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SNCG Gene

protein-coding GIFtS: 65

GC10P088708

synuclein, gamma (breast cancer-specific protein 1)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BCSG1 ^¹, ², ³, ⁵
OTTHUMP00000020013 ^²
PERSYN ^³
PRSN ^³
Persyn ^³
SR ^¹, ², ³
Synoretin ^³
persyn ^¹, ²
synoretin ^²

Descriptions
Breast cancer-specific gene 1 protein ^³
breast cancer-specific protein 1 ^²
synuclein, gamma (breast cancer-specific gene 1) ^²
synuclein, gamma (breast cancer-specific protein 1) ^²

External Ids
HGNC: 11141¹
Entrez Gene: 6623²
UniProtKB: O76070³
Ensembl: ENSG00000173267⁷

Search outside databases for aliases for SNCG gene

Previous GC identifers: GC10P087599 GC10P087941 GC10P088849 GC10P088382

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SNCG:

Summary: This gene encodes a member of the synuclein family of proteins which are believed to be

involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been

associated with breast tumor development. [provided by RefSeq]

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070

Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal

architecture during development and in the adult. In vitro, increases the susceptibility of

neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating

the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By

similarity)

Gene Wiki entry for SNCG (Gamma-synuclein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SNCG gene

Entrez Gene cytogenetic band: 10q23.2-q23.3 Ensembl cytogenetic band: 10q23.2 HGNC cytogenetic band: 10q23.2-q23.3

SNCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P088708: (about GC identifiers)

Start:	88,708,351 bp from pter
End:	88,712,995 bp from pter
Size:	4,645 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070 (See protein sequence)

Recommended Name: Gamma-synuclein

Size: 127 amino acids; 13331 Da

Subunit: May be a centrosome-associated protein

Subcellular location: Cytoplasm, perinuclear region. Centrosome. Spindle. Note=Associated with

centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle

Secondary accessions: O15104 Q96P61

Post-translational modifications:

Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue

phosphorylated by other kinases¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003078.2

ENSEMBL proteins:

ENSP00000344658 ENSP00000361087

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant SNCG Protein
	Sigma-Aldrich Proteins for SNCG
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (gamma Synuclein, pan Synuclein)
	Human Recombinant Proteins from Abnova (SNCG)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005813	centrosome	IEA	--
GO:0005819	spindle	IEA	--

About this table

Antibodies for SNCG:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of SNCG
	Sigma-Aldrich Antibodies for SNCG
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (gamma Synuclein, pan Synuclein), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SNCG)
	Novus Biologicals Antibodies for SNCG

Assays for SNCG:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O76070

ProtoNet protein and cluster: O76070

1 Blocks protein family: IPB001058 Synuclein signature

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070

Similarity: Belongs to the synuclein family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SNCG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SNCG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003087

Applied Biosystems Silencer® siRNAs for SNCG

Sigma-Aldrich siRNA and siRNA Panels for SNCG

Sigma-Aldrich shRNA for SNCG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SNCG
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003087
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003087
untagged cDNA clone in CMV expression vector: NM_003087

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003087

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070

Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal

architecture during development and in the adult. In vitro, increases the susceptibility of

neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating

the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By

gamma synuclein,expressed during pre and postnatal development in the cell bodies and axons of

primary sensory neurons,sympathetic neurons and motoneurons of peripheral and central nervous

system,predominantly expressed in substantia nigra,maybe involved in exocytosis of synaptic

vesicles,putatively involved in the pathogenesis of neurodegenerative diseases (but not found in

amyotrophic lateral sclerosis or familial Parkinson) and overexpressed in breast tumors

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Sncg):

normal

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for SNCG

5/15 Interacting proteins for SNCG (ENSP00000344658³ O76070¹) via UniProtKB, MINT, and/or STRING (see all 15 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DYNLL1	P63167¹	EBI-1053810, EBI-349105
EXT2	Q93063¹	EBI-1053810, EBI-1047761
FABP4	P15090¹	EBI-1053810, EBI-715333
FUBP1	Q96AE4¹	EBI-1053810, EBI-711404
HNF4A	P41235¹	EBI-1053810, EBI-1049011

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SNCG
2 Novoseek chemical compound relationships for SNCG gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
iron	0.00	1	10934140 (1)
tyrosine	0.00	2	12716427 (1), 16392036 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SNCG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SNCG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003087

Sigma-Aldrich siRNA and siRNA Panels for SNCG

Sigma-Aldrich shRNA for SNCG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003087

REFSEQ mRNAs for SNCG gene:

NM_003087.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003087

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003087
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003087
                                 untagged cDNA clone in CMV expression vector: NM_003087

Additional cDNA sequence:

AF010126.1 AF017256.1 AF411524.1 AK223367.1 AK311652.1 AK312141.1 BC014098.2 CR541788.1

CR541790.1 EU019993.1

9 DOTS entries:

DT.444070 DT.121238404 DT.95243972 DT.97843198 DT.121238422 DT.91744356 DT.95169337 DT.121238439

DT.99965408

24/267 AceView cDNA sequences (see all 267 ):

