Aliases for SNCAIP Gene
External Ids for SNCAIP Gene
Previous GeneCards Identifiers for SNCAIP Gene
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2011]
GeneCards Summary for SNCAIP Gene
SNCAIP (Synuclein, Alpha Interacting Protein) is a Protein Coding gene. Diseases associated with SNCAIP include synucleinopathy and lrrk2-related parkinson disease. Among its related pathways are Proteolysis_Putative ubiquitin pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include ubiquitin protein ligase binding.
UniProtKB/Swiss-Prot for SNCAIP Gene
Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.