Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SNCB Gene

protein-coding   GIFtS: 64
GCID: GC05M176047

Synuclein, Beta

  See SNCB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Synuclein, Beta1 2
beta-synuclein2

External Ids:    HGNC: 111401   Entrez Gene: 66202   Ensembl: ENSG000000743177   OMIM: 6025695   UniProtKB: Q161433   
ORGUL members:         

Export aliases for SNCB gene to outside databases

Previous GC identifers: GC05M176394 GC05M176866 GC05M175982 GC05M176028 GC05M175979 GC05M170970


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SNCB Gene:
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed
in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in
neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has
been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in
patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SNCB Gene:
SNCB (synuclein, beta) is a protein-coding gene. Diseases associated with SNCB include tauopathy, and lewy body dementia. GO annotations related to this gene include alpha-tubulin binding and calcium ion binding. An important paralog of this gene is SNCA.

UniProtKB/Swiss-Prot: SYUB_HUMAN, Q16143
Function: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA
aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase
activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by
6OHDA. Not found in the Lewy bodies associated with Parkinson disease

Gene Wiki entry for SNCB (Beta-synuclein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SNCB gene promoter:
         SRF   p53   SRF (504 AA)   NRSF form 1   Pax-2   Pax-2a   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNCB promoter sequence
   Search Chromatin IP Primers for SNCB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNCB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35

SNCB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNCB gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176047:  view genomic region     (about GC identifiers)

Start:
176,047,085 bp from pter      End:
176,057,557 bp from pter
Size:
10,473 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SYUB_HUMAN, Q16143 (See protein sequence)
Recommended Name: Beta-synuclein  
Size: 134 amino acids; 14288 Da
Secondary accessions: Q6IAX7

Explore the universe of human proteins at neXtProt for SNCB: NX_Q16143

Explore proteomics data for SNCB at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation
    by CK1, CK2 and CaM-kinase II1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SNCB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001502.1  NP_003076.1  

    ENSEMBL proteins: 
     ENSP00000308057   ENSP00000377296   ENSP00000424073   ENSP00000422223  

    SNCB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for SNCB
    OriGene Purified Proteins for SNCB
    OriGene Protein Over-expression Lysate for SNCB
    OriGene MassSpec for SNCB
    OriGene Custom Protein Services for SNCB
    GenScript Custom Purified and Recombinant Proteins Services for SNCB
    Novus Biologicals SNCB Proteins
    Novus Biologicals SNCB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SNCB
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SNCB 

     
    antibodies-online proteins for SNCB (21 products) 

     
    antibodies-online peptides for SNCB

    SNCB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SNCB
    R&D Systems Antibodies for SNCB (Synuclein-beta)
    Cell Signaling Technology (CST) Antibodies for SNCB 
    OriGene Antibodies for SNCB
    OriGene Custom Antibody Services for SNCB
    Novus Biologicals SNCB Antibodies
    Abcam antibodies for SNCB
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SNCB
    antibodies-online antibodies for SNCB (68 products) 

    SNCB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SNCB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNCB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SNCB 
    antibodies-online kits for SNCB (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR002461 Synuclein_beta
     IPR001058 Synuclein

    Graphical View of Domain Structure for InterPro Entry Q16143

    ProtoNet protein and cluster: Q16143

    2 Blocks protein domains:
    IPB001058 Synuclein signature
    IPB002461 Beta-synuclein signature


    UniProtKB/Swiss-Prot: SYUB_HUMAN, Q16143
    Similarity: Belongs to the synuclein family


    Find genes that share domains with SNCB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYUB_HUMAN, Q16143
    Function: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA
    aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase
    activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by
    6OHDA. Not found in the Lewy bodies associated with Parkinson disease

         Genatlas biochemistry entry for SNCB:
    beta synuclein,19kDa,homolog to bovine phosphoneuroprotein (PNP14),non A/beta component of Alzheimer amyloid
    precursor,beta,expressed in presynaptic nerve terminals in various areas of the brain,including substantia nigra
    but not the corpus callosum and the caudate nucleus,putatively involved in exocytosis of synaptic vesicles

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity TAS9806846
    GO:0005509calcium ion binding IDA11312271
    GO:0043014alpha-tubulin binding IEA--
    GO:0048487beta-tubulin binding IEA--
         
