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Aliases for SNCB Gene

Aliases for SNCB Gene

  • Synuclein Beta 2 3 5

External Ids for SNCB Gene

Previous GeneCards Identifiers for SNCB Gene

  • GC05M176394
  • GC05M176866
  • GC05M175982
  • GC05M176028
  • GC05M175979
  • GC05M176047
  • GC05M170970

Summaries for SNCB Gene

Entrez Gene Summary for SNCB Gene

  • This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for SNCB Gene

SNCB (Synuclein Beta) is a Protein Coding gene. Diseases associated with SNCB include dementia, lewy body and multiple system atrophy. GO annotations related to this gene include calcium ion binding and alpha-tubulin binding. An important paralog of this gene is SNCG.

UniProtKB/Swiss-Prot for SNCB Gene

  • Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Gene Wiki entry for SNCB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNCB Gene

Genomics for SNCB Gene

Regulatory Elements for SNCB Gene

Genomic Location for SNCB Gene

Chromosome:
5
Start:
176,620,084 bp from pter
End:
176,630,556 bp from pter
Size:
10,473 bases
Orientation:
Minus strand

Genomic View for SNCB Gene

Genes around SNCB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNCB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNCB Gene

Proteins for SNCB Gene

  • Protein details for SNCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16143-SYUB_HUMAN
    Recommended name:
    Beta-synuclein
    Protein Accession:
    Q16143
    Secondary Accessions:
    • Q6IAX7

    Protein attributes for SNCB Gene

    Size:
    134 amino acids
    Molecular mass:
    14288 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SNCB Gene

Proteomics data for SNCB Gene at MOPED

Post-translational modifications for SNCB Gene

  • Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for SNCB (Synuclein-beta)
  • Cell Signaling Technology (CST) Antibodies for SNCB (SNCB)

No data available for DME Specific Peptides for SNCB Gene

Domains & Families for SNCB Gene

Protein Domains for SNCB Gene

Suggested Antigen Peptide Sequences for SNCB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16143

UniProtKB/Swiss-Prot:

SYUB_HUMAN :
  • Belongs to the synuclein family.
Family:
  • Belongs to the synuclein family.
genes like me logo Genes that share domains with SNCB: view

No data available for Gene Families for SNCB Gene

Function for SNCB Gene

Molecular function for SNCB Gene

GENATLAS Biochemistry:
beta synuclein,19kDa,homolog to bovine phosphoneuroprotein (PNP14),non A/beta component of Alzheimer amyloid precursor,beta,expressed in presynaptic nerve terminals in various areas of the brain,including substantia nigra but not the corpus callosum and the caudate nucleus,putatively involved in exocytosis of synaptic vesicles
UniProtKB/Swiss-Prot Function:
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Gene Ontology (GO) - Molecular Function for SNCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity TAS 9806846
GO:0005509 calcium ion binding IDA 11312271
genes like me logo Genes that share ontologies with SNCB: view
genes like me logo Genes that share phenotypes with SNCB: view

Human Phenotype Ontology for SNCB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SNCB Gene

MGI Knock Outs for SNCB:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SNCB Gene

Localization for SNCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNCB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNCB Gene COMPARTMENTS Subcellular localization image for SNCB gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 4
mitochondrion 3
cytoskeleton 1
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SNCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016234 inclusion body IDA 17222866
GO:0043025 neuronal cell body IEA --
GO:0043195 terminal bouton IEA --
genes like me logo Genes that share ontologies with SNCB: view

Pathways & Interactions for SNCB Gene

SuperPathways for SNCB Gene

No Data Available

SIGNOR curated interactions for SNCB Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for SNCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043524 negative regulation of neuron apoptotic process IEA --
genes like me logo Genes that share ontologies with SNCB: view

No data available for Pathways by source for SNCB Gene

Drugs & Compounds for SNCB Gene

(2) Drugs for SNCB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for SNCB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with SNCB: view

Transcripts for SNCB Gene

Unigene Clusters for SNCB Gene

Synuclein, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNCB Gene

No ASD Table

Relevant External Links for SNCB Gene

GeneLoc Exon Structure for
SNCB
ECgene alternative splicing isoforms for
SNCB

Expression for SNCB Gene

mRNA expression in normal human tissues for SNCB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNCB Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.5), Brain - Cortex (x8.2), Brain - Anterior cingulate cortex (BA24) (x7.1), Brain - Amygdala (x5.4), Brain - Cerebellar Hemisphere (x4.6), Brain - Cerebellum (x4.5), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for SNCB Gene

