Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SNCB Gene

protein-coding   GIFtS: 63
GCID: GC05M176047

synuclein, beta
 Explore 21 diseases affiliated with
SNCB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SNCB    

Aliases
for SNCB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Synuclein, Beta1 2
Beta-Synuclein1

External Ids:    HGNC: 111401   Entrez Gene: 66202   Ensembl: ENSG000000743177   OMIM: 6025695   UniProtKB: Q161433   

Export aliases for SNCB gene to outside databases

Previous GC identifers: GC05M176394 GC05M176866 GC05M175982 GC05M176028 GC05M175979 GC05M170970


Summaries
for SNCB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SNCB:
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in
the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal
plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to
be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson
disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the
same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SYUB_HUMAN, Q16143
Function: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA
aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation
in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found
in the Lewy bodies associated with Parkinson disease

Gene Wiki entry for SNCB (Beta-synuclein)


Genomic Views
for SNCB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNCB gene promoter:
         SRF   p53   SRF (504 AA)   NRSF form 1   Pax-2   Pax-2a   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SNCB promoter sequence
   Search SABiosciences Chromatin IP Primers for SNCB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNCB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35

SNCB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNCB gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176047:  view genomic region     (about GC identifiers)

Start:
 176,047,085 bp from pter      End:
 176,057,557 bp from pter
Size:
 10,473 bases      Orientation:
 minus strand

Proteins
for SNCB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SYUB_HUMAN, Q16143 (See protein sequence)
Recommended Name: Beta-synuclein  
Size: 134 amino acids; 14288 Da
Subcellular location: Cytoplasm
Secondary accessions: Q6IAX7

Explore the universe of human proteins at neXtProt for SNCB: NX_Q16143

Post-translational modifications:

  • Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by
    • CK1, CK2 and CaM-kinase II1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16143

    • SNCB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001502.1  NP_003076.1  

    ENSEMBL proteins: 
     ENSP00000308057   ENSP00000377296   ENSP00000424073   ENSP00000422223  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for SNCB
    OriGene Purified Proteins (see all 2): SNCB
    OriGene Protein Over-expression Lysate (see all 2): SNCB
    OriGene Custom Protein Services for SNCB 
    GenScript Custom Purified and Recombinant Proteins Services for SNCB
    Novus Biologicals SNCB Proteins
    Novus Biologicals SNCB Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SNCB
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005794Golgi apparatus IDA--


    SNCB for ontologies           About GeneDecksing



    SNCB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SNCB
    R&D Systems Antibodies for SNCB (Synuclein-beta)
    Cell Signaling Technology (CST) Antibodies for SNCB 
    OriGene Antibodies: SNCB
    OriGene Custom Antibody Services for SNCB 
    GenScript Custom Superior Antibodies Services for SNCB
    Novus Biologicals SNCB Antibodies
    Abcam antibodies for SNCB 
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for SNCB

    Assay Products for SNCB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNCB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for SNCB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SNCB for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002461 Synuclein_beta
     IPR001058 Synuclein

    Graphical View of Domain Structure for InterPro Entry Q16143

    ProtoNet protein and cluster: Q16143

    2 Blocks protein families:
    IPB001058 Synuclein signature
    IPB002461 Beta-synuclein signature


    UniProtKB/Swiss-Prot: SYUB_HUMAN, Q16143
    Similarity: Belongs to the synuclein family


    Function
    for SNCB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SYUB_HUMAN, Q16143
    Function: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA
    aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation
    in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found
    in the Lewy bodies associated with Parkinson disease

         Genatlas biochemistry entry for SNCB:
    beta synuclein,19kDa,homolog to bovine phosphoneuroprotein (PNP14),non A/beta component of Alzheimer amyloid
    precursor,beta,expressed in presynaptic nerve terminals in various areas of the brain,including substantia nigra but
    not the corpus callosum and the caudate nucleus,putatively involved in exocytosis of synaptic vesicles

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): SNCB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNCB
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SNCB (see all 12):
    hsa-miR-185* hsa-miR-330-5p hsa-miR-222 hsa-miR-221 hsa-miR-218 hsa-miR-664 hsa-miR-637 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: SNCB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNCB (see all 7)
    OriGene shRNA RFP: SNCB
    OriGene siRNA: SNCB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNCB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SNCB

