Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SNCG Gene

protein-coding   GIFtS: 63
GCID: GC10P088708

Synuclein, Gamma (Breast Cancer-Specific Protein 1)

  See SNCG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Synuclein, Gamma (Breast Cancer-Specific Protein 1)1 2     persyn2
BCSG12 3 5     PERSYN3
synoretin1 2     PRSN3
Breast Cancer-Specific Gene 1 Protein2 3     Persyn3
SR2 3     Synoretin3
gamma-synuclein2     

External Ids:    HGNC: 111411   Entrez Gene: 66232   Ensembl: ENSG000001732677   OMIM: 6029985   UniProtKB: O760703   

Export aliases for SNCG gene to outside databases

Previous GC identifers: GC10P087599 GC10P087941 GC10P088849 GC10P088382 GC10P082572


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SNCG Gene:
This gene encodes a member of the synuclein family of proteins which are believed to be involved in the
pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor
development. (provided by RefSeq, Jan 2010)

GeneCards Summary for SNCG Gene:
SNCG (synuclein, gamma (breast cancer-specific protein 1)) is a protein-coding gene. Diseases associated with SNCG include follicular dendritic cell sarcoma, and dendritic cell sarcoma. GO annotations related to this gene include alpha-tubulin binding and beta-tubulin binding. An important paralog of this gene is SNCB.

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070
Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture
during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to
calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin.
Activates the MAPK and Elk-1 signal transduction pathway (By similarity)

Gene Wiki entry for SNCG (Gamma-synuclein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNCG gene promoter:
         HOXA9B   HOXA9   AML1a   C/EBPalpha   PPAR-gamma1   HSF2   Meis-1a   PPAR-gamma2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNCG promoter sequence
   Search Chromatin IP Primers for SNCG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNCG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.2-q23.3   Ensembl cytogenetic band:  10q23.2   HGNC cytogenetic band: 10q23.2-q23.3

SNCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNCG gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P088708:  view genomic region     (about GC identifiers)

Start:
88,718,288 bp from pter      End:
88,723,017 bp from pter
Size:
4,730 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070 (See protein sequence)
Recommended Name: Gamma-synuclein  
Size: 127 amino acids; 13331 Da
Subunit: May be a centrosome-associated protein
Secondary accessions: O15104 Q96P61

Explore the universe of human proteins at neXtProt for SNCG: NX_O76070

Explore proteomics data for SNCG at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by
    other kinases1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SNCG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003078.2  
    ENSEMBL proteins: 
     ENSP00000344658   ENSP00000361087  

    SNCG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for SNCG
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SNCG
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SNCG
    GenScript Custom Purified and Recombinant Proteins Services for SNCG
    Novus Biologicals SNCG Proteins
    Novus Biologicals SNCG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SNCG
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SNCG 

    SNCG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SNCG
    R&D Systems Antibodies for SNCG (Synuclein-gamma)
    OriGene Antibodies for SNCG
    OriGene Custom Antibody Services for SNCG
    Novus Biologicals SNCG Antibodies
    Abcam antibodies for SNCG (O76070, Q6FHG5, Q16143)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SNCG
    LSBio Antibodies in human, mouse, rat for SNCG

    SNCG Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SNCG
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNCG
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SNCG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR002462 Synuclein_gamma
     IPR001058 Synuclein

    Graphical View of Domain Structure for InterPro Entry O76070

    ProtoNet protein and cluster: O76070

    1 Blocks protein domain: IPB001058 Synuclein signature

    UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070
    Similarity: Belongs to the synuclein family


    Find genes that share domains with SNCG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYUG_HUMAN, O76070
    Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture
    during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to
    calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin.
    Activates the MAPK and Elk-1 signal transduction pathway (By similarity)

         Genatlas biochemistry entry for SNCG:
    gamma synuclein,expressed during pre and postnatal development in the cell bodies and axons of primary sensory
    neurons,sympathetic neurons and motoneurons of peripheral and central nervous system,predominantly expressed in
    substantia nigra,maybe involved in exocytosis of synaptic vesicles,putatively involved in the pathogenesis of
    neurodegenerative diseases (but not found in amyotrophic lateral sclerosis or familial Parkinson) and
    overexpressed in breast tumors

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0043014alpha-tubulin binding IEA--
    GO:0048487beta-tubulin binding IEA--
         
    Find genes that share ontologies with SNCG           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sncg):
     behavior/neurological  cellular  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with SNCG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sncgtm1Vlb for SNCG

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNCG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNCG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNCG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNCG

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNCG:
    hsa-mir-335-5p (MIRT017445)

