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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNCB Gene

protein-coding   GIFtS: 63
GCID: GC05M176047

Synuclein, Beta

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synuclein, Beta1 2
beta-synuclein2

External Ids:    HGNC: 111401   Entrez Gene: 66202   Ensembl: ENSG000000743177   OMIM: 6025695   UniProtKB: Q161433   

Export aliases for SNCB gene to outside databases

Previous GC identifers: GC05M176394 GC05M176866 GC05M175982 GC05M176028 GC05M175979 GC05M170970


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNCB Gene:
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed
in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in
neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has
been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in
patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SNCB Gene: 
SNCB (synuclein, beta) is a protein-coding gene. Diseases associated with SNCB include multiple system atrophy, and lewy body dementia. GO annotations related to this gene include alpha-tubulin binding and calcium ion binding. An important paralog of this gene is SNCA.

UniProtKB/Swiss-Prot: SYUB_HUMAN, Q16143
Function: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA
aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase
activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by
6OHDA. Not found in the Lewy bodies associated with Parkinson disease

Gene Wiki entry for SNCB (Beta-synuclein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNCB gene promoter:
         SRF   p53   SRF (504 AA)   NRSF form 1   Pax-2   Pax-2a   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSNCB promoter sequence
   Search SABiosciences Chromatin IP Primers for SNCB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNCB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35

SNCB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNCB gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176047:  view genomic region     (about GC identifiers)

Start:
176,047,085 bp from pter      End:
176,057,557 bp from pter
Size:
10,473 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYUB_HUMAN, Q16143 (See protein sequence)
Recommended Name: Beta-synuclein  
Size: 134 amino acids; 14288 Da
Subcellular location: Cytoplasm
Secondary accessions: Q6IAX7

Explore the universe of human proteins at neXtProt for SNCB: NX_Q16143

Explore proteomics data for SNCB at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation
    by CK1, CK2 and CaM-kinase II
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16143

  • SNCB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SNCB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001001502.1  NP_003076.1  

    ENSEMBL proteins: 
     ENSP00000308057   ENSP00000377296   ENSP00000424073   ENSP00000422223  

    Human Recombinant Protein Products for SNCB: 
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    Enzo Life Sciences proteins for SNCB
    OriGene Purified Proteins for SNCB
    OriGene Protein Over-expression Lysate for SNCB
    OriGene MassSpec for SNCB 
    OriGene Custom Protein Services for SNCB
    GenScript Custom Purified and Recombinant Proteins Services for SNCB
    Novus Biologicals SNCB Proteins
    Novus Biologicals SNCB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SNCB
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005794Golgi apparatus IDA--

    SNCB for ontologies           About GeneDecksing



    SNCB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SNCB
    R&D Systems Antibodies for SNCB (Synuclein-beta)
    Cell Signaling Technology (CST) Antibodies for SNCB 
    OriGene Antibodies for SNCB
    OriGene Custom Antibody Services for SNCB
    GenScript Custom Superior Antibodies Services for SNCB
    Novus Biologicals SNCB Antibodies
    Abcam antibodies for SNCB
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for SNCB
    LSBio Antibodies in human, mouse, rat for SNCB 

    Assay Products for SNCB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SNCB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNCB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR002461 Synuclein_beta
     IPR001058 Synuclein

    Graphical View of Domain Structure for InterPro Entry Q16143

    ProtoNet protein and cluster: Q16143

    2 Blocks protein domains:
    IPB001058 Synuclein signature
    IPB002461 Beta-synuclein signature


    UniProtKB/Swiss-Prot: SYUB_HUMAN, Q16143
    Similarity: Belongs to the synuclein family


    SNCB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYUB_HUMAN, Q16143
    Function: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA
    aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase
    activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by
    6OHDA. Not found in the Lewy bodies associated with Parkinson disease

         Genatlas biochemistry entry for SNCB:
    beta synuclein,19kDa,homolog to bovine phosphoneuroprotein (PNP14),non A/beta component of Alzheimer amyloid
    precursor,beta,expressed in presynaptic nerve terminals in various areas of the brain,including substantia nigra
    but not the corpus callosum and the caudate nucleus,putatively involved in exocytosis of synaptic vesicles

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity TAS9806846
    GO:0005509calcium ion binding IDA11312271
    GO:0043014alpha-tubulin binding IEA--
    GO:0048487beta-tubulin binding IEA--
         
    SNCB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SNCB:
     Actin fiber cells 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sncb):
     growth/size  homeostasis/metabolism  mortality/aging  nervous system  no phenotypic analysis 
     normal 

    SNCB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sncbtm1.1Sud for SNCB

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SNCB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SNCB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SNCB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SNCB 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNCB
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SNCB (see all 12):
    hsa-miR-185* hsa-miR-330-5p hsa-miR-222 hsa-miR-221 hsa-miR-218 hsa-miR-664 hsa-miR-637 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidSNCB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SNCB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNCB

