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Aliases for SNCG Gene

Aliases for SNCG Gene

  • Synuclein, Gamma (Breast Cancer-Specific Protein 1) 2 3
  • Synoretin 2 3 4
  • Breast Cancer-Specific Gene 1 Protein 3 4
  • Persyn 3 4
  • BCSG1 3 4
  • SR 3 4
  • PRSN 4

External Ids for SNCG Gene

Previous GeneCards Identifiers for SNCG Gene

  • GC10P087599
  • GC10P087941
  • GC10P088849
  • GC10P088382
  • GC10P088708
  • GC10P082572

Summaries for SNCG Gene

Entrez Gene Summary for SNCG Gene

  • This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]

GeneCards Summary for SNCG Gene

SNCG (Synuclein, Gamma (Breast Cancer-Specific Protein 1)) is a Protein Coding gene. Diseases associated with SNCG include synucleinopathy and multiple system atrophy. GO annotations related to this gene include beta-tubulin binding and alpha-tubulin binding. An important paralog of this gene is SNCB.

UniProtKB/Swiss-Prot for SNCG Gene

  • Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).

Gene Wiki entry for SNCG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNCG Gene

Genomics for SNCG Gene

Regulatory Elements for SNCG Gene

Genomic Location for SNCG Gene

Chromosome:
10
Start:
86,958,531 bp from pter
End:
86,963,260 bp from pter
Size:
4,730 bases
Orientation:
Plus strand

Genomic View for SNCG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNCG Gene

Proteins for SNCG Gene

  • Protein details for SNCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76070-SYUG_HUMAN
    Recommended name:
    Gamma-synuclein
    Protein Accession:
    O76070
    Secondary Accessions:
    • O15104
    • Q96P61

    Protein attributes for SNCG Gene

    Size:
    127 amino acids
    Molecular mass:
    13331 Da
    Quaternary structure:
    • May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggegation (By similarity).

neXtProt entry for SNCG Gene

Proteomics data for SNCG Gene at MOPED

Post-translational modifications for SNCG Gene

  • Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNCG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SNCG (Synuclein-gamma)

No data available for DME Specific Peptides for SNCG Gene

Domains & Families for SNCG Gene

Protein Domains for SNCG Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O76070

UniProtKB/Swiss-Prot:

SYUG_HUMAN :
  • Belongs to the synuclein family.
Family:
  • Belongs to the synuclein family.
genes like me logo Genes that share domains with SNCG: view

No data available for Gene Families for SNCG Gene

Function for SNCG Gene

Molecular function for SNCG Gene

GENATLAS Biochemistry:
gamma synuclein,expressed during pre and postnatal development in the cell bodies and axons of primary sensory neurons,sympathetic neurons and motoneurons of peripheral and central nervous system,predominantly expressed in substantia nigra,maybe involved in exocytosis of synaptic vesicles,putatively involved in the pathogenesis of neurodegenerative diseases (but not found in amyotrophic lateral sclerosis or familial Parkinson) and overexpressed in breast tumors
UniProtKB/Swiss-Prot Function:
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).

Gene Ontology (GO) - Molecular Function for SNCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SNCG: view
genes like me logo Genes that share phenotypes with SNCG: view

Animal Models for SNCG Gene

MGI Knock Outs for SNCG:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SNCG Gene

Localization for SNCG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNCG Gene

Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNCG Gene COMPARTMENTS Subcellular localization image for SNCG gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 2
golgi apparatus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SNCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17222866
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0030424 axon IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with SNCG: view

Pathways & Interactions for SNCG Gene

SuperPathways for SNCG Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission IEA --
GO:0008344 adult locomotory behavior IEA --
GO:0009306 protein secretion IEA --
GO:0014059 regulation of dopamine secretion IEA --
GO:0046928 regulation of neurotransmitter secretion IEA --
genes like me logo Genes that share ontologies with SNCG: view

No data available for Pathways by source and SIGNOR curated interactions for SNCG Gene

Drugs & Compounds for SNCG Gene

(5) Drugs for SNCG Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iron Approved Pharma 957
Paclitaxel Approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2505
Calcium Nutra 0
estrogen Pharma 0
tyrosine Nutra 547

(3) Additional Compounds for SNCG Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
5-Aza-2deoxycytidine
Agar
genes like me logo Genes that share compounds with SNCG: view

Transcripts for SNCG Gene

Unigene Clusters for SNCG Gene

Synuclein, gamma (breast cancer-specific protein 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNCG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7: -

Relevant External Links for SNCG Gene

GeneLoc Exon Structure for
SNCG
ECgene alternative splicing isoforms for
SNCG

Expression for SNCG Gene

mRNA expression in normal human tissues for SNCG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNCG Gene

This gene is overexpressed in Brain - Hypothalamus (x5.0) and Brain - Amygdala (x5.0).