    Find genes that share ontologies with SNCB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SNCB:
     Actin fiber cells 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sncb):
     growth/size/body  homeostasis/metabolism  mortality/aging  nervous system  no phenotypic analysis 
     normal 

    Find genes that share phenotypes with SNCB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sncbtm1.1Sud for SNCB

       genOway: Develop your customized and physiologically relevant rodent model for SNCB

    miRNA
    Products:
        
    miRTarBase miRNAs that target SNCB:
    hsa-mir-335-5p (MIRT018267)

    Block miRNA regulation of human, mouse, rat SNCB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNCB (see all 12):
    hsa-miR-185* hsa-miR-330-5p hsa-miR-222 hsa-miR-221 hsa-miR-218 hsa-miR-664 hsa-miR-637 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidSNCB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SNCB
    Predesigned siRNA for gene silencing in human, mouse, rat SNCB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SNCB

    Clone
    Products:
         
    OriGene clones in human, mouse for SNCB (see all 11)
    OriGene ORF clones in mouse, rat for SNCB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SNCB (NM_003085)
    Sino Biological Human cDNA Clone for SNCB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNCB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SNCB
    Browse ESI BIO Cell Lines and PureStem Progenitors for SNCB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNCB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SYUB_HUMAN, Q16143: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    nucleus4
    cytosol3
    mitochondrion2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005794Golgi apparatus IDA--

    Find genes that share ontologies with SNCB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SNCB About    
    See pathways by source

    SuperPathContained pathways About
    1Neuroscience
    Neuroscience


    Find genes that share SuperPaths with SNCB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SNCB
        Neuroscience



        Pathway & Disease-focused RT2 Profiler PCR Array including SNCB: 
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SNCB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SNCB (Q161432, 3 ENSP000003080574) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission IEA--
    GO:0042417dopamine metabolic process IEA--
    GO:0043086negative regulation of catalytic activity TAS9806846
    GO:0043524negative regulation of neuron apoptotic process IEA--
    GO:0050808synapse organization IEA--

    Find genes that share ontologies with SNCB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SNCB (SYUB)

    1 HMDB Compound for SNCB    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--

    5 Novoseek inferred chemical compound relationships for SNCB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 1.39 4 16597821 (2), 18436957 (1), 17653558 (1)
    iron 1.31 1 10208537 (1)
    h2o2 0.216 2 11790792 (1)
    calcium 0 2 12358748 (1)
    superoxide 0 1 19482226 (1)



    Find genes that share compounds with SNCB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SNCB gene (2 alternative transcripts): 
    NM_001001502.1  NM_003085.3  

    Unigene Cluster for SNCB:

    Synuclein, beta
    Hs.90297  [show with all ESTs]
    Unigene Representative Sequence: BI818916
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310112(uc003mep.3 uc021yig.1 uc021yih.1) ENST00000393693(uc003meq.3 uc021yii.1 uc021yij.1)
    ENST00000510387 ENST00000506696 ENST00000508006(uc010jke.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SNCB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SNCB (see all 12):
    hsa-miR-185* hsa-miR-330-5p hsa-miR-222 hsa-miR-221 hsa-miR-218 hsa-miR-664 hsa-miR-637 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidSNCB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SNCB
    Predesigned siRNA for gene silencing in human, mouse, rat SNCB
    Clone
    Products:
         
    OriGene clones in human, mouse for SNCB (see all 11)
    OriGene ORF clones in mouse, rat for SNCB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SNCB (NM_003085)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNCB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SNCB
    OriGene qSTAR qPCR primer pairs in human, mouse for SNCB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNCB
      QuantiTect SYBR Green Assays in human, mouse, rat SNCB
      QuantiFast Probe-based Assays in human, mouse, rat SNCB

    Additional mRNA sequence: 

    AK309135.1 BC002902.2 BT006627.1 CR457027.1 JF960950.1 JF960951.1 JF960952.1 JF960953.1 
    S69965.1 

    7 DOTS entries:

    DT.452537  DT.100778430  DT.99978225  DT.100778432  DT.91801287  DT.95276308  DT.97846440 

    Selected AceView cDNA sequences (see all 95):

    BF525773 S69965 AA421586 BM543516 CB154497 CB154491 BQ128090 AI937874 
    CR594995 NM_003085 AA495769 NM_001001502 CB154855 BM309966 CB154736 BM693987 
    H19290 AI879167 BM544405 BE793543 BM692337 BC002902 BT006627 BI490841 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SNCB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAGCTA
    SNCB Expression
    About this image