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNCB (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNCB (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SNCB (NM_003085)
    Sino Biological Human cDNA Clone for SNCB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNCB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCB 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SNCB
    Search LifeMap BioReagents cell lines for SNCB

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNCB

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity TAS9806846
    GO:0005509calcium ion binding IDA11312271
    GO:0043014alpha-tubulin binding IEA--
    GO:0048487beta-tubulin binding IEA--


    SNCB for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SNCB:
     Actin fiber cells 

    Animal Models:
         Mouse knock-out Sncbtm1.1Sud for SNCB
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sncb):
     growth/size  homeostasis/metabolism  mortality/aging  nervous system  no phenotypic analysis 
     normal 

    SNCB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SNCB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    		Neuroscience1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SNCB
        Neuroscience



    SNCB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNCB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/11 Interacting proteins for SNCB (Q161432, 3 ENSP000003080574) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    CENPTQ96BT32, 3, ENSP000002191724MINT-64283 I2D: score=4 STRING: ENSP00000219172
    APPP050673, ENSP000002849814I2D: score=2 STRING: ENSP00000284981
    GRK6P432503, ENSP000003772044I2D: score=1 STRING: ENSP00000377204
    HSPA1BP081073I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission IEA--
    GO:0042417dopamine metabolic process IEA--
    GO:0043524negative regulation of neuron apoptotic process IEA--
    GO:0050808synapse organization IEA--


    SNCB for ontologies           About GeneDecksing



    Drugs & Compounds
    for SNCB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SNCB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNCB

    1 HMDB Compound for SNCB    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--
    5 Novoseek chemical compound relationships for SNCB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 1.39 4 16597821 (2), 18436957 (1), 17653558 (1)
    iron 1.31 1 10208537 (1)
    h2o2 0.216 2 11790792 (1)
    calcium 0 2 12358748 (1)
    superoxide 0 1 19482226 (1)

    Search CenterWatch for drugs/clinical trials and news about SNCB / SYUB 

    Transcripts
    for SNCB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SNCB gene (2 alternative transcripts): 
    NM_001001502.1  NM_003085.3  

    Unigene Cluster for SNCB:

    Synuclein, beta
    Hs.90297  [show with all ESTs]
    Unigene Representative Sequence: BI818916
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310112(uc003mep.3 uc021yig.1 uc021yih.1) ENST00000393693(uc003meq.3 uc021yii.1 uc021yij.1)
    ENST00000510387 ENST00000506696 ENST00000508006(uc010jke.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): SNCB
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SNCB
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate SNCB (see all 12):
    hsa-miR-185* hsa-miR-330-5p hsa-miR-222 hsa-miR-221 hsa-miR-218 hsa-miR-664 hsa-miR-637 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: SNCB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNCB (see all 7)
    OriGene shRNA RFP: SNCB
    OriGene siRNA: SNCB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNCB
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNCB (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNCB (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SNCB (NM_003085)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SNCB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCB 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNCB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNCB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNCB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNCB

    Additional cDNA sequence: 

    AK309135.1 BC002902.2 BT006627.1 CR457027.1 JF960950.1 JF960951.1 JF960952.1 JF960953.1 
    S69965.1 

    7 DOTS entries:

    DT.452537  DT.100778430  DT.99978225  DT.100778432  DT.91801287  DT.95276308  DT.97846440 

    24/95 AceView cDNA sequences (see all 95):

    BQ128090 AA495769 AA421586 NM_003085 S69965 AI937874 BM543516 CB154736 
    CR594995 NM_001001502 CB154855 BF525773 CB154497 BM309966 BM693987 CB154491 
    H19290 BM548600 BC002902 BM702230 BM684126 BM544405 BX101058 BM692337 

    GeneLoc Exon Structure


    Expression
    for SNCB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SNCB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATAAAGCTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SNCB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SNCB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SNCB

