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Aliases for SNCG Gene

Aliases for SNCG Gene

  • Synuclein Gamma 2 3 5
  • Synoretin 2 3 4
  • Breast Cancer-Specific Gene 1 Protein 3 4
  • Persyn 3 4
  • BCSG1 3 4
  • SR 3 4
  • Synuclein, Gamma (Breast Cancer-Specific Protein 1) 3
  • Breast Cancer-Specific Gene 1 2
  • ɣ-Synuclein 2
  • Gamma-Synuclein 3
  • PRSN 4

External Ids for SNCG Gene

Previous GeneCards Identifiers for SNCG Gene

  • GC10P087599
  • GC10P087941
  • GC10P088849
  • GC10P088382
  • GC10P088708
  • GC10P082572

Summaries for SNCG Gene

Entrez Gene Summary for SNCG Gene

  • This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]

GeneCards Summary for SNCG Gene

SNCG (Synuclein Gamma) is a Protein Coding gene. Diseases associated with SNCG include Breast Cancer and Synucleinopathy. GO annotations related to this gene include beta-tubulin binding and alpha-tubulin binding. An important paralog of this gene is SNCA.

UniProtKB/Swiss-Prot for SNCG Gene

  • Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).

Gene Wiki entry for SNCG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNCG Gene

Genomics for SNCG Gene

Regulatory Elements for SNCG Gene

Enhancers for SNCG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G086953 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.6 -1.1 -1070 8.0 PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 ZNF143 FOS KLF13 ZNF263 SP3 ENSG00000227896 SNCG LINC00863 NUTM2A-AS1 ADIRF-AS1 GC10P086949
GH10G087081 1.1 Ensembl ENCODE 10.8 +125.0 124991 4.2 FOXA2 BMI1 RARA YY1 ZNF121 FOS RELB IKZF2 ZNF362 JUNB MMRN2 ADIRF SNCG FAM35A NUTM2A-AS1 OPN4 NUTM2D GC10M087058
GH10G086965 1.2 ENCODE dbSUPER 9 +11.3 11301 7.8 HDGF FOXA2 CREB3L1 ARID4B SIN3A DMAP1 BRCA1 YY1 ZNF143 FOS ENSG00000227896 SNCG ADIRF-AS1 ENSG00000261011 BMS1P3 BMPR1A GRID1 LINC00863 NUTM2A MMRN2
GH10G086747 1 ENCODE dbSUPER 10 -210.5 -210470 0.9 ZNF362 PKNOX1 FOXA2 JUN BHLHE40 ZNF10 MAX ZNF384 FEZF1 NR2F2 BMPR1A MMRN2 ADIRF SNCG ENSG00000272631 GC10M086714
GH10G086939 1.2 Ensembl ENCODE 7.8 -19.0 -19002 1.0 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ZNF143 ZNF207 ADIRF MMRN2 ENSG00000151303 SNCG ENSG00000281974 GC10P086921
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SNCG on UCSC Golden Path with GeneCards custom track

Genomic Location for SNCG Gene

Chromosome:
10
Start:
86,958,531 bp from pter
End:
86,963,260 bp from pter
Size:
4,730 bases
Orientation:
Plus strand

Genomic View for SNCG Gene

Genes around SNCG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNCG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNCG Gene

Proteins for SNCG Gene

  • Protein details for SNCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76070-SYUG_HUMAN
    Recommended name:
    Gamma-synuclein
    Protein Accession:
    O76070
    Secondary Accessions:
    • O15104
    • Q96P61

    Protein attributes for SNCG Gene

    Size:
    127 amino acids
    Molecular mass:
    13331 Da
    Quaternary structure:
    • May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation (By similarity).

neXtProt entry for SNCG Gene

Post-translational modifications for SNCG Gene

  • Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNCG Gene

Antibody Products

  • R&D Systems Antibodies for SNCG (gamma-Synuclein)

Assay Products

  • Cloud-Clone Corp Assay Kits for SNCG

No data available for DME Specific Peptides for SNCG Gene

Domains & Families for SNCG Gene

Protein Domains for SNCG Gene

Graphical View of Domain Structure for InterPro Entry

O76070

UniProtKB/Swiss-Prot:

SYUG_HUMAN :
  • Belongs to the synuclein family.
Family:
  • Belongs to the synuclein family.
genes like me logo Genes that share domains with SNCG: view

No data available for Gene Families for SNCG Gene

Function for SNCG Gene

Molecular function for SNCG Gene

GENATLAS Biochemistry:
gamma synuclein,expressed during pre and postnatal development in the cell bodies and axons of primary sensory neurons,sympathetic neurons and motoneurons of peripheral and central nervous system,predominantly expressed in substantia nigra,maybe involved in exocytosis of synaptic vesicles,putatively involved in the pathogenesis of neurodegenerative diseases (but not found in amyotrophic lateral sclerosis or familial Parkinson) and overexpressed in breast tumors
UniProtKB/Swiss-Prot Function:
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).