    SNCB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             Globus Pallidus   
     
     Eye (Sensory Organs)
    SNCB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SNCB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.90297

    UniProtKB/Swiss-Prot: SYUB_HUMAN, Q16143
    Tissue specificity: Expressed predominantly in brain; concentrated in presynaptic nerve terminals

        Pathway & Disease-focused RT2 Profiler PCR Array including SNCB: 
              Alzheimer's Disease in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SNCB
    OriGene qSTAR qPCR primer pairs in human, mouse for SNCB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNCB
    QuantiTect SYBR Green Assays in human, mouse, rat SNCB
    QuantiFast Probe-based Assays in human, mouse, rat SNCB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNCB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SNCB gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sncb1 , 5 synuclein, beta1, 5 90.03(n)1
    97.64(a)1
      13 (29.28 cM)5
    1040691  NM_033610.21  NP_291088.11 
     547588605 
    chicken
    (Gallus gallus)
    Aves SNCB1 synuclein, beta 80.58(n)
    86.61(a)
      395391  NM_204671.1  NP_990002.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNCB6
    synuclein, beta
    83(a)
    1 ↔ 1
    GL343526.1(400339-432460)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.147052 Xenopus laevis transcribed sequence with moderate similarity more 78(n)    CD328779.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc663432 similar to synuclein, beta 74.65(n)   393944  BC055608.1 


    ENSEMBL Gene Tree for SNCB (if available)
    TreeFam Gene Tree for SNCB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SNCB gene
    SNCA2  SNCG2  
    3 SIMAP similar genes for SNCB using alignment to 3 protein entries:     SYUB_HUMAN (see all proteins):
    NACP    SNCG    SNCA

    Find genes that share paralogs with SNCB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SNCB (see all 267)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048939371,2
    C,Fpathogenic1176275730(-) CCCACC/ACCAGG 4 /H /P mis12Minor allele frequency- A:0.00NA EU 5559
    rs1048939361,2
    Cpathogenic1176280982(-) GAGCTA/GTGTTC 4 M V mis10--------
    rs572013721,2
    C--176047241(+) CTCTCG/-GGGGG 2 -- ut312Minor allele frequency- -:0.25NA CSA 4
    rs593190621,2
    C--176049490(+) AACAA-/AACAA/A
    ACAAAACAA
    GCCAG
    2 -- int11NA 2
    rs58735431,2
    C--176053337(+) GCCTG-/GTGTGTG 2 -- int10--------
    rs560079951,2
    C--176053337(+) TGTGT-/GT    
       
    /GTGT
    TTGCC
    2 -- int11NA 2
    rs723224141,2
    C--176053337(+) GCCTGGTGT/-  
            
    GTGTG
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs2006226341,2
    --176053361(+) TGTGT-/GTGTTTGC 2 -- int10--------
    rs107066751,2
    C--176054660(+) CCGGC-/GGGGGG 2 -- int10--------
    rs1114432521,2
    C,F--176274337(+) GGGTCC/TGCACG 2 -- ds50012Minor allele frequency- T:0.07CSA WA 120

    HapMap Linkage Disequilibrium report for SNCB (176047085 - 176057557 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SNCB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883145CNV Loss21882294
    dgv6375n71CNV Loss21882294
    nsv883144CNV Loss21882294

    Human Gene Mutation Database (HGMD): SNCB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SNCB
    DNA2.0 Custom Variant and Variant Library Synthesis for SNCB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602569   
    OMIM disorders: 127750  
    5 diseases for SNCB:    
    About MalaCards
    tauopathy    lewy body dementia    multiple system atrophy    parkinson's disease
    alzheimer's disease

    3 diseases from the University of Copenhagen DISEASES database for SNCB:
    Lewy body dementia     Parkinson's disease     Multiple system atrophy

    Find genes that share disorders with SNCB           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SNCB gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 79.9 15 11683992 (1), 17381514 (1), 17681539 (1), 10557341 (1) (see all 14)
    neurodegenerative diseases 73.8 7 11091093 (1), 11683992 (1), 17681539 (1), 11474193 (1) (see all 7)
    multiple system atrophy 71.1 1 14534420 (1)
    lewy body disease 69.5 1 17381514 (1)
    dementia 64.5 6 17652097 (2), 17681539 (1), 10557341 (1), 15365127 (1) (see all 5)
    neurodegeneration 63.2 4 11474193 (2), 19246516 (1), 11683992 (1)
    alzheimers disease 60.5 1 10557341 (1)
    parkinsonism 56.5 2 15026413 (1)
    fibrillation 51.8 6 15966733 (5), 17381514 (1)
    neurological disorders 0 1 10557341 (1)

