External Ids for SNCB Gene
Previous GeneCards Identifiers for SNCB Gene
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SNCB Gene
SNCB (Synuclein, Beta) is a Protein Coding gene. Diseases associated with SNCB include dementia, lewy body and tauopathy. Among its related pathways are Neuroscience. GO annotations related to this gene include calcium ion binding and alpha-tubulin binding. An important paralog of this gene is SNCA.
UniProtKB/Swiss-Prot for SNCB Gene
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease