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Aliases for SNCB Gene

Aliases for SNCB Gene

  • Synuclein, Beta 2 3
  • Beta-Synuclein 3

External Ids for SNCB Gene

Previous GeneCards Identifiers for SNCB Gene

  • GC05M176394
  • GC05M176866
  • GC05M175982
  • GC05M176028
  • GC05M175979
  • GC05M176047
  • GC05M170970

Summaries for SNCB Gene

Entrez Gene Summary for SNCB Gene

  • The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNCB Gene

SNCB (Synuclein, Beta) is a Protein Coding gene. Diseases associated with SNCB include dementia, lewy body and tauopathy. Among its related pathways are Neuroscience. GO annotations related to this gene include calcium ion binding and alpha-tubulin binding. An important paralog of this gene is SNCA.

UniProtKB/Swiss-Prot for SNCB Gene

  • Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease

Gene Wiki entry for SNCB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNCB Gene

Genomics for SNCB Gene

Regulatory Elements for SNCB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SNCB Gene

Start:
176,620,084 bp from pter
End:
176,630,556 bp from pter
Size:
10,473 bases
Orientation:
Minus strand

Genomic View for SNCB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNCB Gene

Proteins for SNCB Gene

  • Protein details for SNCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16143-SYUB_HUMAN
    Recommended name:
    Beta-synuclein
    Protein Accession:
    Q16143
    Secondary Accessions:
    • Q6IAX7

    Protein attributes for SNCB Gene

    Size:
    134 amino acids
    Molecular mass:
    14288 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SNCB Gene

Proteomics data for SNCB Gene at MOPED

Post-translational modifications for SNCB Gene

  • Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNCB Gene

Antibody Products

  • R&D Systems Antibodies for SNCB (Synuclein-beta)
  • Cell Signaling Technology (CST) Antibodies for SNCB (SNCB)

No data available for DME Specific Peptides for SNCB Gene

Domains for SNCB Gene

Protein Domains for SNCB Gene

Suggested Antigen Peptide Sequences for SNCB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16143

UniProtKB/Swiss-Prot:

SYUB_HUMAN :
  • Q16143
Family:
  • Belongs to the synuclein family.
genes like me logo Genes that share domains with SNCB: view

No data available for Gene Families for SNCB Gene

Function for SNCB Gene

Molecular function for SNCB Gene

GENATLAS Biochemistry: beta synuclein,19kDa,homolog to bovine phosphoneuroprotein (PNP14),non A/beta component of Alzheimer amyloid precursor,beta,expressed in presynaptic nerve terminals in various areas of the brain,including substantia nigra but not the corpus callosum and the caudate nucleus,putatively involved in exocytosis of synaptic vesicles
UniProtKB/Swiss-Prot Function: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease

Gene Ontology (GO) - Molecular Function for SNCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity TAS 9806846
GO:0005509 calcium ion binding IDA 11312271
GO:0043014 alpha-tubulin binding IEA --
GO:0048487 beta-tubulin binding IEA --
genes like me logo Genes that share ontologies with SNCB: view
genes like me logo Genes that share phenotypes with SNCB: view

Animal Models for SNCB Gene

MGI Knock Outs for SNCB:

miRNA for SNCB Gene

miRTarBase miRNAs that target SNCB

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SNCB Gene

Localization for SNCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNCB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNCB Gene COMPARTMENTS Subcellular localization image for SNCB gene
Compartment Confidence
golgi apparatus 4
nucleus 4
cytosol 3
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SNCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with SNCB: view

Pathways for SNCB Gene

SuperPathways for SNCB Gene

Superpath Contained pathways
1 Neuroscience
genes like me logo Genes that share pathways with SNCB: view

Pathways by source for SNCB Gene

1 Cell Signaling Technology pathway for SNCB Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SNCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission IEA --
GO:0042417 dopamine metabolic process IEA --
GO:0043086 negative regulation of catalytic activity TAS 9806846
GO:0043524 negative regulation of neuron apoptotic process IEA --
GO:0050808 synapse organization IEA --
genes like me logo Genes that share ontologies with SNCB: view

Compounds for SNCB Gene

(1) HMDB Compounds for SNCB Gene

Compound Synonyms Cas Number PubMed IDs
Iron
  • Armco iron
7439-89-6

(5) Novoseek inferred chemical compound relationships for SNCB Gene

Compound -log(P) Hits PubMed IDs
lipid 1.39 4
iron 1.31 1
h2o2 0.216 1
calcium 0 1
superoxide 0 1
genes like me logo Genes that share compounds with SNCB: view

Transcripts for SNCB Gene

Unigene Clusters for SNCB Gene

Synuclein, beta:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SNCB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNCB Gene

