Aliases for SNCAIP Gene
External Ids for SNCAIP Gene
Previous GeneCards Identifiers for SNCAIP Gene
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
GeneCards Summary for SNCAIP Gene
SNCAIP (Synuclein Alpha Interacting Protein) is a Protein Coding gene. Diseases associated with SNCAIP include synucleinopathy and dementia, lewy body. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Chks in Checkpoint Regulation. GO annotations related to this gene include identical protein binding and ubiquitin protein ligase binding.
UniProtKB/Swiss-Prot for SNCAIP Gene
Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.