External Ids for SNCB Gene
Previous GeneCards Identifiers for SNCB Gene
This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for SNCB Gene
SNCB (Synuclein Beta) is a Protein Coding gene. Diseases associated with SNCB include dementia, lewy body and multiple system atrophy. GO annotations related to this gene include calcium ion binding and alpha-tubulin binding. An important paralog of this gene is SNCG.
UniProtKB/Swiss-Prot for SNCB Gene
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.