    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SNCB (NM_003085)
    Sino Biological Human cDNA Clone for SNCB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNCB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCB
    Sirion Biotech Customized lentivirus for stable overexpression of SNCB 
                         Customized lentivirus expression plasmids for stable overexpression of SNCB 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SNCB
    Search LifeMap BioReagents cell lines for SNCB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNCB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SNCB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Neuroscience
    Neuroscience

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SNCB
        Neuroscience




    SNCB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNCB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/19 Interacting proteins for SNCB (Q161432, 3 ENSP000003080574) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission IEA--
    GO:0042417dopamine metabolic process IEA--
    GO:0043524negative regulation of neuron apoptotic process IEA--
    GO:0050808synapse organization IEA--

    SNCB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SNCB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNCB (SYUB)

    1 HMDB Compound for SNCB    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--

    5 Novoseek inferred chemical compound relationships for SNCB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 1.39 4 16597821 (2), 18436957 (1), 17653558 (1)
    iron 1.31 1 10208537 (1)
    h2o2 0.216 2 11790792 (1)
    calcium 0 2 12358748 (1)
    superoxide 0 1 19482226 (1)

    Search CenterWatch for drugs/clinical trials and news about SNCB / SYUB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SNCB gene (2 alternative transcripts): 
    NM_001001502.1  NM_003085.3  

    Unigene Cluster for SNCB:

    Synuclein, beta
    Hs.90297  [show with all ESTs]
    Unigene Representative Sequence: BI818916
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310112(uc003mep.3 uc021yig.1 uc021yih.1) ENST00000393693(uc003meq.3 uc021yii.1 uc021yij.1)
    ENST00000510387 ENST00000506696 ENST00000508006(uc010jke.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNCB
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SNCB (see all 12):
    hsa-miR-185* hsa-miR-330-5p hsa-miR-222 hsa-miR-221 hsa-miR-218 hsa-miR-664 hsa-miR-637 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidSNCB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SNCB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNCB
    Clone
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    OriGene clones in human, mouse for SNCB (see all 13)
    OriGene ORF clones in mouse, rat for SNCB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SNCB (NM_003085)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNCB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCB
    Sirion Biotech Customized lentivirus for stable overexpression of SNCB 
                         Customized lentivirus expression plasmids for stable overexpression of SNCB 
    Primer
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    OriGene qPCR primer pairs and template standards for SNCB
    OriGene qSTAR qPCR primer pairs in human, mouse for SNCB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNCB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNCB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNCB

    Additional mRNA sequence: 

    AK309135.1 BC002902.2 BT006627.1 CR457027.1 JF960950.1 JF960951.1 JF960952.1 JF960953.1 
    S69965.1 

    7 DOTS entries:

    DT.452537  DT.100778430  DT.99978225  DT.100778432  DT.91801287  DT.95276308  DT.97846440 

    24/95 AceView cDNA sequences (see all 95):

    CB154736 S69965 BM543516 BQ128090 H19290 CR594995 AA495769 BM309966 
    BM693987 CB154497 NM_003085 BF525773 NM_001001502 CB154491 AA421586 AI937874 
    CB154855 BM664916 BC002902 BU733755 BX101058 BM893761 CB117565 BI669744 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNCB expression in normal human tissues (normalized intensities)      SNCB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAGCTA
    SNCB Expression
    About this image


    SNCB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             Subthalamic Nucleus   
     
     Eye (Sensory Organs)

    See SNCB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNCB

    SOURCE GeneReport for Unigene cluster: Hs.90297

    UniProtKB/Swiss-Prot: SYUB_HUMAN, Q16143
    Tissue specificity: Expressed predominantly in brain; concentrated in presynaptic nerve terminals

        SABiosciences Expression via Pathway-Focused PCR Array including SNCB: 
              Alzheimer's Disease in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNCB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNCB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SNCB gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sncb1 , 5 synuclein, beta1, 5 89.72(n)1
    97.74(a)1
      13 (29.28 cM)5
    1040691  NM_033610.21  NP_291088.11 
     547588605 
    chicken
    (Gallus gallus)
    Aves SNCB1 synuclein, beta 80.7(n)
    87.22(a)
      395391  NM_204671.1  NP_990002.1 
    lizard
    (Anolis carolinensis)
    Reptilia SNCB6
    SNCG6
    Uncharacterized protein
    83(a)
    43(a)
    1 ↔ 1
    possible ortholog
    GL343526.1(400339-432460)
    GL343199.1(4187882-4233335)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.147052 Xenopus laevis transcribed sequence with moderate similarity more 78(n)    CD328779.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc663432 similar to synuclein, beta 74.65(n)   393944  BC055608.1 


    ENSEMBL Gene Tree for SNCB (if available)
    TreeFam Gene Tree for SNCB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNCB gene
    SNCA2  SNCG2  
    3 SIMAP similar genes for SNCB using alignment to 3 protein entries:     SYUB_HUMAN (see all proteins):
    NACP    SNCG    SNCA