    SOURCE GeneReport for Unigene cluster: Hs.90297

    UniProtKB/Swiss-Prot: SYUB_HUMAN, Q16143
    Tissue specificity: Expressed predominantly in brain; concentrated in presynaptic nerve terminals

        SABiosciences Expression via Pathway-Focused PCR Array including SNCB: 
              Alzheimer's Disease in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNCB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SNCB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNCB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNCB
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNCB

    Orthologs
    for SNCB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SNCB gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sncb1 , 5 synuclein, beta1, 5 89.72(n)1
    97.74(a)1    		   13 (29.28 cM)5
    1040691  NM_033610.21  NP_291088.11 
     547588605 
    chicken
    (Gallus gallus)    		 Aves SNCB1 synuclein, beta 80.7(n)
    87.22(a)    		   395391  NM_204671.1  NP_990002.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SNCB6
    		 --
    		 83(a)
    		 1 ↔ 1
    		 GL343526.1(400339-432460)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.147052 Xenopus laevis transcribed sequence with moderate similarity more 78(n)    CD328779.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc663432 similar to synuclein, beta 74.65(n)   393944  BC055608.1 


    ENSEMBL Gene Tree for SNCB (if available)
    TreeFam Gene Tree for SNCB (if available) 

    Paralogs
    for SNCB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SNCB gene
    SNCA2  SNCG2  
    3 SIMAP similar genes for SNCB using alignment to 3 protein entries:     SYUB_HUMAN (see all proteins):
    NACP    SNCG    SNCA

    SNCB for paralogs           About GeneDecksing



    Genomic Variants
    for SNCB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/191 NCBI SNPs in SNCB are shown (see all 191)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1048939361,2
    		Cpathogenic173065196(-) GAGCTA/GTGTTC 4 M V mis10--------
    rs1048939371,2
    		C,F,pathogenic173070368(-) CCCACC/ACCAGG 4 /H /P mis12Minor allele frequency- A:0.00NA EU 5559
    rs1114432521,2
    		--170970607(+) GGGTCC/TGCACG 2 -- ds50012Minor allele frequency- T:0.07CSA WA 120
    rs733321231,2
    		C,--170971139(+) GGGGGG/ACGGGG 2 -- ut312Minor allele frequency- A:0.02WA NA 122
    rs763680191,2
    		C,F,--170971736(+) TAGCAC/TATTCC 2 -- int13Minor allele frequency- T:0.12CSA WA 125
    rs1127547731,2
    		--170972551(+) GTGTGA/GCCTCG 2 -- int10--------
    rs119488481,2
    		C,F,H,--170972890(+) GACCAC/TGTCTG 2 -- int16Minor allele frequency- T:0.03NS EA CSA WA 540
    rs1129630211,2
    		--170973513(+) CTTCAC/TGATGA 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs749342081,2
    		--170974244(+) CCAGAC/TACCTC 2 -- int13Minor allele frequency- T:0.10CSA WA 121
    rs768388501,2
    		--170976186(+) TTTACA/CAGTGA 2 -- int11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for SNCB (176047085 - 176057557 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SNCB: --
    Human Gene Mutation Database (HGMD): SNCB

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNCB
    DNA2.0 Custom Variant and Variant Library Synthesis for SNCB

    Disorders / Diseases
    for SNCB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SNCB for disorders           About GeneDecksing

    OMIM gene information: 602569   
    OMIM disorders: 127750  
    20/21 diseases for SNCB (see all 21):    About MalaCards
    parkinson's disease    alzheimer's disease    lewy body dementia    multiple system atrophy
    cocaine abuse    corpus callosum    frontotemporal dementia    neuronitis
    dementia    neurodegenerative disease    aphasia    neurodegeneration
    tauopathy    glaucoma    down syndrome    medulloblastoma
    ovarian carcinoma    cerebritis    retinitis    schizophrenia

    3 diseases from the University of Copenhagen DISEASES database for SNCB:
    Lewy body dementia     Parkinson's disease     Multiple system atrophy