AI637713 BQ430954 H49348 BM748818 AB075855 BM668990 BQ218148 CB107161

NM_006829 AJ346418 CD722742 BM704419 BG413520 CR541788 AI434794 BE299889

BE566379 CR541790 CB045310 BI836596 AA486472 CA434240 CA406377 BQ219402

highest scoring ESTs for SNCG:

AA055968 AA056035 AA235594 AA293803 AA365132 AA394097 AA402624 AA410737 AA411094 AA421708

Unigene Cluster for SNCG:

Synuclein, gamma (breast cancer-specific protein 1)

Hs.349470 [show with all ESTs]

Unigene Representative Sequence: BU595229

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SNCG (see all 7 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d
SP1:									-				-		-		-				-				-
SP2:									-				-		-						-				-
SP3:									-				-								-				-
SP4:									-				-		-		-				-
SP5:													-		-		-				-				-

About this scheme

ECgene alternative splicing isoforms for SNCG

2 Ensembl transcripts including schematic representations:

ENST00000348795 ENST00000372017

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SNCG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SNCG

¹ / ² / ³

5 probe-sets matching SNCG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36555_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	AF044311	0.20	1.00	0.72	1
209877_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF010126	0.80	1.00	0.91	1
208584_at*²^{, 3}	U133-A	NULL	0.00	0.00	--	--	NM_016432	0.20	1.00	0.72	1
209877_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208584_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks SNCG for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CGGCTGCCCA

SOURCE GeneReport for Unigene cluster: Hs.349470
Expression variation in blood from EXPOLDB for SNCG
UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070
Tissue specificity: Highly expressed in brain, particularly in the substantia nigra. Also expressed
in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression
in pancreas, kidney and lung

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SNCG gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SNCG¹	--	synuclein, gamma (breast cancer-specific protein 1)	86.36(n) 84.55(a)	611053 XM_848680.1 XP_853773.1
chimpanzee (Pan troglodytes)	SNCG¹	--	synuclein, gamma (breast cancer-specific protein 1)	99.21(n) 98.43(a)	450574 XM_507891.2 XP_507891.2
cow (Bos taurus)	SNCG¹	--	synuclein, gamma (breast cancer-specific protein 1)	86.88(n) 86.61(a)	281494 NM_174186.2 NP_776611.1
rat (Rattus norvegicus)	Sncg¹	--	synuclein, gamma (breast cancer-specific protein 1)	83.47(n) 85.37(a)	64347 NM_031688.1 NP_113876.1
mouse (Mus musculus)	Sncg^{1, 5}	14 (12.50 cM)⁵	synuclein, gamma^{1, 5}	85.37(n)¹ 89.43(a)¹	20618¹ NM_011430.2¹ NP_035560.1¹ AA690669⁵ AF017255⁵ (see all 13)

About this table Species with no ortholog for SNCG

ENSEMBL Gene Tree for SNCG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SNCG gene

SNCB² SNCA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/37 NCBI SNPs in SNCG are shown (see all 37 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 67)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7074229^1,2	A,C,F,H	88713026(+)	`AGCTTG/CAGGAG`	1	--	ng3¹		4		EU EA WA	414
	rs1802015^1,2	A,C,F,H	88712938(+)	`CCCACT/ATATGC`	1	--	ut3¹ ese³		6		NA EU EA	400
	rs9864^1,2	C,F,H	88712378(+)	`GGGTGA/TGGCAT`	1	E/V	mis¹		18		MN EU EA WA NA	1832
	rs10232^1,2	F	88712845(+)	`CGTCTC/TCCTGG`	1	--	ut3¹ ese³		1		MN	184
	rs7096355^1,2	C	88712970(+)	`ATGATG/TCCAAA`	1	--	ut3¹ ese³		0	--	--	--	--
	rs2131395^1,2	C	88713474(-)	`CACCTC/TCTGTC`	1	--	ng3¹		0	--	--	--	--
	rs760113^1,2	A,F	88709769(+)	`AACGCC/GGTGAG`	1	A/A	syn¹		1		MN	184
--	rs9420407^1,2	C,F,H	88711015(+)	`CTCGTC/TGTATG`	1	--	int¹		8		EU EA WA	822
	rs760112^1,2	C,F,H	88709549(+)	`ACCATA/GAGGCT`	1	--	int¹		11		EA NA EU WA	710
--	rs7091084^1,2	A,C	88711004(+)	`AGTTCC/TCCTTT`	1	--	int¹ trp³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for SNCG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602998