    Block miRNA regulation of human, mouse, rat SNCG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNCG (see all 10):
    hsa-miR-3673 hsa-miR-15a hsa-miR-497 hsa-miR-103a hsa-miR-424 hsa-miR-15b* hsa-miR-195 hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidSNCG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNCG
    Predesigned siRNA for gene silencing in human, mouse, rat SNCG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNCG

    Clone
    Products:
         
    OriGene clones in human, mouse for SNCG (see all 6)
    OriGene ORF clones in mouse, rat for SNCG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNCG (NM_003087)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNCG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SNCG
    Browse ESI BIO Cell Lines and PureStem Progenitors for SNCG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNCG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SYUG_HUMAN, O76070: Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In
    mitotic cells, localized to the poles of the spindle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    golgi apparatus2
    plasma membrane2
    extracellular1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005815microtubule organizing center IEA--
    GO:0005819spindle IEA--
    GO:0005886plasma membrane IEA--
    GO:0030424axon ----

    Find genes that share ontologies with SNCG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SNCG
    Interactions:

        GeneGlobe Interaction Network for SNCG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for SNCG (O760703 ENSP000003610874) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284823, ENSP000002158324I2D: score=4 STRING: ENSP00000215832
    MAPK3P273613, ENSP000002630254I2D: score=4 STRING: ENSP00000263025
    MAPK8P459833, ENSP000003534834I2D: score=4 STRING: ENSP00000353483
    DYNLL1P631673, ENSP000002425774I2D: score=2 STRING: ENSP00000242577
    FUBP1Q96AE43, ENSP000003598044I2D: score=2 STRING: ENSP00000359804
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002118aggressive behavior IEA--
    GO:0007268synaptic transmission IEA--
    GO:0008344adult locomotory behavior IEA--
    GO:0014059regulation of dopamine secretion IEA--
    GO:0042220response to cocaine IEA--

    Find genes that share ontologies with SNCG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNCG (SYUG)

    2 HMDB Compounds for SNCG    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--

    6 Novoseek inferred chemical compound relationships for SNCG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 40.7 3 11526506 (1), 12566312 (1)
    paclitaxel 27.1 7 16773211 (3), 12121974 (2), 12959183 (1)
    estrogen 11.5 5 12873981 (3), 15231664 (1)
    agar 5.5 2 11016747 (1), 12970872 (1)
    iron 0 1 10934140 (1)
    tyrosine 0 2 12716427 (1), 16392036 (1)



    Find genes that share compounds with SNCG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SNCG gene: 
    NM_003087.2  

    Unigene Cluster for SNCG:

    Synuclein, gamma (breast cancer-specific protein 1)
    Hs.349470  [show with all ESTs]
    Unigene Representative Sequence: BU595229
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465679 ENST00000348795 ENST00000372017(uc001keb.2) ENST00000483064

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SNCG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNCG (see all 10):
    hsa-miR-3673 hsa-miR-15a hsa-miR-497 hsa-miR-103a hsa-miR-424 hsa-miR-15b* hsa-miR-195 hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidSNCG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SNCG
    Predesigned siRNA for gene silencing in human, mouse, rat SNCG
    Clone
    Products:
         
    OriGene clones in human, mouse for SNCG (see all 6)
    OriGene ORF clones in mouse, rat for SNCG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SNCG (NM_003087)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNCG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCG
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNCG
    OriGene qSTAR qPCR primer pairs in human, mouse for SNCG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNCG
      QuantiTect SYBR Green Assays in human, mouse, rat SNCG
      QuantiFast Probe-based Assays in human, mouse, rat SNCG

    Additional mRNA sequence: 

    AF010126.1 AF017256.1 AF411524.1 AK223367.1 AK311652.1 AK312141.1 BC014098.2 CR541788.1 
    CR541790.1 EU019993.1 

    9 DOTS entries:

    DT.444070  DT.121238404  DT.95243972  DT.97843198  DT.121238422  DT.91744356  DT.95169337  DT.121238439 
    DT.99965408 

    Selected AceView cDNA sequences (see all 267):

    AA486472 BQ219402 BE566379 BM838642 AI637713 AA878084 AW006481 CB107161 
    BQ694475 BM748818 CR541790 AI434794 BM668990 CA434240 BM693306 CR541788 
    CA406377 AB075855 F30398 AJ346418 H49348 BI836596 CD722742 CB045310 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SNCG (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d
    SP1:                          -           -     -     -           -           -                           
    SP2:                          -           -     -                 -           -                           
    SP3:                          -           -                       -           -                           
    SP4:                          -           -     -     -           -                                       
    SP5:                                      -     -     -           -           -                           