    10/11 Novoseek disease relationships for SNCB gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 79.9 15 11683992 (1), 17381514 (1), 17681539 (1), 10557341 (1) (see all 14)
    neurodegenerative diseases 73.8 7 11091093 (1), 11683992 (1), 17681539 (1), 11474193 (1) (see all 7)
    multiple system atrophy 71.1 1 14534420 (1)
    lewy body disease 69.5 1 17381514 (1)
    dementia 64.5 6 17652097 (2), 17681539 (1), 10557341 (1), 15365127 (1) (see all 5)
    neurodegeneration 63.2 4 11474193 (2), 19246516 (1), 11683992 (1)
    alzheimers disease 60.5 1 10557341 (1)
    parkinsonism 56.5 2 15026413 (1)
    fibrillation 51.8 6 15966733 (5), 17381514 (1)
    neurological disorders 0 1 10557341 (1)

    Human Genome Epidemiology (HuGE) Navigator: SNCB (4 documents)

    Export disorders for SNCB gene to outside databases

    Publications
    for SNCB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SNCB gene, integrated from 9 sources (see all 117):
    (articles sorted by number of sources associating them with SNCB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and expression of the human beta-synuclein gene (SNCB). (PubMed id 9806846)1, 2, 3, 9 Lavedan C.... Polymeropoulos M.H. (1998)
    2. Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35. (PubMed id 7558013)1, 3, 9 Spillantini M.G....Goedert M. (1995)
    3. Identification of two distinct synucleins from human brain. (PubMed id 8194594)1, 2, 9 Jakes R.... Goedert M. (1994)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. (PubMed id 10852916)1, 2 Pronin A.N.... Benovic J.L. (2000)
    6. beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor. (PubMed id 11683992)1, 9 Hashimoto M....Masliah E. (2001)
    7. beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein. (PubMed id 15591046)1, 9 Snyder H....Wolozin B. (2005)
    8. Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease. (PubMed id 12867415)1, 9 da Costa C.A....Checler F. (2003)
    9. Expression of beta-synuclein in normal human astrocytes. (PubMed id 11588588)1, 9 Tanji K....Wakabayashi K. (2001)
    10. Molecular determinants of the aggregation behavior of alpha- and beta-synuclein. (PubMed id 18436957)1, 9 Rivers R.C....Christodoulou J. (2008)

    External Searches for SNCB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SNCB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6620 HGNC: 11140 AceView: SNCB Ensembl:ENSG00000074317 euGenes: HUgn6620
    ECgene: SNCB H-InvDB: SNCB

    Other Databases showing SNCB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SNCB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SNCB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SNCB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SNCB gene:
    Search GeneIP for patents involving SNCB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SNCB gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SNCB
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for SNCB (Synuclein-beta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for SNCB   OriGene shRNA RFP for SNCB  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SNCB   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SNCB  
     OriGene Protein Over-expression Lysate for SNCB   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SNCB   OriGene 3'-UTR Clone for SNCB  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SNCB   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SNCB  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SNCB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SNCB   OriGene Custom Protein Services for SNCB  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SNCB
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SNCB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SNCB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SNCB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SNCB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SNCB
     GenScript Custom Purified and Recombinant Proteins Services for SNCB GenScript cDNA clones with any tag delivered in your preferred vector for SNCB
     GenScript Custom Assay Services for SNCB GenScript Custom Superior Antibodies Services for SNCB
     GenScript Custom overexpressing Cell Line Services for SNCB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for SNCB 

     Regulatory tfbs in SNCB promoter
     Search Chromatin IP Primers for SNCB
     RT2 qPCR Primer Assay in human, mouse, rat SNCB
     GNC Network for SNCB
     SABiosciences PCR Arrays including human, mouse, rat SNCB
     Search Tocris compounds for SNCB
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for SNCB
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Proteins for SNCB
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SNCB antibodies
     SNCB proteins
     SNCB lysates
     Antibodies for SNCB
     See all of Abcam's Antibodies, Kits and Proteins for SNCB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SNCB




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for SNCB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SNCB
     SwitchGear 3'UTR luciferase reporter plasmids for SNCB
     SwitchGear Promoter luciferase reporter plasmids for SNCB
     ThermoFisher Antibodies for SNCB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SNCB
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SNCB gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4