative splicing isoforms for SNCG

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SNCG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGCTGCCCA

About this image

SNCG expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Ganglion Cell Layer

Mature Ganglion Cells

Ganglion, Retina

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Testis

Body Subcutaneous White Adipose

Adipose

Visceral White Adipose

Adipose

Brain

Eye

Neural Tube

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

Ventral/hypothalamic-like neurons (Generation of midbra...)

See SNCG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SNCG

SOURCE GeneReport for Unigene cluster: Hs.349470

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070

Tissue specificity: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus

callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung

SABiosciences Custom PCR Arrays for SNCG

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SNCG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNCG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNCG

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SNCG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SNCG gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SNCG¹	synuclein, gamma (breast cancer-specific protein 1)	75.89(n) 82.14(a)		395392 NM_204672.1 NP_990003.1
lizard (Anolis carolinensis)	Reptilia	SNCG⁶	--	82(a)	1 ↔ 1	GL343199.1(4208583-4233082)
zebrafish (Danio rerio)	Actinopterygii	BG306962.1²	--	74.25(n)		BG306962.1

ENSEMBL Gene Tree for SNCG (if available)
TreeFam Gene Tree for SNCG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SNCG gene

SNCB² SNCA²

3 SIMAP similar genes for SNCG using alignment to 4 protein entries: SYUG_HUMAN (see all proteins):

NACP SNCA SNCB

SNCG for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73353632^1,2	C,	--	82571282(+)	`GGGGCC/TGCCAA`	1	--	us2k¹		1		WA	2
rs74150416^1,2	C,	--	82571764(+)	`CCCTAC/TCTAGG`	1	--	us2k¹		2		WA	120
rs113805468^1,2	C,	--	82572156(+)	`CGCTGC/TGGCAG`	1	--	us2k¹		0	--	--	--	--
rs79742456^1,2	F,	--	82572595(+)	`GACAGG/AGCTGG`	1	--	us2k¹		3		CSA WA	123
rs78801716^1,2	F,	--	82572714(+)	`CACACG/AGGAGC`	1	--	us2k¹		1		WA	118
rs112740007^1,2	F,	--	82572977(+)	`CCCCAC/AATTCT`	1	--	us2k¹		2		CSA	4
rs111404092^1,2		--	82573073(+)	`CCTTAT/CCCCCC`	1	--	us2k¹		1		CSA	1
rs73334931^1,2	C,	--	82576455(+)	`TCAGGG/ATGGCC`	1	--	int¹		2		WA	120
rs10232^1,2	C,	--	82576654(+)	`NNNNTC/TCCTGG`	1	--	ut3¹ ese³		3		MN NA	306
rs74889276^1,2		--	82576851(+)	`CCCAGG/TTCCTC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SNCG (88718288 - 88723017 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SNCG
5 CNVs: 6891 48665 48663 3815 48664

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNCG

DNA2.0 Custom Variant and Variant Library Synthesis for SNCG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SNCG for disorders           About GeneDecksing

OMIM gene information: 602998    OMIM disorders: --

20/44 diseases for SNCG (see all 44):    About MalaCards

neurodegenerative disease breast cancer dendritic cell sarcoma follicular dendritic cell sarcoma

lewy body dementia multiple system atrophy corpus callosum amyotrophic lateral sclerosis

lateral sclerosis esophageal squamous cell carcinoma squamous cell carcinoma pancreatic ductal adenocarcinoma

glaucoma amyloidosis gaucher's disease neurodegeneration

parkinson's disease dementia ovarian endometriosis ovarian carcinoma

3 diseases from the University of Copenhagen DISEASES database for SNCG:

Parkinson's disease Lewy body dementia Multiple system atrophy

10/30 Novoseek disease relationships for SNCG gene (see all 30) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neurodegenerative diseases	73	17	11091093 (1), 11369507 (1), 17681534 (1), 12559990 (1) (see all 14)
parkinson disease	71.9	14	10557341 (2), 17681534 (1), 19711118 (1), 10852916 (1) (see all 13)
multiple system atrophy	70.7	1	9749615 (1)
lewy body disease	66.9	4	18577885 (2), 10557341 (1)
breast carcinoma	57.7	28	12072430 (2), 11526506 (2), 16773211 (2), 17234772 (1) (see all 14)
neurodegeneration	53.3	4	19246516 (1), 10934140 (1), 9700196 (1)
alzheimers disease	52.7	11	11433431 (2), 9044857 (1), 10777786 (1), 18461469 (1) (see all 9)
dementia	49.8	4	18577885 (2), 17681539 (1), 10557341 (1)
breast cancer	46.8	97	14504205 (6), 16142440 (6), 16821081 (5), 17534899 (5) (see all 22)
fibrillation	42.5	5	17088319 (3), 11812782 (1)

Genetic Association Database (GAD): SNCG
Human Genome Epidemiology (HuGE) Navigator: SNCG (6 documents)
Tumor Gene Database (TGDB): SNCG

Export disorders for SNCG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SNCG gene, integrated from 9 sources (see all 146):
(articles sorted by number of sources associating them with SNCG)

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Organization, expression and polymorphism of the human persyn gene. (PubMed id 9700196)^{1, 2, 3, 9} Ninkina N.N.... Buchman V.L. (1998)
Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. (PubMed id 9044857)^{1, 2, 3, 9} Ji H.... Shi Y.E. (1997)
Gamma synuclein: subcellular localization in neuronal and non- neuronal cells and effect on signal transduction. (PubMed id 11746666)^{1, 2, 9} Surguchov A.... Surgucheva I. (2001)
Identification, localization and characterization of the human gamma- synuclein gene. (PubMed id 9737786)^{1, 2, 9} Lavedan C.... Polymeropoulos M.H. (1998)
Synucleins are a novel class of substrates for G protein-coupled receptor kinases. (PubMed id 10852916)^{1, 2, 9} Pronin A.N.... Benovic J.L. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
[Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease] (PubMed id 14556204)^{1, 4} Su J.J....Ren D.M. (2003)
Evaluation of the gamma-synuclein gene in German Parkinson's disease patients. (PubMed id 11585599)^{1, 4} Kruger R....Riess O. (2001)
Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis. (PubMed id 16821081)^{1, 9} Wu K....Shi Y.E. (2007)
Blockade of AP1 transactivation abrogates the abnormal expression of breast cancer-specific gene 1 in breast cancer cells. (PubMed id 12072430)^{1, 9} Lu A....Liu J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6623	HGNC: 11141	AceView: SNCGandC10orf116andKIAA1975	Ensembl:ENSG00000173267	euGenes: HUgn6623
ECgene: SNCG	H-InvDB: SNCG

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SNCG	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SNCG	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SNCG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SNCG gene:
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synuclein, gamma (breast cancer-specific protein 1)

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