    ECgene alternative splicing isoforms for SNCG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SNCG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCTGCCCA
    SNCG Expression
    About this image


    SNCG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Cerebellum
             Ventral/hypothalamic-like neurons
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
             Ventral/hypothalamic-like neurons
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Retina
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
    SNCG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNCG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.349470

    UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070
    Tissue specificity: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus
    callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung

        Custom PCR Arrays for SNCG
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SNCG
    OriGene qSTAR qPCR primer pairs in human, mouse for SNCG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNCG
    QuantiTect SYBR Green Assays in human, mouse, rat SNCG
    QuantiFast Probe-based Assays in human, mouse, rat SNCG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNCG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SNCG gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sncg1 , 5 synuclein, gamma1, 5 86.73(n)1
    92.59(a)1
      14 (20.81 cM)5
    206181  NM_011430.31  NP_035560.11 
     343702745 
    chicken
    (Gallus gallus)
    Aves SNCG1 synuclein, gamma (breast cancer-specific protein 1) 75.89(n)
    82.14(a)
      395392  NM_204672.1  NP_990003.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNCG6
    synuclein, gamma (breast cancer-specific protein 1...
    65(a)
    1 ↔ 1
    GL343199.1(4187882-4233335)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sncg1 synuclein, gamma (breast cancer-specific protein 1) 68.85(n)
    76.64(a)
      548856  NM_001016102.2  NP_001016102.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BG306962.12   -- 74.25(n)    BG306962.1 


    ENSEMBL Gene Tree for SNCG (if available)
    TreeFam Gene Tree for SNCG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SNCG gene
    SNCB2  SNCA2  
    3 SIMAP similar genes for SNCG using alignment to 4 protein entries:     SYUG_HUMAN (see all proteins):
    NACP    SNCA    SNCB

    Find genes that share paralogs with SNCG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SNCG (see all 122)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs42449731,2
    C,F,A--88717140(+) CGTCCA/TACGGG 1 -- us2k113Minor allele frequency- T:0.03NA WA CSA EU 5833
    rs1132555961,2
    C--88719432(+) CTCAGG/TTGAGA 1 -- spd10--------
    rs1125304441,2
    C--88719433(+) TCAGGG/TGAGAA 1 -- spd10--------
    rs7601121,2
    C,F,H--88719569(+) ACCATA/GAGGCT 1 -- int124Minor allele frequency- T:0.00EA NA NS WA 2614
    rs1429577511,2
    C,F--88719758(+) CATAGT/CGGCCG 2 /A /V mis11Minor allele frequency- C:0.00NA 3856
    rs1998519041,2
    --88719788(+) CAACGC/TCGTGA 2 A V mis10--------
    rs7601131,2
    C,F,A--88719789(+) AACGCC/GGTGAG 2 A syn112Minor allele frequency- G:0.25MN NA WA CSA EA EU 5552
    rs1448195431,2
    C--88719814(+) GCAGCG/ATCAAC 2 /I /V mis11Minor allele frequency- A:0.00NA 4460
    rs1492343891,2
    C,F--88719859(+) ACATCG/ACGGTC 2 /T /A mis11Minor allele frequency- A:0.00NA 4494
    rs1118001781,2
    C,F--88719873(+) TCCGGG/AGTGGT 2 /G syn11Minor allele frequency- A:0.01NA 4474

    HapMap Linkage Disequilibrium report for SNCG (88718288 - 88723017 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SNCG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428236CNV Loss18775914
    nsv895859CNV Loss21882294
    nsv895858CNV Loss21882294
    esv33376CNV Loss17666407
    nsv470969CNV Loss18288195
    nsv517487CNV Gain+Loss19592680
    dgv312e1CNV Complex17122850
    dgv310e1CNV Complex17122850
    dgv311e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNCG
    DNA2.0 Custom Variant and Variant Library Synthesis for SNCG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602998    OMIM disorders: --

    4 diseases for SNCG:    
    About MalaCards
    follicular dendritic cell sarcoma    dendritic cell sarcoma    breast cancer    parkinson's disease

    3 diseases from the University of Copenhagen DISEASES database for SNCG:
    Parkinson's disease     Lewy body dementia     Multiple system atrophy