No ASD Table

Relevant External Links for SNCB Gene

GeneLoc Exon Structure for
SNCB
ECgene alternative splicing isoforms for
SNCB

Expression for SNCB Gene

mRNA expression in normal human tissues for SNCB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNCB Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.5), Brain - Cortex (8.2), Brain - Anterior cingulate cortex (BA24) (7.1), Brain - Amygdala (5.4), Brain - Cerebellar Hemisphere (4.6), Brain - Cerebellum (4.5), and Brain - Hippocampus (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SNCB Gene

SOURCE GeneReport for Unigene cluster for SNCB Gene Hs.90297

mRNA Expression by UniProt/SwissProt for SNCB Gene

Q16143-SYUB_HUMAN
Tissue specificity: Expressed predominantly in brain; concentrated in presynaptic nerve terminals
genes like me logo Genes that share expressions with SNCB: view

In Situ Assay Products

Orthologs for SNCB Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNCB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNCB 35
  • 99.5 (n)
  • 100 (a)
SNCB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNCB 35
  • 91.93 (n)
  • 97.66 (a)
SNCB 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNCB 35
  • 92.91 (n)
  • 97.64 (a)
SNCB 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sncb 35
  • 90.03 (n)
  • 97.64 (a)
Sncb 16
Sncb 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNCB 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sncb 35
  • 91.15 (n)
  • 97.66 (a)
chicken
(Gallus gallus)
Aves SNCB 35
  • 80.58 (n)
  • 86.61 (a)
SNCB 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNCB 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14705 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sncb 35
  • 76.82 (n)
  • 85.16 (a)
zebrafish
(Danio rerio)
Actinopterygii sncb 35
  • 69.28 (n)
  • 70.43 (a)
sncb 36
  • 72 (a)
OneToOne
zgc66343 35
Species with no ortholog for SNCB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNCB Gene

ENSEMBL:
Gene Tree for SNCB (if available)
TreeFam:
Gene Tree for SNCB (if available)

Paralogs for SNCB Gene

Paralogs for SNCB Gene

Selected SIMAP similar genes for SNCB Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SNCB: view

Variants for SNCB Gene

Sequence variations from dbSNP and Humsavar for SNCB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs923321 -- 176,621,957(-) ACATA(C/T)ATGTG intron-variant
rs923322 -- 176,625,370(+) gccaa(A/C)aatct intron-variant
rs970094 -- 176,621,862(-) AGCGG(G/T)TGGGG intron-variant
rs1009655 -- 176,622,147(+) CAGCG(C/T)CAGCT intron-variant
rs1801347 -- 176,620,438(-) CAGAG(C/T)ACCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SNCB Gene

Variant ID Type Subtype PubMed ID
dgv6375n71 CNV Loss 21882294
nsv883144 CNV Loss 21882294
nsv883145 CNV Loss 21882294

Relevant External Links for SNCB Gene

HapMap Linkage Disequilibrium report
SNCB
Human Gene Mutation Database (HGMD)
SNCB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNCB Gene

Disorders for SNCB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (5) Diseases for SNCB Gene including...

Search for SNCB Gene in MalaCards »

(1) OMIM Diseases for SNCB Gene (602569)

(3) University of Copenhagen DISEASES for SNCB Gene

(11) Novoseek inferred disease relationships for SNCB Gene

Disease -log(P) Hits PubMed IDs
parkinson disease 79.9 14
neurodegenerative diseases 73.8 7
multiple system atrophy 71.1 1
lewy body disease 69.5 1
dementia 64.5 6

Relevant External Links for SNCB

Genetic Association Database (GAD)
SNCB
Human Genome Epidemiology (HuGE) Navigator
SNCB
genes like me logo Genes that share disorders with SNCB: view

No data available for UniProtKB/Swiss-Prot for SNCB Gene

Publications for SNCB Gene

  1. Genomic organization and expression of the human beta-synuclein gene (SNCB). (PMID: 9806846) Lavedan C. … Polymeropoulos M.H. (Genomics 1998) 2 3 4 23
  2. Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35. (PMID: 7558013) Spillantini M.G. … Goedert M. (Genomics 1995) 2 3 23
  3. Identification of two distinct synucleins from human brain. (PMID: 8194594) Jakes R. … Goedert M. (FEBS Lett. 1994) 3 4 23
  4. Beta-synuclein gene variants and Parkinson's disease: a preliminary case-control study. (PMID: 17556099) Brighina L. … Maraganore D.M. (Neurosci. Lett. 2007) 3 23 48
  5. Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease. (PMID: 11578596) Rockenstein E. … Masliah E. (Brain Res. 2001) 3 23

Products for SNCB Gene

Sources for SNCB Gene

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