    SNCB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/267 SNPs in SNCB are shown (see all 267)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048939371,2
    C,Fpathogenic1176275730(-) CCCACC/ACCAGG 4 /H /P mis12Minor allele frequency- A:0.00NA EU 5559
    rs1048939361,2
    Cpathogenic1176280982(-) GAGCTA/GTGTTC 4 M V mis10--------
    rs572013721,2
    C--176047241(+) CTCTCG/-GGGGG 2 -- ut312Minor allele frequency- -:0.25NA CSA 4
    rs593190621,2
    C--176049490(+) AACAA-/AACAA/A
    ACAAAACAA
    GCCAG
    2 -- int11NA 2
    rs58735431,2
    C--176053337(+) GCCTG-/GTGTGTG 2 -- int10--------
    rs560079951,2
    C--176053337(+) TGTGT-/GT    
       
    /GTGT
    TTGCC
    2 -- int11NA 2
    rs723224141,2
    C--176053337(+) GCCTGGTGT/-  
            
    GTGTG
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs2006226341,2
    --176053361(+) TGTGT-/GTGTTTGC 2 -- int10--------
    rs107066751,2
    C--176054660(+) CCGGC-/GGGGGG 2 -- int10--------
    rs1114432521,2
    C,F--176274337(+) GGGTCC/TGCACG 2 -- ds50012Minor allele frequency- T:0.07CSA WA 120

    HapMap Linkage Disequilibrium report for SNCB (176047085 - 176057557 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SNCB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883145CNV Loss21882294
    dgv6375n71CNV Loss21882294
    nsv883144CNV Loss21882294


    Human Gene Mutation Database (HGMD): SNCB
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SNCB
    DNA2.0 Custom Variant and Variant Library Synthesis for SNCB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602569   
    OMIM disorders: 127750  
    16 diseases for SNCB:    About MalaCards
    multiple system atrophy    lewy body dementia    cocaine abuse    aphasia
    parkinson's disease    dementia    tauopathy    frontotemporal dementia
    alzheimer's disease    medulloblastoma    down syndrome    neuronitis
    glaucoma    schizophrenia    retinitis    cerebritis

    3 diseases from the University of Copenhagen DISEASES database for SNCB:
    Lewy body dementia     Parkinson's disease     Multiple system atrophy

    SNCB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/11 Novoseek inferred disease relationships for SNCB gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 79.9 15 11683992 (1), 17381514 (1), 17681539 (1), 10557341 (1) (see all 14)
    neurodegenerative diseases 73.8 7 11091093 (1), 11683992 (1), 17681539 (1), 11474193 (1) (see all 7)
    multiple system atrophy 71.1 1 14534420 (1)
    lewy body disease 69.5 1 17381514 (1)
    dementia 64.5 6 17652097 (2), 17681539 (1), 10557341 (1), 15365127 (1) (see all 5)
    neurodegeneration 63.2 4 11474193 (2), 19246516 (1), 11683992 (1)
    alzheimers disease 60.5 1 10557341 (1)
    parkinsonism 56.5 2 15026413 (1)
    fibrillation 51.8 6 15966733 (5), 17381514 (1)
    neurological disorders 0 1 10557341 (1)

    Genetic Association Database (GAD): SNCB
    Human Genome Epidemiology (HuGE) Navigator: SNCB (4 documents)

    Export disorders for SNCB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNCB gene, integrated from 9 sources (see all 119):
    (articles sorted by number of sources associating them with SNCB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and expression of the human beta-synuclein gene (SNCB). (PubMed id 9806846)1, 2, 3, 9 Lavedan C.... Polymeropoulos M.H. (1998)
    2. Beta-synuclein gene variants and Parkinson's disease: a preliminary case-control study. (PubMed id 17556099)1, 4, 9 Brighina L....Maraganore D.M. (2007)
    3. Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35. (PubMed id 7558013)1, 3, 9 Spillantini M.G....Goedert M. (1995)
    4. Identification of two distinct synucleins from human brain. (PubMed id 8194594)1, 2, 9 Jakes R.... Goedert M. (1994)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. (PubMed id 10852916)1, 2 Pronin A.N.... Benovic J.L. (2000)
    7. beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor. (PubMed id 11683992)1, 9 Hashimoto M....Masliah E. (2001)
    8. beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein. (PubMed id 15591046)1, 9 Snyder H....Wolozin B. (2005)
    9. Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease. (PubMed id 12867415)1, 9 da Costa C.A....Checler F. (2003)
    10. Expression of beta-synuclein in normal human astrocytes. (PubMed id 11588588)1, 9 Tanji K....Wakabayashi K. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6620 HGNC: 11140 AceView: SNCB Ensembl:ENSG00000074317 euGenes: HUgn6620
    ECgene: SNCB H-InvDB: SNCB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNCB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SNCB gene:
    Search GeneIP for patents involving SNCB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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