Gene Ontology (GO) - Molecular Function for SNCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with SNCG: view
genes like me logo Genes that share phenotypes with SNCG: view

Animal Models for SNCG Gene

MGI Knock Outs for SNCG:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNCG Gene

Localization for SNCG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNCG Gene

Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNCG gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 4
plasma membrane 2
golgi apparatus 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SNCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17222866
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with SNCG: view

Pathways & Interactions for SNCG Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 chemical synaptic transmission IEA --
GO:0008344 adult locomotory behavior IEA --
GO:0009306 protein secretion IEA --
GO:0014059 regulation of dopamine secretion IEA --
GO:0046928 regulation of neurotransmitter secretion IEA --
genes like me logo Genes that share ontologies with SNCG: view

No data available for Pathways by source and SIGNOR curated interactions for SNCG Gene

Drugs & Compounds for SNCG Gene

(5) Drugs for SNCG Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(3) Additional Compounds for SNCG Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with SNCG: view

Transcripts for SNCG Gene

Unigene Clusters for SNCG Gene

Synuclein, gamma (breast cancer-specific protein 1):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNCG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7: -

Relevant External Links for SNCG Gene

GeneLoc Exon Structure for
SNCG
ECgene alternative splicing isoforms for
SNCG

Expression for SNCG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNCG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNCG Gene

This gene is overexpressed in Brain - Hypothalamus (x5.0) and Brain - Amygdala (x5.0).

Protein differential expression in normal tissues from HIPED for SNCG Gene

This gene is overexpressed in Seminal vesicle (15.8), Brain (12.6), and Adipocyte (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNCG Gene



Protein tissue co-expression partners for SNCG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNCG Gene:

SNCG

SOURCE GeneReport for Unigene cluster for SNCG Gene:

Hs.349470

mRNA Expression by UniProt/SwissProt for SNCG Gene:

O76070-SYUG_HUMAN
Tissue specificity: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.

Evidence on tissue expression from TISSUES for SNCG Gene

  • Intestine(4.3)
  • Nervous system(4.2)
  • Adrenal gland(2.1)
  • Eye(2)
genes like me logo Genes that share expression patterns with SNCG: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SNCG Gene

Orthologs for SNCG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNCG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNCG 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia SNCG 34 35
  • 87.4 (n)
mouse
(Mus musculus)
Mammalia Sncg 34 16 35
  • 86.73 (n)
dog
(Canis familiaris)
Mammalia SNCG 34 35
  • 86.16 (n)
rat
(Rattus norvegicus)
Mammalia Sncg 34
  • 84.26 (n)
oppossum
(Monodelphis domestica)
Mammalia SNCG 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNCG 34
  • 75.89 (n)
SNCG1 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNCG 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sncg 34
  • 68.85 (n)
zebrafish
(Danio rerio)
Actinopterygii sncga 34
  • 66.32 (n)
sncgb 35
  • 51 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4626 34
Species where no ortholog for SNCG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNCG Gene

ENSEMBL:
Gene Tree for SNCG (if available)
TreeFam:
Gene Tree for SNCG (if available)

Paralogs for SNCG Gene

Paralogs for SNCG Gene

(3) SIMAP similar genes for SNCG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SNCG: view

Variants for SNCG Gene

Sequence variations from dbSNP and Humsavar for SNCG Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000069376 -- 86,958,989(+) TGCAC(A/G)CCTAT intron-variant, upstream-variant-2KB
rs1000381601 -- 86,961,934(+) GTCCT(A/G)CACAC intron-variant
rs1000705529 -- 86,963,047(+) CCCCT(C/T)CTAGC intron-variant, utr-variant-3-prime
rs1000985153 -- 86,963,224(+) TTTTT(A/T)TAAAT intron-variant, utr-variant-3-prime
rs1001473450 -- 86,958,039(+) CAGCC(A/G)GAGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNCG Gene

Variant ID Type Subtype PubMed ID
esv2759774 CNV gain+loss 17122850
esv33376 CNV loss 17666407
nsv1141879 OTHER inversion 24896259
nsv428236 CNV loss 18775914
nsv470969 CNV loss 18288195
nsv517487 CNV gain+loss 19592680

Variation tolerance for SNCG Gene

Residual Variation Intolerance Score: 89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.99; 74.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNCG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNCG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNCG Gene

Disorders for SNCG Gene

MalaCards: The human disease database

(7) MalaCards diseases for SNCG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
synucleinopathy
  • alpha synucleinopathies
dementia, lewy body
  • lewy body dementia
dementia
  • presenile dementia
movement disease
  • movement disorders
- elite association - COSMIC cancer census association via MalaCards
Search SNCG in MalaCards View complete list of genes associated with diseases

Relevant External Links for SNCG

Genetic Association Database (GAD)
SNCG
Human Genome Epidemiology (HuGE) Navigator
SNCG
Tumor Gene Database (TGDB):
SNCG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNCG
genes like me logo Genes that share disorders with SNCG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNCG Gene

Publications for SNCG Gene

  1. Organization, expression and polymorphism of the human persyn gene. (PMID: 9700196) Ninkina N.N. … Buchman V.L. (Hum. Mol. Genet. 1998) 2 3 4 22 64
  2. Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. (PMID: 9044857) Ji H. … Shi Y.E. (Cancer Res. 1997) 2 3 4 22 64
  3. Gamma synuclein: subcellular localization in neuronal and non- neuronal cells and effect on signal transduction. (PMID: 11746666) Surguchov A. … Surgucheva I. (Cell Motil. Cytoskeleton 2001) 3 4 22 64
  4. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. (PMID: 10852916) Pronin A.N. … Benovic J.L. (J. Biol. Chem. 2000) 3 4 22 64
  5. Identification, localization and characterization of the human gamma- synuclein gene. (PMID: 9737786) Lavedan C. … Polymeropoulos M.H. (Hum. Genet. 1998) 3 4 22 64

Products for SNCG Gene

Sources for SNCG Gene

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