    Find genes that share disorders with SNCG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SNCG gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegenerative diseases 73 17 11091093 (1), 11369507 (1), 17681534 (1), 12559990 (1) (see all 14)
    parkinson disease 71.9 14 10557341 (2), 17681534 (1), 19711118 (1), 10852916 (1) (see all 13)
    multiple system atrophy 70.7 1 9749615 (1)
    lewy body disease 66.9 4 18577885 (2), 10557341 (1)
    breast carcinoma 57.7 28 12072430 (2), 11526506 (2), 16773211 (2), 17234772 (1) (see all 14)
    neurodegeneration 53.3 4 19246516 (1), 10934140 (1), 9700196 (1)
    alzheimers disease 52.7 11 11433431 (2), 9044857 (1), 10777786 (1), 18461469 (1) (see all 9)
    dementia 49.8 4 18577885 (2), 17681539 (1), 10557341 (1)
    breast cancer 46.8 97 14504205 (6), 16142440 (6), 16821081 (5), 17534899 (5) (see all 22)
    fibrillation 42.5 5 17088319 (3), 11812782 (1)

    Genetic Association Database (GAD): SNCG
    Human Genome Epidemiology (HuGE) Navigator: SNCG (6 documents)
    Tumor Gene Database (TGDB): SNCG

    Export disorders for SNCG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SNCG gene, integrated from 10 sources (see all 150):
    (articles sorted by number of sources associating them with SNCG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization, expression and polymorphism of the human persyn gene. (PubMed id 9700196)1, 2, 3, 9 Ninkina N.N.... Buchman V.L. (Hum. Mol. Genet. 1998)
    2. Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. (PubMed id 9044857)1, 2, 3, 9 Ji H.... Shi Y.E. (Cancer Res. 1997)
    3. Gamma synuclein: subcellular localization in neuronal and non- neuronal cells and effect on signal transduction. (PubMed id 11746666)1, 2, 9 Surguchov A.... Surgucheva I. (Cell Motil. Cytoskeleton 2001)
    4. Identification, localization and characterization of the human gamma- synuclein gene. (PubMed id 9737786)1, 2, 9 Lavedan C.... Polymeropoulos M.H. (Hum. Genet. 1998)
    5. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. (PubMed id 10852916)1, 2, 9 Pronin A.N.... Benovic J.L. (J. Biol. Chem. 2000)
    6. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PubMed id 17373700)1, 4 Morgan A.R....Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. [Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease]. (PubMed id 14556204)1, 4 Su J.J....Ren D.M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003)
    9. Evaluation of the gamma-synuclein gene in German Parkinson's disease patients. (PubMed id 11585599)1, 4 KrA1ger R....Riess O. (Neurosci. Lett. 2001)
    10. Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis. (PubMed id 16821081)1, 9 Wu K....Shi Y.E. (Breast Cancer Res. Treat. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6623 HGNC: 11141 AceView: SNCGandC10orf116andKIAA1975 Ensembl:ENSG00000173267 euGenes: HUgn6623
    ECgene: SNCG H-InvDB: SNCG

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SNCG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SNCG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SNCG gene:
    Search GeneIP for patents involving SNCG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SNCG
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for SNCG (Synuclein-gamma)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SNCG   OriGene RNAi products in human, mouse, rat for SNCG  
     OriGene qPCR primer pairs and template standards for SNCG   OriGene Protein Over-expression Lysate for SNCG  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SNCG  
     OriGene qSTAR qPCR primer pairs in human, mouse for SNCG   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SNCG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SNCG   OriGene Custom Protein Services for SNCG  

     
     
     Block miRNA regulation of human, mouse, rat SNCG using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SNCG
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNCG Predesigned siRNA for gene silencing in human, mouse, rat SNCG
     QuantiFast Probe-based Assays in human, mouse, rat SNCG QuantiTect SYBR Green Assays in human, mouse, rat SNCG
     Custom PCR Arrays for SNCG Search Chromatin IP Primers for SNCG
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNCG  GeneGlobe Interaction Network for SNCG
     Regulatory tfbs in SNCG promoter
     GenScript Custom Purified and Recombinant Proteins Services for SNCG GenScript cDNA clones with any tag delivered in your preferred vector for SNCG
     GenScript Custom Assay Services for SNCG GenScript Custom overexpressing Cell Line Services for SNCG
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SNCG (SYUG)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for SNCG
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SNCG antibodies
     SNCG proteins
     SNCG lysates
     Antibodies for SNCG
     See all of Abcam's Antibodies, Kits and Proteins for SNCG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SNCG
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SNCG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNCG
     SwitchGear 3'UTR luciferase reporter plasmids for SNCG
     SwitchGear Promoter luciferase reporter plasmids for SNCG
     ThermoFisher Antibodies for SNCG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCG
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SNCG
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SNCG
     LSBio Antibodies in human, mouse, rat for SNCG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SNCG
      Search eBioscience for proteins for SNCG
      Search eBioscience for elisas for SNCG
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SNCG gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4