This gene is overexpressed in Frontal cortex (31.5) and Brain (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNCB Gene



SOURCE GeneReport for Unigene cluster for SNCB Gene Hs.90297

mRNA Expression by UniProt/SwissProt for SNCB Gene

Q16143-SYUB_HUMAN
Tissue specificity: Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
genes like me logo Genes that share expression patterns with SNCB: view

Protein tissue co-expression partners for SNCB Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SNCB Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNCB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNCB 35
  • 99.5 (n)
  • 100 (a)
SNCB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNCB 36
  • 97 (a)
OneToOne
SNCB 35
  • 91.93 (n)
  • 97.66 (a)
dog
(Canis familiaris)
Mammalia SNCB 35
  • 92.91 (n)
  • 97.64 (a)
SNCB 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sncb 36
  • 97 (a)
OneToOne
Sncb 16
Sncb 35
  • 90.03 (n)
  • 97.64 (a)
oppossum
(Monodelphis domestica)
Mammalia SNCB 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sncb 35
  • 91.15 (n)
  • 97.66 (a)
chicken
(Gallus gallus)
Aves SNCB 36
  • 87 (a)
OneToOne
SNCB 35
  • 80.58 (n)
  • 86.61 (a)
lizard
(Anolis carolinensis)
Reptilia SNCB 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14705 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sncb 35
  • 76.82 (n)
  • 85.16 (a)
zebrafish
(Danio rerio)
Actinopterygii sncb 36
  • 72 (a)
OneToOne
sncb 35
  • 69.28 (n)
  • 70.43 (a)
zgc66343 35
Species with no ortholog for SNCB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNCB Gene

ENSEMBL:
Gene Tree for SNCB (if available)
TreeFam:
Gene Tree for SNCB (if available)

Paralogs for SNCB Gene

Paralogs for SNCB Gene

(3) SIMAP similar genes for SNCB Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SNCB: view

Variants for SNCB Gene

Sequence variations from dbSNP and Humsavar for SNCB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs923321 -- 176,621,957(-) ACATA(C/T)ATGTG intron-variant
rs923322 -- 176,625,370(+) gccaa(A/C)aatct intron-variant
rs1009655 -- 176,622,147(+) CAGCG(C/T)CAGCT intron-variant
rs1801347 -- 176,620,438(-) CAGAG(C/T)ACCCC utr-variant-3-prime
rs1976141 -- 176,624,818(+) AAAAA(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNCB Gene

Variant ID Type Subtype PubMed ID
dgv6375n71 CNV Loss 21882294
nsv883144 CNV Loss 21882294
nsv883145 CNV Loss 21882294

Variation tolerance for SNCB Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SNCB Gene

HapMap Linkage Disequilibrium report
SNCB
Human Gene Mutation Database (HGMD)
SNCB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNCB Gene

Disorders for SNCB Gene

MalaCards: The human disease database

(7) MalaCards diseases for SNCB Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dementia, lewy body
  • lewy body dementia
multiple system atrophy
  • shy-drager syndrome
synucleinopathy
  • alpha synucleinopathies
tauopathy
  • tauopathies
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search SNCB in MalaCards View complete list of genes associated with diseases

Relevant External Links for SNCB

Genetic Association Database (GAD)
SNCB
Human Genome Epidemiology (HuGE) Navigator
SNCB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNCB
genes like me logo Genes that share disorders with SNCB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNCB Gene

Publications for SNCB Gene

  1. Genomic organization and expression of the human beta-synuclein gene (SNCB). (PMID: 9806846) Lavedan C. … Polymeropoulos M.H. (Genomics 1998) 2 3 4 23 67
  2. Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35. (PMID: 7558013) Spillantini M.G. … Goedert M. (Genomics 1995) 2 3 23
  3. Molecular determinants of the aggregation behavior of alpha- and beta-synuclein. (PMID: 18436957) Rivers R.C. … Christodoulou J. (Protein Sci. 2008) 3 23
  4. Beta-synuclein gene variants and Parkinson's disease: a preliminary case-control study. (PMID: 17556099) Brighina L. … Maraganore D.M. (Neurosci. Lett. 2007) 3 23
  5. Neuronal and glial accumulation of alpha- and beta-synucleins in human lipidoses. (PMID: 17653558) Suzuki K. … Hirayasu Y. (Acta Neuropathol. 2007) 3 23

Products for SNCB Gene

Sources for SNCB Gene

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