Protein differential expression in normal tissues from HIPED for SNCG Gene

This gene is overexpressed in Seminal vesicle (15.8), Brain (12.6), and Adipocyte (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNCG Gene



SOURCE GeneReport for Unigene cluster for SNCG Gene Hs.349470

mRNA Expression by UniProt/SwissProt for SNCG Gene

O76070-SYUG_HUMAN
Tissue specificity: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung
genes like me logo Genes that share expression patterns with SNCG: view

Protein tissue co-expression partners for SNCG Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SNCG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNCG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNCG 35
  • 87.4 (n)
  • 87.4 (a)
SNCG 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNCG 35
  • 86.16 (n)
  • 85.59 (a)
SNCG 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sncg 35
  • 86.73 (n)
  • 92.59 (a)
Sncg 16
Sncg 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNCG 35
  • 99.74 (n)
  • 99.21 (a)
SNCG 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sncg 35
  • 84.26 (n)
  • 87.04 (a)
oppossum
(Monodelphis domestica)
Mammalia SNCG 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNCG 35
  • 75.89 (n)
  • 82.14 (a)
SNCG1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNCG 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sncg 35
  • 68.85 (n)
  • 76.64 (a)
zebrafish
(Danio rerio)
Actinopterygii sncga 35
  • 66.32 (n)
  • 60.42 (a)
sncgb 36
  • 51 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4626 35
Species with no ortholog for SNCG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNCG Gene

ENSEMBL:
Gene Tree for SNCG (if available)
TreeFam:
Gene Tree for SNCG (if available)

Paralogs for SNCG Gene

Paralogs for SNCG Gene

(3) SIMAP similar genes for SNCG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SNCG: view

Variants for SNCG Gene

Sequence variations from dbSNP and Humsavar for SNCG Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_007455 -

Structural Variations from Database of Genomic Variants (DGV) for SNCG Gene

Variant ID Type Subtype PubMed ID
dgv310e1 CNV Complex 17122850
dgv311e1 CNV Complex 17122850
dgv312e1 CNV Complex 17122850
nsv428236 CNV Loss 18775914
nsv517487 CNV Gain+Loss 19592680
nsv470969 CNV Loss 18288195
nsv895858 CNV Loss 21882294
nsv895859 CNV Loss 21882294
esv33376 CNV Loss 17666407

Variation tolerance for SNCG Gene

Residual Variation Intolerance Score: 88.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.99; 74.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNCG Gene

HapMap Linkage Disequilibrium report
SNCG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNCG Gene

Disorders for SNCG Gene

MalaCards: The human disease database

(6) MalaCards diseases for SNCG Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
synucleinopathy
  • alpha synucleinopathies
multiple system atrophy
  • spinal muscular atrophy
dementia, lewy body
  • lewy body dementia
parkinson disease, late-onset
  • kufor-rakeb syndrome
breast cancer
  • breast cancer, invasive ductal
- elite association
Search SNCG in MalaCards View complete list of genes associated with diseases

Relevant External Links for SNCG

Genetic Association Database (GAD)
SNCG
Human Genome Epidemiology (HuGE) Navigator
SNCG
Tumor Gene Database (TGDB):
SNCG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNCG
genes like me logo Genes that share disorders with SNCG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNCG Gene

Publications for SNCG Gene

  1. Organization, expression and polymorphism of the human persyn gene. (PMID: 9700196) Ninkina N.N. … Buchman V.L. (Hum. Mol. Genet. 1998) 2 23 67
  2. Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. (PMID: 9044857) Ji H. … Shi Y.E. (Cancer Res. 1997) 2 23 67
  3. Expression of alpha-, beta- and gamma-synuclein in colorectal cancer, and potential clinical significance in progression of the disease. (PMID: 20043104) Ye Q. … Zheng M.H. (Oncol. Rep. 2010) 23 67
  4. Up-regulation of gamma-synuclein contributes to cancer cell survival under endoplasmic reticulum stress. (PMID: 19009586) Hua H. … Jiang Y. (J. Pathol. 2009) 23 67
  5. Partial regulation of serotonin transporter function by gamma-synuclein. (PMID: 19429025) Wersinger C. … Sidhu A. (Neurosci. Lett. 2009) 23 67

Products for SNCG Gene

Sources for SNCG Gene

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