UniProtKB/Swiss-Prot: SYUG_HUMAN, O76070

Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare

neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy

body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is

found in spheroids but not in inclusions

10/30 Novoseek disease relationships for SNCG gene (see all 30 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neurodegenerative diseases	73.90	16	11091093 (1), 11369507 (1), 17681534 (1), 12559990 (1) (see all 13)
parkinson disease	71.79	13	10557341 (2), 17681534 (1), 10852916 (1), 12446933 (1) (see all 12)
multiple system atrophy	71.47	1	9749615 (1)
lewy body disease	67.93	4	18577885 (2), 10557341 (1)
breast carcinoma	58.52	28	12072430 (2), 11526506 (2), 16773211 (2), 17234772 (1) (see all 14)
alzheimers disease	54.13	11	11433431 (2), 9044857 (1), 10777786 (1), 18461469 (1) (see all 9)
neurodegeneration	52.89	4	19246516 (1), 10934140 (1), 9700196 (1)
dementia	49.67	4	18577885 (2), 17681539 (1), 10557341 (1)
breast cancer	47.19	96	14504205 (6), 16142440 (6), 16821081 (5), 17534899 (5) (see all 21)
neuropathology	42.66	1	10934140 (1)

About this table

Genetic Association Database: SNCG
Human Genome Epidemiology Navigator: SNCG (3 documents)
Tumor Gene Database: SNCG
Breast Cancer Gene Database: SNCG

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/123 PubMed articles for SNCG gene (see all 123 ):

Organization, expression and polymorphism of the human persyn gene. (PubMed id 9700196)^{1, 2, 3, 4} Ninkina N.N....Buchman V.L. (1998)
Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. (PubMed id 9044857)^{1, 2, 3, 4} Ji H.... Shi Y.E. (1997)
Gamma synuclein: subcellular localization in neuronal and non- neuronal cells and effect on signal transduction. (PubMed id 11746666)^{1, 3, 4} Surguchov A.... Surgucheva I. (2001)
Identification, localization and characterization of the human gamma- synuclein gene. (PubMed id 9737786)^{1, 3, 4} Lavedan C.... Polymeropoulos M.H. (1998)
Evaluation of the gamma-synuclein gene in German Parkinson's disease patients. (PubMed id 11585599)^{1, 3, 6} Kruger R....Riess O. (2001)
Synucleins are a novel class of substrates for G protein-coupled receptor kinases. (PubMed id 10852916)^{1, 3, 4} Pronin A.N.... Benovic J.L. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
[Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease] (PubMed id 14556204)^{3, 6} Su J.J....Ren D.M. (2003)
Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis. (PubMed id 16821081)^{1, 3} Wu K....Shi Y.E. (2007)
Blockade of AP1 transactivation abrogates the abnormal expression of breast cancer-specific gene 1 in breast cancer cells. (PubMed id 12072430)^{1, 3} Lu A....Liu J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6623	HGNC: 11141	AceView: SNCGandC10orf116andKIAA1975	Ensembl:ENSG00000173267	euGenes: HUgn6623
ECgene: SNCG	H-InvDB: SNCG

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for SNCG	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SNCG
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SNCG:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SNCG-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SNCG		Antibodies for SNCG
	Explore super-pooled esiRNAs		Proteins for SNCG
	Lentivirus-delivered shRNAs for SNCG		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SNCG)
	Antibodies (SNCG)
	Chimera RNAi (SNCG)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (gamma Synuclein, pan Synuclein)
	Antibodies (gamma Synuclein, pan Synuclein)

Search OriGene for SNCG

Search Tocris compounds for SNCG

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SNCG

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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SNCG Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for SNCG

Summaries
for SNCG

Genomic Location
for SNCG

Proteins
for SNCG

Protein Domains/
Families
for SNCG

Gene Function
for SNCG

Pathways & Interactions
for SNCG

Drugs & Compounds
for SNCG

Transcripts
for SNCG

Expression
for SNCG

Orthologs
for SNCG

Paralogs
for SNCG

SNPs/Variants
for SNCG

Disorders & Mutations
for SNCG

Medical News
for SNCG

Publications
for SNCG

Search for SNCG

Genome Databases showing SNCG

Other Databases showing SNCG

Specialized Databases showing SNCG

Licensable Technologies
for SNCG

Services
for SNCG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SNCG Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor SNCG

Summariesfor SNCG

Genomic Locationfor SNCG

Proteinsfor SNCG

Protein Domains/Familiesfor SNCG

Gene Functionfor SNCG

Pathways & Interactionsfor SNCG

Drugs & Compoundsfor SNCG

Transcriptsfor SNCG

Expression for SNCG

Orthologsfor SNCG

Paralogsfor SNCG

SNPs/Variantsfor SNCG

Disorders & Mutationsfor SNCG

Medical Newsfor SNCG

Publicationsfor SNCG

Search for SNCG

Genome Databases showing SNCG

Other Databases showing SNCG

Specialized Databases showing SNCG

Licensable Technologiesfor SNCG

Servicesfor SNCG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SNCG

Summaries
for SNCG

Genomic Location
for SNCG

Proteins
for SNCG

Protein Domains/
Families
for SNCG

Gene Function
for SNCG

Pathways & Interactions
for SNCG

Drugs & Compounds
for SNCG

Transcripts
for SNCG

Expression
for SNCG

Orthologs
for SNCG

Paralogs
for SNCG

SNPs/Variants
for SNCG

Disorders & Mutations
for SNCG

Medical News
for SNCG

Publications
for SNCG

Licensable Technologies
for SNCG

Services
for SNCG