    Genetic Association Database (GAD): SNCB
    Human Genome Epidemiology (HuGE) Navigator: SNCB (4 documents)

    Export disorders for SNCB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SNCB gene, integrated from 10 sources (see all 120):
    (articles sorted by number of sources associating them with SNCB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and expression of the human beta-synuclein gene (SNCB). (PubMed id 9806846)1, 2, 3, 9 Lavedan C.... Polymeropoulos M.H. (Genomics 1998)
    2. Beta-synuclein gene variants and Parkinson's disease: a preliminary case-control study. (PubMed id 17556099)1, 4, 9 Brighina L....Maraganore D.M. (Neurosci. Lett. 2007)
    3. Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35. (PubMed id 7558013)1, 3, 9 Spillantini M.G....Goedert M. (Genomics 1995)
    4. Identification of two distinct synucleins from human brain. (PubMed id 8194594)1, 2, 9 Jakes R.... Goedert M. (FEBS Lett. 1994)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. (PubMed id 10852916)1, 2 Pronin A.N.... Benovic J.L. (J. Biol. Chem. 2000)
    7. beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor. (PubMed id 11683992)1, 9 Hashimoto M....Masliah E. (Neuron 2001)
    8. beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein. (PubMed id 15591046)1, 9 Snyder H....Wolozin B. (J. Biol. Chem. 2005)
    9. Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease. (PubMed id 12867415)1, 9 da Costa C.A....Checler F. (J. Biol. Chem. 2003)
    10. Expression of beta-synuclein in normal human astrocytes. (PubMed id 11588588)1, 9 Tanji K....Wakabayashi K. (Neuroreport 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6620 HGNC: 11140 AceView: SNCB Ensembl:ENSG00000074317 euGenes: HUgn6620
    ECgene: SNCB H-InvDB: SNCB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SNCB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SNCB gene:
    Search GeneIP for patents involving SNCB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SNCB
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for SNCB (Synuclein-beta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SNCB   OriGene RNAi products in human, mouse, rat for SNCB  
     OriGene qPCR primer pairs and template standards for SNCB   OriGene Protein Over-expression Lysate for SNCB  
     OriGene MassSpec for SNCB   OriGene clones in human, mouse for SNCB  
     OriGene qSTAR qPCR primer pairs in human, mouse for SNCB   OriGene Purified Protein for SNCB  
     OriGene ORF clones in mouse, rat for SNCB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SNCB   OriGene Custom Protein Services for SNCB  

     
     
     Block miRNA regulation of human, mouse, rat SNCB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SNCB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SNCB Predesigned siRNA for gene silencing in human, mouse, rat SNCB
     QuantiFast Probe-based Assays in human, mouse, rat SNCB QuantiTect SYBR Green Assays in human, mouse, rat SNCB
     PCR Arrays including human, mouse, rat SNCB Search Chromatin IP Primers for SNCB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SNCB  GeneGlobe Interaction Network for SNCB
     Regulatory tfbs in SNCB promoter
     GenScript Custom Purified and Recombinant Proteins Services for SNCB GenScript cDNA clones with any tag delivered in your preferred vector for SNCB
     GenScript Custom Assay Services for SNCB GenScript Custom overexpressing Cell Line Services for SNCB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for SNCB 

     Search Tocris compounds for SNCB (SYUB)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SNCB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for SNCB
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SNCB antibodies
     SNCB proteins
     SNCB lysates
     Antibodies for SNCB
     See all of Abcam's Antibodies, Kits and Proteins for SNCB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SNCB
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SNCB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNCB
     SwitchGear 3'UTR luciferase reporter plasmids for SNCB
     SwitchGear Promoter luciferase reporter plasmids for SNCB
     ThermoFisher Antibodies for SNCB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCB
     Browse compounds at ApexBio
     Search Addgene for plasmids for SNCB
      Search eBioscience for proteins for SNCB
      Search eBioscience for elisas for SNCB
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SNCB
     antibodies-online antibodies for SNCB (68 products)
     antibodies-online kits for SNCB (14 products)
     antibodies-online peptides for SNCB
     antibodies-online proteins for SNCB (21 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SNCB gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4